Development Level

Tbio 20 | 10,625
Tchem 15 | 1,890
Tdark 2 | 7,003

IMPC Term

decreased total body fat amoun... 5 | 186
abnormal behavior 3 | 226
decreased body length 3 | 108
decreased lean body mass 3 | 195
decreased prepulse inhibition 3 | 52
increased grip strength 3 | 83
decreased circulating HDL chol... 2 | 77
increased bone mineral content 2 | 92
increased lean body mass 2 | 107
preweaning lethality, complete... 2 | 633
short tibia 2 | 82
abnormal bone mineralization 1 | 55
abnormal bone structure 1 | 131
abnormal gait 1 | 51
abnormal locomotor activation 1 | 26
abnormal pancreas morphology 1 | 6
abnormal retina morphology 1 | 100
abnormal retinal pigmentation 1 | 61
abnormal seminal vesicle morph... 1 | 47
abnormal startle reflex 1 | 14
cardiovascular system phenotyp... 1 | 35
corneal opacity 1 | 25
decreased body weight 1 | 174
decreased bone mineral content 1 | 157
decreased bone mineral density 1 | 126
decreased circulating LDL chol... 1 | 37
decreased circulating alanine ... 1 | 53
decreased circulating alkaline... 1 | 41
decreased circulating choleste... 1 | 85
decreased circulating iron lev... 1 | 25
decreased circulating serum al... 1 | 79
decreased eosinophil cell numb... 1 | 41
decreased erythrocyte cell num... 1 | 43
decreased hematocrit 1 | 25
decreased hemoglobin content 1 | 53
decreased leukocyte cell numbe... 1 | 54
decreased mean corpuscular vol... 1 | 50
decreased rib number 1 | 59
enlarged spleen 1 | 26
hydrometra 1 | 13
hypoactivity 1 | 89
increased blood urea nitrogen ... 1 | 44
increased bone mineral density 1 | 52
increased circulating HDL chol... 1 | 63
increased circulating LDL chol... 1 | 15
increased circulating amylase ... 1 | 13
increased circulating triglyce... 1 | 24
increased mean corpuscular hem... 1 | 93
increased mean platelet volume 1 | 19
increased neutrophil cell numb... 1 | 15
increased sacral vertebrae num... 1 | 62
limb grasping 1 | 35
male infertility 1 | 62
prolonged QRS complex duration 1 | 2
shortened RR interval 1 | 19
small testis 1 | 37
thrombocytopenia 1 | 46

