Development Level

Tbio 11 | 11,445
Tchem 8 | 1,598
Tdark 2 | 6,588

IMPC Phenotype

abnormal behavior 2 | 298
abnormal eye morphology 2 | 68
abnormal tooth morphology 2 | 24
decreased vertical activity 2 | 208
preweaning lethality, incomple... 2 | 499
abnormal cornea morphology 1 | 31
abnormal cranium morphology 1 | 36
abnormal embryo size 1 | 220
abnormal eye pigmentation 1 | 3
abnormal eye size 1 | 7
abnormal eyelid aperture 1 | 2
abnormal iris morphology 1 | 13
abnormal maxilla morphology 1 | 17
corneal opacity 1 | 32
corneal vascularization 1 | 6
decreased body length 1 | 101
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased circulating choleste... 1 | 93
decreased circulating creatine... 1 | 4
decreased circulating glucose ... 1 | 126
decreased fasted circulating g... 1 | 65
decreased hemoglobin content 1 | 68
decreased lean body mass 1 | 135
decreased total body fat amoun... 1 | 207
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
eyelids fail to open 1 | 3
hyperactivity 1 | 148
impaired glucose tolerance 1 | 75
increased bone mineral content 1 | 108
increased circulating creatine... 1 | 5
increased lean body mass 1 | 172
persistence of hyaloid vascula... 1 | 33

Disease

Carcinoma 18 | 11,493
osteosarcoma 14 | 7,950
ovarian cancer 12 | 8,520
Kidney cancer 11 | 2,613
Cancer 9 | 2,499
medulloblastoma, large-cell 9 | 6,241
Breast cancer 8 | 3,578
atypical teratoid / rhabdoid tumor 8 | 5,112
psoriasis 8 | 6,694
glioblastoma 7 | 5,792
lung cancer 7 | 4,740
Intellectual disability 6 | 1,016
Dull intelligence 5 | 645
Low intelligence 5 | 645
Mental Retardation 5 | 645
Mental deficiency 5 | 645
Poor school performance 5 | 645
astrocytoma 5 | 1,146
group 3 medulloblastoma 5 | 4,104
Adenoid Cystic Carcinoma 4 | 99
Atrial Septal Defects 4 | 85
Blepharoptosis 4 | 231
Carcinoma, Adenoid Cystic 4 | 99
Cognitive delay 4 | 608
Delayed bone age 4 | 136
Endometrial cancer 4 | 311
Feeding difficulties in infancy 4 | 175
Global developmental delay 4 | 608
Low posterior hairline 4 | 52
Low set ears 4 | 181
Mental and motor retardation 4 | 608
Muscle hypotonia 4 | 571
Rheumatoid arthritis 4 | 1,191
Schizophrenia 4 | 1,160
Short stature 4 | 531
Small head 4 | 374
Strabismus 4 | 270
Ventricular Septal Defects 4 | 119
oligodendroglioma 4 | 2,850
Acquired scoliosis 3 | 281
Agenesis of corpus callosum 3 | 83
Bilateral fifth finger clinodactyly 3 | 110
Bipolar Disorder 3 | 666
Breast Neoplasms 3 | 445
Broad flat nasal bridge 3 | 236
Broad thumbs 3 | 28
Byzanthine arch palate 3 | 194
Carcinoma, Squamous Cell 3 | 110
Cardiac Arrhythmia 3 | 103
Cardiac conduction abnormalities 3 | 78
Cataract 3 | 297
Conduction disorder of the heart 3 | 79
Congenital Epicanthus 3 | 177
Congenital deafness 3 | 185
Constipation 3 | 181
Curvature of little finger 3 | 110
Curvature of spine 3 | 282
Deafness 3 | 198
Delayed speech and language development 3 | 112
Downward slant of palpebral fissure 3 | 158
Dyschezia 3 | 135
EKG abnormalities 3 | 78
Electrocardiogram abnormal 3 | 81
Electrocardiogram change 3 | 78
Enophthalmos 3 | 75
Epilepsy 3 | 792
Exophthalmos 3 | 112
Hearing Loss, Partial 3 | 185
Hirsutism 3 | 47
Hyperplasia of nose 3 | 23
Hypertrophy of nose 3 | 23
Hypoplastic mandible condyle 3 | 275
Immune system cancer 3 | 140
Language Delay 3 | 112
Large nose 3 | 23
Liver cancer 3 | 604
Long eyelashes 3 | 37
Mammary Neoplasms 3 | 425
Mandibular hypoplasia 3 | 275
Micrognathism 3 | 275
Nasal bridge wide 3 | 236
Patent ductus arteriosus 3 | 90
Pectus excavatum 3 | 100
Polyhydramnios 3 | 108
Prominent eyes 3 | 96
Prominent globes 3 | 96
Prostatic Neoplasms 3 | 495
Protruding eyes 3 | 96
Respiratory distress 3 | 43
Rubinstein-Taybi syndrome 3 | 10
Seizures 3 | 596
Speech Delay 3 | 112
Speech impairment 3 | 112
Squamous cell carcinoma 3 | 129
Sunken eyes 3 | 63
adult high grade glioma 3 | 3,801
hearing impairment 3 | 199
malignant mesothelioma 3 | 3,232
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
primitive neuroectodermal tumor 3 | 3,035

Tissue

Endocrine System 21 | 18,159
Male tissues 19 | 17,142
Blood and immune system 18 | 16,909
Cardiovascular System 18 | 15,192
Digestive Tract 18 | 17,369
Female tissues 18 | 17,400
Liver and Pancreas 18 | 16,750
Nervous System 18 | 16,725
Respiratory system 18 | 16,393
Skin and soft tissues 18 | 17,230
Urinary Tract 18 | 16,678

Target Family

Epigenetic 15 | 242
TF/Epigenetic 2 | 38
Enzyme 1 | 4,145
Kinase 1 | 634
Non-IDG 1 | 12,091
Transcription Factor 1 | 1,400

GO Function

histone acetyltransferase acti... 21 | 21
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Testis-specific chromodomain protein Y 1 CDY1 Tbio Epigenetic -1.26646 18.6 30
Helicase SRCAP SRCAP Tbio Enzyme -1.89315 84.2 67
Transcription initiation factor TFIID subunit 1-like TAF1L Tchem Epigenetic -0.42674 2.72 43
Histone acetyltransferase KAT2A KAT2A Tbio Epigenetic -2.46487 271.9 262
Cysteine-rich protein 2-binding protein KAT14 Tbio Non-IDG -0.90082 7.81 111
Transcription initiation factor TFIID subunit 1 TAF1 Tchem Kinase -2.64215 426.1 228
Cyclic AMP-dependent transcription factor ATF-2 ATF2 Tbio Transcription Factor -2.23104 170.7 1819
Nuclear receptor coactivator 3 NCOA3 Tbio Epigenetic -2.64583 480.2 417
Testis-specific chromodomain protein Y 2 CDY2A Tdark Epigenetic -0.96042 8.97 25
General transcription factor 3C polypeptide 4 GTF3C4 Tdark Epigenetic -0.65321 4.19 122