Development Level

Tchem 3 | 1,598
Tbio 2 | 11,445

IMPC Phenotype

decreased body length 1 | 101
decreased body weight 1 | 161
decreased circulating alanine ... 1 | 47
decreased total body fat amoun... 1 | 207
increased thermal nociceptive ... 1 | 9
preweaning lethality, incomple... 1 | 499

Disease

osteosarcoma 4 | 7,950
Cancer 3 | 2,499
Carcinoma 3 | 11,493
Kidney cancer 3 | 2,613
atypical teratoid / rhabdoid tumor 3 | 5,112
ovarian cancer 3 | 8,520
Breast cancer 2 | 3,578
Pick disease 2 | 1,894
Sotos syndrome 2 | 13
Wolf-Hirschhorn syndrome 2 | 32
glioblastoma 2 | 5,792
group 3 medulloblastoma 2 | 4,104
primitive neuroectodermal tumor 2 | 3,035
Abnormally-shaped vertebrae 1 | 31
Accessory proximal metacarpal ossification centers 1 | 7
Aplasia/Hypoplasia of the lungs 1 | 13
Arachnodactyly 1 | 49
Atrial Septal Defects 1 | 85
Auricular malformation 1 | 41
Bowed and upward slanting eyebrows 1 | 41
Bowen-Conradi syndrome 1 | 16
Breast Neoplasms 1 | 445
Calvarial defect 1 | 10
Cell Transformation, Neoplastic 1 | 97
Chromosome 5, monosomy 5q35 1 | 2
Claw hand 1 | 26
Congenital anomaly of the kidney 1 | 12
Congenital deafness 1 | 185
Congenital diaphragmatic hernia 1 | 67
Congenital ectopic pupil 1 | 7
Convex nasal ridge 1 | 37
Cranial defect 1 | 10
Deafness 1 | 198
Decreased muscle mass 1 | 28
Dilated ventricles (finding) 1 | 121
Downturned corners of mouth 1 | 48
Downward slant of palpebral fissure 1 | 158
Fused vertebrae 1 | 25
Generalized hypotonia 1 | 37
Hearing Loss, Partial 1 | 185
Heart valve disease 1 | 39
Hemangioma 1 | 69
High anterior hairline 1 | 7
High forehead 1 | 102
Hyperconvex fingernails 1 | 7
Hyperkyphosis 1 | 111
Hypodontia 1 | 81
Hypoplasia of thumb 1 | 26
Immunodeficiency with hyper-IgM type 2 1 | 3
Kidney Diseases 1 | 114
Kyphosis deformity of spine 1 | 114
Learning disability 1 | 17
Leukemia, Myelocytic, Acute 1 | 120
Long narrow head 1 | 75
Low posterior hairline 1 | 52
Macrocephaly 1 | 11
Mammary Neoplasms 1 | 425
Mastitis 1 | 48
Metatarsus Varus 1 | 24
Monoclonal gammopathy of uncertain significance 1 | 4
Narrow cranium shape 1 | 75
Narrow head shape 1 | 75
Narrow skull shape 1 | 75
Narrowing of ear canal 1 | 13
Neoplastic Cell Transformation 1 | 89
Penile hypospadias 1 | 106
Periventricular cysts 1 | 7
Polydactyly preaxial type 1 1 | 9
Preauricular Fistulae, Congenital 1 | 27
Preauricular dimple 1 | 27
Preauricular sinus 1 | 27
Preauricular skin tag 1 | 19
Precocious Puberty 1 | 28
Radioulnar synostosis 1 | 35
Rib fusion 1 | 16
Rib segmentation abnormalities 1 | 8
Rieger syndrome 1 | 8
Scoliosis 1 | 44
Severe postnatal growth retardation 1 | 16
Short hallux 1 | 16
Short philtrum 1 | 53
Short upper lip 1 | 7
Simple ear 1 | 41
Skin tag on the posterior cheek 1 | 19
Skull defect 1 | 10
Sotos' syndrome 1 | 3
Spinal fusion 1 | 25
Stenosis of external auditory canal 1 | 13
Stereotyped Behavior 1 | 37
Stereotypic Movement Disorder 1 | 42
Tall forehead 1 | 102
Tethered Cord Syndrome 1 | 7
Thick, flared eyebrows 1 | 41
Toeing-in 1 | 24
Turridolichocephaly 1 | 75
Type 1 diabetes mellitus 4 1 | 7
VALVULAR ABNORMALITY 1 | 12
Vertebral body fusion 1 | 25
Weaver syndrome 1 | 7
hearing impairment 1 | 199

Tissue

Blood and immune system 5 | 16,909
Cardiovascular System 5 | 15,192
Digestive Tract 5 | 17,369
Endocrine System 5 | 18,159
Female tissues 5 | 17,400
Liver and Pancreas 5 | 16,750
Male tissues 5 | 17,142
Nervous System 5 | 16,725
Respiratory system 5 | 16,393
Skin and soft tissues 5 | 17,230
Urinary Tract 5 | 16,678

Target Family

Epigenetic 4 | 242
TF/Epigenetic 1 | 38

GO Function

histone methyltransferase acti... 5 | 5
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone-lysine N-methyltransferase KMT5C KMT5C Tchem Epigenetic 1.18 0.06 46
Histone-lysine N-methyltransferase NSD2 NSD2 Tbio TF/Epigenetic -2.43336 275.2 123
N-lysine methyltransferase KMT5A KMT5A Tchem Epigenetic -1.89071 71.7 420
Histone-lysine N-methyltransferase KMT5B KMT5B Tchem Epigenetic -1.20275 14.3 158
Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific NSD1 Tbio Epigenetic -2.16239 142.5 123