Development Level

Tbio 213 | 11,651
Tchem 75 | 1,388
Tclin 37 | 612
Tdark 15 | 6,593

Collection

Kinase: IDG Consortium (Target... 2 | 125
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 32 | 979
preweaning lethality, incomple... 15 | 499
embryonic lethality prior to t... 9 | 278
embryonic lethality prior to o... 8 | 239
abnormal behavior 7 | 298
decreased mean corpuscular vol... 6 | 79
decreased total body fat amoun... 6 | 207
abnormal embryo size 5 | 220
abnormal gait 5 | 69
increased startle reflex 5 | 112
decreased lean body mass 4 | 135
decreased prepulse inhibition 4 | 82
decreased vertical activity 4 | 208
increased lean body mass 4 | 172
increased total body fat amoun... 4 | 134
abnormal lens morphology 3 | 81
abnormal seminal vesicle morph... 3 | 114
cataract 3 | 92
decreased circulating glucose ... 3 | 126
decreased circulating triglyce... 3 | 79
decreased grip strength 3 | 116
embryonic growth retardation 3 | 106
enlarged heart 3 | 210
increased bone mineral density 3 | 72
increased circulating HDL chol... 3 | 80
increased circulating alkaline... 3 | 122
increased circulating choleste... 3 | 66
increased hemoglobin content 3 | 45
increased neutrophil cell numb... 3 | 46
prenatal lethality prior to he... 3 | 87
thrombocytopenia 3 | 56
abnormal embryo development 2 | 7
abnormal heart morphology 2 | 162
abnormal retina morphology 2 | 71
abnormal spleen morphology 2 | 55
decreased bone mineral density 2 | 126
decreased circulating creatini... 2 | 39
decreased fasted circulating g... 2 | 65
decreased hemoglobin content 2 | 68
decreased leukocyte cell numbe... 2 | 73
decreased lymphocyte cell numb... 2 | 83
decreased mean platelet volume 2 | 25
enlarged kidney 2 | 14
enlarged lymph nodes 2 | 37
hyperactivity 2 | 148
hypoactivity 2 | 132
impaired glucose tolerance 2 | 75
improved glucose tolerance 2 | 79
increased blood urea nitrogen ... 2 | 48
increased bone mineral content 2 | 108
increased leukocyte cell numbe... 2 | 47
increased lymphocyte cell numb... 2 | 32
increased monocyte cell number 2 | 63
abnormal blood vessel morpholo... 1 | 5
abnormal body wall morphology 1 | 9
abnormal embryo turning 1 | 31
abnormal epididymis morphology 1 | 42
abnormal head morphology 1 | 10
abnormal heart left ventricle ... 1 | 16
abnormal neural tube closure 1 | 46
abnormal pericardium morpholog... 1 | 26
abnormal retinal blood vessel ... 1 | 26
abnormal retinal inner nuclear... 1 | 8
abnormal retinal vasculature m... 1 | 27
abnormal sensory capabilities-... 1 | 8
abnormal somite shape 1 | 5
abnormal startle reflex 1 | 15
abnormal vertebrae morphology 1 | 18
abnormal vibrissa morphology 1 | 25
abnormal vitelline vasculature... 1 | 6
cardiovascular system phenotyp... 1 | 36
decreased body length 1 | 101
decreased circulating bilirubi... 1 | 19
decreased circulating insulin ... 1 | 76
decreased circulating magnesiu... 1 | 13
decreased eosinophil cell numb... 1 | 24
decreased heart left ventricle... 1 | 28
decreased neutrophil cell numb... 1 | 42
decreased total retina thickne... 1 | 17
edema 1 | 59
hemorrhage 1 | 23
impaired righting response 1 | 26
increased body length 1 | 32
increased circulating chloride... 1 | 41
increased circulating creatini... 1 | 38
increased circulating glucose ... 1 | 24
increased circulating phosphat... 1 | 26
increased circulating potassiu... 1 | 29
increased circulating serum al... 1 | 22
increased circulating total pr... 1 | 28
increased hematocrit 1 | 46
increased mean corpuscular vol... 1 | 92
microphthalmia 1 | 26
polycystic kidney 1 | 15
premature death 1 | 5
small kidney 1 | 16
small spleen 1 | 19
thin ventricular wall 1 | 24
thrombocytosis 1 | 27
tremors 1 | 39

