Development Level
Tbio | 137 | 11,445 | |
Tchem | 13 | 1,598 | |
Tclin | 9 | 613 | |
Tdark | 3 | 6,588 |
IMPC Phenotype
preweaning lethality, complete... | 12 | 979 | |
decreased vertical activity | 4 | 208 | |
embryonic lethality prior to t... | 4 | 278 | |
increased mean corpuscular vol... | 4 | 92 | |
abnormal embryo size | 3 | 220 | |
decreased circulating glucose ... | 3 | 126 | |
abnormal bone structure | 2 | 187 | |
abnormal retinal vasculature m... | 2 | 27 | |
cataract | 2 | 92 | |
corneal opacity | 2 | 32 | |
decreased bone mineral content | 2 | 151 | |
decreased circulating fructosa... | 2 | 30 | |
decreased circulating insulin ... | 2 | 76 | |
decreased erythrocyte cell num... | 2 | 62 | |
decreased hematocrit | 2 | 46 | |
decreased mean corpuscular vol... | 2 | 79 | |
enlarged heart | 2 | 210 | |
enlarged lymph nodes | 2 | 37 | |
hydrometra | 2 | 53 | |
hypoactivity | 2 | 132 | |
impaired pupillary reflex | 2 | 26 | |
impaired righting response | 2 | 26 | |
increased circulating HDL chol... | 2 | 80 | |
increased circulating choleste... | 2 | 66 | |
limb grasping | 2 | 41 | |
preweaning lethality, incomple... | 2 | 499 | |
short tibia | 2 | 97 | |
abnormal body wall morphology | 1 | 9 | |
abnormal cornea morphology | 1 | 31 | |
abnormal femur morphology | 1 | 14 | |
abnormal gait | 1 | 69 | |
abnormal humerus morphology | 1 | 11 | |
abnormal kidney morphology | 1 | 65 | |
abnormal lens morphology | 1 | 81 | |
abnormal locomotor behavior | 1 | 24 | |
abnormal optic disc morphology | 1 | 10 | |
abnormal response to tactile s... | 1 | 17 | |
abnormal retina morphology | 1 | 71 | |
abnormal retinal blood vessel ... | 1 | 26 | |
abnormal seminal vesicle morph... | 1 | 114 | |
abnormal sleep behavior | 1 | 70 | |
abnormal startle reflex | 1 | 15 | |
abnormal tail morphology | 1 | 25 | |
abnormal testis morphology | 1 | 43 | |
absent startle reflex | 1 | 24 | |
cleft palate | 1 | 8 | |
decreased B cell number | 1 | 5 | |
decreased body weight | 1 | 161 | |
decreased circulating creatini... | 1 | 39 | |
decreased circulating free fat... | 1 | 31 | |
decreased circulating serum al... | 1 | 82 | |
decreased circulating triglyce... | 1 | 79 | |
decreased eosinophil cell numb... | 1 | 24 | |
decreased fasted circulating g... | 1 | 65 | |
decreased grip strength | 1 | 116 | |
decreased hemoglobin content | 1 | 68 | |
decreased lean body mass | 1 | 135 | |
decreased leukocyte cell numbe... | 1 | 73 | |
decreased neutrophil cell numb... | 1 | 42 | |
decreased prepulse inhibition | 1 | 82 | |
decreased spleen weight | 1 | 10 | |
decreased startle reflex | 1 | 75 | |
edema | 1 | 59 | |
embryonic lethality prior to o... | 1 | 239 | |
enlarged uterus | 1 | 11 | |
female infertility | 1 | 60 | |
fused cornea and lens | 1 | 5 | |
hemorrhage | 1 | 23 | |
hyperactivity | 1 | 148 | |
improved glucose tolerance | 1 | 79 | |
increased bone mineral content | 1 | 108 | |
increased bone mineral density | 1 | 72 | |
increased circulating alanine ... | 1 | 13 | |
increased circulating potassiu... | 1 | 29 | |
increased circulating sodium l... | 1 | 71 | |
increased circulating triglyce... | 1 | 42 | |
increased hematocrit | 1 | 46 | |
increased mean corpuscular hem... | 1 | 96 | |
increased mean corpuscular hem... | 1 | 36 | |
increased monocyte cell number | 1 | 63 | |
increased startle reflex | 1 | 112 | |
increased total body fat amoun... | 1 | 134 | |
iris synechia | 1 | 3 | |
male infertility | 1 | 123 | |
narrow eye opening | 1 | 12 | |
no spontaneous movement | 1 | 1 | |
persistence of hyaloid vascula... | 1 | 33 | |
prenatal lethality | 1 | 28 | |
prenatal lethality prior to he... | 1 | 87 | |
small superior vagus ganglion | 1 | 74 | |
thrombocytopenia | 1 | 56 | |
thrombocytosis | 1 | 27 | |
tremors | 1 | 39 | |
vertebral fusion | 1 | 23 |
Disease
Tissue
Endocrine System | 155 | 18,159 | |
Digestive Tract | 149 | 17,369 | |
Female tissues | 148 | 17,400 | |
Liver and Pancreas | 146 | 16,750 | |
Skin and soft tissues | 146 | 17,230 | |
Male tissues | 145 | 17,142 | |
Urinary Tract | 144 | 16,678 | |
Nervous System | 143 | 16,725 | |
Blood and immune system | 142 | 16,909 | |
Respiratory system | 138 | 16,393 | |
