Development Level

Tbio 76 | 11,651
Tchem 28 | 1,388
Tclin 18 | 612
Tdark 7 | 6,593

IMPC Phenotype

decreased total body fat amoun... 5 | 207
enlarged heart 5 | 210
preweaning lethality, incomple... 5 | 499
abnormal behavior 4 | 298
increased bone mineral content 4 | 108
abnormal bone structure 3 | 187
abnormal heart morphology 3 | 162
cataract 3 | 92
decreased blood urea nitrogen ... 3 | 51
decreased bone mineral content 3 | 151
decreased vertical activity 3 | 208
increased circulating alkaline... 3 | 122
abnormal femur morphology 2 | 14
abnormal lens morphology 2 | 81
abnormal seminal vesicle morph... 2 | 114
decreased bone mineral density 2 | 126
decreased circulating alkaline... 2 | 46
decreased circulating choleste... 2 | 93
decreased circulating insulin ... 2 | 76
decreased circulating phosphat... 2 | 27
decreased circulating triglyce... 2 | 79
hypoactivity 2 | 132
improved glucose tolerance 2 | 79
increased circulating HDL chol... 2 | 80
increased circulating choleste... 2 | 66
increased fasted circulating g... 2 | 76
increased lean body mass 2 | 172
small kidney 2 | 16
abnormal behavioral response t... 1 | 66
abnormal clavicle morphology 1 | 6
abnormal cranium morphology 1 | 36
abnormal embryo size 1 | 220
abnormal eye morphology 1 | 68
abnormal fibula morphology 1 | 2
abnormal gait 1 | 69
abnormal humerus morphology 1 | 11
abnormal joint morphology 1 | 23
abnormal kidney morphology 1 | 65
abnormal male genitalia morpho... 1 | 3
abnormal pelvic girdle bone mo... 1 | 12
abnormal radius morphology 1 | 8
abnormal rib morphology 1 | 10
abnormal scapula morphology 1 | 3
abnormal sensory capabilities-... 1 | 8
abnormal sleep behavior 1 | 70
abnormal testis morphology 1 | 43
abnormal tibia morphology 1 | 14
abnormal ulna morphology 1 | 8
abnormal vertebrae morphology 1 | 18
abnormal vibrissa morphology 1 | 25
abnormal vocalization 1 | 21
absent mammary gland 1 | 1
decreased body length 1 | 101
decreased cardiac output 1 | 3
decreased circulating HDL chol... 1 | 68
decreased circulating amylase ... 1 | 28
decreased circulating bilirubi... 1 | 19
decreased circulating calcium ... 1 | 36
decreased circulating iron lev... 1 | 32
decreased circulating serum al... 1 | 82
decreased erythrocyte cell num... 1 | 62
decreased grip strength 1 | 116
decreased heart weight 1 | 27
decreased lean body mass 1 | 135
decreased mean platelet volume 1 | 25
decreased monocyte cell number 1 | 8
edema 1 | 59
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged seminal vesicle 1 | 10
hydrometra 1 | 53
hyperactivity 1 | 148
impaired glucose tolerance 1 | 75
impaired righting response 1 | 26
increased anti-nuclear antigen... 1 | 19
increased blood urea nitrogen ... 1 | 48
increased circulating amylase ... 1 | 25
increased circulating bilirubi... 1 | 16
increased circulating creatini... 1 | 38
increased circulating sodium l... 1 | 71
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular hem... 1 | 96
increased monocyte cell number 1 | 63
increased spleen weight 1 | 10
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
microphthalmia 1 | 26
persistence of hyaloid vascula... 1 | 33
polydactyly 1 | 7
short tibia 1 | 97
small heart 1 | 10
small ovary 1 | 1
small spleen 1 | 19
small superior vagus ganglion 1 | 74
small testis 1 | 58
small uterus 1 | 3
stereotypic behavior 1 | 3
thin skin 1 | 2
thin ventricular wall 1 | 24
trunk curl 1 | 16

