Development Level

Tbio 10 | 11,651
Tclin 6 | 612
Tchem 2 | 1,388

IMPC Phenotype

abnormal behavior 1 | 298
decreased circulating chloride... 1 | 30
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
hyperactivity 1 | 148
improved glucose tolerance 1 | 79
preweaning lethality, incomple... 1 | 499
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36

Disease

Carcinoma 17 | 11,493
Kidney cancer 12 | 2,613
ovarian cancer 9 | 8,520
adult high grade glioma 8 | 3,801
atypical teratoid / rhabdoid tumor 8 | 5,112
lung cancer 8 | 4,740
medulloblastoma, large-cell 8 | 6,241
osteosarcoma 8 | 7,950
ependymoma 7 | 4,679
glioblastoma 7 | 5,792
intraductal papillary-mucinous carcinoma (IPMC) 7 | 2,989
lung carcinoma 7 | 2,843
Astrocytoma, Pilocytic 6 | 3,081
Autosomal recessive predisposition 6 | 1,442
astrocytic glioma 6 | 2,597
group 3 medulloblastoma 6 | 4,104
non-small cell lung cancer 6 | 2,890
primitive neuroectodermal tumor 6 | 3,035
Breast cancer 5 | 3,578
Decompensated cardiac failure 5 | 9
breast carcinoma 5 | 1,638
gastric carcinoma 5 | 807
interstitial cystitis 5 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,955
invasive ductal carcinoma 5 | 2,951
lung adenocarcinoma 5 | 2,716
psoriasis 5 | 6,694
ulcerative colitis 5 | 1,819
Acquired metabolic disease 4 | 336
Angina Pectoris 4 | 32
Angina Pectoris Prevention 4 | 4
Chronic heart failure 4 | 46
Controlled Hypotension 4 | 6
Hypertension 4 | 396
Hypertensive disorder 4 | 57
Hypertensive urgency 4 | 10
Left ventricular cardiac dysfunction 4 | 9
Malignant essential hypertension 4 | 5
Perioperative hypertension 4 | 5
Persistent pulmonary hypertension of the newborn 4 | 8
Pulmonary hypertension 4 | 86
pancreatic cancer 4 | 2,398
Bipolar Disorder 3 | 666
Depressive disorder 3 | 409
Hypertensive disease 3 | 292
Melanoma 3 | 711
Mental Depression 3 | 333
Mood Disorders 3 | 184
Pick disease 3 | 1,894
colon cancer 3 | 1,478
malignant mesothelioma 3 | 3,232
oligodendroglioma 3 | 2,850
Alcoholic Intoxication, Chronic 2 | 289
Clostridium difficile colitis 2 | 12
Colorectal Neoplasms 2 | 243
Cone dystrophy 2 | 71
Diabetic Angiopathies 2 | 16
Epilepsy 2 | 792
Fibrosis 2 | 44
Hyperactive behavior 2 | 91
Hyperkinesis 2 | 32
Leber congenital amaurosis 2 | 69
Liver cancer 2 | 604
Major Depressive Disorder 2 | 301
Muscle hypotonia 2 | 571
Skin cancer 2 | 469
Substance Withdrawal Syndrome 2 | 55
Unipolar Depression 2 | 250
acute myeloid leukemia 2 | 783
ductal carcinoma in situ 2 | 1,745
group 4 medulloblastoma 2 | 1,855
intraductal papillary-mucinous neoplasm (IPMN) 2 | 3,291
medulloblastoma 2 | 720
non primary Sjogren syndrome sicca 2 | 891
pancreatic carcinoma 2 | 562
pituitary cancer 2 | 1,972
primary Sjogren syndrome 2 | 735
spina bifida 2 | 1,074
subependymal giant cell astrocytoma 2 | 2,287
tuberculosis 2 | 2,010
Cerebellar vermis aplasia or hypoplasia 1 | 12
Cerebellar vermis aplasia/ hypoplasia 1 | 12
Chronic idiopathic constipation 1 | 3
Chronic thromboembolic pulmonary hypertension 1 | 4
Color vision defect, severe 1 | 31
Cone/cone-rod dystrophy 1 | 20
Congenital hypoplasia of radius 1 | 23
Eosinophilic meningitis 1 | 5
Erectile dysfunction 1 | 32
Granulomatous amebic encephalitis 1 | 8
Irritable bowel syndrome characterized by constipation 1 | 3
Meningoencephalitis 1 | 13
Optic disc abnormalities 1 | 12
Osteoblastoma 1 | 8
Polycystic liver disease 1 | 16
Radial ray hypoplasia 1 | 23
Short metatarsal 1 | 21
Small Cell Lung Carcinoma 1 | 41
Small cell carcinoma of lung 1 | 45
Tunnel visual field constriction 1 | 5

Tissue

Endocrine System 17 | 18,159
Blood and immune system 16 | 16,909
Digestive Tract 16 | 17,369
Female tissues 16 | 17,400
Male tissues 16 | 17,142
Skin and soft tissues 16 | 17,230
Cardiovascular System 15 | 15,192
Liver and Pancreas 15 | 16,750
Nervous System 15 | 16,725
Respiratory system 15 | 16,393
Urinary Tract 15 | 16,678

Target Family

Enzyme 13 | 4,145
Kinase 5 | 634

GO Function

guanylate cyclase activity 18 | 18
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Adenylate cyclase type 2 ADCY2 Tbio Enzyme -1.37166 21.4 117
Guanylate cyclase soluble subunit alpha-2 GUCY1A2 Tclin Enzyme -1.39335 23.9 101
Atrial natriuretic peptide receptor 2 NPR2 Tbio Kinase -2.11421 138.1 180
Adenylate cyclase type 1 ADCY1 Tchem Enzyme -1.61657 45.3 134
Adenylate cyclase type 4 ADCY4 Tbio Enzyme -2.04603 107.6 156
Guanylate cyclase soluble subunit beta-2 GUCY1B2 Tclin Enzyme 0.00000 0
Adenylate cyclase type 8 ADCY8 Tbio Enzyme -2.04645 112.4 147
Adenylate cyclase type 6 ADCY6 Tbio Enzyme -2.05332 113.7 111
Retinal guanylyl cyclase 2 GUCY2F Tbio Kinase -1.00236 7.60 84
Adenylate cyclase type 7 ADCY7 Tbio Enzyme -1.68806 49.1 114