Development Level

Tbio 6 | 11,445
Tchem 1 | 1,598
Tdark 1 | 6,588

IMPC Phenotype

preweaning lethality, complete... 3 | 979
decreased total body fat amoun... 2 | 207
abnormal behavior 1 | 298
abnormal bone structure 1 | 187
abnormal coat appearance 1 | 31
abnormal pancreas morphology 1 | 13
abnormal seminal vesicle morph... 1 | 114
abnormal vertebrae morphology 1 | 18
cardiovascular system phenotyp... 1 | 36
decreased body weight 1 | 161
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating alanine ... 1 | 47
decreased circulating alkaline... 1 | 46
decreased circulating choleste... 1 | 93
decreased circulating glycerol... 1 | 16
decreased leukocyte cell numbe... 1 | 73
decreased prepulse inhibition 1 | 82
enlarged spleen 1 | 41
hydrometra 1 | 53
impaired pupillary reflex 1 | 26
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating alkaline... 1 | 122
increased circulating triglyce... 1 | 42
increased heart weight 1 | 62
increased lean body mass 1 | 172
increased startle reflex 1 | 112
short tibia 1 | 97
small testis 1 | 58
tremors 1 | 39

Disease

Carcinoma 7 | 11,493
Kidney cancer 6 | 2,613
Cancer 5 | 2,499
Liver cancer 5 | 604
osteosarcoma 5 | 7,950
psoriasis 5 | 6,694
Breast cancer 4 | 3,578
medulloblastoma, large-cell 4 | 6,241
ovarian cancer 4 | 8,520
Bladder Neoplasm 3 | 112
Carcinoma, Hepatocellular 3 | 228
Intellectual disability 3 | 1,016
Liver carcinoma 3 | 240
Lymphoid leukemia 3 | 160
Neurodevelopmental Disorders 3 | 70
Urinary Bladder Neoplasms 3 | 114
atypical teratoid / rhabdoid tumor 3 | 5,112
glioblastoma 3 | 5,792
malignant mesothelioma 3 | 3,232
spina bifida 3 | 1,074
Adenocarcinoma 2 | 122
Byzanthine arch palate 2 | 194
Carcinoma, Transitional Cell 2 | 32
Corneal staphyloma 2 | 5
DOID:2627 2 | 94
Dull intelligence 2 | 645
Endometrial cancer 2 | 311
Esophageal Squamous Cell Carcinoma 2 | 77
Failure to gain weight 2 | 365
Immune system cancer 2 | 140
Kabuki syndrome 2 | 27
Large intestine cancer 2 | 126
Leukemia, Myelocytic, Acute 2 | 120
Leukemia, Myeloid, Acute 2 | 105
Low intelligence 2 | 645
Mental Retardation 2 | 645
Mental deficiency 2 | 645
Muscle hypotonia 2 | 571
Pediatric failure to thrive 2 | 365
Pick disease 2 | 1,894
Poor school performance 2 | 645
Schizophrenia 2 | 1,160
Sezary Syndrome 2 | 27
Short middle phalanges 2 | 12
Short stature 2 | 531
Skin cancer 2 | 469
Squamous cell carcinoma of esophagus 2 | 77
Stomach Neoplasms 2 | 300
Strabismus 2 | 270
acute myeloid leukemia 2 | 783
adult high grade glioma 2 | 3,801
astrocytic glioma 2 | 2,597
group 3 medulloblastoma 2 | 4,104
group 4 medulloblastoma 2 | 1,855
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 2 | 3,291
oligodendroglioma 2 | 2,850
pancreatic cancer 2 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962
posterior fossa group B ependymoma 2 | 416
primitive neuroectodermal tumor 2 | 3,035
Acute monocytic leukemia 1 | 13
Anemia, Hemolytic 1 | 55
Atrial Septal Defects 1 | 85
Autoimmune thrombocytopenia 1 | 22
Birthmark 1 | 35
Blue sclera 1 | 32
Breast Neoplasms 1 | 445
Broad-based gait 1 | 19
Bushy eyebrows 1 | 49
Cafe-au-Lait Spots 1 | 37
Cholangiocarcinoma 1 | 35
Congenital hemivertebra 1 | 25
DOID:9917 1 | 31
Decreased size of teeth 1 | 62
Decreased width of tooth 1 | 59
Dental abnormalities 1 | 60
Diffuse large B-cell lymphoma 1 | 39
ENSP00000256078 1 | 30
Facioscapulohumeral muscular dystrophy 1 | 26
Hirsutism 1 | 47
Hypertrichosis 1 | 46
Hypodontia 1 | 81
Hypoplastic toes 1 | 29
Idiopathic thrombocytopenia 1 | 22
Immune thrombocytopenic purpura 1 | 24
Leukemia, Monocytic, Acute 1 | 2
Microdontia (disorder) 1 | 59
Obstruction of pelviureteric junction 1 | 8
Preauricular Fistulae, Congenital 1 | 27
Preauricular dimple 1 | 27
Preauricular sinus 1 | 27
Recurrent aspiration pneumonia 1 | 4
Recurrent infections 1 | 48
Recurrent otitis media 1 | 42
Sparse eyebrow 1 | 42
Synophrys 1 | 40
Thin upper lip vermilion 1 | 67
Tooth Abnormalities 1 | 69
inflammatory breast cancer 1 | 286

Tissue

Blood and immune system 8 | 16,909
Cardiovascular System 8 | 15,192
Digestive Tract 8 | 17,369
Endocrine System 8 | 18,159
Female tissues 8 | 17,400
Liver and Pancreas 8 | 16,750
Male tissues 8 | 17,142
Nervous System 8 | 16,725
Respiratory system 8 | 16,393
Skin and soft tissues 8 | 17,230
Urinary Tract 8 | 16,678

Target Family

Epigenetic 8 | 242

GO Function

histone methyltransferase acti... 8 | 8
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone-lysine N-methyltransferase SETD1A SETD1A Tbio Epigenetic -2.57679 365.2 125
Histone-lysine N-methyltransferase 2B KMT2B Tbio Epigenetic -1.93899 84.8 153
Histone-lysine N-methyltransferase 2C KMT2C Tbio Epigenetic -1.87625 76.5 68
Histone-lysine N-methyltransferase 2D KMT2D Tbio Epigenetic -2.08086 118.1 133
Histone-lysine N-methyltransferase ASH1L ASH1L Tbio Epigenetic -1.28102 19.8 111
Histone-lysine N-methyltransferase 2A KMT2A Tchem Epigenetic -2.88228 736.0 334
Histone-lysine N-methyltransferase setd3 SETD3 Tdark Epigenetic -0.53887 4.67 95
Histone-lysine N-methyltransferase SETMAR SETMAR Tbio Epigenetic -1.33346 26.5 119