Development Level

Tbio 75 | 11,445
Tchem 19 | 1,598
Tclin 11 | 613
Tdark 2 | 6,588

IMPC Phenotype

preweaning lethality, complete... 11 | 979
abnormal behavior 3 | 298
abnormal heart morphology 3 | 162
decreased circulating glucose ... 3 | 126
decreased lymphocyte cell numb... 3 | 83
enlarged heart 3 | 210
preweaning lethality, incomple... 3 | 499
abnormal lens morphology 2 | 81
cataract 2 | 92
decreased leukocyte cell numbe... 2 | 73
decreased neutrophil cell numb... 2 | 42
decreased startle reflex 2 | 75
decreased vertical activity 2 | 208
embryonic lethality prior to o... 2 | 239
embryonic lethality prior to t... 2 | 278
increased startle reflex 2 | 112
abnormal blood vessel morpholo... 1 | 5
abnormal chorioallantoic fusio... 1 | 8
abnormal coat appearance 1 | 31
abnormal embryo development 1 | 7
abnormal embryo size 1 | 220
abnormal embryo turning 1 | 31
abnormal forebrain development 1 | 20
abnormal gait 1 | 69
abnormal hindbrain development 1 | 16
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal pharyngeal arch morph... 1 | 8
abnormal retinal blood vessel ... 1 | 26
abnormal retinal inner nuclear... 1 | 8
abnormal retinal vasculature m... 1 | 27
abnormal snout morphology 1 | 23
abnormal somite shape 1 | 5
abnormal visceral yolk sac mor... 1 | 6
abnormal vitelline vasculature... 1 | 6
abnormal vocalization 1 | 21
cardiovascular system phenotyp... 1 | 36
decreased blood urea nitrogen ... 1 | 51
decreased body weight 1 | 161
decreased circulating LDL chol... 1 | 38
decreased circulating alanine ... 1 | 47
decreased circulating choleste... 1 | 93
decreased circulating free fat... 1 | 31
decreased circulating serum al... 1 | 82
decreased circulating triglyce... 1 | 79
decreased circulating unsatura... 1 | 2
decreased eosinophil cell numb... 1 | 24
decreased grip strength 1 | 116
decreased large unstained cell... 1 | 11
decreased prepulse inhibition 1 | 82
decreased total body fat amoun... 1 | 207
decreased total retina thickne... 1 | 17
embryonic growth retardation 1 | 106
fusion of vertebral arches 1 | 7
hypoactivity 1 | 132
increased body length 1 | 32
increased body temperature 1 | 9
increased body weight 1 | 25
increased bone mineral content 1 | 108
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating choleste... 1 | 66
increased circulating glucose ... 1 | 24
increased circulating glycerol... 1 | 9
increased circulating sodium l... 1 | 71
increased grip strength 1 | 41
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased mean platelet volume 1 | 45
increased monocyte cell number 1 | 63
increased or absent threshold ... 1 | 101
increased prepulse inhibition 1 | 32
increased total body fat amoun... 1 | 134
male infertility 1 | 123
pale yolk sac 1 | 25
pallor 1 | 34
short tibia 1 | 97
small superior vagus ganglion 1 | 74
thrombocytopenia 1 | 56
tremors 1 | 39
trunk curl 1 | 16
vertebral fusion 1 | 23
vertebral transformation 1 | 12

