Development Level

Tbio 3 | 11,651

IMPC Phenotype

decreased mean corpuscular hem... 1 | 31
enlarged urinary bladder 1 | 8
increased body weight 1 | 25
increased fasted circulating g... 1 | 76

Disease

Carcinoma 3 | 11,493
Gastrointestinal Stromal Tumors 3 | 48
Abnormally small eyeball 2 | 97
Accessory rib 2 | 10
Acquired scoliosis 2 | 281
Basal Cell Nevus Syndrome 2 | 5
Basal cell carcinoma 2 | 54
Basal cell nevi 2 | 23
Big calvaria 2 | 147
Brachydactyly 2 | 156
Broad flat nasal bridge 2 | 236
Calcification of falx cerebri 2 | 6
Cancer 2 | 2,499
Carcinoma, Basal Cell 2 | 28
Cardiac fibroma 2 | 3
Cardiac rhabdomyoma 2 | 5
Cataract 2 | 297
Cerebral calcification 2 | 43
Chronic obstructive pulmonary disease 2 | 184
Class III malocclusion 2 | 78
Cleft Lip 2 | 141
Cleft Palate 2 | 271
Coarse facial features 2 | 108
Coloboma of iris 2 | 38
Congenital anomaly of neck 2 | 19
Congenital fusion of ribs 2 | 4
Congenital hemivertebra 2 | 25
Curvature of spine 2 | 282
Decreased size of eyeball 2 | 97
Deformity of neck 2 | 19
Endometriosis 2 | 540
Frontal bossing 2 | 157
Fused vertebrae 2 | 25
Glaucoma 2 | 239
Gorlin syndrome 2 | 4
Hamartomatous stomach polyps 2 | 3
Highly variable severity 2 | 157
Holoprosencephaly 2 | 56
Hydrocephalus 2 | 152
Hypertrophy of lower jaw 2 | 78
Increased head circumference 2 | 147
Increased size of cranium 2 | 147
Increased size of mandible 2 | 78
Increased size of skull 2 | 147
Irregular ossification of hand bones 2 | 3
Keratocystic Odontogenic Tumor 2 | 3
Kyphoscoliosis deformity of spine 2 | 60
Lens Opacities 2 | 231
Malformation of the neck 2 | 19
Mandibular hyperplasia 2 | 78
Melanocytic nevus 2 | 43
Microphthalmos 2 | 100
Milium Cyst 2 | 16
Motor delay 2 | 147
Nasal bridge wide 2 | 236
Nevoid basal cell carcinoma syndrome 2 | 16
No development of motor milestones 2 | 147
Noncancerous mole 2 | 28
Orbital cyst 2 | 8
Orbital separation excessive 2 | 244
Ovarian Fibromata 2 | 3
Palmar pit 2 | 4
Parietal bossing 2 | 5
Plantar pits 2 | 4
Polydactyly 2 | 107
Sella Turcica, Bridged 2 | 3
Short 4th metacarpal 2 | 7
Short ribs 2 | 30
Short thumb terminal phalanx 2 | 5
Skin tag 2 | 14
Sloping shoulders 2 | 21
Spinal fusion 2 | 25
Sprengel deformity 2 | 16
Sternal anomalies 2 | 19
Strabismus 2 | 270
Thickened facial skin with coarse facial features 2 | 108
Uranostaphyloschisis 2 | 167
Variable expressivity 2 | 157
Vertebral body fusion 2 | 25
Vertebral wedging 2 | 4
atypical teratoid / rhabdoid tumor 2 | 5,112
interstitial cystitis 2 | 2,312
lung cancer 2 | 4,740
mandibular excess (physical finding) 2 | 78
medulloblastoma 2 | 720
ovarian cancer 2 | 8,520
spina bifida 2 | 1,074
subependymal giant cell astrocytoma 2 | 2,287
Abnormality of the ribs 1 | 32
Advanced bone age 1 | 35
Decreased projection of maxilla 1 | 66
Deficiency of upper jaw bones 1 | 66
Hyperactive behavior 1 | 91
Hypoplasia of the maxilla 1 | 66
Hypotrophic maxilla 1 | 66
Late tooth eruption 1 | 61
Maxillary retrognathia 1 | 66
Retrusion of upper jaw bones 1 | 66
Tall stature 1 | 34
Tinea capitis 1 | 14

Tissue

Blood and immune system 3 | 16,909
Digestive Tract 3 | 17,369
Endocrine System 3 | 18,159
Female tissues 3 | 17,400
Liver and Pancreas 3 | 16,750
Male tissues 3 | 17,142
Nervous System 3 | 16,725
Respiratory system 3 | 16,393
Skin and soft tissues 3 | 17,230
Urinary Tract 3 | 16,678
Cardiovascular System 2 | 15,192

Target Family

Non-IDG 3 | 12,091

GO Function

hedgehog family protein bindin... 3 | 3
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Protein patched homolog 1 PTCH1 Tbio Non-IDG -3.04637 1057.4 452
Hedgehog-interacting protein HHIP Tbio Non-IDG -1.83526 65.4 193
Protein patched homolog 2 PTCH2 Tbio Non-IDG -1.80541 50.4 92