Development Level

Tbio 62 | 10,625
Tchem 17 | 1,890
Tdark 6 | 7,003
Tclin 1 | 602

IMPC Term

preweaning lethality, complete... 6 | 633
abnormal behavior 3 | 226
abnormal bone structure 3 | 131
abnormal embryo size 3 | 112
decreased body length 3 | 108
decreased body weight 3 | 174
decreased caudal vertebrae num... 3 | 49
decreased erythrocyte cell num... 3 | 43
decreased lean body mass 3 | 195
decreased total body fat amoun... 3 | 186
increased bone mineral content 3 | 92
increased sacral vertebrae num... 3 | 62
preweaning lethality, incomple... 3 | 260
abnormal iris morphology 2 | 12
abnormal retina morphology 2 | 100
abnormal rib morphology 2 | 28
decreased bone mineral content 2 | 157
decreased circulating LDL chol... 2 | 37
decreased circulating serum al... 2 | 79
decreased hematocrit 2 | 25
decreased hemoglobin content 2 | 53
decreased leukocyte cell numbe... 2 | 54
decreased lumbar vertebrae num... 2 | 62
embryonic lethality prior to o... 2 | 148
narrow eye opening 2 | 15
prenatal lethality prior to he... 2 | 64
short tibia 2 | 82
abnormal bone mineralization 1 | 55
abnormal coat/ hair morphology 1 | 18
abnormal coat/hair pigmentatio... 1 | 54
abnormal cranium morphology 1 | 32
abnormal digit morphology 1 | 13
abnormal embryo turning 1 | 15
abnormal eye morphology 1 | 38
abnormal femur morphology 1 | 14
abnormal maxilla morphology 1 | 16
abnormal neural tube closure 1 | 37
abnormal neural tube morpholog... 1 | 8
abnormal placement of pupils 1 | 4
abnormal snout morphology 1 | 18
abnormal tail morphology 1 | 17
abnormal tooth morphology 1 | 24
abnormal vertebrae morphology 1 | 14
abnormal vertebral arch morpho... 1 | 9
decreased basophil cell number 1 | 11
decreased bone mineral density 1 | 126
decreased cervical vertebrae n... 1 | 12
decreased circulating HDL chol... 1 | 77
decreased circulating choleste... 1 | 85
decreased circulating magnesiu... 1 | 11
decreased circulating total pr... 1 | 41
decreased circulating triglyce... 1 | 83
decreased heart rate 1 | 10
decreased mean corpuscular hem... 1 | 34
decreased mean platelet volume 1 | 12
decreased rib number 1 | 59
embryonic growth retardation 1 | 28
embryonic lethality prior to t... 1 | 187
female infertility 1 | 34
hydrops fetalis 1 | 22
hypoactivity 1 | 89
increased blood urea nitrogen ... 1 | 44
increased blood uric acid leve... 1 | 5
increased body weight 1 | 42
increased circulating alkaline... 1 | 119
increased circulating chloride... 1 | 43
increased circulating phosphat... 1 | 24
increased grip strength 1 | 83
increased hemoglobin content 1 | 45
increased mean corpuscular hem... 1 | 25
increased mean corpuscular vol... 1 | 91
increased or absent threshold ... 1 | 128
increased thermal nociceptive ... 1 | 9
increased total body fat amoun... 1 | 57
irregularly shaped pupil 1 | 7
prolonged RR interval 1 | 2
thrombocytosis 1 | 23
tremors 1 | 34
vertebral fusion 1 | 23
vertebral transformation 1 | 12

