Development Level

Tbio 32 | 11,445
Tchem 5 | 1,598
Tdark 1 | 6,588

IMPC Phenotype

abnormal heart morphology 2 | 162
preweaning lethality, complete... 2 | 979
abnormal brain morphology 1 | 13
abnormal iris morphology 1 | 13
abnormal kidney morphology 1 | 65
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating bilirubi... 1 | 19
decreased startle reflex 1 | 75
decreased vertical activity 1 | 208
edema 1 | 59
enlarged heart 1 | 210
hydroencephaly 1 | 14
increased blood urea nitrogen ... 1 | 48
increased circulating glucose ... 1 | 24
premature death 1 | 5
preweaning lethality, incomple... 1 | 499
short tibia 1 | 97
small heart 1 | 10

Disease

Carcinoma 30 | 11,493
Cancer 21 | 2,499
ovarian cancer 19 | 8,520
psoriasis 16 | 6,694
group 3 medulloblastoma 13 | 4,104
interstitial cystitis 13 | 2,312
osteosarcoma 13 | 7,950
ependymoma 12 | 4,679
glioblastoma 12 | 5,792
medulloblastoma, large-cell 11 | 6,241
Breast cancer 10 | 3,578
atypical teratoid / rhabdoid tumor 10 | 5,112
cystic fibrosis 9 | 1,696
lung cancer 9 | 4,740
astrocytic glioma 8 | 2,597
Astrocytoma, Pilocytic 7 | 3,081
Hypoplastic mandible condyle 7 | 275
Mandibular hypoplasia 7 | 275
Micrognathism 7 | 275
Osteoporosis 7 | 363
breast carcinoma 7 | 1,638
ductal carcinoma in situ 7 | 1,745
invasive ductal carcinoma 7 | 2,951
Autosomal recessive predisposition 6 | 1,442
Robinow syndrome 6 | 11
colon cancer 6 | 1,478
lung adenocarcinoma 6 | 2,716
lung carcinoma 6 | 2,843
malignant mesothelioma 6 | 3,232
non-small cell lung cancer 6 | 2,890
oligodendroglioma 6 | 2,850
Cognitive delay 5 | 608
Global developmental delay 5 | 608
Mental and motor retardation 5 | 608
Obesity 5 | 678
Pick disease 5 | 1,894
adrenocortical carcinoma 5 | 1,428
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,955
primitive neuroectodermal tumor 5 | 3,035
subependymal giant cell astrocytoma 5 | 2,287
ulcerative colitis 5 | 1,819
Broad flat nasal bridge 4 | 236
Cleft Palate 4 | 271
Congenital clinodactyly 4 | 57
Cryptorchidism 4 | 296
Curvature of digit 4 | 57
Dull intelligence 4 | 645
Intellectual disability 4 | 1,016
Low intelligence 4 | 645
Mental Retardation 4 | 645
Mental deficiency 4 | 645
Nasal bridge wide 4 | 236
Poor school performance 4 | 645
acute myeloid leukemia 4 | 783
adult high grade glioma 4 | 3,801
autosomal dominant Emery-Dreifuss muscular dystrophy 4 | 510
fibroadenoma 4 | 559
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,989
non primary Sjogren syndrome sicca 4 | 891
pancreatic cancer 4 | 2,398
Anteverted nostril 3 | 191
Big calvaria 3 | 147
Brachydactyly 3 | 156
Breast Neoplasms 3 | 445
Delayed bone age 3 | 136
Downward slant of palpebral fissure 3 | 158
Exophthalmos 3 | 112
Flat face 3 | 52
Frontal bossing 3 | 157
Gingival Hyperplasia 3 | 34
Gingival Hypertrophy 3 | 34
Gingival Overgrowth 3 | 36
Hernia, Inguinal 3 | 89
Hydronephrosis 3 | 89
Hypotrophic malar bone 3 | 129
Increased head circumference 3 | 147
Increased size of cranium 3 | 147
Increased size of skull 3 | 147
Kidney cancer 3 | 2,613
Long philtrum 3 | 137
Macroglossia 3 | 65
Malar flattening 3 | 129
Mammary Neoplasms 3 | 425
Parkinson's disease 3 | 392
Pectus excavatum 3 | 100
Posteriorly rotated ear 3 | 61
Prominent eyes 3 | 96
Prominent globes 3 | 96
Protruding eyes 3 | 96
Schizophrenia 3 | 1,160
Thin upper lip vermilion 3 | 67
Umbilical hernia 3 | 93
Wide anterior fontanel 3 | 44
acute quadriplegic myopathy 3 | 1,158
astrocytoma 3 | 1,146
chronic rhinosinusitis 3 | 512
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,291
nasopharyngeal carcinoma 3 | 1,058
pituitary cancer 3 | 1,972
posterior fossa group A ependymoma 3 | 468

Tissue

Female tissues 37 | 17,400
Digestive Tract 36 | 17,369
Endocrine System 36 | 18,159
Nervous System 36 | 16,725
Blood and immune system 35 | 16,909
Male tissues 35 | 17,142
Skin and soft tissues 35 | 17,230
Urinary Tract 35 | 16,678
Liver and Pancreas 33 | 16,750
Respiratory system 32 | 16,393
Cardiovascular System 28 | 15,192

Target Family

Non-IDG 32 | 12,091
Enzyme 2 | 4,145
GPCR 2 | 408
Kinase 2 | 634

GO Function

frizzled binding 38 | 38
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Myocilin MYOC Tbio Non-IDG -2.65916 482.8 169
Putative segment polarity protein dishevelled homolog DVL1P1 DVL1P1 Tdark Non-IDG -2.11561 188.4 0
Protein Wnt-6 WNT6 Tbio Non-IDG -1.65830 46.6 186
Frizzled-7 FZD7 Tbio GPCR -1.81873 66.4 345
Protein Wnt-7b WNT7B Tbio Non-IDG -1.76807 52.2 46
Collagen triple helix repeat-containing protein 1 CTHRC1 Tbio Non-IDG -1.72221 62.3 202
Protein Wnt-2b WNT2B Tbio Non-IDG -1.76988 58.0 172
Protein Wnt-10a WNT10A Tbio Non-IDG -2.66153 436.3 118
Protein Wnt-5b WNT5B Tbio Non-IDG -1.62833 40.2 161
Frizzled-1 FZD1 Tbio GPCR -2.07049 78.4 286