Development Level

Tbio 164 | 10,625
Tchem 74 | 1,890
Tclin 34 | 602
Tdark 14 | 7,003

Collection

Eligible Kinase Proteins 1 | 134

IMPC Term

preweaning lethality, complete... 23 | 633
preweaning lethality, incomple... 9 | 260
embryonic lethality prior to t... 6 | 187
decreased lean body mass 5 | 195
decreased total body fat amoun... 4 | 186
increased lean body mass 4 | 107
abnormal behavior 3 | 226
decreased bone mineral density 3 | 126
decreased grip strength 3 | 123
decreased mean corpuscular vol... 3 | 50
embryonic lethality prior to o... 3 | 148
increased circulating HDL chol... 3 | 63
increased exploration in new e... 3 | 56
increased or absent threshold ... 3 | 128
abnormal coping response 2 | 12
abnormal gait 2 | 51
abnormal lens morphology 2 | 73
abnormal retina morphology 2 | 100
abnormal spleen morphology 2 | 36
decreased body length 2 | 108
decreased circulating creatini... 2 | 31
decreased circulating glycerol... 2 | 19
decreased circulating total pr... 2 | 41
decreased eosinophil cell numb... 2 | 41
decreased fasted circulating g... 2 | 49
decreased hemoglobin content 2 | 53
decreased lumbar vertebrae num... 2 | 62
decreased prepulse inhibition 2 | 52
decreased total retina thickne... 2 | 20
enlarged lymph nodes 2 | 27
increased blood urea nitrogen ... 2 | 44
increased bone mineral content 2 | 92
increased bone mineral density 2 | 52
increased circulating alkaline... 2 | 119
increased circulating aspartat... 2 | 17
increased circulating potassiu... 2 | 31
increased grip strength 2 | 83
increased leukocyte cell numbe... 2 | 37
increased sacral vertebrae num... 2 | 62
increased total body fat amoun... 2 | 57
prenatal lethality prior to he... 2 | 64
abnormal embryo size 1 | 112
abnormal eyelid morphology 1 | 6
abnormal femur morphology 1 | 14
abnormal hair growth 1 | 8
abnormal head morphology 1 | 10
abnormal iris morphology 1 | 12
abnormal retinal blood vessel ... 1 | 18
abnormal retinal inner nuclear... 1 | 5
abnormal retinal pigmentation 1 | 61
abnormal retinal vasculature m... 1 | 15
abnormal sensory capabilities/... 1 | 3
abnormal snout morphology 1 | 18
abnormal startle reflex 1 | 14
abnormal tooth morphology 1 | 24
absent vibrissae 1 | 14
cataract 1 | 26
craniofacial phenotype 1 | 9
decreased CD4-positive, CD25-p... 1 | 24
decreased Ly6C high monocyte n... 1 | 18
decreased basophil cell number 1 | 11
decreased caudal vertebrae num... 1 | 49
decreased circulating bilirubi... 1 | 14
decreased circulating magnesiu... 1 | 11
decreased circulating triglyce... 1 | 83
decreased heart rate 1 | 10
decreased hematocrit 1 | 25
decreased mean corpuscular hem... 1 | 34
decreased monocyte cell number 1 | 28
decreased neutrophil cell numb... 1 | 37
decreased rib number 1 | 59
decreased spleen weight 1 | 13
head bobbing 1 | 3
hydrops fetalis 1 | 22
impaired glucose tolerance 1 | 52
increased B cell number 1 | 23
increased circulating calcium ... 1 | 32
increased circulating choleste... 1 | 53
increased circulating creatini... 1 | 29
increased circulating glucose ... 1 | 16
increased circulating serum al... 1 | 25
increased circulating triglyce... 1 | 24
increased erythrocyte cell num... 1 | 26
increased granulocyte number 1 | 8
increased mean corpuscular vol... 1 | 91
increased startle reflex 1 | 38
irregularly shaped pupil 1 | 7
narrow eye opening 1 | 15
persistence of hyaloid vascula... 1 | 22
polycystic kidney 1 | 9
premature death 1 | 5
small adrenal glands 1 | 15
small heart 1 | 8
small kidney 1 | 10
small liver 1 | 8
small lung 1 | 5
small spleen 1 | 11
thrombocytopenia 1 | 46
thrombocytosis 1 | 23
tremors 1 | 34

