Development Level

Tchem 15 | 1,598
Tbio 9 | 11,445

IMPC Phenotype

preweaning lethality, complete... 5 | 979
abnormal behavior 2 | 298
abnormal retinal blood vessel ... 2 | 26
hypoactivity 2 | 132
increased body length 2 | 32
abnormal glucose homeostasis 1 | 4
abnormal iris pigmentation 1 | 4
abnormal response to tactile s... 1 | 17
abnormal retinal vasculature m... 1 | 27
decreased basophil cell number 1 | 16
decreased circulating iron lev... 1 | 32
decreased circulating phosphat... 1 | 27
decreased circulating serum al... 1 | 82
decreased circulating total pr... 1 | 49
decreased grip strength 1 | 116
decreased heart left ventricle... 1 | 28
decreased hemoglobin content 1 | 68
decreased red blood cell distr... 1 | 41
decreased spleen weight 1 | 10
embryonic lethality prior to t... 1 | 278
increased body weight 1 | 25
increased circulating creatini... 1 | 38
increased lean body mass 1 | 172
increased startle reflex 1 | 112
preweaning lethality, incomple... 1 | 499
small heart 1 | 10
small kidney 1 | 16
small liver 1 | 8
small lung 1 | 5
small spleen 1 | 19
vertebral transformation 1 | 12

Disease

Carcinoma 21 | 11,493
osteosarcoma 14 | 7,950
ovarian cancer 13 | 8,520
medulloblastoma, large-cell 11 | 6,241
psoriasis 11 | 6,694
group 3 medulloblastoma 10 | 4,104
Cancer 9 | 2,499
glioblastoma 9 | 5,792
lung cancer 8 | 4,740
malignant mesothelioma 8 | 3,232
Kidney cancer 7 | 2,613
ependymoma 7 | 4,679
astrocytoma 6 | 1,146
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 6 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,291
Intellectual disability 5 | 1,016
atypical teratoid / rhabdoid tumor 5 | 5,112
Breast cancer 4 | 3,578
dermatomyositis 4 | 966
juvenile dermatomyositis 4 | 1,187
oligodendroglioma 4 | 2,850
tuberculosis 4 | 2,010
Adenoid Cystic Carcinoma 3 | 99
Carcinoma, Adenoid Cystic 3 | 99
Cryptorchidism 3 | 296
Rheumatoid arthritis 3 | 1,191
acute myeloid leukemia 3 | 783
acute quadriplegic myopathy 3 | 1,158
invasive ductal carcinoma 3 | 2,951
lung adenocarcinoma 3 | 2,716
non-small cell lung cancer 3 | 2,890
pancreatic cancer 3 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
primary pancreatic ductal adenocarcinoma 3 | 1,109
primitive neuroectodermal tumor 3 | 3,035
sonic hedgehog group medulloblastoma 3 | 467
subependymal giant cell astrocytoma 3 | 2,287
Alzheimer's disease 2 | 658
Amyotrophic lateral sclerosis 2 | 451
Astrocytoma, Pilocytic 2 | 3,081
Autistic Disorder 2 | 364
Broad nasal tip 2 | 28
Cleft Palate 2 | 271
Colonic Neoplasms 2 | 142
Congenital hypoplasia of penis 2 | 176
Dull intelligence 2 | 645
Epilepsy 2 | 792
Kabuki syndrome 2 | 27
Large auricle 2 | 87
Large dysplastic ears 2 | 87
Large hand 2 | 18
Large pinnae 2 | 87
Large prominent ears 2 | 87
Large protruding ears 2 | 87
Large, floppy ears 2 | 87
Liver cancer 2 | 604
Low intelligence 2 | 645
Macrotia 2 | 87
Male infertility 2 | 206
Mental Retardation 2 | 645
Mental deficiency 2 | 645
Pick disease 2 | 1,894
Poor school performance 2 | 645
Seizures 2 | 596
Short stature 2 | 531
Systemic lupus erythematosus 2 | 194
adrenocortical carcinoma 2 | 1,428
adult high grade glioma 2 | 3,801
breast carcinoma 2 | 1,638
cystic fibrosis 2 | 1,696
group 4 medulloblastoma 2 | 1,855
medulloblastoma 2 | 720
non diabetic and post-ischemic heart failure 2 | 200
non primary Sjogren syndrome sicca 2 | 891
pediatric high grade glioma 2 | 1,064
pituitary cancer 2 | 1,972
spina bifida 2 | 1,074
ulcerative colitis 2 | 1,819
Carcinoma, Non-Small-Cell Lung 1 | 107
Carcinoma, Renal Cell 1 | 124
Congenital hemivertebra 1 | 25
Dental abnormalities 1 | 60
Dental caries 1 | 164
Hypodontia 1 | 81
Hypoplastic feet 1 | 66
Obstruction of pelviureteric junction 1 | 8
Periodontal disease 1 | 40
Preauricular Fistulae, Congenital 1 | 27
Preauricular dimple 1 | 27
Preauricular sinus 1 | 27
Progressive mental retardation 1 | 37
Recurrent infections 1 | 48
Recurrent otitis media 1 | 42
Renal Cell Carcinoma 1 | 214
Small testicle 1 | 75
Tooth Abnormalities 1 | 69
Underweight 1 | 17
Weight less than 3rd percentile 1 | 17
X- linked recessive 1 | 110

Tissue

Blood and immune system 24 | 16,909
Cardiovascular System 24 | 15,192
Digestive Tract 24 | 17,369
Endocrine System 24 | 18,159
Female tissues 24 | 17,400
Liver and Pancreas 24 | 16,750
Male tissues 24 | 17,142
Nervous System 24 | 16,725
Respiratory system 24 | 16,393
Skin and soft tissues 24 | 17,230
Urinary Tract 24 | 16,678

Target Family

Epigenetic 18 | 242
TF/Epigenetic 4 | 38
Enzyme 1 | 4,145
Transcription Factor 1 | 1,400

GO Function

histone demethylase activity 24 | 24
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Lysine-specific demethylase 3A KDM3A Tchem Epigenetic -1.83544 74.7 253
Lysine-specific demethylase 2A KDM2A Tchem Epigenetic -1.51861 36.3 183
Lysine-specific demethylase 5C KDM5C Tchem TF/Epigenetic -1.94004 86.4 135
AT-rich interactive domain-containing protein 5B ARID5B Tbio Transcription Factor -1.71561 54.6 97
Lysine-specific demethylase 6B KDM6B Tchem Epigenetic -2.22888 174.2 272
Lysine-specific demethylase 4D KDM4D Tchem Epigenetic -1.51327 28.3 162
Lysine-specific demethylase 6A KDM6A Tchem Epigenetic -2.27999 176.8 119
Lysine-specific histone demethylase 1B KDM1B Tbio Epigenetic -1.45110 27.6 106
Lysine-specific demethylase 3B KDM3B Tbio Epigenetic -1.04920 11.3 286
Lysine-specific demethylase 4A KDM4A Tchem Epigenetic -3.06159 1089.8 271