Development Level

Tbio 10 | 11,445
Tclin 7 | 613
Tchem 6 | 1,598

IMPC Phenotype

preweaning lethality, incomple... 6 | 499
preweaning lethality, complete... 3 | 979
abnormal bone structure 2 | 187
abnormal embryo size 2 | 220
decreased total body fat amoun... 2 | 207
abnormal behavioral response t... 1 | 66
abnormal bone mineralization 1 | 38
abnormal brain morphology 1 | 13
abnormal craniofacial morpholo... 1 | 33
abnormal eye morphology 1 | 68
abnormal pericardium morpholog... 1 | 26
abnormal sleep behavior 1 | 70
anophthalmia 1 | 33
cardiovascular system phenotyp... 1 | 36
decreased body length 1 | 101
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating alanine ... 1 | 47
decreased circulating glucose ... 1 | 126
decreased heart weight 1 | 27
decreased hemoglobin content 1 | 68
decreased lean body mass 1 | 135
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular hem... 1 | 31
decreased startle reflex 1 | 75
decreased vertical activity 1 | 208
embryonic lethality prior to t... 1 | 278
impaired pupillary reflex 1 | 26
increased B cell number 1 | 9
increased bone mineral density 1 | 72
increased prepulse inhibition 1 | 32
increased total body fat amoun... 1 | 134
microphthalmia 1 | 26
pale yolk sac 1 | 25
pallor 1 | 34
thrombocytopenia 1 | 56

Disease

Carcinoma 21 | 11,493
ovarian cancer 19 | 8,520
glioblastoma 17 | 5,792
invasive ductal carcinoma 15 | 2,951
lung adenocarcinoma 14 | 2,716
osteosarcoma 14 | 7,950
Breast cancer 13 | 3,578
lung cancer 13 | 4,740
medulloblastoma, large-cell 13 | 6,241
Astrocytoma, Pilocytic 12 | 3,081
Cancer 12 | 2,499
intraductal papillary-mucinous neoplasm (IPMN) 12 | 3,291
Kidney cancer 11 | 2,613
adult high grade glioma 11 | 3,801
atypical teratoid / rhabdoid tumor 11 | 5,112
intraductal papillary-mucinous carcinoma (IPMC) 11 | 2,989
lung carcinoma 11 | 2,843
malignant mesothelioma 11 | 3,232
non-small cell lung cancer 11 | 2,890
psoriasis 11 | 6,694
intraductal papillary-mucinous adenoma (IPMA) 9 | 2,955
ulcerative colitis 9 | 1,819
cystic fibrosis 8 | 1,696
ependymoma 8 | 4,679
interstitial cystitis 8 | 2,312
pancreatic cancer 8 | 2,398
group 3 medulloblastoma 7 | 4,104
oligodendroglioma 7 | 2,850
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,962
Melanoma 6 | 711
astrocytic glioma 6 | 2,597
breast carcinoma 6 | 1,638
colon cancer 6 | 1,478
ductal carcinoma in situ 6 | 1,745
fibroadenoma 6 | 559
pituitary cancer 6 | 1,972
Autosomal recessive predisposition 5 | 1,442
Skin cancer 5 | 469
adrenocortical carcinoma 5 | 1,428
diabetes mellitus 5 | 1,728
gastric carcinoma 5 | 807
primary pancreatic ductal adenocarcinoma 5 | 1,109
primitive neuroectodermal tumor 5 | 3,035
subependymal giant cell astrocytoma 5 | 2,287
Breast Neoplasms 4 | 445
Mammary Neoplasms 4 | 425
Myocardial Ischemia 4 | 169
Pick disease 4 | 1,894
Prostatic Neoplasms 4 | 495
Renal Cell Carcinoma 4 | 214
Retinopathy of prematurity 4 | 22
Short stature 4 | 531
aldosterone-producing adenoma 4 | 665
nasopharyngeal carcinoma 4 | 1,058
non-small cell lung carcinoma 4 | 317
Atopic dermatitis 3 | 952
Capillary hemangioma 3 | 12
Carcinoma of thyroid 3 | 17
Diabetic retinopathy 3 | 56
Down syndrome 3 | 499
Duchenne muscular dystrophy 3 | 601
Follicular thyroid carcinoma 3 | 14
Gastrointestinal stromal tumor 3 | 62
Hamman-Rich syndrome 3 | 34
Hemangiosarcoma 3 | 18
Hypertension 3 | 396
Hypoplastic mandible condyle 3 | 275
Keratitis 3 | 62
Liver cell carcinoma 3 | 15
Mandibular hypoplasia 3 | 275
Mental Depression 3 | 333
Micrognathism 3 | 275
Osteochondrodysplasias 3 | 72
Pancreatic Neuroendocrine Tumor 3 | 45
Papillary thyroid carcinoma 3 | 43
Polycystic ovary syndrome 3 | 360
Rheumatoid arthritis 3 | 1,191
Sarcoma of soft tissue 3 | 11
Schizophrenia 3 | 1,160
Vascular disease 3 | 319
active ulcerative colitis 3 | 764
acute quadriplegic myopathy 3 | 1,158
astrocytoma 3 | 1,146
mucosa-associated lymphoid tissue lymphoma 3 | 484
posterior fossa group A ependymoma 3 | 468
progressive supranuclear palsy 3 | 676
pterygium 3 | 76
spina bifida 3 | 1,074
tuberculosis 3 | 2,010
urothelial carcinoma 3 | 318
Arthritis 2 | 290
Delayed bone age 2 | 136
Depressive disorder 2 | 409
Endometriosis 2 | 540
Glaucoma 2 | 239
Kidney disease 2 | 430
Reperfusion Injury 2 | 86
autosomal dominant Emery-Dreifuss muscular dystrophy 2 | 510
chronic lymphosyte leukemia 2 | 204
chronic rhinosinusitis 2 | 512

Tissue

Endocrine System 23 | 18,159
Liver and Pancreas 23 | 16,750
Urinary Tract 23 | 16,678
Blood and immune system 22 | 16,909
Cardiovascular System 22 | 15,192
Digestive Tract 22 | 17,369
Female tissues 22 | 17,400
Male tissues 22 | 17,142
Nervous System 22 | 16,725
Respiratory system 22 | 16,393
Skin and soft tissues 22 | 17,230

Target Family

Non-IDG 10 | 12,091
Kinase 9 | 634
Enzyme 3 | 4,145
GPCR 1 | 408

GO Function

growth factor binding 23 | 23
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Activin receptor type-2A ACVR2A Tchem Kinase -2.08745 108.0 315
Latent-transforming growth factor beta-binding protein 2 LTBP2 Tbio Non-IDG -1.22721 18.2 100
Leukemia inhibitory factor receptor LIFR Tbio Non-IDG -2.35146 221.3 249
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
Fibroblast growth factor-binding protein 2 FGFBP2 Tbio Non-IDG -0.80217 7.36 63
Bone morphogenetic protein receptor type-2 BMPR2 Tchem Kinase -2.66587 458.1 390
Vascular endothelial growth factor receptor 1 FLT1 Tclin Kinase -3.38913 2189.4 953
Vascular endothelial growth factor receptor 3 FLT4 Tclin Kinase -2.72966 518.8 744
Inactive rhomboid protein 1 RHBDF1 Tbio Enzyme -1.43005 24.3 20
Vascular endothelial growth factor receptor 2 KDR Tclin Kinase -3.67555 4544.8 2373