Development Level

Tbio 88 | 11,445
Tdark 8 | 6,588
Tchem 6 | 1,598
Tclin 4 | 613

Collection

Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 10 | 979
abnormal behavior 3 | 298
preweaning lethality, incomple... 3 | 499
decreased IgG1 level 2 | 8
decreased caudal vertebrae num... 2 | 53
decreased circulating choleste... 2 | 93
decreased granulocyte number 2 | 6
decreased grip strength 2 | 116
decreased mean corpuscular vol... 2 | 79
hyperactivity 2 | 148
increased startle reflex 2 | 112
short tibia 2 | 97
abnormal eye morphology 1 | 68
abnormal motor capabilities-co... 1 | 5
abnormal response to tactile s... 1 | 17
abnormal retina morphology 1 | 71
abnormal seminal vesicle morph... 1 | 114
abnormal sensory capabilities-... 1 | 8
abnormal vibrissa morphology 1 | 25
decreased IgE level 1 | 6
decreased IgG2b level 1 | 4
decreased T cell number 1 | 15
decreased body weight 1 | 161
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating alanine ... 1 | 47
decreased circulating aspartat... 1 | 34
decreased circulating fructosa... 1 | 30
decreased circulating glucose ... 1 | 126
decreased circulating insulin ... 1 | 76
decreased circulating serum al... 1 | 82
decreased circulating triglyce... 1 | 79
decreased heart left ventricle... 1 | 28
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular hem... 1 | 31
decreased threshold for audito... 1 | 26
decreased total body fat amoun... 1 | 207
decreased total retina thickne... 1 | 17
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
enlarged lymph nodes 1 | 37
hypoactivity 1 | 132
impaired pupillary reflex 1 | 26
increased bone mineral density 1 | 72
increased circulating alkaline... 1 | 122
increased circulating calcium ... 1 | 34
increased circulating choleste... 1 | 66
increased circulating free fat... 1 | 20
increased circulating phosphat... 1 | 26
increased circulating total pr... 1 | 28
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased mature B cell number 1 | 1
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
increased thermal nociceptive ... 1 | 9
increased total body fat amoun... 1 | 134
persistence of hyaloid vascula... 1 | 33
thin ventricular wall 1 | 24
tremors 1 | 39

