Development Level

Tbio 46 | 11,445
Tchem 5 | 1,598
Tdark 5 | 6,588

IMPC Phenotype

preweaning lethality, complete... 5 | 979
embryonic lethality prior to o... 3 | 239
abnormal behavior 2 | 298
abnormal retina morphology 2 | 71
decreased body weight 2 | 161
decreased circulating serum al... 2 | 82
decreased lean body mass 2 | 135
embryonic lethality prior to t... 2 | 278
increased circulating alkaline... 2 | 122
abnormal coat- hair morphology 1 | 19
abnormal embryo size 1 | 220
absent spleen 1 | 3
decreased IgG1 level 1 | 8
decreased body length 1 | 101
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating alanine ... 1 | 47
decreased circulating amylase ... 1 | 28
decreased circulating aspartat... 1 | 34
decreased circulating choleste... 1 | 93
decreased circulating fructosa... 1 | 30
decreased circulating total pr... 1 | 49
decreased circulating triglyce... 1 | 79
decreased grip strength 1 | 116
decreased lumbar vertebrae num... 1 | 2
decreased neutrophil cell numb... 1 | 42
decreased red blood cell distr... 1 | 41
decreased spleen weight 1 | 10
hyperactivity 1 | 148
increased aggression 1 | 4
increased bone mineral density 1 | 72
increased circulating potassiu... 1 | 29
increased grip strength 1 | 41
increased hemoglobin content 1 | 45
increased mean corpuscular hem... 1 | 96
increased total body fat amoun... 1 | 134
prenatal lethality 1 | 28
preweaning lethality, incomple... 1 | 499

Disease

Carcinoma 49 | 11,493
ovarian cancer 35 | 8,520
osteosarcoma 33 | 7,950
psoriasis 30 | 6,694
medulloblastoma, large-cell 27 | 6,241
Kidney cancer 25 | 2,613
lung cancer 25 | 4,740
Breast cancer 23 | 3,578
glioblastoma 22 | 5,792
atypical teratoid / rhabdoid tumor 18 | 5,112
group 3 medulloblastoma 17 | 4,104
primitive neuroectodermal tumor 15 | 3,035
malignant mesothelioma 14 | 3,232
Cancer 13 | 2,499
adult high grade glioma 13 | 3,801
ependymoma 13 | 4,679
Intellectual disability 12 | 1,016
Astrocytoma, Pilocytic 10 | 3,081
Dull intelligence 10 | 645
Low intelligence 10 | 645
Mental Retardation 10 | 645
Mental deficiency 10 | 645
Poor school performance 10 | 645
Short stature 10 | 531
dermatomyositis 10 | 966
lung adenocarcinoma 10 | 2,716
Liver cancer 9 | 604
invasive ductal carcinoma 9 | 2,951
Autosomal recessive predisposition 8 | 1,442
Cockayne syndrome 8 | 60
Cryptorchidism 8 | 296
Fetal Growth Retardation 8 | 189
Infant, Small for Gestational Age 8 | 176
Intrauterine retardation 8 | 176
Small head 8 | 374
Waldenstrons macroglobulinemia 8 | 765
colon cancer 8 | 1,478
intraductal papillary-mucinous neoplasm (IPMN) 8 | 3,291
juvenile dermatomyositis 8 | 1,187
lung carcinoma 8 | 2,843
nasopharyngeal carcinoma 8 | 1,058
non-small cell lung cancer 8 | 2,890
Pick disease 7 | 1,894
Rheumatoid arthritis 7 | 1,191
intraductal papillary-mucinous carcinoma (IPMC) 7 | 2,989
pancreatic cancer 7 | 2,398
Cognitive delay 6 | 608
Global developmental delay 6 | 608
Hypogonadism 6 | 173
Mental and motor retardation 6 | 608
Multiple myeloma 6 | 1,332
astrocytic glioma 6 | 2,597
hearing impairment 6 | 199
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,955
oligodendroglioma 6 | 2,850
tuberculosis 6 | 2,010
Concave bridge of nose 5 | 195
Congenital deafness 5 | 185
Deafness 5 | 198
Depressed nasal bridge 5 | 195
Depressed nasal root/bridge 5 | 195
Epilepsy 5 | 792
Fanconi anemia 5 | 56
Hearing Loss, Partial 5 | 185
Hypoplastic mandible condyle 5 | 275
Macrostomia 5 | 72
Mandibular hypoplasia 5 | 275
Melanoma 5 | 711
Micrognathism 5 | 275
Muscle hypotonia 5 | 571
Optic Atrophy 5 | 242
Schimke immuno-osseous dysplasia 5 | 8
Seizures 5 | 596
Strabismus 5 | 270
acute myeloid leukemia 5 | 783
adrenocortical carcinoma 5 | 1,428
breast carcinoma 5 | 1,638
cutaneous lupus erythematosus 5 | 1,057
cystic fibrosis 5 | 1,696
diabetes mellitus 5 | 1,728
group 4 medulloblastoma 5 | 1,855
medulloblastoma 5 | 720
pediatric high grade glioma 5 | 1,064
pituitary cancer 5 | 1,972
Abnormally small eyeball 4 | 97
Cataract 4 | 297
Decreased size of eyeball 4 | 97
Delayed bone age 4 | 136
Failure to gain weight 4 | 365
Lens Opacities 4 | 231
Microphthalmos 4 | 100
Schizophrenia 4 | 1,160
Short neck 4 | 140
acute quadriplegic myopathy 4 | 1,158
astrocytoma 4 | 1,146
ductal carcinoma in situ 4 | 1,745
primary Sjogren syndrome 4 | 735
progressive supranuclear palsy 4 | 676
subependymal giant cell astrocytoma 4 | 2,287
ulcerative colitis 4 | 1,819

Tissue

Blood and immune system 55 | 16,909
Digestive Tract 55 | 17,369
Endocrine System 55 | 18,159
Female tissues 55 | 17,400
Liver and Pancreas 55 | 16,750
Male tissues 55 | 17,142
Nervous System 55 | 16,725
Respiratory system 55 | 16,393
Skin and soft tissues 55 | 17,230
Urinary Tract 55 | 16,678
Cardiovascular System 54 | 15,192

Target Family

Enzyme 24 | 4,145
Non-IDG 23 | 12,091
Epigenetic 9 | 242

GO Function

helicase activity 56 | 56
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Probable global transcription activator SNF2L1 SMARCA1 Tbio Non-IDG -2.20560 145.6 116
ATP-dependent DNA helicase Q4 RECQL4 Tbio Enzyme 0.00000 0
E3 ubiquitin-protein ligase SHPRH SHPRH Tbio Epigenetic -0.99196 10.7 137
DNA annealing helicase and endonuclease ZRANB3 ZRANB3 Tbio Enzyme -2.18014 154.3 36
Putative helicase MOV-10 MOV10 Tbio Enzyme -1.55297 38.5 121
Probable helicase with zinc finger domain HELZ Tbio Enzyme -1.50209 22.1 63
Helicase with zinc finger domain 2 HELZ2 Tdark Enzyme -0.50849 4.27 30
Chromodomain-helicase-DNA-binding protein 3 CHD3 Tbio Epigenetic -1.95633 85.2 190
Probable ATP-dependent RNA helicase DDX60-like DDX60L Tdark Enzyme 0.23 0.83 72
Transcription termination factor 2 TTF2 Tbio Non-IDG -0.36173 2.95 140