Development Level

Tbio 24 | 11,651
Tchem 12 | 1,388
Tdark 3 | 6,593

IMPC Phenotype

preweaning lethality, complete... 8 | 979
decreased prepulse inhibition 4 | 82
abnormal behavior 3 | 298
abnormal bone structure 3 | 187
decreased total body fat amoun... 3 | 207
increased lean body mass 3 | 172
increased startle reflex 3 | 112
decreased blood urea nitrogen ... 2 | 51
decreased body weight 2 | 161
decreased circulating alanine ... 2 | 47
decreased mean corpuscular vol... 2 | 79
impaired pupillary reflex 2 | 26
increased blood urea nitrogen ... 2 | 48
increased mean corpuscular hem... 2 | 96
preweaning lethality, incomple... 2 | 499
short tibia 2 | 97
abnormal coat appearance 1 | 31
abnormal embryo size 1 | 220
abnormal iris morphology 1 | 13
abnormal locomotor activation 1 | 16
abnormal optic disc morphology 1 | 10
abnormal pancreas morphology 1 | 13
abnormal pericardium morpholog... 1 | 26
abnormal retina morphology 1 | 71
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal seminal vesicle morph... 1 | 114
abnormal startle reflex 1 | 15
cardiovascular system phenotyp... 1 | 36
corneal opacity 1 | 32
decreased body length 1 | 101
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating alkaline... 1 | 46
decreased circulating choleste... 1 | 93
decreased circulating iron lev... 1 | 32
decreased circulating serum al... 1 | 82
decreased erythrocyte cell num... 1 | 62
decreased fasted circulating g... 1 | 65
decreased heart left ventricle... 1 | 28
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased leukocyte cell numbe... 1 | 73
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged spleen 1 | 41
hemorrhage 1 | 23
hydrometra 1 | 53
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
increased CD4-positive, alpha ... 1 | 4
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating LDL chol... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating amylase ... 1 | 25
increased circulating calcium ... 1 | 34
increased circulating glucose ... 1 | 24
increased circulating triglyce... 1 | 42
increased heart weight 1 | 62
increased mean corpuscular hem... 1 | 36
increased mean corpuscular vol... 1 | 92
increased mean platelet volume 1 | 45
increased neutrophil cell numb... 1 | 46
increased thermal nociceptive ... 1 | 9
increased total body fat amoun... 1 | 134
irregularly shaped pupil 1 | 7
limb grasping 1 | 41
male infertility 1 | 123
persistence of hyaloid vascula... 1 | 33
prolonged QRS complex duration 1 | 8
small spleen 1 | 19
small testis 1 | 58
thrombocytopenia 1 | 56
tremors 1 | 39
trunk curl 1 | 16