Disease

Carcinoma 79 | 11,493
ovarian cancer 65 | 8,520
osteosarcoma 57 | 7,950
Cancer 53 | 2,499
medulloblastoma, large-cell 51 | 6,241
psoriasis 46 | 6,694
lung cancer 42 | 4,740
glioblastoma 41 | 5,792
atypical teratoid / rhabdoid tumor 34 | 5,112
group 3 medulloblastoma 34 | 4,104
ependymoma 33 | 4,679
Breast cancer 31 | 3,578
oligodendroglioma 29 | 2,850
malignant mesothelioma 27 | 3,232
primitive neuroectodermal tumor 26 | 3,035
adult high grade glioma 24 | 3,801
Multiple myeloma 23 | 1,332
intraductal papillary-mucinous neoplasm (IPMN) 23 | 3,291
lung adenocarcinoma 23 | 2,716
invasive ductal carcinoma 21 | 2,951
non-small cell lung cancer 21 | 2,890
pancreatic cancer 21 | 2,398
Schizophrenia 19 | 1,160
intraductal papillary-mucinous carcinoma (IPMC) 19 | 2,989
Breast Neoplasms 18 | 445
Mammary Neoplasms 17 | 425
astrocytoma 17 | 1,146
Astrocytoma, Pilocytic 15 | 3,081
Kidney cancer 15 | 2,613
Pick disease 15 | 1,894
Rheumatoid arthritis 15 | 1,191
intraductal papillary-mucinous adenoma (IPMA) 15 | 2,955
acute quadriplegic myopathy 14 | 1,158
astrocytic glioma 14 | 2,597
interstitial cystitis 14 | 2,312
subependymal giant cell astrocytoma 14 | 2,287
tuberculosis 14 | 2,010
Waldenstrons macroglobulinemia 13 | 765
cystic fibrosis 13 | 1,696
colon cancer 12 | 1,478
diabetes mellitus 12 | 1,728
ductal carcinoma in situ 12 | 1,745
juvenile dermatomyositis 12 | 1,187
pediatric high grade glioma 12 | 1,064
pituitary cancer 12 | 1,972
primary pancreatic ductal adenocarcinoma 12 | 1,109
ulcerative colitis 12 | 1,819
Endometriosis 11 | 540
Intellectual disability 11 | 1,016
breast carcinoma 11 | 1,638
group 4 medulloblastoma 11 | 1,855
pancreatic ductal adenocarcinoma liver metastasis 11 | 1,962
Epilepsy 10 | 792
Peripheral T-cell lymphoma 10 | 25
Primary cutaneous T-cell lymphoma 10 | 29
acute myeloid leukemia 10 | 783
dermatomyositis 10 | 966
lung carcinoma 10 | 2,843
nasopharyngeal carcinoma 10 | 1,058
Mental Depression 9 | 333
Mood Disorders 9 | 184
Prostatic Neoplasms 9 | 495
Seizures 9 | 596
adrenocortical carcinoma 9 | 1,428
medulloblastoma 9 | 720
Bipolar Disorder 8 | 666
atypical teratoid/rhabdoid tumor 8 | 357
Amyotrophic lateral sclerosis 7 | 451
Anteverted nostril 7 | 191
Atherosclerosis 7 | 291
Atopic dermatitis 7 | 952
Heart disease 7 | 306
Melanoma 7 | 711
Neoplasm Metastasis 7 | 168
Neurodegenerative disease 7 | 414
Obesity 7 | 678
Short nose 7 | 132
Small nose 7 | 132
Unipolar Depression 7 | 250
Vascular disease 7 | 319
gastric cancer 7 | 459
gastric carcinoma 7 | 807
spina bifida 7 | 1,074
Alzheimer's disease 6 | 658
Brain Ischemia 6 | 110
Carcinoma, Hepatocellular 6 | 228
Colonic Neoplasms 6 | 142
Depressive disorder 6 | 409
Liver cancer 6 | 604
Liver carcinoma 6 | 240
Low set ears 6 | 181
Major Depressive Disorder 6 | 301
Neoplastic Cell Transformation 6 | 89
Parkinson's disease 6 | 392
Short stature 6 | 531
Stomach Neoplasms 6 | 300
non primary Sjogren syndrome sicca 6 | 891
non-small cell lung carcinoma 6 | 317
pancreatic carcinoma 6 | 562
progressive supranuclear palsy 6 | 676

Tissue

Endocrine System 107 | 18,159
Skin and soft tissues 105 | 17,230
Blood and immune system 104 | 16,909
Digestive Tract 104 | 17,369
Female tissues 104 | 17,400
Liver and Pancreas 104 | 16,750
Male tissues 104 | 17,142
Nervous System 104 | 16,725
Urinary Tract 104 | 16,678
Respiratory system 103 | 16,393
Cardiovascular System 100 | 15,192

Target Family

Non-IDG 42 | 12,091
Transcription Factor 33 | 1,400
Epigenetic 15 | 242
Enzyme 10 | 4,145
Kinase 3 | 634
Nuclear Receptor 3 | 48
TF/Epigenetic 1 | 38

GO Function

histone deacetylase binding 107 | 107
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone deacetylase 9 HDAC9 Tclin Epigenetic -2.27309 185.2 431
Chromodomain-helicase-DNA-binding protein 4 CHD4 Tbio Epigenetic -2.22229 159.7 203
Breast cancer metastasis-suppressor 1-like protein BRMS1L Tbio Non-IDG -1.71309 57.0 107
Homeobox protein Nkx-3.1 NKX3-1 Tbio Transcription Factor -2.13442 140.5 524
Histone H1.5 HIST1H1B Tbio Non-IDG -2.13224 134.1 103
Krueppel-like factor 4 KLF4 Tbio Transcription Factor -2.89447 774.1 686
Heat shock 70 kDa protein 1A HSPA1B Tchem Non-IDG -3.10995 0.00000 1174
Heat shock 70 kDa protein 1B HSPA1B Tbio Non-IDG -1.61862 0.00000 60
PHD finger protein 6 PHF6 Tbio Epigenetic -1.79561 64.2 134
Nuclear receptor subfamily 2 group C member 1 NR2C1 Tbio Nuclear Receptor -1.39182 24.4 294