Development Level

Tbio 11 | 11,445
Tchem 2 | 1,598

IMPC Phenotype

decreased total body fat amoun... 3 | 207
decreased body weight 2 | 161
decreased circulating HDL chol... 2 | 68
decreased exploration in new e... 2 | 11
abnormal behavior 1 | 298
abnormal craniofacial morpholo... 1 | 33
abnormal embryo size 1 | 220
abnormal eye morphology 1 | 68
abnormal hindbrain morphology 1 | 10
abnormal midbrain morphology 1 | 10
abnormal neural tube closure 1 | 46
abnormal pericardium morpholog... 1 | 26
abnormal placenta size 1 | 20
abnormal retina morphology 1 | 71
decreased bone mineral content 1 | 151
decreased circulating LDL chol... 1 | 38
decreased circulating aspartat... 1 | 34
decreased circulating choleste... 1 | 93
decreased grip strength 1 | 116
decreased lean body mass 1 | 135
embryonic growth retardation 1 | 106
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
increased bone mineral content 1 | 108
increased circulating chloride... 1 | 41
increased circulating sodium l... 1 | 71
increased lean body mass 1 | 172
increased mean corpuscular vol... 1 | 92
increased or absent threshold ... 1 | 101
pale yolk sac 1 | 25
prenatal lethality prior to he... 1 | 87
preweaning lethality, complete... 1 | 979
tremors 1 | 39

Disease

Carcinoma 12 | 11,493
astrocytic glioma 8 | 2,597
osteosarcoma 8 | 7,950
ovarian cancer 8 | 8,520
ependymoma 7 | 4,679
medulloblastoma, large-cell 7 | 6,241
subependymal giant cell astrocytoma 7 | 2,287
atypical teratoid / rhabdoid tumor 6 | 5,112
group 3 medulloblastoma 6 | 4,104
lung carcinoma 6 | 2,843
psoriasis 6 | 6,694
Kidney cancer 5 | 2,613
glioblastoma 5 | 5,792
non-small cell lung cancer 5 | 2,890
oligodendroglioma 5 | 2,850
Astrocytoma, Pilocytic 4 | 3,081
Intellectual disability 4 | 1,016
Pick disease 4 | 1,894
Schizophrenia 4 | 1,160
adult high grade glioma 4 | 3,801
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,291
Bipolar Disorder 3 | 666
Breast cancer 3 | 3,578
Chromosome 3q29 microdeletion syndrome 3 | 11
FG syndrome 3 | 16
Major Depressive Disorder 3 | 301
Melanoma 3 | 711
Unipolar Depression 3 | 250
lung adenocarcinoma 3 | 2,716
lung cancer 3 | 4,740
malignant mesothelioma 3 | 3,232
pituitary cancer 3 | 1,972
primitive neuroectodermal tumor 3 | 3,035
spina bifida 3 | 1,074
Amyotrophic lateral sclerosis 2 | 451
Cleft Palate 2 | 271
Cognitive delay 2 | 608
Down syndrome 2 | 499
Dull intelligence 2 | 645
Epilepsy 2 | 792
Fragile X syndrome 2 | 34
Global developmental delay 2 | 608
Low intelligence 2 | 645
Mental Retardation 2 | 645
Mental Retardation, X-Linked 2 | 23
Mental and motor retardation 2 | 608
Mental deficiency 2 | 645
Mood Disorders 2 | 184
Nance-Horan syndrome 2 | 25
Neurodevelopmental Disorders 2 | 70
Poor school performance 2 | 645
Strabismus 2 | 270
interstitial cystitis 2 | 2,312
invasive ductal carcinoma 2 | 2,951
juvenile dermatomyositis 2 | 1,187
nasopharyngeal carcinoma 2 | 1,058
non primary Sjogren syndrome sicca 2 | 891
pancreatic cancer 2 | 2,398
primary pancreatic ductal adenocarcinoma 2 | 1,109
Adult T-Cell Lymphoma/Leukemia 1 | 30
Animal Mammary Neoplasms 1 | 136
Axial hypotonia 1 | 46
Broad forehead 1 | 59
Broad nasal tip 1 | 28
Charcot-Marie-Tooth disease 1 | 62
Congenital nystagmus 1 | 26
Early infantile epileptic encephalopathy with suppression bursts 1 | 10
Gaucher disease type 1 1 | 180
Global developmental delay, severe 1 | 47
Hypertension, Portal 1 | 22
Hypohidrosis 1 | 34
Large dysplastic ears 1 | 87
Large intestine cancer 1 | 126
Large pinnae 1 | 87
Large prominent ears 1 | 87
Leukemia-Lymphoma, Adult T-Cell 1 | 30
Liver Failure 1 | 73
Lymphoid leukemia 1 | 160
Lymphoma 1 | 81
Mammary Neoplasms, Animal 1 | 136
Mammary Neoplasms, Experimental 1 | 154
Moderate mental retardation (I.Q. 35-49) 1 | 28
Muscle Weakness 1 | 170
Nephrosis 1 | 21
Nonsyndromic deafness 1 | 142
Osteoporosis 1 | 363
Partington syndrome 1 | 9
Pruritus 1 | 58
Renal Cell Carcinoma 1 | 214
Rickets 1 | 49
Scotoma 1 | 22
Sensorineural Hearing Loss (disorder) 1 | 284
Severe psychomotor retardation 1 | 47
Steatorrhea 1 | 34
Weight decreased 1 | 103
X-linked dominant 1 | 57
hearing impairment 1 | 199
interstitial lung disease 1 | 298

Tissue

Blood and immune system 13 | 16,909
Cardiovascular System 13 | 15,192
Digestive Tract 13 | 17,369
Endocrine System 13 | 18,159
Female tissues 13 | 17,400
Liver and Pancreas 13 | 16,750
Male tissues 13 | 17,142
Nervous System 13 | 16,725
Respiratory system 13 | 16,393
Skin and soft tissues 13 | 17,230
Urinary Tract 13 | 16,678

Target Family

Non-IDG 9 | 12,091
Enzyme 2 | 4,145
Kinase 2 | 634

GO Function

guanylate kinase activity 13 | 13
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 MAGI3 Tbio Enzyme -1.20980 18.0 42
Caspase recruitment domain-containing protein 11 CARD11 Tbio Enzyme -2.17228 139.2 235
Peripheral plasma membrane protein CASK CASK Tchem Kinase -2.12241 130.2 227
MAGUK p55 subfamily member 3 MPP3 Tbio Non-IDG -1.26124 17.3 186
Disks large homolog 1 DLG1 Tbio Non-IDG -2.19822 171.8 185
Disks large homolog 2 DLG2 Tbio Non-IDG -1.75838 53.6 227
Disks large homolog 4 DLG4 Tchem Non-IDG -2.98766 883.9 559
55 kDa erythrocyte membrane protein MPP1 Tbio Non-IDG -1.31115 20.6 257
Disks large homolog 3 DLG3 Tbio Non-IDG -2.03959 106.4 200
MAGUK p55 subfamily member 2 MPP2 Tbio Non-IDG -1.06328 10.2 162