Disease

osteosarcoma 24 | 7,933
ovarian cancer 21 | 8,484
Cancer 18 | 2,346
Carcinoma 15 | 2,147
medulloblastoma, large-cell 15 | 6,234
psoriasis 14 | 6,685
atypical teratoid / rhabdoid tumor 12 | 4,369
malignant mesothelioma 12 | 3,162
primitive neuroectodermal tumor 12 | 3,031
Breast cancer 11 | 3,094
glioblastoma 11 | 5,572
Pick disease 9 | 1,893
lung cancer 9 | 4,466
group 3 medulloblastoma 7 | 2,254
intraductal papillary-mucinous adenoma (IPMA) 7 | 2,956
invasive ductal carcinoma 7 | 2,950
non-small cell lung cancer 7 | 2,798
oligodendroglioma 7 | 2,849
Leukemia 6 | 88
Rheumatoid Arthritis 6 | 1,160
ependymoma 6 | 2,514
intraductal papillary-mucinous carcinoma (IPMC) 6 | 2,988
Intellectual disability 5 | 573
Kabuki syndrome 5 | 27
Mammary Neoplasms 5 | 410
ductal carcinoma in situ 5 | 1,745
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,289
medulloblastoma 5 | 1,524
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,795
pediatric high grade glioma 5 | 2,712
pilocytic astrocytoma 5 | 3,086
spina bifida 5 | 1,064
Leukemia, Myelocytic, Acute 4 | 113
Lymphoid leukemia 4 | 69
acute quadriplegic myopathy 4 | 1,157
adrenocortical carcinoma 4 | 1,427
astrocytic glioma 4 | 2,241
atypical teratoid/rhabdoid tumor 4 | 1,095
juvenile dermatomyositis 4 | 1,189
lung adenocarcinoma 4 | 2,713
posterior fossa group A ependymoma 4 | 1,511
subependymal giant cell astrocytoma 4 | 2,287
Adenoid Cystic Carcinoma 3 | 99
Bladder Neoplasm 3 | 109
Liver carcinoma 3 | 217
Myeloid Leukemia 3 | 19
Sotos syndrome 3 | 13
Weaver syndrome 3 | 6
Wolf-Hirschhorn syndrome 3 | 32
acute myeloid leukemia 3 | 780
breast carcinoma 3 | 1,614
group 4 medulloblastoma 3 | 1,875
interstitial cystitis 3 | 2,299
nasopharyngeal carcinoma 3 | 1,056
pituitary cancer 3 | 1,972
Adenocarcinoma 2 | 115
Alzheimer's disease 2 | 644
Amphetamine-Related Disorders 2 | 74
Amyotrophic Lateral Sclerosis 2 | 431
Autistic Disorder 2 | 320
Carcinoma, Transitional Cell 2 | 31
Chromosome 1p36 deletion syndrome 2 | 24
Congenital heart disease 2 | 63
Corneal staphyloma 2 | 4
Diffuse large B-cell lymphoma 2 | 41
Immune system cancer 2 | 38
Kidney cancer 2 | 118
Kleefstra syndrome 2 | 9
Left ventricular noncompaction 2 | 23
Lymphoma, Follicular 2 | 20
MYELODYSPLASTIC SYNDROME 2 | 36
Male infertility 2 | 170
Melanoma 2 | 261
Migraine Disorders 2 | 26
Phyllodes Tumor 2 | 5
Precursor Cell Lymphoblastic Leukemia Lymphoma 2 | 42
Sezary Syndrome 2 | 26
Shigellosis 2 | 16
Sotos' syndrome 2 | 3
Squamous cell carcinoma of esophagus 2 | 82
Stomach Neoplasms 2 | 282
adult high grade glioma 2 | 2,148
astrocytoma 2 | 1,493
dermatomyositis 2 | 933
gastric cancer 2 | 430
hepatocellular carcinoma 2 | 532
interstitial lung disease 2 | 291
lung carcinoma 2 | 2,844
pancreatic cancer 2 | 2,300
tuberculosis and treatment for 6 months 2 | 686
Acquired metabolic disease 1 | 267
Cardiomyopathy 1 | 110
Cardiovascular system disease 1 | 194
Degenerative polyarthritis 1 | 93
Gaucher disease type 1 1 | 171
Microcephaly 1 | 149
Osteoporosis 1 | 257
Turner syndrome 1 | 31
cystic fibrosis and chronic rhinosinusitis 1 | 213
facioscapulohumeral dystrophy 1 | 286

Tissue

Digestive Tract 37 | 18,473
Endocrine System 37 | 18,512
Female tissues 37 | 18,647
Liver and Pancreas 37 | 18,136
Nervous System 37 | 18,561
Skin and soft tissues 37 | 18,115
Urinary Tract 37 | 18,444
Blood and immune system 36 | 17,995
Cardiovascular System 36 | 17,958
Male tissues 36 | 17,969
Respiratory system 36 | 17,484

