Development Level

Tbio 38 | 11,445
Tchem 11 | 1,598
Tdark 6 | 6,588
Tclin 5 | 613

IMPC Phenotype

preweaning lethality, complete... 7 | 979
abnormal behavior 3 | 298
male infertility 2 | 123
abnormal epididymis morphology 1 | 42
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal stomach morphology 1 | 10
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased grip strength 1 | 116
decreased lean body mass 1 | 135
embryonic lethality prior to o... 1 | 239
female infertility 1 | 60
hypoactivity 1 | 132
increased circulating sodium l... 1 | 71
increased spleen weight 1 | 10
increased vertical activity 1 | 24
small heart 1 | 10
small kidney 1 | 16
small liver 1 | 8
small lung 1 | 5
small spleen 1 | 19

Disease

Carcinoma 45 | 11,493
ovarian cancer 31 | 8,520
osteosarcoma 27 | 7,950
psoriasis 24 | 6,694
Autosomal recessive predisposition 23 | 1,442
pancreatic ductal adenocarcinoma liver metastasis 22 | 1,962
non-small cell lung cancer 21 | 2,890
lung cancer 20 | 4,740
ependymoma 17 | 4,679
medulloblastoma, large-cell 17 | 6,241
lung carcinoma 16 | 2,843
Muscle hypotonia 15 | 571
intraductal papillary-mucinous neoplasm (IPMN) 15 | 3,291
invasive ductal carcinoma 15 | 2,951
Cognitive delay 13 | 608
Epilepsy 13 | 792
Global developmental delay 13 | 608
Mental and motor retardation 13 | 608
Seizures 13 | 596
atypical teratoid / rhabdoid tumor 13 | 5,112
group 3 medulloblastoma 13 | 4,104
malignant mesothelioma 13 | 3,232
Astrocytoma, Pilocytic 12 | 3,081
glioblastoma 12 | 5,792
interstitial cystitis 12 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 12 | 2,955
ulcerative colitis 12 | 1,819
Cancer 11 | 2,499
Hypoglycemia 11 | 152
intraductal papillary-mucinous carcinoma (IPMC) 11 | 2,989
lung adenocarcinoma 11 | 2,716
Breast cancer 10 | 3,578
adult high grade glioma 10 | 3,801
breast carcinoma 10 | 1,638
cystic fibrosis 10 | 1,696
ductal carcinoma in situ 10 | 1,745
Kidney cancer 9 | 2,613
Liver Cirrhosis, Experimental 9 | 769
adrenocortical carcinoma 9 | 1,428
colon cancer 9 | 1,478
pancreatic cancer 9 | 2,398
pituitary cancer 9 | 1,972
tuberculosis 9 | 2,010
Failure to gain weight 8 | 365
Lethargy 8 | 77
Pediatric failure to thrive 8 | 365
Hepatomegaly 7 | 285
Hypertension 7 | 396
Multiple acyl-CoA dehydrogenase deficiency 7 | 25
Schizophrenia 7 | 1,160
Vomiting 7 | 116
active Crohn's disease 7 | 922
diabetes mellitus 7 | 1,728
primitive neuroectodermal tumor 7 | 3,035
Autistic Disorder 6 | 364
Colonic Neoplasms 6 | 142
Depressive disorder 6 | 409
Heart failure 6 | 162
Kidney disease 6 | 430
Muscle Weakness 6 | 170
Small head 6 | 374
cutaneous lupus erythematosus 6 | 1,057
Anemia 5 | 365
Atherosclerosis 5 | 291
Bipolar Disorder 5 | 666
Cerebrovascular disease 5 | 238
Colorectal Neoplasms 5 | 243
Diabetes Mellitus, Experimental 5 | 108
Hypertrophic Cardiomyopathy 5 | 117
Isovaleric acidemia 5 | 15
Major Depressive Disorder 5 | 301
Metabolic acidosis 5 | 90
Myopathy 5 | 185
Nystagmus 5 | 317
Obesity 5 | 678
Osteoarthritis 5 | 184
Pick disease 5 | 1,894
Rheumatoid arthritis 5 | 1,191
Short chain acyl-CoA dehydrogenase deficiency 5 | 9
Stomach Neoplasms 5 | 300
aldosterone-producing adenoma 5 | 665
nephrosclerosis 5 | 333
oligodendroglioma 5 | 2,850
subependymal giant cell astrocytoma 5 | 2,287
Alzheimer's disease 4 | 658
Brain Ischemia 4 | 110
Concave bridge of nose 4 | 195
Coronary artery disease 4 | 268
Depressed nasal bridge 4 | 195
Depressed nasal root/bridge 4 | 195
Heart disease 4 | 306
Lipid metabolism disorder 4 | 114
Mental Depression 4 | 333
Prostatic Neoplasms 4 | 495
Reperfusion Injury 4 | 86
Strabismus 4 | 270
active ulcerative colitis 4 | 764
astrocytic glioma 4 | 2,597
astrocytoma 4 | 1,146
non diabetic and post-ischemic heart failure 4 | 200

Tissue

Blood and immune system 59 | 16,909
Digestive Tract 59 | 17,369
Endocrine System 59 | 18,159
Female tissues 59 | 17,400
Liver and Pancreas 59 | 16,750
Male tissues 59 | 17,142
Skin and soft tissues 59 | 17,230
Urinary Tract 59 | 16,678
Nervous System 58 | 16,725
Respiratory system 58 | 16,393
Cardiovascular System 55 | 15,192

Target Family

Enzyme 54 | 4,145
Non-IDG 4 | 12,091
Epigenetic 1 | 242
Ion Channel 1 | 344

GO Function

flavin adenine dinucleotide bi... 60 | 60
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Isobutyryl-CoA dehydrogenase, mitochondrial ACAD8 Tbio Enzyme -1.14784 13.9 150
Thioredoxin reductase 3 TXNRD3 Tdark Enzyme -1.72626 60.0 0
Acyl-coenzyme A oxidase-like protein ACOXL Tdark Enzyme -0.18122 1.46 28
Methylenetetrahydrofolate reductase MTHFR Tbio Enzyme -3.68447 5032.2 275
NADPH--cytochrome P450 reductase POR Tbio Enzyme -2.43541 216.2 257
Protein MTO1 homolog, mitochondrial MTO1 Tbio Non-IDG -2.45185 260.9 53
Dihydropyrimidine dehydrogenase [NADP(+)] DPYD Tclin Enzyme -2.62432 395.0 159
tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like DUS1L Tdark Enzyme -0.47712 2.58 98
Cytochrome b-245 heavy chain CYBB Tchem Ion Channel -3.09698 1276.8 315
Choline dehydrogenase, mitochondrial CHDH Tbio Enzyme -1.44261 27.1 85