Disease

Carcinoma 33 | 11,493
osteosarcoma 25 | 7,950
ovarian cancer 22 | 8,520
Cancer 19 | 2,499
Kidney cancer 17 | 2,613
atypical teratoid / rhabdoid tumor 16 | 5,112
medulloblastoma, large-cell 16 | 6,241
Breast cancer 15 | 3,578
group 3 medulloblastoma 14 | 4,104
psoriasis 14 | 6,694
malignant mesothelioma 13 | 3,232
glioblastoma 12 | 5,792
primitive neuroectodermal tumor 12 | 3,035
lung cancer 11 | 4,740
Pick disease 9 | 1,894
ependymoma 9 | 4,679
intraductal papillary-mucinous adenoma (IPMA) 8 | 2,955
Intellectual disability 7 | 1,016
intraductal papillary-mucinous carcinoma (IPMC) 7 | 2,989
invasive ductal carcinoma 7 | 2,951
non-small cell lung cancer 7 | 2,890
oligodendroglioma 7 | 2,850
Kabuki syndrome 6 | 27
Leukemia 6 | 104
Liver cancer 6 | 604
Neurodevelopmental Disorders 6 | 70
Rheumatoid arthritis 6 | 1,191
astrocytic glioma 6 | 2,597
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,291
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,962
spina bifida 6 | 1,074
Astrocytoma, Pilocytic 5 | 3,081
Breast Neoplasms 5 | 445
Leukemia, Myelocytic, Acute 5 | 120
Lymphoid leukemia 5 | 160
Mammary Neoplasms 5 | 425
Melanoma 5 | 711
Muscle hypotonia 5 | 571
adult high grade glioma 5 | 3,801
ductal carcinoma in situ 5 | 1,745
Bladder Neoplasm 4 | 112
Cognitive delay 4 | 608
Downward slant of palpebral fissure 4 | 158
Dull intelligence 4 | 645
Endometrial cancer 4 | 311
Global developmental delay 4 | 608
Immune system cancer 4 | 140
Low intelligence 4 | 645
Mental Retardation 4 | 645
Mental and motor retardation 4 | 608
Mental deficiency 4 | 645
Orbital separation excessive 4 | 244
Poor school performance 4 | 645
Sotos syndrome 4 | 13
Strabismus 4 | 270
Urinary Bladder Neoplasms 4 | 114
acute myeloid leukemia 4 | 783
acute quadriplegic myopathy 4 | 1,158
adrenocortical carcinoma 4 | 1,428
juvenile dermatomyositis 4 | 1,187
lung adenocarcinoma 4 | 2,716
pancreatic cancer 4 | 2,398
subependymal giant cell astrocytoma 4 | 2,287
Acquired scoliosis 3 | 281
Adenoid Cystic Carcinoma 3 | 99
Byzanthine arch palate 3 | 194
Carcinoma, Adenoid Cystic 3 | 99
Carcinoma, Hepatocellular 3 | 228
Congenital Epicanthus 3 | 177
Cryptorchidism 3 | 296
Curvature of spine 3 | 282
DOID:2627 3 | 94
Dilated ventricles (finding) 3 | 121
Epilepsy 3 | 792
Failure to gain weight 3 | 365
Feeding difficulties in infancy 3 | 175
Large auricle 3 | 87
Large dysplastic ears 3 | 87
Large intestine cancer 3 | 126
Large pinnae 3 | 87
Large prominent ears 3 | 87
Large protruding ears 3 | 87
Large, floppy ears 3 | 87
Leukemia, Myeloid 3 | 18
Leukemia, Myeloid, Acute 3 | 105
Liver carcinoma 3 | 240
Macrotia 3 | 87
Myeloid Leukemia 3 | 19
Pediatric failure to thrive 3 | 365
Schizophrenia 3 | 1,160
Seizures 3 | 596
Short stature 3 | 531
Skin cancer 3 | 469
Weaver syndrome 3 | 7
Wolf-Hirschhorn syndrome 3 | 32
breast carcinoma 3 | 1,638
interstitial cystitis 3 | 2,312
pediatric high grade glioma 3 | 1,064
pituitary cancer 3 | 1,972
Speech Delay 2 | 112

Tissue

Endocrine System 39 | 18,159
Female tissues 38 | 17,400
Liver and Pancreas 38 | 16,750
Male tissues 38 | 17,142
Nervous System 38 | 16,725
Skin and soft tissues 38 | 17,230
Blood and immune system 37 | 16,909
Cardiovascular System 37 | 15,192
Digestive Tract 37 | 17,369
Urinary Tract 37 | 16,678
Respiratory system 36 | 16,393

Target Family

Epigenetic 27 | 242
TF/Epigenetic 8 | 38
Non-IDG 3 | 12,091
Enzyme 1 | 4,145

GO Function

histone-lysine N-methyltransfe... 39 | 39
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific NSD1 Tbio Epigenetic -2.16239 142.5 123
Histone-lysine N-methyltransferase SETDB2 SETDB2 Tbio TF/Epigenetic -1.05387 12.8 177
Histone-lysine N-methyltransferase SUV39H1 SUV39H1 Tchem Epigenetic -2.27556 174.3 306
Histone-lysine N-methyltransferase setd3 SETD3 Tdark Epigenetic -0.53887 4.67 95
Histone-lysine N-methyltransferase SMYD1 SMYD1 Tbio Epigenetic -1.26595 18.7 147
WD repeat-containing protein 5 WDR5 Tchem Non-IDG -2.10077 115.4 299
MDS1 and EVI1 complex locus protein EVI1 MECOM Tbio TF/Epigenetic -1.84060 124.5 317
Histone-lysine N-methyltransferase EHMT1 EHMT1 Tchem Epigenetic -2.34943 219.8 425
Histone-lysine N-methyltransferase SETDB1 SETDB1 Tbio TF/Epigenetic -2.25204 181.6 274
Histone-lysine N-methyltransferase SUV39H2 SUV39H2 Tbio Epigenetic -1.37270 21.1 301