Development Level

Tbio 3 | 11,445
Tchem 2 | 1,598
Tdark 1 | 6,588

IMPC Phenotype

abnormal bone structure 2 | 187
short tibia 2 | 97
abnormal behavior 1 | 298
abnormal coat appearance 1 | 31
abnormal pancreas morphology 1 | 13
abnormal retina morphology 1 | 71
abnormal seminal vesicle morph... 1 | 114
abnormal vertebrae morphology 1 | 18
cardiovascular system phenotyp... 1 | 36
decreased body weight 1 | 161
decreased caudal vertebrae num... 1 | 53
decreased circulating glycerol... 1 | 16
decreased mean corpuscular vol... 1 | 79
decreased prepulse inhibition 1 | 82
hydrometra 1 | 53
impaired pupillary reflex 1 | 26
increased bone mineral content 1 | 108
increased circulating HDL chol... 1 | 80
increased circulating LDL chol... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating triglyce... 1 | 42
increased heart weight 1 | 62
increased startle reflex 1 | 112
preweaning lethality, complete... 1 | 979
prolonged QRS complex duration 1 | 8
small testis 1 | 58
tremors 1 | 39

Disease

Carcinoma 5 | 11,493
Kidney cancer 4 | 2,613
osteosarcoma 4 | 7,950
ovarian cancer 4 | 8,520
atypical teratoid / rhabdoid tumor 3 | 5,112
Adenoid Cystic Carcinoma 2 | 99
Cancer 2 | 2,499
Carcinoma, Adenoid Cystic 2 | 99
Intellectual disability 2 | 1,016
Liver cancer 2 | 604
Neurodevelopmental Disorders 2 | 70
Pick disease 2 | 1,894
Rheumatoid arthritis 2 | 1,191
Sotos syndrome 2 | 13
Sotos' syndrome 2 | 3
adult high grade glioma 2 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 2 | 3,291
malignant mesothelioma 2 | 3,232
medulloblastoma, large-cell 2 | 6,241
psoriasis 2 | 6,694
Abnormality of immune system physiology 1 | 16
Advanced bone age 1 | 35
Alzheimer's disease 1 | 658
Anteverted nostril 1 | 191
Astrocytoma, Pilocytic 1 | 3,081
Autism spectrum disorder 1 | 101
Autistic Disorder 1 | 364
Becker muscular dystrophy 1 | 191
Big calvaria 1 | 147
Bowen-Conradi syndrome 1 | 16
Breast Neoplasms 1 | 445
Breast cancer 1 | 3,578
Bulging forehead 1 | 66
Byzanthine arch palate 1 | 194
Carcinoma, Renal Cell 1 | 124
Class III malocclusion 1 | 78
Conductive hearing loss 1 | 123
Decubitus ulcer 1 | 13
Dilated ventricles (finding) 1 | 121
Downward slant of palpebral fissure 1 | 158
Endometrial cancer 1 | 311
Esophageal Neoplasms 1 | 69
Facioscapulohumeral muscular dystrophy 1 | 26
Frontal bossing 1 | 157
Gaucher disease type 1 1 | 180
High forehead 1 | 102
Hypertrophy of lower jaw 1 | 78
Hypoglycemia 1 | 152
Hypoplasia or absence of the corpus callosum 1 | 23
Increased head circumference 1 | 147
Increased size of cranium 1 | 147
Increased size of mandible 1 | 78
Increased size of skull 1 | 147
Large auricle 1 | 87
Large dysplastic ears 1 | 87
Large intestine cancer 1 | 126
Large pinnae 1 | 87
Large prominent ears 1 | 87
Large protruding ears 1 | 87
Large, floppy ears 1 | 87
Learning disability 1 | 17
Leukemia 1 | 104
Leukemia, Myelocytic, Acute 1 | 120
Liver neoplasms 1 | 130
Long narrow head 1 | 75
Macrocephaly 1 | 11
Macrotia 1 | 87
Mammary Neoplasms 1 | 425
Mandibular hyperplasia 1 | 78
Marshall-Smith syndrome 1 | 5
Mesothelioma, Malignant 1 | 105
Microcephaly 1 | 166
Microsatellite Instability 1 | 12
Narrow cranium shape 1 | 75
Narrow head shape 1 | 75
Narrow skull shape 1 | 75
Oxyphilic adenoma 1 | 22
Pneumothorax 1 | 23
Precocious Puberty 1 | 28
Premature tooth eruption 1 | 5
Prominent forehead 1 | 66
Renal Cell Carcinoma 1 | 214
Scoliosis 1 | 44
Skin cancer 1 | 469
Tall forehead 1 | 102
Tall stature 1 | 34
Turridolichocephaly 1 | 75
Wolf-Hirschhorn syndrome 1 | 32
acute myeloid leukemia 1 | 783
astrocytic glioma 1 | 2,597
dermatomyositis 1 | 966
inflammatory breast cancer 1 | 286
intraductal papillary-mucinous adenoma (IPMA) 1 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 1 | 2,989
mandibular excess (physical finding) 1 | 78
oligodendroglioma 1 | 2,850
pancreatic ductal adenocarcinoma liver metastasis 1 | 1,962
posterior fossa group B ependymoma 1 | 416
progressive supranuclear palsy 1 | 676
spina bifida 1 | 1,074

Tissue

Blood and immune system 6 | 16,909
Cardiovascular System 6 | 15,192
Digestive Tract 6 | 17,369
Endocrine System 6 | 18,159
Female tissues 6 | 17,400
Liver and Pancreas 6 | 16,750
Male tissues 6 | 17,142
Nervous System 6 | 16,725
Respiratory system 6 | 16,393
Skin and soft tissues 6 | 17,230
Urinary Tract 6 | 16,678

Target Family

Epigenetic 6 | 242

GO Function

histone methyltransferase acti... 6 | 6
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone-lysine N-methyltransferase SETD2 SETD2 Tchem Epigenetic -2.83266 645.3 214
Histone-lysine N-methyltransferase ASH1L ASH1L Tbio Epigenetic -1.28102 19.8 111
Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific NSD1 Tbio Epigenetic -2.16239 142.5 123
Histone-lysine N-methyltransferase setd3 SETD3 Tdark Epigenetic -0.53887 4.67 95
Histone-lysine N-methyltransferase SETMAR SETMAR Tbio Epigenetic -1.33346 26.5 119
N-lysine methyltransferase SMYD2 SMYD2 Tchem Epigenetic -1.64698 52.7 219