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Development Level

Tbio 137 | 11,445
Tchem 13 | 1,598
Tclin 9 | 613
Tdark 3 | 6,588

IMPC Phenotype

preweaning lethality, complete... 12 | 979
decreased vertical activity 4 | 208
embryonic lethality prior to t... 4 | 278
increased mean corpuscular vol... 4 | 92
abnormal embryo size 3 | 220
decreased circulating glucose ... 3 | 126
abnormal bone structure 2 | 187
abnormal retinal vasculature m... 2 | 27
cataract 2 | 92
corneal opacity 2 | 32
decreased bone mineral content 2 | 151
decreased circulating fructosa... 2 | 30
decreased circulating insulin ... 2 | 76
decreased erythrocyte cell num... 2 | 62
decreased hematocrit 2 | 46
decreased mean corpuscular vol... 2 | 79
enlarged heart 2 | 210
enlarged lymph nodes 2 | 37
hydrometra 2 | 53
hypoactivity 2 | 132
impaired pupillary reflex 2 | 26
impaired righting response 2 | 26
increased circulating HDL chol... 2 | 80
increased circulating choleste... 2 | 66
limb grasping 2 | 41
preweaning lethality, incomple... 2 | 499
short tibia 2 | 97
abnormal body wall morphology 1 | 9
abnormal cornea morphology 1 | 31
abnormal femur morphology 1 | 14
abnormal gait 1 | 69
abnormal humerus morphology 1 | 11
abnormal kidney morphology 1 | 65
abnormal lens morphology 1 | 81
abnormal locomotor behavior 1 | 24
abnormal optic disc morphology 1 | 10
abnormal response to tactile s... 1 | 17
abnormal retina morphology 1 | 71
abnormal retinal blood vessel ... 1 | 26
abnormal seminal vesicle morph... 1 | 114
abnormal sleep behavior 1 | 70
abnormal startle reflex 1 | 15
abnormal tail morphology 1 | 25
abnormal testis morphology 1 | 43
absent startle reflex 1 | 24
cleft palate 1 | 8
decreased B cell number 1 | 5
decreased body weight 1 | 161
decreased circulating creatini... 1 | 39
decreased circulating free fat... 1 | 31
decreased circulating serum al... 1 | 82
decreased circulating triglyce... 1 | 79
decreased eosinophil cell numb... 1 | 24
decreased fasted circulating g... 1 | 65
decreased grip strength 1 | 116
decreased hemoglobin content 1 | 68
decreased lean body mass 1 | 135
decreased leukocyte cell numbe... 1 | 73
decreased neutrophil cell numb... 1 | 42
decreased prepulse inhibition 1 | 82
decreased spleen weight 1 | 10
decreased startle reflex 1 | 75
edema 1 | 59
embryonic lethality prior to o... 1 | 239
enlarged uterus 1 | 11
female infertility 1 | 60
fused cornea and lens 1 | 5
hemorrhage 1 | 23
hyperactivity 1 | 148
improved glucose tolerance 1 | 79
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating alanine ... 1 | 13
increased circulating potassiu... 1 | 29
increased circulating sodium l... 1 | 71
increased circulating triglyce... 1 | 42
increased hematocrit 1 | 46
increased mean corpuscular hem... 1 | 96
increased mean corpuscular hem... 1 | 36
increased monocyte cell number 1 | 63
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
iris synechia 1 | 3
male infertility 1 | 123
narrow eye opening 1 | 12
no spontaneous movement 1 | 1
persistence of hyaloid vascula... 1 | 33
prenatal lethality 1 | 28
prenatal lethality prior to he... 1 | 87
small superior vagus ganglion 1 | 74
thrombocytopenia 1 | 56
thrombocytosis 1 | 27
tremors 1 | 39
vertebral fusion 1 | 23