Disease

ovarian cancer 53 | 8,484
osteosarcoma 42 | 7,933
medulloblastoma, large-cell 38 | 6,234
glioblastoma 35 | 5,572
psoriasis 30 | 6,685
lung cancer 28 | 4,466
atypical teratoid / rhabdoid tumor 27 | 4,369
Cancer 24 | 2,346
primitive neuroectodermal tumor 21 | 3,031
pediatric high grade glioma 20 | 2,712
group 3 medulloblastoma 19 | 2,254
malignant mesothelioma 18 | 3,162
Breast cancer 17 | 3,094
Carcinoma 15 | 2,147
lung adenocarcinoma 15 | 2,713
oligodendroglioma 15 | 2,849
invasive ductal carcinoma 14 | 2,950
Pick disease 13 | 1,893
acute myeloid leukemia 13 | 780
astrocytoma 13 | 1,493
tuberculosis 13 | 1,557
Intellectual disability 12 | 573
dermatomyositis 12 | 933
intraductal papillary-mucinous neoplasm (IPMN) 12 | 3,289
non-small cell lung cancer 12 | 2,798
pancreatic cancer 12 | 2,300
sonic hedgehog group medulloblastoma 12 | 1,482
Multiple myeloma 11 | 1,327
breast carcinoma 11 | 1,614
colon cancer 11 | 1,475
juvenile dermatomyositis 11 | 1,189
subependymal giant cell astrocytoma 11 | 2,287
Waldenstrons macroglobulinemia 10 | 765
diabetes mellitus 10 | 1,663
ependymoma 10 | 2,514
primary Sjogren syndrome 10 | 789
ulcerative colitis 10 | 2,087
Atopic dermatitis 9 | 944
Rheumatoid Arthritis 9 | 1,160
ductal carcinoma in situ 9 | 1,745
intraductal papillary-mucinous carcinoma (IPMC) 9 | 2,988
medulloblastoma 8 | 1,524
pilocytic astrocytoma 8 | 3,086
adrenocortical carcinoma 7 | 1,427
interstitial cystitis 7 | 2,299
lung carcinoma 7 | 2,844
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,795
progressive supranuclear palsy 7 | 674
acute quadriplegic myopathy 6 | 1,157
atypical teratoid/rhabdoid tumor 6 | 1,095
cutaneous lupus erythematosus 6 | 1,056
group 4 medulloblastoma 6 | 1,875
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,956
primary pancreatic ductal adenocarcinoma 6 | 1,271
Alzheimer's disease 5 | 644
Autistic Disorder 5 | 320
Down syndrome 5 | 548
Endometriosis 5 | 535
IGA Glomerulonephritis 5 | 454
hepatocellular carcinoma 5 | 532
inflammatory breast cancer 5 | 404
nasopharyngeal carcinoma 5 | 1,056
posterior fossa group A ependymoma 5 | 1,511
tuberculosis and treatment for 6 months 5 | 686
Crohn's disease 4 | 304
Multiple Sclerosis 4 | 498
active Crohn's disease 4 | 918
adult high grade glioma 4 | 2,148
astrocytic glioma 4 | 2,241
cystic fibrosis 4 | 1,665
gastric carcinoma 4 | 832
hereditary spastic paraplegia 4 | 313
non-small cell lung carcinoma 4 | 413
pancreatic carcinoma 4 | 567
pituitary cancer 4 | 1,972
sarcoidosis 4 | 358
systemic lupus erythematosus 4 | 156
Adenoid Cystic Carcinoma 3 | 99
Fanconi's anemia 3 | 50
Hypersensitivity reaction type II disease 3 | 235
Kidney disease 3 | 396
Obesity 3 | 616
Parkinson's disease 3 | 364
Polycystic Ovary Syndrome 3 | 332
Prostatic Neoplasms 3 | 471
Stomach Neoplasms 3 | 282
Thalassemia 3 | 46
aldosterone-producing adenoma 3 | 664
gastric cancer 3 | 430
posterior fossa group B ependymoma 3 | 1,530
spina bifida 3 | 1,064
urothelial carcinoma 3 | 318
Arthritis 2 | 248
Diabetes Mellitus, Non-Insulin-Dependent 2 | 157
Heart disease 2 | 279
Schizophrenia 2 | 501
Vascular disease 2 | 281
chronic lymphosyte leukemia 2 | 232
esophageal adenocarcinoma 2 | 737
tuberculosis and treatment for 3 months 2 | 327

Tissue

Blood and immune system 85 | 17,995
Cardiovascular System 85 | 17,958
Digestive Tract 85 | 18,473
Female tissues 85 | 18,647
Liver and Pancreas 85 | 18,136
Male tissues 85 | 17,969
Nervous System 85 | 18,561
Endocrine System 84 | 18,512
Respiratory system 84 | 17,484
Urinary Tract 84 | 18,444
Skin and soft tissues 83 | 18,115

Target Family

Non-IDG 42 | 11,971
Epigenetic 22 | 242
Enzyme 11 | 4,146
Transcription Factor 5 | 1,400
Kinase 3 | 634
TF/Epigenetic 3 | 38