Cardiovascular System | 128 | 15,192 |
Target Family
Non-IDG | 149 | 12,091 | |
Enzyme | 10 | 4,145 | |
Epigenetic | 2 | 242 | |
Ion Channel | 1 | 344 |
GO Function
growth factor activity | 162 | 162 | |
metal ion binding | 2,256 | 2,256 | |
DNA binding | 1,481 | 1,481 | |
ATP binding | 1,477 | 1,477 | |
RNA binding | 1,383 | 1,383 | |
identical protein binding | 1,084 | 1,084 | |
zinc ion binding | 828 | 828 | |
transcription factor activity,... | 816 | 816 | |
protein homodimerization activ... | 801 | 801 | |
calcium ion binding | 690 | 690 | |
G-protein coupled receptor act... | 658 | 658 | |
protein heterodimerization act... | 473 | 473 | |
olfactory receptor activity | 425 | 425 | |
protein kinase binding | 410 | 410 | |
chromatin binding | 378 | 378 | |
receptor binding | 374 | 374 | |
sequence-specific DNA binding | 374 | 374 | |
GTP binding | 372 | 372 | |
protein serine-threonine kinas... | 360 | 360 | |
RNA polymerase II core promote... | 346 | 346 | |
enzyme binding | 340 | 340 | |
ubiquitin protein ligase bindi... | 301 | 301 | |
transcription factor binding | 297 | 297 | |
GTPase activity | 286 | 286 | |
GTPase activator activity | 281 | 281 | |
cadherin binding | 277 | 277 | |
transcriptional activator acti... | 274 | 274 | |
actin binding | 272 | 272 | |
ubiquitin-protein transferase ... | 260 | 260 | |
transcription coactivator acti... | 249 | 249 | |
serine-type endopeptidase acti... | 246 | 246 | |
protein domain specific bindin... | 241 | 241 | |
protein complex binding | 231 | 231 | |
structural molecule activity | 229 | 229 | |
microtubule binding | 212 | 212 | |
nucleic acid binding | 210 | 210 | |
signal transducer activity | 208 | 208 | |
transcription regulatory regio... | 205 | 205 | |
RNA polymerase II regulatory r... | 204 | 204 | |
receptor activity | 202 | 202 | |
transmembrane signaling recept... | 202 | 202 | |
ubiquitin protein ligase activ... | 202 | 202 | |
transcription corepressor acti... | 200 | 200 | |
magnesium ion binding | 197 | 197 | |
calmodulin binding | 194 | 194 | |
protein C-terminus binding | 191 | 191 | |
protein kinase activity | 182 | 182 | |
carbohydrate binding | 178 | 178 | |
RNA polymerase II transcriptio... | 174 | 174 | |
cytokine activity | 171 | 171 | |
antigen binding | 169 | 169 | |
heparin binding | 161 | 161 | |
protein dimerization activity | 161 | 161 | |
structural constituent of ribo... | 161 | 161 | |
actin filament binding | 151 | 151 | |
iron ion binding | 139 | 139 | |
transcriptional activator acti... | 139 | 139 | |
Rab GTPase binding | 138 | 138 | |
transcriptional repressor acti... | 135 | 135 | |
transporter activity | 134 | 134 | |
heme binding | 129 | 129 | |
ATPase activity | 128 | 128 | |
lipid binding | 127 | 127 | |
SH3 domain binding | 125 | 125 | |
protein tyrosine kinase activi... | 122 | 122 | |
ion channel binding | 118 | 118 | |
mRNA binding | 118 | 118 | |
Ras guanyl-nucleotide exchange... | 116 | 116 | |
metalloendopeptidase activity | 115 | 115 | |
unfolded protein binding | 113 | 113 | |
integrin binding | 112 | 112 | |
histone binding | 111 | 111 | |
protease binding | 108 | 108 | |
histone deacetylase binding | 107 | 107 | |
structural constituent of cyto... | 107 | 107 | |
guanyl-nucleotide exchange fac... | 106 | 106 | |
protein N-terminus binding | 106 | 106 | |
peptide antigen binding | 103 | 103 | |
hormone activity | 96 | 96 | |
serine-type endopeptidase inhi... | 96 | 96 | |
odorant binding | 94 | 94 | |
kinase binding | 92 | 92 | |
single-stranded DNA binding | 92 | 92 | |
chaperone binding | 91 | 91 | |
oxidoreductase activity | 91 | 91 | |
protein tyrosine phosphatase a... | 91 | 91 | |
PDZ domain binding | 87 | 87 | |
thiol-dependent ubiquitinyl hy... | 86 | 86 | |
kinase activity | 84 | 84 | |
transcriptional repressor acti... | 84 | 84 | |
beta-catenin binding | 83 | 83 | |
hydrolase activity | 80 | 80 | |
peptidase activity | 80 | 80 | |
protein binding, bridging | 80 | 80 | |
ATPase binding | 79 | 79 | |
double-stranded DNA binding | 79 | 79 | |
phospholipid binding | 78 | 78 | |
phosphatidylinositol binding | 77 | 77 | |
thiol-dependent ubiquitin-spec... | 76 | 76 | |
drug binding | 75 | 75 |
This is where graphics are reside..