Disease

Cancer 80 | 2,499
Carcinoma 77 | 11,493
psoriasis 75 | 6,694
lung cancer 64 | 4,740
ovarian cancer 63 | 8,520
malignant mesothelioma 56 | 3,232
glioblastoma 51 | 5,792
osteosarcoma 51 | 7,950
Breast cancer 45 | 3,578
ependymoma 41 | 4,679
medulloblastoma, large-cell 41 | 6,241
interstitial cystitis 39 | 2,312
diabetes mellitus 38 | 1,728
atypical teratoid / rhabdoid tumor 37 | 5,112
lung adenocarcinoma 37 | 2,716
lung carcinoma 37 | 2,843
intraductal papillary-mucinous adenoma (IPMA) 34 | 2,955
invasive ductal carcinoma 34 | 2,951
Schizophrenia 31 | 1,160
intraductal papillary-mucinous neoplasm (IPMN) 31 | 3,291
Astrocytoma, Pilocytic 29 | 3,081
cystic fibrosis 29 | 1,696
group 3 medulloblastoma 29 | 4,104
pancreatic cancer 29 | 2,398
Autosomal recessive predisposition 28 | 1,442
intraductal papillary-mucinous carcinoma (IPMC) 28 | 2,989
Liver Cirrhosis, Experimental 27 | 769
adult high grade glioma 27 | 3,801
non-small cell lung cancer 27 | 2,890
ulcerative colitis 27 | 1,819
colon cancer 26 | 1,478
oligodendroglioma 26 | 2,850
Breast Neoplasms 25 | 445
Mammary Neoplasms 25 | 425
pituitary cancer 25 | 1,972
tuberculosis 24 | 2,010
ductal carcinoma in situ 23 | 1,745
Pulmonary Fibrosis 22 | 106
Depressive disorder 21 | 409
Arthritis 20 | 290
Kidney disease 20 | 430
breast carcinoma 20 | 1,638
Asthma 19 | 385
Obesity 19 | 678
Atherosclerosis 18 | 291
Atopic dermatitis 18 | 952
Bipolar Disorder 18 | 666
Mental Depression 18 | 333
group 4 medulloblastoma 18 | 1,855
primitive neuroectodermal tumor 18 | 3,035
subependymal giant cell astrocytoma 18 | 2,287
Anemia 17 | 365
Cleft Palate 17 | 271
Rheumatoid arthritis 17 | 1,191
gastric carcinoma 17 | 807
Heart disease 16 | 306
Liver carcinoma 16 | 240
Neuropathy 16 | 261
Osteoporosis 16 | 363
astrocytic glioma 16 | 2,597
Alzheimer's disease 15 | 658
Coronary artery disease 15 | 268
Endometriosis 15 | 540
adrenocortical carcinoma 15 | 1,428
juvenile dermatomyositis 15 | 1,187
pancreatic ductal adenocarcinoma liver metastasis 15 | 1,962
Carcinoma, Hepatocellular 14 | 228
Liver disease 14 | 237
Neoplasm Metastasis 14 | 168
Polycystic ovary syndrome 14 | 360
Prostatic Neoplasms 14 | 495
Vascular disease 14 | 319
Cerebrovascular disease 13 | 238
Hypertension 13 | 396
Lung disease 13 | 142
Major Depressive Disorder 13 | 301
Mesothelioma, Malignant 13 | 105
Multiple Sclerosis 13 | 540
autosomal dominant Emery-Dreifuss muscular dystrophy 13 | 510
cutaneous lupus erythematosus 13 | 1,057
primary pancreatic ductal adenocarcinoma 13 | 1,109
Autistic Disorder 12 | 364
Cleft Lip 12 | 141
Duchenne muscular dystrophy 12 | 601
Hypersensitivity reaction type II disease 12 | 253
Hypertensive disease 12 | 292
Inflammation 12 | 120
Inflammatory bowel disease 12 | 151
Liver Cirrhosis 12 | 181
Nerve Degeneration 12 | 121
Parkinson's disease 12 | 392
Thrombocytopenia 12 | 197
fibroadenoma 12 | 559
Abortion, Spontaneous 11 | 109
Down syndrome 11 | 499
Reperfusion Injury 11 | 86
Spontaneous abortion 11 | 113
esophageal adenocarcinoma 11 | 737
nasopharyngeal carcinoma 11 | 1,058
pediatric high grade glioma 11 | 1,064

Tissue

Endocrine System 155 | 18,159
Digestive Tract 149 | 17,369
Female tissues 148 | 17,400
Liver and Pancreas 146 | 16,750
Skin and soft tissues 146 | 17,230
Male tissues 145 | 17,142
Urinary Tract 144 | 16,678
Nervous System 143 | 16,725
Blood and immune system 142 | 16,909
Respiratory system 138 | 16,393
Cardiovascular System 128 | 15,192

Target Family

Non-IDG 149 | 12,091
Enzyme 10 | 4,145
Epigenetic 2 | 242
Ion Channel 1 | 344

GO Function

growth factor activity 162 | 162
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Leukemia inhibitory factor LIF Tbio Non-IDG -2.86943 538.7 413
Pro-neuregulin-4, membrane-bound isoform NRG4 Tbio Non-IDG -1.33564 24.6 137
Thrombopoietin THPO Tbio Non-IDG -3.23551 1632.3 440
Growth/differentiation factor 15 GDF15 Tbio Non-IDG -2.84344 761.3 702
Growth/differentiation factor 2 GDF2 Tbio Non-IDG -2.16825 176.4 239
Fibroblast growth factor 19 FGF19 Tbio Non-IDG -2.54882 334.2 305
Neurturin NRTN Tbio Non-IDG -2.21792 170.4 331
Interleukin-9 IL9 Tbio Non-IDG -2.50811 334.4 459
Hepatoma-derived growth factor-related protein 3 HDGFL3 Tbio Epigenetic -0.42051 3.29 139
Beta-nerve growth factor NGF Tchem Non-IDG -4.01592 10936.7 735