Development Level

Tbio 9 | 11,445
Tdark 4 | 6,588
Tchem 3 | 1,598

IMPC Phenotype

embryonic lethality prior to o... 2 | 239
embryonic lethality prior to t... 2 | 278
preweaning lethality, complete... 2 | 979
decreased vertical activity 1 | 208
preweaning lethality, incomple... 1 | 499

Disease

osteosarcoma 9 | 7,950
Carcinoma 8 | 11,493
lung cancer 8 | 4,740
ovarian cancer 7 | 8,520
psoriasis 7 | 6,694
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,291
group 3 medulloblastoma 5 | 4,104
malignant mesothelioma 5 | 3,232
medulloblastoma, large-cell 5 | 6,241
Breast cancer 4 | 3,578
Cancer 4 | 2,499
cutaneous lupus erythematosus 4 | 1,057
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,989
invasive ductal carcinoma 4 | 2,951
Endometriosis 3 | 540
atypical teratoid / rhabdoid tumor 3 | 5,112
colon cancer 3 | 1,478
ductal carcinoma in situ 3 | 1,745
glioblastoma 3 | 5,792
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
non-small cell lung cancer 3 | 2,890
primitive neuroectodermal tumor 3 | 3,035
ulcerative colitis 3 | 1,819
Aicardi-Goutieres syndrome 2 | 19
Autosomal recessive predisposition 2 | 1,442
Bloom syndrome 2 | 29
Cockayne syndrome 2 | 60
Colorectal Neoplasms 2 | 243
Congestive heart failure 2 | 113
Crohn's disease 2 | 321
Diabetes Mellitus, Non-Insulin-Dependent 2 | 145
Heart failure 2 | 162
Hyperkeratosis 2 | 50
Kidney cancer 2 | 2,613
Liver Cirrhosis, Experimental 2 | 769
Microphthalmia with limb anomalies 2 | 40
Multiple myeloma 2 | 1,332
Myocardial Infarction 2 | 151
Osteosclerosis 2 | 31
Rheumatoid arthritis 2 | 1,191
Short stature 2 | 531
Werner syndrome 2 | 29
Xeroderma pigmentosum 2 | 43
cystic fibrosis 2 | 1,696
diabetes mellitus 2 | 1,728
lung adenocarcinoma 2 | 2,716
pancreatic cancer 2 | 2,398
pituitary cancer 2 | 1,972
sonic hedgehog group medulloblastoma 2 | 467
subependymal giant cell astrocytoma 2 | 2,287
Abnormal trabecular bone morphology 1 | 6
Abnormality of the cerebral vasculature 1 | 6
Ankylosis 1 | 28
Aplasia/Hypoplasia of the skin 1 | 16
Baller-Gerold syndrome 1 | 12
Benign epilepsy with centrotemporal spikes 1 | 13
Calcinosis 1 | 70
Calcium pyrophosphate deposition disease 1 | 13
Chondrocalcinosis 1 | 9
Convex nasal ridge 1 | 37
Decreased fertility 1 | 33
Dental abscess 1 | 4
Diabetes Mellitus, Noninsulin-Dependent 1 | 31
Endometrial Hyperplasia 1 | 5
Enthesitis 1 | 3
Exanthema 1 | 43
Excess nuchal skin 1 | 30
Excessive wrinkled skin 1 | 16
Hepatitis 1 | 67
Hip joint varus deformity - observation 1 | 24
Hyperphosphaturia 1 | 21
Hypophosphatasia 1 | 10
Hypophosphatemic Rickets 1 | 11
Lack of skin elasticity 1 | 10
Linear atrophy 1 | 15
Liver neoplasm 1 | 7
Lynch syndrome 1 | 35
Meningioma 1 | 41
Narrow face 1 | 54
Ollier disease 1 | 18
Pharyngitis 1 | 17
Polyarthritis 1 | 11
Premature canities 1 | 24
Pseudoxanthoma elasticum 1 | 18
Rapadilino syndrome 1 | 7
Renal phosphate wasting 1 | 7
Retinal Hemorrhage 1 | 6
Rothmund-Thomson syndrome 1 | 19
SPINOCEREBELLAR ATAXIA, AUTOSOMAL RECESSIVE, WITH AXONAL NEUROPATHY 1 | 1
Skin Ulcer 1 | 48
Slender build 1 | 14
Small hand 1 | 36
Sparse scalp hair 1 | 42
Spinal canal stenosis 1 | 12
Stretched skin 1 | 10
Thin face 1 | 54
Tibial bowing 1 | 19
Urine phosphorous concentration above normal 1 | 21
Vitelliform macular dystrophy 1 | 14
Xeroderma pigmentosum group G 1 | 16

Tissue

Blood and immune system 15 | 16,909
Cardiovascular System 15 | 15,192
Digestive Tract 15 | 17,369
Endocrine System 15 | 18,159
Female tissues 15 | 17,400
Liver and Pancreas 15 | 16,750
Male tissues 15 | 17,142
Nervous System 15 | 16,725
Respiratory system 15 | 16,393
Skin and soft tissues 15 | 17,230
Urinary Tract 15 | 16,678

Target Family

Enzyme 14 | 4,145
Non-IDG 2 | 12,091

GO Function

exonuclease activity 16 | 16
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Tyrosyl-DNA phosphodiesterase 1 TDP1 Tchem Enzyme -2.09041 139.4 210
Putative exonuclease GOR REXO1L1P Tdark Enzyme -1.82597 59.0 0
ERI1 exoribonuclease 3 ERI3 Tbio Enzyme -0.80731 5.34 67
Exonuclease 1 EXO1 Tbio Enzyme -2.64302 437.0 263
RNA exonuclease 5 REXO5 Tdark Enzyme -0.36798 0.44 31
RNA exonuclease 1 homolog REXO1 Tdark Enzyme 0.25 0.75 150
RNA exonuclease 4 REXO4 Tbio Enzyme -1.59595 38.8 87
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1 Tchem Enzyme -2.74480 552.8 275
2',5'-phosphodiesterase 12 PDE12 Tbio Enzyme -1.46115 31.6 90
Telomerase RNA component interacting RNase TRIR Tdark Non-IDG 0.00000 1.00 22