Disease

Carcinoma 90 | 11,493
psoriasis 64 | 6,694
osteosarcoma 51 | 7,950
ovarian cancer 50 | 8,520
lung cancer 41 | 4,740
Cancer 40 | 2,499
glioblastoma 37 | 5,792
medulloblastoma, large-cell 35 | 6,241
interstitial cystitis 32 | 2,312
ependymoma 31 | 4,679
lung carcinoma 30 | 2,843
group 3 medulloblastoma 29 | 4,104
Hypertension 28 | 396
adult high grade glioma 28 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 28 | 3,291
non-small cell lung cancer 28 | 2,890
Autosomal recessive predisposition 27 | 1,442
intraductal papillary-mucinous adenoma (IPMA) 27 | 2,955
lung adenocarcinoma 27 | 2,716
pancreatic ductal adenocarcinoma liver metastasis 27 | 1,962
atypical teratoid / rhabdoid tumor 26 | 5,112
diabetes mellitus 25 | 1,728
Breast cancer 24 | 3,578
invasive ductal carcinoma 24 | 2,951
Astrocytoma, Pilocytic 23 | 3,081
Prostatic Neoplasms 23 | 495
intraductal papillary-mucinous carcinoma (IPMC) 23 | 2,989
pancreatic cancer 23 | 2,398
tuberculosis 23 | 2,010
ulcerative colitis 22 | 1,819
oligodendroglioma 21 | 2,850
primitive neuroectodermal tumor 21 | 3,035
Kidney disease 20 | 430
malignant mesothelioma 19 | 3,232
Breast Neoplasms 18 | 445
Kidney cancer 18 | 2,613
Mammary Neoplasms 18 | 425
Hypertensive disease 17 | 292
breast carcinoma 17 | 1,638
cystic fibrosis 16 | 1,696
ductal carcinoma in situ 16 | 1,745
adrenocortical carcinoma 15 | 1,428
astrocytic glioma 15 | 2,597
pituitary cancer 15 | 1,972
Chemical and Drug Induced Liver Injury 14 | 195
Liver Cirrhosis, Experimental 14 | 769
Schizophrenia 14 | 1,160
cutaneous lupus erythematosus 14 | 1,057
Anemia 13 | 365
Atherosclerosis 13 | 291
Depressive disorder 13 | 409
Liver disease 13 | 237
Obesity 13 | 678
Heart disease 12 | 306
Hepatomegaly 12 | 285
Pick disease 12 | 1,894
gastric carcinoma 12 | 807
group 4 medulloblastoma 12 | 1,855
subependymal giant cell astrocytoma 12 | 2,287
Atopic dermatitis 11 | 952
Endometriosis 11 | 540
Heart failure 11 | 162
Malaria 11 | 160
Melanoma 11 | 711
Alzheimer's disease 10 | 658
Brain Ischemia 10 | 110
Cerebrovascular disease 10 | 238
Coronary artery disease 10 | 268
Osteoporosis 10 | 363
Short stature 10 | 531
Splenomegaly 10 | 190
Thalassemia 10 | 53
active Crohn's disease 10 | 922
aldosterone-producing adenoma 10 | 665
Acute kidney injury 9 | 70
Diabetes Mellitus, Experimental 9 | 108
Diabetes Mellitus, Non-Insulin-Dependent 9 | 145
Dull intelligence 9 | 645
Increase in blood pressure 9 | 119
Intellectual disability 9 | 1,016
Kidney Failure, Chronic 9 | 46
Low intelligence 9 | 645
Lung Neoplasms 9 | 232
Mental Retardation 9 | 645
Mental deficiency 9 | 645
Myocardial Infarction 9 | 151
Poor school performance 9 | 645
Rheumatoid arthritis 9 | 1,191
Seizures 9 | 596
Vascular disease 9 | 319
astrocytoma 9 | 1,146
chronic rhinosinusitis 9 | 512
primary pancreatic ductal adenocarcinoma 9 | 1,109
Asthma 8 | 385
colon cancer 8 | 1,478
esophageal adenocarcinoma 8 | 737
pancreatic carcinoma 8 | 562
pediatric high grade glioma 8 | 1,064
periodontitis 8 | 293
primary Sjogren syndrome 8 | 735

Tissue

Endocrine System 122 | 18,159
Female tissues 120 | 17,400
Digestive Tract 118 | 17,369
Liver and Pancreas 118 | 16,750
Skin and soft tissues 116 | 17,230
Male tissues 113 | 17,142
Blood and immune system 112 | 16,909
Urinary Tract 110 | 16,678
Respiratory system 108 | 16,393
Nervous System 105 | 16,725
Cardiovascular System 83 | 15,192

Target Family

Non-IDG 63 | 12,091
Enzyme 57 | 4,145
Kinase 3 | 634
Transcription Factor 2 | 1,400
Transporter 2 | 473
Ion Channel 1 | 344
Nuclear Receptor 1 | 48

GO Function

heme binding 129 | 129
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Myeloperoxidase MPO Tchem Enzyme -3.51470 3209.3 1255
Dual oxidase 2 DUOX2 Tbio Enzyme -2.45061 251.8 126
Dual oxidase 1 DUOX1 Tbio Enzyme -2.50131 279.5 85
Hemoglobin subunit zeta HBZ Tbio Non-IDG -2.38422 251.3 201
Noelin OLFM1 Tbio Non-IDG -1.29218 21.3 300
NADPH oxidase 5 NOX5 Tbio Enzyme -1.82693 76.8 174
7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase CYP8B1 Tbio Enzyme -1.65191 40.5 121
Myoglobin MB Tbio Non-IDG -3.94731 8640.3 951
Cytochrome P450 1A1 CYP1A1 Tchem Non-IDG -3.54987 3641.5 384
Cytochrome b5 CYB5A Tbio Non-IDG -3.24845 1711.7 270