Target Family

Epigenetic 25 | 242
TF/Epigenetic 8 | 38
Non-IDG 3 | 11,971
Enzyme 1 | 4,146

GO Function

histone-lysine N-methyltransfe... 37 | 37
metal ion binding 1,917 | 1,917
ATP binding 1,467 | 1,467
DNA binding 1,432 | 1,432
zinc ion binding 1,155 | 1,155
poly(A) RNA binding 1,107 | 1,107
transcription factor activity,... 853 | 853
calcium ion binding 695 | 695
G-protein coupled receptor act... 661 | 661
protein homodimerization activ... 569 | 569
RNA binding 445 | 445
olfactory receptor activity 424 | 424
sequence-specific DNA binding 398 | 398
GTP binding 374 | 374
chromatin binding 372 | 372
protein serine/threonine kinas... 336 | 336
RNA polymerase II core promote... 332 | 332
identical protein binding 311 | 311
nucleotide binding 311 | 311
receptor binding 303 | 303
protein kinase binding 289 | 289
enzyme binding 286 | 286
cadherin binding involved in c... 277 | 277
GTPase activator activity 273 | 273
ubiquitin protein ligase bindi... 258 | 258
ubiquitin-protein transferase ... 253 | 253
serine-type endopeptidase acti... 246 | 246
transcription coactivator acti... 241 | 241
transcription factor binding 240 | 240
structural molecule activity 232 | 232
GTPase activity 231 | 231
transcriptional activator acti... 230 | 230
ligase activity 227 | 227
protein heterodimerization act... 227 | 227
structural constituent of ribo... 212 | 212
transcription regulatory regio... 202 | 202
transmembrane signaling recept... 201 | 201
RNA polymerase II regulatory r... 200 | 200
receptor activity 200 | 200
transcription corepressor acti... 198 | 198
magnesium ion binding 197 | 197
signal transducer activity 196 | 196
nucleic acid binding 184 | 184
protein kinase activity 183 | 183
carbohydrate binding 180 | 180
ubiquitin protein ligase activ... 173 | 173
RNA polymerase II transcriptio... 162 | 162
heparin binding 160 | 160
iron ion binding 141 | 141
lipid binding 136 | 136
transporter activity 136 | 136
actin binding 133 | 133
ATPase activity 132 | 132
protein C-terminus binding 129 | 129
heme binding 127 | 127
microtubule binding 123 | 123
protein tyrosine kinase activi... 119 | 119
cytokine activity 118 | 118
Ras guanyl-nucleotide exchange... 113 | 113
mRNA binding 112 | 112
metalloendopeptidase activity 112 | 112
transcriptional repressor acti... 110 | 110
structural constituent of cyto... 108 | 108
Rab GTPase binding 105 | 105
antigen binding 104 | 104
protein domain specific bindin... 102 | 102
peptide antigen binding 101 | 101
guanyl-nucleotide exchange fac... 98 | 98
protein complex binding 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 92 | 92
oxidoreductase activity 91 | 91
transcriptional activator acti... 91 | 91
actin filament binding 89 | 89
hydrolase activity 89 | 89
ion channel binding 89 | 89
protein tyrosine phosphatase a... 88 | 88
electron carrier activity 87 | 87
protease binding 87 | 87
histone binding 86 | 86
integrin binding 83 | 83
growth factor activity 82 | 82
phospholipid binding 82 | 82
single-stranded DNA binding 81 | 81
unfolded protein binding 77 | 77
kinase activity 75 | 75
thiol-dependent ubiquitin-spec... 75 | 75
phosphatidylinositol binding 74 | 74
calmodulin binding 73 | 73
histone deacetylase binding 73 | 73
Rho guanyl-nucleotide exchange... 72 | 72
drug binding 71 | 71
double-stranded DNA binding 70 | 70
peptidase activity 70 | 70
protein N-terminus binding 70 | 70
virus receptor activity 68 | 68
beta-catenin binding 67 | 67
microtubule motor activity 67 | 67
protein transporter activity 67 | 67
calcium channel activity 66 | 66
ubiquitin binding 66 | 66

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone-lysine N-methyltransferase SETD1B SETD1B Tbio Epigenetic -1.20916 14.6 78
Histone-lysine N-methyltransferase SETD1A SETD1A Tbio Epigenetic -2.53375 346.3 108
Histone-lysine N-methyltransferase 2E KMT2E Tbio Epigenetic -1.45323 38.7 150
Histone-lysine N-methyltransferase SMYD1 SMYD1 Tbio Epigenetic -1.23315 17.8 123
Histone-lysine N-methyltransferase NSD3 NSD3 Tbio Epigenetic -1.10607 15.4 192
Histone-lysine N-methyltransferase SETD2 SETD2 Tchem Epigenetic -2.76087 585.6 192
Histone-lysine N-methyltransferase SUV39H1 SUV39H1 Tchem Epigenetic -2.18679 149.4 267
Histone-lysine N-methyltransferase SETD7 SETD7 Tchem Epigenetic -2.08116 127.0 297
Histone-lysine N-methyltransferase setd3 SETD3 Tdark Epigenetic -0.41218 3.66 84
Histone-lysine N-methyltransferase SETDB2 SETDB2 Tbio TF/Epigenetic -0.84851 10.8 171