Development Level

Tclin 1 | 613

Disease

Abdominal Pain 1 | 98
Acquired polycythemia 1 | 1
Acute blood cancer 1 | 6
Acute leukemia 1 | 15
Amaurosis Fugax 1 | 8
Angina Pectoris 1 | 32
Arterial thrombosis 1 | 9
Arthralgia 1 | 90
Ascites 1 | 22
Bleeding tendency 1 | 37
Bleeding time prolonged 1 | 31
Bone marrow cancer 1 | 3
Brain hemorrhage 1 | 14
Budd-Chiari syndrome 1 | 12
Calcinosis 1 | 70
Cerebral Hemorrhage 1 | 42
Cerebral Ischemia 1 | 37
Chest Pain 1 | 38
Colitis, Ulcerative 1 | 59
Decreased platelet count 1 | 111
Dizziness 1 | 26
Dyspnea on exertion 1 | 24
Ecchymosis 1 | 66
Elevated hepatic transaminases 1 | 81
Embolism and Thrombosis 1 | 6
Epistaxis 1 | 43
Erythromelalgia 1 | 7
Esophageal Varices 1 | 6
Essential thrombocythemia 1 | 10
Familial thrombocytosis 1 | 3
Fatigue 1 | 182
Fever 1 | 138
Florid red complexion (finding) 1 | 3
Gastrointestinal Hemorrhage 1 | 52
Gingival Hemorrhage 1 | 18
Headache 1 | 37
Heart Valve Diseases 1 | 25
Heart valve disease 1 | 39
Hematocrit increased 1 | 5
Hemoglobin increased 1 | 6
Hyperhidrosis disorder 1 | 81
Hypertension, Portal 1 | 22
Hypoplastic myelodysplasia 1 | 18
Increased megakaryocyte count 1 | 6
Increased number of platelets 1 | 14
Increased red blood cell mass 1 | 4
Increased sweating 1 | 81
Increased tendency to bruise 1 | 66
Inflammation 1 | 120
Isolated cases 1 | 72
Leukemia, Myelocytic, Acute 1 | 120
Leukemia, Myeloid, Acute 1 | 105
Leukocytosis 1 | 17
Liver Cirrhosis, Experimental 1 | 769
Liver Neoplasms, Experimental 1 | 59
Liver function test increased 1 | 81
Lymphoid leukemia 1 | 160
MYELODYSPLASTIC SYNDROME 1 | 53
Mesenteric vascular occlusion 1 | 3
Myelofibrosis 1 | 14
Myeloproliferative Disorders 1 | 7
Myeloproliferative disease 1 | 16
Myeloproliferative disorder 1 | 2
Myocardial Infarction 1 | 151
Non-alcoholic Fatty Liver Disease 1 | 42
Paresthesia 1 | 32
Peripheral arterial occlusive disease 1 | 4
Peripheral thrombosis 1 | 3
Peripheral vascular insufficiency 1 | 4
Platelet morphology abnormal 1 | 9
Polycythemia 1 | 25
Polycythemia vera 1 | 27
Polycythemia, primary familial and congenital 1 | 3
Portal hypertension 1 | 20
Portal vein thrombosis 1 | 12
Pregnancy Complications 1 | 3
Primary Myelofibrosis 1 | 5
Primary polycythemia 1 | 8
Pruritus 1 | 58
Respiratory Insufficiency 1 | 132
Respiratory function loss 1 | 121
Somatic mutation 1 | 61
Subclinical abnormal liver function tests 1 | 81
Sweating 1 | 81
Systemic lupus erythematosus 1 | 194
THROMBOCYTHEMIA 1 1 | 3
THROMBOCYTHEMIA 2 1 | 3
THROMBOCYTHEMIA 3 1 | 3
Thrombocythemia, Essential 1 | 12
Thrombocytopenia 1 | 197
Thrombocytosis 1 | 38
Thromboembolism 1 | 15
Tinnitus 1 | 19
Transient Cerebral Ischemia 1 | 25
Uterine Cervical Neoplasms 1 | 26
Venous Thrombosis 1 | 47
Vertigo 1 | 29
Weight decreased 1 | 103
familial erythrocytosis 1 1 | 3
vascular disease occlusive 1 | 4

Tissue

Blood and immune system 1 | 16,909
Cardiovascular System 1 | 15,192
Digestive Tract 1 | 17,369
Endocrine System 1 | 18,159
Female tissues 1 | 17,400
Liver and Pancreas 1 | 16,750
Male tissues 1 | 17,142
Nervous System 1 | 16,725
Respiratory system 1 | 16,393
Skin and soft tissues 1 | 17,230
Urinary Tract 1 | 16,678

Target Family

Kinase 1 | 634

GO Function

histone kinase activity (H3-Y4... 1 | 1
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Tyrosine-protein kinase JAK2 JAK2 Tclin Kinase -3.54037 3339.7 801