Disease

ovarian cancer 168 | 8,484
osteosarcoma 141 | 7,933
psoriasis 133 | 6,685
Cancer 126 | 2,346
medulloblastoma, large-cell 122 | 6,234
lung cancer 120 | 4,466
glioblastoma 114 | 5,572
atypical teratoid / rhabdoid tumor 85 | 4,369
malignant mesothelioma 70 | 3,162
Breast cancer 69 | 3,094
intraductal papillary-mucinous carcinoma (IPMC) 67 | 2,988
intraductal papillary-mucinous neoplasm (IPMN) 67 | 3,289
non-small cell lung cancer 67 | 2,798
pancreatic cancer 59 | 2,300
oligodendroglioma 58 | 2,849
invasive ductal carcinoma 55 | 2,950
lung adenocarcinoma 55 | 2,713
primitive neuroectodermal tumor 55 | 3,031
lung carcinoma 52 | 2,844
pediatric high grade glioma 52 | 2,712
intraductal papillary-mucinous adenoma (IPMA) 51 | 2,956
pilocytic astrocytoma 50 | 3,086
diabetes mellitus 49 | 1,663
subependymal giant cell astrocytoma 48 | 2,287
astrocytoma 45 | 1,493
interstitial cystitis 45 | 2,299
pancreatic ductal adenocarcinoma liver metastasis 43 | 1,795
Carcinoma 42 | 2,147
ependymoma 41 | 2,514
Pick disease 40 | 1,893
colon cancer 40 | 1,475
group 3 medulloblastoma 40 | 2,254
Mammary Neoplasms 39 | 410
Multiple myeloma 39 | 1,327
adult high grade glioma 39 | 2,148
group 4 medulloblastoma 38 | 1,875
Prostatic Neoplasms 37 | 471
ductal carcinoma in situ 36 | 1,745
ulcerative colitis 36 | 2,087
acute quadriplegic myopathy 34 | 1,157
cystic fibrosis 34 | 1,665
pituitary cancer 34 | 1,972
tuberculosis 34 | 1,557
astrocytic glioma 33 | 2,241
breast carcinoma 33 | 1,614
Rheumatoid Arthritis 31 | 1,160
adrenocortical carcinoma 31 | 1,427
dermatomyositis 31 | 933
juvenile dermatomyositis 31 | 1,189
posterior fossa group A ependymoma 30 | 1,511
Alzheimer's disease 29 | 644
medulloblastoma 29 | 1,524
Waldenstrons macroglobulinemia 28 | 765
Vascular disease 26 | 281
Liver carcinoma 25 | 217
Lung Neoplasms 25 | 171
primary pancreatic ductal adenocarcinoma 25 | 1,271
Parkinson's disease 24 | 364
Endometriosis 23 | 535
esophageal adenocarcinoma 23 | 737
Obesity 22 | 616
nasopharyngeal carcinoma 22 | 1,056
Atopic dermatitis 21 | 944
Colorectal Neoplasms 21 | 217
Down syndrome 21 | 548
acute myeloid leukemia 21 | 780
Heart disease 20 | 279
Schizophrenia 20 | 501
Stomach Neoplasms 20 | 282
aldosterone-producing adenoma 20 | 664
atypical teratoid/rhabdoid tumor 20 | 1,095
cutaneous lupus erythematosus 20 | 1,056
Adenocarcinoma 19 | 115
Toxic encephalopathy 19 | 131
sonic hedgehog group medulloblastoma 19 | 1,482
Asthma 18 | 349
Kidney disease 18 | 396
Liver disease 18 | 219
Lung disease 18 | 132
Colonic Neoplasms 17 | 126
Neurodegenerative disease 17 | 383
Osteoporosis 17 | 257
non-small cell lung carcinoma 17 | 413
pancreatic carcinoma 17 | 567
Arthritis 16 | 248
Atherosclerosis 16 | 275
Cerebrovascular disease 16 | 231
Drug-Induced Liver Injury 16 | 118
Coronary artery disease 15 | 240
Melanoma 15 | 261
Peripheral Neuropathy 15 | 303
autosomal dominant Emery-Dreifuss muscular dystrophy 15 | 499
posterior fossa group B ependymoma 15 | 1,530
tuberculosis and treatment for 6 months 15 | 686
Adenoma 14 | 165
Amyotrophic Lateral Sclerosis 14 | 431
Squamous cell carcinoma 14 | 94
Hypertensive disease 13 | 193
IGA Glomerulonephritis 13 | 454
gastric carcinoma 13 | 832

Tissue

Digestive Tract 285 | 18,473
Liver and Pancreas 285 | 18,136
Urinary Tract 285 | 18,444
Blood and immune system 284 | 17,995
Endocrine System 282 | 18,512
Nervous System 282 | 18,561
Female tissues 281 | 18,647
Skin and soft tissues 281 | 18,115
Male tissues 279 | 17,969
Cardiovascular System 278 | 17,958
Respiratory system 276 | 17,484

Target Family

Non-IDG 145 | 11,971
Enzyme 74 | 4,146
Kinase 18 | 634
Transcription Factor 18 | 1,400
Epigenetic 15 | 242
Nuclear Receptor 9 | 48
Ion Channel 3 | 341
Transporter 3 | 473
GPCR 1 | 406

