Development Level

Tbio 9 | 11,445
Tdark 3 | 6,588

Disease

Carcinoma 7 | 11,493
osteosarcoma 6 | 7,950
ovarian cancer 6 | 8,520
glioblastoma 4 | 5,792
psoriasis 4 | 6,694
ependymoma 3 | 4,679
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,989
lung cancer 3 | 4,740
Autosomal recessive predisposition 2 | 1,442
Big calvaria 2 | 147
Breast cancer 2 | 3,578
Cognitive delay 2 | 608
Global developmental delay 2 | 608
Increased head circumference 2 | 147
Increased size of cranium 2 | 147
Increased size of skull 2 | 147
Mental and motor retardation 2 | 608
Muscle hypotonia 2 | 571
active Crohn's disease 2 | 922
adult high grade glioma 2 | 3,801
cystic fibrosis 2 | 1,696
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 2 | 3,291
invasive ductal carcinoma 2 | 2,951
lung carcinoma 2 | 2,843
malignant mesothelioma 2 | 3,232
medulloblastoma, large-cell 2 | 6,241
non primary Sjogren syndrome sicca 2 | 891
pancreatic cancer 2 | 2,398
pediatric high grade glioma 2 | 1,064
pituitary cancer 2 | 1,972
Abnormal pigmentation 1 | 25
Abnormal skeletal development 1 | 60
Acquired flat foot 1 | 72
Amyotrophic lateral sclerosis 1 | 451
Arachnodactyly 1 | 49
Atrophic scar 1 | 18
Blood Coagulation Disorders 1 | 42
Broad flat nasal bridge 1 | 236
Burkitt Lymphoma 1 | 20
Cardiovascular system disease 1 | 246
Coagulation abnormalities 1 | 27
Congenital Disorder Of Glycosylation, Type IIID 1 | 1
Congenital Epicanthus 1 | 177
Congenital anomaly of face 1 | 56
Congenital disorder of glycosylation 1 | 54
Congenital disorder of glycosylation type 2D 1 | 1
Congenital muscular dystrophy 1 | 29
Contracture 1 | 96
Contracture of joint 1 | 93
Coxa valga 1 | 22
Coxa valga deformity 1 | 22
Craniofacial Abnormalities 1 | 151
Creatine phosphokinase serum increased 1 | 110
Desbuquois dysplasia 1 | 13
Distortion of face 1 | 46
Dysmorphic facies 1 | 46
Ehlers-Danlos syndrome 1 | 43
Elevated creatine kinase 1 | 110
Exophthalmos 1 | 112
Failure to gain weight 1 | 365
Flatfoot 1 | 73
Flexion contracture 1 | 93
Flexion contractures of joints 1 | 93
Funny looking face 1 | 46
Generalized elastolysis 1 | 24
Generalized osteopenia 1 | 99
Gout 1 | 106
Hanging skin 1 | 24
Hemorrhagic Disorders 1 | 30
Lissencephaly 1 | 69
Liver Cirrhosis, Experimental 1 | 769
Microstomia 1 | 78
Muscle eye brain disease 1 | 8
Muscle-eye-brain disease 1 | 8
Muscular dystrophy 1 | 75
Myopathy 1 | 185
Narrow thorax 1 | 53
Nasal bridge wide 1 | 236
Neurogenic Muscular Atrophy 1 | 139
Neurogenic muscle atrophy, especially in the lower limbs 1 | 139
Osteochondrodysplasias 1 | 72
Osteochondrosis 1 | 17
Osteopenia 1 | 99
Pediatric failure to thrive 1 | 365
Prominent eyes 1 | 96
Prominent globes 1 | 96
Protruding eyes 1 | 96
Pulmonary Stenosis 1 | 45
Radioulnar synostosis 1 | 35
Skeletal muscle atrophy 1 | 139
Skin hyperelastic 1 | 32
Telecanthus 1 | 62
Thin skin 1 | 47
Walker-Warburg congenital muscular dystrophy 1 | 14
Walker-Warburg syndrome 1 | 20
atypical teratoid/rhabdoid tumor 1 | 357
facial deformity 1 | 46
medulloblastoma 1 | 720
muscle degeneration 1 | 139

Tissue

Blood and immune system 11 | 16,909
Digestive Tract 11 | 17,369
Endocrine System 11 | 18,159
Female tissues 11 | 17,400
Male tissues 11 | 17,142
Nervous System 11 | 16,725
Respiratory system 11 | 16,393
Skin and soft tissues 11 | 17,230
Urinary Tract 11 | 16,678
Cardiovascular System 10 | 15,192
Liver and Pancreas 10 | 16,750

Target Family

Enzyme 12 | 4,145

GO Function

galactosyltransferase activity 12 | 12
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

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