Development Level

Tbio 23 | 11,445
Tclin 10 | 613
Tchem 3 | 1,598

IMPC Phenotype

preweaning lethality, complete... 5 | 979
abnormal behavior 3 | 298
preweaning lethality, incomple... 3 | 499
decreased body weight 2 | 161
decreased bone mineral density 2 | 126
decreased grip strength 2 | 116
hypoactivity 2 | 132
increased circulating alkaline... 2 | 122
trunk curl 2 | 16
abnormal bone mineralization 1 | 38
abnormal coat appearance 1 | 31
abnormal gait 1 | 69
abnormal heart left ventricle ... 1 | 16
abnormal lens morphology 1 | 81
abnormal maxilla morphology 1 | 17
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal tooth morphology 1 | 24
abnormal vocalization 1 | 21
aorta stenosis 1 | 2
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
decreased body length 1 | 101
decreased bone mineral content 1 | 151
decreased caudal vertebrae num... 1 | 53
decreased circulating LDL chol... 1 | 38
decreased circulating free fat... 1 | 31
decreased circulating glucose ... 1 | 126
decreased heart left ventricle... 1 | 28
decreased heart rate 1 | 18
decreased hemoglobin content 1 | 68
decreased lean body mass 1 | 135
decreased lumbar vertebrae num... 1 | 2
decreased mean platelet volume 1 | 25
decreased sacral vertebrae num... 1 | 1
decreased threshold for audito... 1 | 26
embryonic lethality prior to o... 1 | 239
increased body temperature 1 | 9
increased circulating HDL chol... 1 | 80
increased circulating calcium ... 1 | 34
increased circulating choleste... 1 | 66
increased circulating creatini... 1 | 38
increased circulating sodium l... 1 | 71
increased circulating triglyce... 1 | 42
increased hemoglobin content 1 | 45
increased lumbar vertebrae num... 1 | 1
increased sacral vertebrae num... 1 | 1
increased total body fat amoun... 1 | 134
small heart 1 | 10
small kidney 1 | 16
small liver 1 | 8
small lung 1 | 5
small spleen 1 | 19
thin ventricular wall 1 | 24
thrombocytopenia 1 | 56
tremors 1 | 39

