Development Level

Tbio 3 | 11,445

IMPC Phenotype

male infertility 1 | 123
small testis 1 | 58

Disease

Abdominal Pain 3 | 98
Abnormality of the abdomen 3 | 14
Adenoma 3 | 167
Anxiety 3 | 136
Anxiety disease 3 | 113
Attention deficit hyperactivity disorder 3 | 278
Autosomal recessive predisposition 3 | 1,442
Axillary freckling 3 | 5
Basal cell carcinoma 3 | 54
Basal cell nevi 3 | 23
Birthmark 3 | 35
Cafe-au-Lait Spots 3 | 37
Cancer 3 | 2,499
Carcinoma 3 | 11,493
Colorectal Neoplasms, Hereditary Nonpolyposis 3 | 9
Colorectal cancer 3 | 25
Constipation 3 | 181
Death in early adulthood 3 | 24
Death in early childhood 3 | 82
Death in infancy 3 | 82
Depressive disorder 3 | 409
Dyschezia 3 | 135
Epilepsy 3 | 792
Familial adenomatous polyposis 3 | 32
Fatigue 3 | 182
Fibrous skin tumor of tuberous sclerosis 3 | 18
Gastrointestinal Hemorrhage 3 | 52
Hematologic Neoplasms 3 | 22
Hereditary Nonpolyposis Colorectal Cancer 3 | 11
Hereditary Nonpolyposis Colorectal Neoplasms 3 | 8
Hyperpigmented macules 3 | 42
Increased gastric cancer 3 | 21
Intermittent migraine headaches 3 | 68
Intracranial hypertension 3 | 32
Irritation - emotion 3 | 68
Kidney cancer 3 | 2,613
Leukemia 3 | 104
Lymphoma 3 | 81
Lynch Syndrome 1 3 | 4
Lynch syndrome 3 | 35
Malabsorption 3 | 82
Malignant tumor of colon 3 | 19
Migraine Disorders 3 | 76
Muir-Torre syndrome 3 | 4
Muscle Hypertonia 3 | 88
Muscle hypotonia 3 | 571
Nausea and vomiting 3 | 97
Neuroblastoma 3 | 80
Rectal Neoplasms 3 | 18
Rhabdomyosarcoma 3 | 39
Sebaceous adenoma 3 | 26
Seizures 3 | 596
Stomach Neoplasms 3 | 300
Torre-Muir syndrome 3 | 3
Turcot syndrome 3 | 5
Turcot syndrome (disorder) 3 | 5
Weight decreased 3 | 103
ependymoma 3 | 4,679
glioblastoma 3 | 5,792
medulloblastoma 3 | 720
ovarian cancer 3 | 8,520
Adenocarcinoma of duodenum 2 | 2
Benign digestive system neoplasms 2 | 2
Benign genitourinary tract neoplasm 2 | 2
Breast cancer 2 | 3,578
Cafe au lait spots, multiple 2 | 17
Carcinoma of larynx 2 | 2
Colon diverticulum anatomic structure 2 | 15
Colorectal Neoplasms 2 | 243
Diverticular disease of colon 2 | 15
Duodenal Cancer 2 | 2
Malignant genitourinary tract tumors 2 | 2
Ovarian Neoplasms 2 | 102
Sebaceous Adenocarcinoma 2 | 2
atypical teratoid / rhabdoid tumor 2 | 5,112
breast carcinoma 2 | 1,638
group 3 medulloblastoma 2 | 4,104
lung adenocarcinoma 2 | 2,716
lung cancer 2 | 4,740
medulloblastoma, large-cell 2 | 6,241
nasopharyngeal carcinoma 2 | 1,058
non-small cell lung cancer 2 | 2,890
ovarian neoplasm 2 | 99
psoriasis 2 | 6,694
Adenocarcinoma of lung 1 | 142
Chronic obstructive pulmonary disease 1 | 184
Colonic Neoplasms 1 | 142
DOID:2627 1 | 94
Down syndrome 1 | 499
Endometrial Neoplasms 1 | 55
Endometrial cancer 1 | 311
Endometrial carcinoma 1 | 15
Glioma 1 | 74
Microsatellite Instability 1 | 12
Neoplasm Metastasis 1 | 168
Pain agnosia 1 | 104
Waldenstrons macroglobulinemia 1 | 765
Xeroderma pigmentosum 1 | 43
pediatric high grade glioma 1 | 1,064
pituitary cancer 1 | 1,972

Tissue

Blood and immune system 3 | 16,909
Cardiovascular System 3 | 15,192
Digestive Tract 3 | 17,369
Endocrine System 3 | 18,159
Female tissues 3 | 17,400
Liver and Pancreas 3 | 16,750
Male tissues 3 | 17,142
Nervous System 3 | 16,725
Respiratory system 3 | 16,393
Skin and soft tissues 3 | 17,230
Urinary Tract 3 | 16,678

Target Family

Non-IDG 2 | 12,091
Epigenetic 1 | 242

GO Function

guanine-thymine mispair bindin... 3 | 3
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA mismatch repair protein Msh6 MSH6 Tbio Epigenetic -2.72594 572.3 479
DNA mismatch repair protein Mlh1 MLH1 Tbio Non-IDG -3.34283 2352.6 495
DNA mismatch repair protein Msh2 MSH2 Tbio Non-IDG -3.15616 1465.0 503