GO Function

enzyme binding 286 | 286
metal ion binding 1,917 | 1,917
ATP binding 1,467 | 1,467
DNA binding 1,432 | 1,432
zinc ion binding 1,155 | 1,155
poly(A) RNA binding 1,107 | 1,107
transcription factor activity,... 853 | 853
calcium ion binding 695 | 695
G-protein coupled receptor act... 661 | 661
protein homodimerization activ... 569 | 569
RNA binding 445 | 445
olfactory receptor activity 424 | 424
sequence-specific DNA binding 398 | 398
GTP binding 374 | 374
chromatin binding 372 | 372
protein serine/threonine kinas... 336 | 336
RNA polymerase II core promote... 332 | 332
identical protein binding 311 | 311
nucleotide binding 311 | 311
receptor binding 303 | 303
protein kinase binding 289 | 289
cadherin binding involved in c... 277 | 277
GTPase activator activity 273 | 273
ubiquitin protein ligase bindi... 258 | 258
ubiquitin-protein transferase ... 253 | 253
serine-type endopeptidase acti... 246 | 246
transcription coactivator acti... 241 | 241
transcription factor binding 240 | 240
structural molecule activity 232 | 232
GTPase activity 231 | 231
transcriptional activator acti... 230 | 230
ligase activity 227 | 227
protein heterodimerization act... 227 | 227
structural constituent of ribo... 212 | 212
transcription regulatory regio... 202 | 202
transmembrane signaling recept... 201 | 201
RNA polymerase II regulatory r... 200 | 200
receptor activity 200 | 200
transcription corepressor acti... 198 | 198
magnesium ion binding 197 | 197
signal transducer activity 196 | 196
nucleic acid binding 184 | 184
protein kinase activity 183 | 183
carbohydrate binding 180 | 180
ubiquitin protein ligase activ... 173 | 173
RNA polymerase II transcriptio... 162 | 162
heparin binding 160 | 160
iron ion binding 141 | 141
lipid binding 136 | 136
transporter activity 136 | 136
actin binding 133 | 133
ATPase activity 132 | 132
protein C-terminus binding 129 | 129
heme binding 127 | 127
microtubule binding 123 | 123
protein tyrosine kinase activi... 119 | 119
cytokine activity 118 | 118
Ras guanyl-nucleotide exchange... 113 | 113
mRNA binding 112 | 112
metalloendopeptidase activity 112 | 112
transcriptional repressor acti... 110 | 110
structural constituent of cyto... 108 | 108
Rab GTPase binding 105 | 105
antigen binding 104 | 104
protein domain specific bindin... 102 | 102
peptide antigen binding 101 | 101
guanyl-nucleotide exchange fac... 98 | 98
protein complex binding 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 92 | 92
oxidoreductase activity 91 | 91
transcriptional activator acti... 91 | 91
actin filament binding 89 | 89
hydrolase activity 89 | 89
ion channel binding 89 | 89
protein tyrosine phosphatase a... 88 | 88
electron carrier activity 87 | 87
protease binding 87 | 87
histone binding 86 | 86
integrin binding 83 | 83
growth factor activity 82 | 82
phospholipid binding 82 | 82
single-stranded DNA binding 81 | 81
unfolded protein binding 77 | 77
kinase activity 75 | 75
thiol-dependent ubiquitin-spec... 75 | 75
phosphatidylinositol binding 74 | 74
calmodulin binding 73 | 73
histone deacetylase binding 73 | 73
Rho guanyl-nucleotide exchange... 72 | 72
drug binding 71 | 71
double-stranded DNA binding 70 | 70
peptidase activity 70 | 70
protein N-terminus binding 70 | 70
virus receptor activity 68 | 68
beta-catenin binding 67 | 67
microtubule motor activity 67 | 67
protein transporter activity 67 | 67
calcium channel activity 66 | 66
ubiquitin binding 66 | 66

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Antileukoproteinase SLPI Tbio Enzyme -2.56514 434.2 290
Proliferating cell nuclear antigen PCNA Tchem Non-IDG -1.10426 11.5 1277
mRNA decay activator protein ZFP36 ZFP36 Tbio Non-IDG -2.38153 220.3 0
Ubiquitin carboxyl-terminal hydrolase 22 USP22 Tbio Enzyme -1.59877 51.0 199
Replication protein A 32 kDa subunit RPA2 Tbio Non-IDG -1.76828 59.7 468
Dymeclin DYM Tbio Non-IDG -1.45800 31.6 59
E3 ubiquitin-protein ligase Mdm2 MDM2 Tchem Enzyme -3.38438 2174.7 1062
Replication factor C subunit 5 RFC5 Tbio Non-IDG -1.02728 11.1 64
TNF receptor-associated factor 2 TRAF2 Tbio Non-IDG -1.85843 68.9 516
Apolipoprotein A-I APOA1 Tchem Non-IDG -3.60439 3516.7 901