Disease

Carcinoma 24 | 11,493
osteosarcoma 23 | 7,950
ovarian cancer 19 | 8,520
medulloblastoma, large-cell 16 | 6,241
Cancer 15 | 2,499
glioblastoma 14 | 5,792
Multiple myeloma 13 | 1,332
atypical teratoid / rhabdoid tumor 12 | 5,112
lung cancer 11 | 4,740
Peripheral T-cell lymphoma 10 | 25
Primary cutaneous T-cell lymphoma 10 | 29
adult high grade glioma 10 | 3,801
primitive neuroectodermal tumor 10 | 3,035
ependymoma 9 | 4,679
psoriasis 9 | 6,694
Schizophrenia 8 | 1,160
group 3 medulloblastoma 8 | 4,104
subependymal giant cell astrocytoma 7 | 2,287
Kidney cancer 6 | 2,613
astrocytoma 6 | 1,146
malignant mesothelioma 6 | 3,232
Mental Depression 5 | 333
Mood Disorders 5 | 184
acute quadriplegic myopathy 5 | 1,158
dermatomyositis 5 | 966
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,291
invasive ductal carcinoma 5 | 2,951
medulloblastoma 5 | 720
non-small cell lung cancer 5 | 2,890
tuberculosis 5 | 2,010
Astrocytoma, Pilocytic 4 | 3,081
Endometriosis 4 | 540
Intellectual disability 4 | 1,016
Rheumatoid arthritis 4 | 1,191
diabetes mellitus 4 | 1,728
lung adenocarcinoma 4 | 2,716
Breast cancer 3 | 3,578
Depressive disorder 3 | 409
Epilepsy 3 | 792
Familial primary pulmonary hypertension 3 | 11
Heart Diseases 3 | 43
Huntington's disease 3 | 76
Obesity 3 | 678
Retinoblastoma 3 | 19
Seizures 3 | 596
adrenocortical carcinoma 3 | 1,428
gastric carcinoma 3 | 807
group 4 medulloblastoma 3 | 1,855
juvenile dermatomyositis 3 | 1,187
oligodendroglioma 3 | 2,850
Adenoid Cystic Carcinoma 2 | 99
Brain infarction 2 | 22
Carcinoma, Adenoid Cystic 2 | 99
Carcinoma, Squamous Cell 2 | 110
Chronic obstructive pulmonary disease 2 | 184
Cocaine-Related Disorders 2 | 92
Cognitive delay 2 | 608
Colonic Neoplasms 2 | 142
Decreased calcification of skull 2 | 10
Defect of skull ossification 2 | 10
Downturned corners of mouth 2 | 48
Frontal bossing 2 | 157
Global developmental delay 2 | 608
Hypoplastic feet 2 | 66
Major Depressive Disorder 2 | 301
Melanoma 2 | 711
Mental and motor retardation 2 | 608
Neoplasm Invasiveness 2 | 161
Neoplasm Metastasis 2 | 168
Nephroblastoma 2 | 51
Neurodegenerative disease 2 | 414
Neuronal ceroid lipofuscinosis 2 2 | 17
Parkinson's disease 2 | 392
Prostatic Neoplasms 2 | 495
Right bundle branch block 2 | 17
Short hands 2 | 50
Short stature 2 | 531
Squamous cell carcinoma 2 | 129
Thin hypoplastic alae nasi 2 | 51
Type 2 diabetes mellitus 2 | 272
Unipolar Depression 2 | 250
Waldenstrons macroglobulinemia 2 | 765
astrocytic glioma 2 | 2,597
atypical teratoid/rhabdoid tumor 2 | 357
autosomal dominant Emery-Dreifuss muscular dystrophy 2 | 510
breast carcinoma 2 | 1,638
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,989
lung carcinoma 2 | 2,843
non primary Sjogren syndrome sicca 2 | 891
sonic hedgehog group medulloblastoma 2 | 467
ulcerative colitis 2 | 1,819
Accessory nipple 1 | 11
Decreased projection of midface 1 | 105
Hypotrophic midface 1 | 105
Midface retrusion 1 | 105
Round face 1 | 45
Round, full face 1 | 45
Small midface 1 | 105
Syndactyly of fingers 1 | 48

Tissue

Endocrine System 36 | 18,159
Female tissues 36 | 17,400
Blood and immune system 35 | 16,909
Cardiovascular System 35 | 15,192
Digestive Tract 35 | 17,369
Liver and Pancreas 35 | 16,750
Male tissues 35 | 17,142
Nervous System 35 | 16,725
Respiratory system 35 | 16,393
Skin and soft tissues 35 | 17,230
Urinary Tract 35 | 16,678

Target Family

Epigenetic 16 | 242
Non-IDG 7 | 12,091
Transcription Factor 7 | 1,400
Enzyme 4 | 4,145
TF/Epigenetic 2 | 38

GO Function

histone deacetylase activity 36 | 36
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Methyl-CpG-binding domain protein 3 MBD3 Tbio Transcription Factor -0.85800 7.92 309
Histone deacetylase 9 HDAC9 Tclin Epigenetic -2.27309 185.2 431
Metastasis-associated protein MTA3 MTA3 Tbio Transcription Factor -1.36174 24.5 204
Chromodomain-helicase-DNA-binding protein 4 CHD4 Tbio Epigenetic -2.22229 159.7 203
Chromodomain-helicase-DNA-binding protein 3 CHD3 Tbio Epigenetic -1.95633 85.2 190
Metastasis-associated protein MTA2 MTA2 Tbio Transcription Factor -1.59201 32.3 283
Histone deacetylase 8 HDAC8 Tclin Epigenetic -2.41838 263.5 487
PHD finger protein 21A PHF21A Tbio Epigenetic -0.73864 7.14 164
Histone deacetylase complex subunit SAP30 SAP30 Tbio Enzyme -1.22814 13.9 145
Ataxin-3-like protein ATXN3L Tbio Non-IDG -0.28506 1.65 37