Disease

Carcinoma 244 | 11,493
ovarian cancer 209 | 8,520
osteosarcoma 168 | 7,950
psoriasis 162 | 6,694
Cancer 153 | 2,499
glioblastoma 145 | 5,792
medulloblastoma, large-cell 143 | 6,241
lung cancer 142 | 4,740
atypical teratoid / rhabdoid tumor 116 | 5,112
malignant mesothelioma 94 | 3,232
Breast cancer 93 | 3,578
ependymoma 91 | 4,679
group 3 medulloblastoma 89 | 4,104
intraductal papillary-mucinous neoplasm (IPMN) 82 | 3,291
non-small cell lung cancer 80 | 2,890
adult high grade glioma 78 | 3,801
intraductal papillary-mucinous carcinoma (IPMC) 76 | 2,989
pancreatic cancer 76 | 2,398
oligodendroglioma 71 | 2,850
invasive ductal carcinoma 68 | 2,951
lung adenocarcinoma 68 | 2,716
Schizophrenia 66 | 1,160
primitive neuroectodermal tumor 66 | 3,035
Kidney cancer 65 | 2,613
Astrocytoma, Pilocytic 62 | 3,081
Autosomal recessive predisposition 60 | 1,442
intraductal papillary-mucinous adenoma (IPMA) 60 | 2,955
subependymal giant cell astrocytoma 60 | 2,287
diabetes mellitus 59 | 1,728
pancreatic ductal adenocarcinoma liver metastasis 57 | 1,962
lung carcinoma 56 | 2,843
interstitial cystitis 53 | 2,312
Multiple myeloma 52 | 1,332
Pick disease 50 | 1,894
astrocytic glioma 49 | 2,597
breast carcinoma 49 | 1,638
tuberculosis 49 | 2,010
colon cancer 48 | 1,478
astrocytoma 45 | 1,146
ductal carcinoma in situ 45 | 1,745
Breast Neoplasms 44 | 445
Mammary Neoplasms 44 | 425
Prostatic Neoplasms 44 | 495
pituitary cancer 44 | 1,972
cystic fibrosis 41 | 1,696
Epilepsy 40 | 792
acute quadriplegic myopathy 39 | 1,158
group 4 medulloblastoma 39 | 1,855
dermatomyositis 38 | 966
ulcerative colitis 38 | 1,819
adrenocortical carcinoma 37 | 1,428
juvenile dermatomyositis 37 | 1,187
Rheumatoid arthritis 34 | 1,191
Seizures 34 | 596
Alzheimer's disease 32 | 658
Depressive disorder 32 | 409
Waldenstrons macroglobulinemia 32 | 765
pediatric high grade glioma 32 | 1,064
Bipolar Disorder 31 | 666
Intellectual disability 31 | 1,016
Carcinoma, Hepatocellular 30 | 228
Liver carcinoma 30 | 240
Neurodegenerative disease 30 | 414
Obesity 30 | 678
Lung Neoplasms 29 | 232
primary pancreatic ductal adenocarcinoma 29 | 1,109
Atopic dermatitis 28 | 952
Liver Cirrhosis, Experimental 28 | 769
Osteoporosis 28 | 363
Vascular disease 28 | 319
nasopharyngeal carcinoma 28 | 1,058
Endometriosis 26 | 540
Heart disease 26 | 306
Parkinson's disease 26 | 392
Stomach Neoplasms 26 | 300
esophageal adenocarcinoma 25 | 737
Cognitive delay 24 | 608
Global developmental delay 24 | 608
Liver disease 24 | 237
Melanoma 24 | 711
Mental and motor retardation 24 | 608
Asthma 23 | 385
Colorectal Neoplasms 23 | 243
Down syndrome 23 | 499
Dull intelligence 23 | 645
Hypertension 23 | 396
Kidney disease 23 | 430
Low intelligence 23 | 645
Mental Retardation 23 | 645
Mental deficiency 23 | 645
Muscle hypotonia 23 | 571
Poor school performance 23 | 645
Renal Cell Carcinoma 23 | 214
Adenocarcinoma 22 | 122
Anemia 22 | 365
Atherosclerosis 22 | 291
Colonic Neoplasms 21 | 142
Lung disease 21 | 142
Mental Depression 21 | 333
Toxic encephalopathy 21 | 141

Tissue

Digestive Tract 337 | 17,369
Skin and soft tissues 336 | 17,230
Female tissues 332 | 17,400
Blood and immune system 331 | 16,909
Endocrine System 331 | 18,159
Liver and Pancreas 331 | 16,750
Male tissues 331 | 17,142
Urinary Tract 329 | 16,678
Nervous System 326 | 16,725
Respiratory system 324 | 16,393
Cardiovascular System 309 | 15,192

Target Family

Non-IDG 174 | 12,091
Enzyme 88 | 4,145
Kinase 24 | 634
Transcription Factor 21 | 1,400
Epigenetic 16 | 242
Nuclear Receptor 9 | 48
Transporter 4 | 473
Ion Channel 3 | 344
GPCR 1 | 408

GO Function

enzyme binding 340 | 340
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 346 ZNF346 Tbio Non-IDG -2.28393 188.7 213
Protein arginine methyltransferase NDUFAF7, mitochondrial NDUFAF7 Tbio Enzyme -0.45102 2.70 64
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 PLCB1 Tbio Enzyme -2.50444 332.8 190
Chromobox protein homolog 3 CBX3 Tbio Epigenetic -2.00023 90.5 366
Estrogen receptor ESR1 Tclin Nuclear Receptor -4.00480 8421.6 2610
B-cell lymphoma/leukemia 10 BCL10 Tbio Non-IDG -0.53932 4.30 895
Active regulator of SIRT1 RPS19BP1 Tbio Non-IDG -1.70998 49.5 84
Protein phosphatase 1 regulatory subunit 3B PPP1R3B Tbio Enzyme -2.49697 300.9 94
Importin subunit beta-1 KPNB1 Tbio Non-IDG -1.63038 38.8 174
14-3-3 protein beta/alpha YWHAB Tchem Non-IDG -2.06798 109.1 482