Development Level

Tchem 4 | 1,598
Tbio 1 | 11,445

IMPC Phenotype

decreased basophil cell number 1 | 16
decreased circulating iron lev... 1 | 32
vertebral transformation 1 | 12

Disease

Carcinoma 4 | 11,493
osteosarcoma 4 | 7,950
psoriasis 4 | 6,694
Intellectual disability 3 | 1,016
glioblastoma 3 | 5,792
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,291
medulloblastoma, large-cell 3 | 6,241
Adenoid Cystic Carcinoma 2 | 99
Broad nasal tip 2 | 28
Cancer 2 | 2,499
Carcinoma, Adenoid Cystic 2 | 99
Cleft Palate 2 | 271
Cryptorchidism 2 | 296
Dull intelligence 2 | 645
Kabuki syndrome 2 | 27
Low intelligence 2 | 645
Mental Retardation 2 | 645
Mental deficiency 2 | 645
Poor school performance 2 | 645
atypical teratoid / rhabdoid tumor 2 | 5,112
group 3 medulloblastoma 2 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,989
lung cancer 2 | 4,740
malignant mesothelioma 2 | 3,232
tuberculosis 2 | 2,010
Abnormal vertebral bodies 1 | 16
Anemia, Hemolytic 1 | 55
Angle class 2 malocclusion 1 | 57
Angle class 3 malocclusion 1 | 57
Atrial Septal Defects 1 | 85
Autistic Disorder 1 | 364
Autoimmune thrombocytopenia 1 | 22
Birthmark 1 | 35
Bladder Neoplasm 1 | 112
Blepharoptosis 1 | 231
Blue sclera 1 | 32
Bowed and upward slanting eyebrows 1 | 41
Cafe-au-Lait Spots 1 | 37
Carcinoma, Transitional Cell 1 | 32
Conductive hearing loss 1 | 123
Congenital anomaly of spine 1 | 16
Congenital deafness 1 | 185
Congenital hemivertebra 1 | 25
Deafness 1 | 198
Decreased size of teeth 1 | 62
Decreased width of tooth 1 | 59
Dental abnormalities 1 | 60
Depressed nasal tip 1 | 11
Dilated ventricles (finding) 1 | 121
Esophageal Squamous Cell Carcinoma 1 | 77
Hearing Loss, Partial 1 | 185
Hip Dislocation, Congenital 1 | 48
Hirsutism 1 | 47
Hypodontia 1 | 81
Idiopathic thrombocytopenia 1 | 22
Immune thrombocytopenic purpura 1 | 24
Infertility 1 | 188
Joint hyperflexibility 1 | 78
Large auricle 1 | 87
Large dysplastic ears 1 | 87
Large pinnae 1 | 87
Large prominent ears 1 | 87
Large protruding ears 1 | 87
Large, floppy ears 1 | 87
Long eyelashes 1 | 37
Macrotia 1 | 87
Malabsorption 1 | 82
Malocclusion 1 | 57
Microdontia (disorder) 1 | 59
Mild Mental Retardation 1 | 70
Multiple vertebral anomalies 1 | 16
Neonatal hypoglycemia 1 | 17
Neoplasms 1 | 63
Obstruction of pelviureteric junction 1 | 8
Postnatal growth retardation 1 | 57
Preauricular Fistulae, Congenital 1 | 27
Preauricular dimple 1 | 27
Preauricular sinus 1 | 27
Prominent ear 1 | 56
Protruding ears 1 | 56
Range of joint movement increased 1 | 32
Recurrent aspiration pneumonia 1 | 4
Recurrent infections 1 | 48
Recurrent otitis media 1 | 42
Sensorineural Hearing Loss (disorder) 1 | 284
Short fifth finger 1 | 9
Small testicle 1 | 75
Sparse eyebrow 1 | 42
Squamous cell carcinoma of esophagus 1 | 77
Thick, flared eyebrows 1 | 41
Tooth Abnormalities 1 | 69
Turner syndrome 1 | 28
Underweight 1 | 17
Urinary Bladder Neoplasms 1 | 114
Weight decreased 1 | 103
Weight less than 3rd percentile 1 | 17
Widely spaced teeth 1 | 31
X-linked dominant 1 | 57
hearing impairment 1 | 199

Tissue

Blood and immune system 5 | 16,909
Cardiovascular System 5 | 15,192
Digestive Tract 5 | 17,369
Endocrine System 5 | 18,159
Female tissues 5 | 17,400
Liver and Pancreas 5 | 16,750
Male tissues 5 | 17,142
Nervous System 5 | 16,725
Respiratory system 5 | 16,393
Skin and soft tissues 5 | 17,230
Urinary Tract 5 | 16,678

Target Family

Epigenetic 5 | 242

GO Function

histone demethylase activity (... 5 | 5
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Lysine-specific demethylase 6B KDM6B Tchem Epigenetic -2.22888 174.2 272
Lysine-specific demethylase 6A KDM6A Tchem Epigenetic -2.27999 176.8 119
Lysine-specific demethylase 7A KDM7A Tchem Epigenetic -1.02284 9.06 88
Histone demethylase UTY UTY Tbio Epigenetic -1.58873 35.0 110
Histone lysine demethylase PHF8 PHF8 Tchem Epigenetic -1.50422 40.0 77