Development Level

Tchem 7 | 1,598
Tbio 4 | 11,445

IMPC Phenotype

preweaning lethality, complete... 2 | 979
decreased heart left ventricle... 1 | 28
decreased neutrophil cell numb... 1 | 42
increased circulating HDL chol... 1 | 80
increased circulating creatini... 1 | 38
increased circulating triglyce... 1 | 42
increased mean corpuscular hem... 1 | 96
increased startle reflex 1 | 112
male infertility 1 | 123

Disease

Carcinoma 7 | 11,493
osteosarcoma 7 | 7,950
Cancer 6 | 2,499
medulloblastoma, large-cell 6 | 6,241
ovarian cancer 6 | 8,520
group 3 medulloblastoma 5 | 4,104
psoriasis 5 | 6,694
atypical teratoid / rhabdoid tumor 4 | 5,112
ependymoma 4 | 4,679
glioblastoma 4 | 5,792
lung cancer 4 | 4,740
Breast cancer 3 | 3,578
astrocytic glioma 3 | 2,597
malignant mesothelioma 3 | 3,232
non-small cell lung cancer 3 | 2,890
primitive neuroectodermal tumor 3 | 3,035
Astrocytoma, Pilocytic 2 | 3,081
Endometrial Neoplasms 2 | 55
Nerve Sheath Neoplasms 2 | 5
Nerve Sheath Tumors 2 | 5
Neurilemmoma 2 | 23
Weaver syndrome 2 | 7
adult high grade glioma 2 | 3,801
dermatomyositis 2 | 966
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,989
oligodendroglioma 2 | 2,850
Abnormality of the fingernails 1 | 51
Abnormality of the metaphyses 1 | 48
Absence of septum pellucidum 1 | 13
Acquired immunodeficiency syndrome 1 | 197
Acquired metabolic disease 1 | 336
Adenocarcinoma of lung 1 | 142
Adenocarcinoma of lung (disorder) 1 | 60
Advanced bone age 1 | 35
Azoospermia 1 | 110
Big calvaria 1 | 147
Breast Neoplasms 1 | 445
Broad feet 1 | 19
Broad forehead 1 | 59
Broad thumbs 1 | 28
Calcaneovalgus deformity 1 | 8
Chromosome 17q11.2 deletion syndrome, 1.4Mb 1 | 15
Class III malocclusion 1 | 78
Congenital Camptodactyly 1 | 40
Contracture of joint of hand 1 | 30
Coxa valga 1 | 22
Coxa valga deformity 1 | 22
Deep philtrum 1 | 21
Depressed philtrum 1 | 21
Diffuse large B-cell lymphoma 1 | 39
Dilation of lateral ventricles 1 | 4
Downward slant of palpebral fissure 1 | 158
Dyslexia 1 | 43
Endometrial stromal nodule 1 | 11
Endometrial stromal sarcoma 1 | 15
Fine hair 1 | 42
Flexion contracture of proximal interphalangeal joint 1 | 75
Glioma 1 | 74
Hoarseness 1 | 31
Hyperkyphosis 1 | 111
Hypertrophy of lower jaw 1 | 78
Hypoplastic toenails 1 | 22
Increased head circumference 1 | 147
Increased size of cranium 1 | 147
Increased size of mandible 1 | 78
Increased size of skull 1 | 147
Joint stiffness 1 | 84
Juvenile Myelomonocytic Leukemia 1 | 21
Kyphosis deformity of spine 1 | 114
Large dysplastic ears 1 | 87
Large hand 1 | 18
Large pinnae 1 | 87
Large prominent ears 1 | 87
Large, floppy ears 1 | 87
Leukemia, Megakaryoblastic, of Down Syndrome 1 | 8
Leukemia, Myelomonocytic, Juvenile 1 | 20
Limited elbow extension 1 | 19
Limited knee extension 1 | 3
Lymphoid leukemia 1 | 160
Lymphoma, Follicular 1 | 18
Lymphoma, Large B-Cell, Diffuse 1 | 34
MYELODYSPLASTIC SYNDROME 1 | 53
Mammary Neoplasms 1 | 425
Mandibular hyperplasia 1 | 78
Melanocytic nevus 1 | 43
Metatarsus Varus 1 | 24
Myelodysplastic Syndromes 1 | 26
Neurofibroma 1 | 8
Neurofibromatosis 1 | 40
Osteoarthritis 1 | 184
Polycythemia vera 1 | 27
Primary Myelofibrosis 1 | 5
Retrognathia 1 | 54
Round face 1 | 45
Round, full face 1 | 45
Short ribs 1 | 30
Tall stature 1 | 34
Thin, sparse hair 1 | 59
Toeing-in 1 | 24
mandibular excess (physical finding) 1 | 78

Tissue

Blood and immune system 10 | 16,909
Cardiovascular System 10 | 15,192
Digestive Tract 10 | 17,369
Endocrine System 10 | 18,159
Female tissues 10 | 17,400
Liver and Pancreas 10 | 16,750
Male tissues 10 | 17,142
Nervous System 10 | 16,725
Respiratory system 10 | 16,393
Skin and soft tissues 10 | 17,230
Urinary Tract 10 | 16,678

Target Family

Epigenetic 7 | 242
Non-IDG 2 | 12,091
Enzyme 1 | 4,145
TF/Epigenetic 1 | 38

GO Function

histone methyltransferase acti... 11 | 11
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone-arginine methyltransferase CARM1 CARM1 Tchem Epigenetic -2.04034 130.8 476
N-terminal Xaa-Pro-Lys N-methyltransferase 1 NTMT1 Tbio Enzyme -1.08039 12.3 89
PR domain zinc finger protein 13 PRDM13 Tbio TF/Epigenetic -0.94201 9.57 80
Histone-lysine N-methyltransferase, H3 lysine-79 specific DOT1L Tchem Epigenetic -2.29797 199.6 330
Histone-lysine N-methyltransferase SUV39H1 SUV39H1 Tchem Epigenetic -2.27556 174.3 306
Protein arginine N-methyltransferase 1 PRMT1 Tchem Epigenetic -2.35804 229.5 394
Polycomb protein EED EED Tchem Non-IDG -2.23450 157.4 278
Polycomb protein SUZ12 SUZ12 Tbio Non-IDG -2.14022 107.7 232
Protein arginine N-methyltransferase 2 PRMT2 Tbio Epigenetic -1.20252 18.8 325
Histone-lysine N-methyltransferase EZH2 EZH2 Tchem Epigenetic -3.16893 1399.0 606