GO Function

histone binding 86 | 86
metal ion binding 1,917 | 1,917
ATP binding 1,467 | 1,467
DNA binding 1,432 | 1,432
zinc ion binding 1,155 | 1,155
poly(A) RNA binding 1,107 | 1,107
transcription factor activity,... 853 | 853
calcium ion binding 695 | 695
G-protein coupled receptor act... 661 | 661
protein homodimerization activ... 569 | 569
RNA binding 445 | 445
olfactory receptor activity 424 | 424
sequence-specific DNA binding 398 | 398
GTP binding 374 | 374
chromatin binding 372 | 372
protein serine/threonine kinas... 336 | 336
RNA polymerase II core promote... 332 | 332
identical protein binding 311 | 311
nucleotide binding 311 | 311
receptor binding 303 | 303
protein kinase binding 289 | 289
enzyme binding 286 | 286
cadherin binding involved in c... 277 | 277
GTPase activator activity 273 | 273
ubiquitin protein ligase bindi... 258 | 258
ubiquitin-protein transferase ... 253 | 253
serine-type endopeptidase acti... 246 | 246
transcription coactivator acti... 241 | 241
transcription factor binding 240 | 240
structural molecule activity 232 | 232
GTPase activity 231 | 231
transcriptional activator acti... 230 | 230
ligase activity 227 | 227
protein heterodimerization act... 227 | 227
structural constituent of ribo... 212 | 212
transcription regulatory regio... 202 | 202
transmembrane signaling recept... 201 | 201
RNA polymerase II regulatory r... 200 | 200
receptor activity 200 | 200
transcription corepressor acti... 198 | 198
magnesium ion binding 197 | 197
signal transducer activity 196 | 196
nucleic acid binding 184 | 184
protein kinase activity 183 | 183
carbohydrate binding 180 | 180
ubiquitin protein ligase activ... 173 | 173
RNA polymerase II transcriptio... 162 | 162
heparin binding 160 | 160
iron ion binding 141 | 141
lipid binding 136 | 136
transporter activity 136 | 136
actin binding 133 | 133
ATPase activity 132 | 132
protein C-terminus binding 129 | 129
heme binding 127 | 127
microtubule binding 123 | 123
protein tyrosine kinase activi... 119 | 119
cytokine activity 118 | 118
Ras guanyl-nucleotide exchange... 113 | 113
mRNA binding 112 | 112
metalloendopeptidase activity 112 | 112
transcriptional repressor acti... 110 | 110
structural constituent of cyto... 108 | 108
Rab GTPase binding 105 | 105
antigen binding 104 | 104
protein domain specific bindin... 102 | 102
peptide antigen binding 101 | 101
guanyl-nucleotide exchange fac... 98 | 98
protein complex binding 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 92 | 92
oxidoreductase activity 91 | 91
transcriptional activator acti... 91 | 91
actin filament binding 89 | 89
hydrolase activity 89 | 89
ion channel binding 89 | 89
protein tyrosine phosphatase a... 88 | 88
electron carrier activity 87 | 87
protease binding 87 | 87
integrin binding 83 | 83
growth factor activity 82 | 82
phospholipid binding 82 | 82
single-stranded DNA binding 81 | 81
unfolded protein binding 77 | 77
kinase activity 75 | 75
thiol-dependent ubiquitin-spec... 75 | 75
phosphatidylinositol binding 74 | 74
calmodulin binding 73 | 73
histone deacetylase binding 73 | 73
Rho guanyl-nucleotide exchange... 72 | 72
drug binding 71 | 71
double-stranded DNA binding 70 | 70
peptidase activity 70 | 70
protein N-terminus binding 70 | 70
virus receptor activity 68 | 68
beta-catenin binding 67 | 67
microtubule motor activity 67 | 67
protein transporter activity 67 | 67
calcium channel activity 66 | 66
ubiquitin binding 66 | 66

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
V(D)J recombination-activating protein 1 RAG1 Tbio Non-IDG -3.00063 1061.1 65
Alpha-synuclein SNCA Tchem Non-IDG -3.59982 3997.3 1484
E3 ubiquitin-protein ligase RNF168 RNF168 Tbio Enzyme -1.46566 28.7 150
Spermatid-specific linker histone H1-like protein HILS1 Tbio Non-IDG 0.00000 0
Histone H4 HIST2H4A Tbio Non-IDG -2.57230 138.5 770
Histone H3.3 H3F3B Tbio Non-IDG -2.06154 100.6 415
Transcriptional repressor CTCFL CTCFL Tbio Transcription Factor -1.73078 41.1 129
PHD finger protein 6 PHF6 Tbio Epigenetic -1.80020 66.8 119
Elongator complex protein 2 ELP2 Tbio Non-IDG -1.29817 19.8 58
E3 ubiquitin-protein ligase RNF8 RNF8 Tbio Enzyme -1.74520 64.0 226