Disease

Carcinoma 90 | 11,493
osteosarcoma 60 | 7,950
ovarian cancer 57 | 8,520
medulloblastoma, large-cell 48 | 6,241
glioblastoma 45 | 5,792
atypical teratoid / rhabdoid tumor 41 | 5,112
psoriasis 41 | 6,694
Kidney cancer 40 | 2,613
ependymoma 38 | 4,679
adult high grade glioma 33 | 3,801
non-small cell lung cancer 32 | 2,890
Astrocytoma, Pilocytic 30 | 3,081
primitive neuroectodermal tumor 30 | 3,035
group 3 medulloblastoma 29 | 4,104
lung cancer 29 | 4,740
invasive ductal carcinoma 28 | 2,951
oligodendroglioma 28 | 2,850
Breast cancer 26 | 3,578
lung adenocarcinoma 26 | 2,716
astrocytic glioma 24 | 2,597
malignant mesothelioma 24 | 3,232
subependymal giant cell astrocytoma 24 | 2,287
intraductal papillary-mucinous carcinoma (IPMC) 21 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 20 | 2,955
Pick disease 19 | 1,894
interstitial cystitis 19 | 2,312
Cancer 18 | 2,499
ductal carcinoma in situ 18 | 1,745
group 4 medulloblastoma 18 | 1,855
lung carcinoma 18 | 2,843
pituitary cancer 18 | 1,972
ulcerative colitis 18 | 1,819
pancreatic cancer 16 | 2,398
intraductal papillary-mucinous neoplasm (IPMN) 15 | 3,291
tuberculosis 15 | 2,010
Intellectual disability 14 | 1,016
spina bifida 13 | 1,074
cystic fibrosis 12 | 1,696
primary Sjogren syndrome 11 | 735
adrenocortical carcinoma 10 | 1,428
colon cancer 10 | 1,478
cutaneous lupus erythematosus 10 | 1,057
Liver cancer 9 | 604
aldosterone-producing adenoma 9 | 665
breast carcinoma 9 | 1,638
pancreatic ductal adenocarcinoma liver metastasis 9 | 1,962
Autosomal recessive predisposition 8 | 1,442
progressive supranuclear palsy 8 | 676
Amyotrophic lateral sclerosis 7 | 451
Endometrial cancer 7 | 311
Muscle hypotonia 7 | 571
Schizophrenia 7 | 1,160
acute quadriplegic myopathy 7 | 1,158
juvenile dermatomyositis 7 | 1,187
sarcoidosis 7 | 370
Aarskog syndrome 6 | 12
Cardiovascular system disease 6 | 246
Chronic Lymphocytic Leukemia 6 | 262
Dull intelligence 6 | 645
Low intelligence 6 | 645
Mental Retardation 6 | 645
Mental deficiency 6 | 645
Poor school performance 6 | 645
Rheumatoid arthritis 6 | 1,191
diabetes mellitus 6 | 1,728
mucosa-associated lymphoid tissue lymphoma 6 | 484
pediatric high grade glioma 6 | 1,064
primary pancreatic ductal adenocarcinoma 6 | 1,109
Acquired scoliosis 5 | 281
Alzheimer's disease 5 | 658
Atopic dermatitis 5 | 952
Crohn's disease 5 | 321
Curvature of spine 5 | 282
Epilepsy 5 | 792
Obesity 5 | 678
Short stature 5 | 531
active Crohn's disease 5 | 922
astrocytoma 5 | 1,146
dermatomyositis 5 | 966
esophageal adenocarcinoma 5 | 737
gastric cancer 5 | 459
gastric carcinoma 5 | 807
hepatocellular carcinoma 5 | 547
medulloblastoma 5 | 720
Adenocarcinoma of lung 4 | 142
Bipolar Disorder 4 | 666
Down syndrome 4 | 499
Dysarthria 4 | 192
Liver Cirrhosis, Experimental 4 | 769
Low-set, posteriorly rotated ears 4 | 110
Melanoma 4 | 711
Optic Atrophy 4 | 242
Prostatic Neoplasms 4 | 495
Seizures 4 | 596
Strabismus 4 | 270
Waldenstrons macroglobulinemia 4 | 765
active ulcerative colitis 4 | 764
nasopharyngeal carcinoma 4 | 1,058
tuberculosis and treatment for 6 months 4 | 409
urothelial carcinoma 4 | 318

Tissue

Digestive Tract 106 | 17,369
Endocrine System 106 | 18,159
Liver and Pancreas 106 | 16,750
Skin and soft tissues 106 | 17,230
Blood and immune system 105 | 16,909
Female tissues 105 | 17,400
Nervous System 105 | 16,725
Urinary Tract 105 | 16,678
Cardiovascular System 104 | 15,192
Male tissues 104 | 17,142
Respiratory system 104 | 16,393

Target Family

Non-IDG 87 | 12,091
Enzyme 10 | 4,145
GPCR 5 | 408
Kinase 3 | 634
Transcription Factor 1 | 1,400

GO Function

guanyl-nucleotide exchange fac... 106 | 106
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Exosome complex exonuclease RRP44 DIS3 Tbio Enzyme -1.80730 64.2 141
SH2 domain-containing protein 3A SH2D3A Tbio Non-IDG -2.47559 291.4 103
Rho guanine nucleotide exchange factor 17 ARHGEF17 Tbio Non-IDG -1.38408 25.0 61
Ankyrin repeat domain-containing protein 27 ANKRD27 Tbio Non-IDG -1.12548 14.6 65
Rap guanine nucleotide exchange factor-like 1 RAPGEFL1 Tdark Non-IDG 0.25 0.39 60
GTPase-activating protein and VPS9 domain-containing protein 1 GAPVD1 Tbio Enzyme -0.69565 4.71 73
T-lymphoma invasion and metastasis-inducing protein 2 TIAM2 Tbio Non-IDG -1.27322 19.7 151
Rho guanine nucleotide exchange factor 18 ARHGEF18 Tbio Non-IDG -0.76671 7.19 177
Rho guanine nucleotide exchange factor 11 ARHGEF11 Tbio Non-IDG -1.61227 42.0 183
Guanine nucleotide exchange factor DBS MCF2L Tbio Non-IDG -0.98363 12.4 115