Development Level

Tbio 28 | 11,178
Tchem 12 | 1,885
Tdark 7 | 6,569
Tclin 1 | 612

IMPC Phenotype

preweaning lethality, complete... 6 | 979
abnormal behavior 2 | 298
abnormal embryo size 2 | 220
abnormal eye morphology 2 | 68
anophthalmia 2 | 33
embryonic lethality prior to o... 2 | 239
hyperactivity 2 | 148
abnormal cornea morphology 1 | 31
abnormal cranium morphology 1 | 36
abnormal embryo turning 1 | 31
abnormal esophagus morphology 1 | 5
abnormal eye size 1 | 7
abnormal heart morphology 1 | 162
abnormal motor learning 1 | 3
abnormal pancreas morphology 1 | 13
abnormal pharyngeal arch morph... 1 | 8
abnormal placement of pupils 1 | 6
abnormal seminal vesicle morph... 1 | 114
abnormal skin coloration 1 | 25
abnormal thyroid gland morphol... 1 | 3
abnormal trachea morphology 1 | 3
absent lymph nodes 1 | 3
athymia 1 | 2
corneal opacity 1 | 32
decreased circulating chloride... 1 | 30
decreased circulating phosphat... 1 | 27
decreased circulating triglyce... 1 | 79
decreased coping response 1 | 8
decreased grip strength 1 | 116
decreased heart rate 1 | 18
decreased total body fat amoun... 1 | 207
embryonic growth retardation 1 | 106
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
enlarged spleen 1 | 41
hydrometra 1 | 53
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating choleste... 1 | 66
increased circulating sodium l... 1 | 71
increased mean corpuscular hem... 1 | 96
increased startle reflex 1 | 112
preweaning lethality, incomple... 1 | 499
prolonged PR interval 1 | 15
prolonged RR interval 1 | 8
small superior vagus ganglion 1 | 74

Disease

ovarian cancer 22 | 8,297
osteosarcoma 21 | 7,766
Carcinoma 20 | 11,192
glioblastoma 14 | 5,635
lung cancer 14 | 4,607
medulloblastoma, large-cell 14 | 6,086
psoriasis 13 | 6,514
group 3 medulloblastoma 10 | 4,002
intraductal papillary-mucinous neoplasm (IPMN) 10 | 3,204
intraductal papillary-mucinous carcinoma (IPMC) 9 | 2,902
Cancer 8 | 2,388
atypical teratoid / rhabdoid tumor 8 | 4,971
Autosomal recessive predisposition 7 | 1,407
invasive ductal carcinoma 7 | 2,867
lung adenocarcinoma 7 | 2,627
lung carcinoma 7 | 2,755
adult high grade glioma 6 | 3,701
malignant mesothelioma 6 | 3,135
non-small cell lung cancer 6 | 2,799
tuberculosis 6 | 1,963
Breast cancer 5 | 3,469
Kidney cancer 5 | 2,548
Pick disease 5 | 1,856
acute myeloid leukemia 5 | 760
acute quadriplegic myopathy 5 | 1,133
adrenocortical carcinoma 5 | 1,385
astrocytoma 5 | 1,113
cutaneous lupus erythematosus 5 | 1,016
ependymoma 5 | 4,559
interstitial cystitis 5 | 2,237
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,872
oligodendroglioma 5 | 2,768
pancreatic cancer 5 | 2,322
primitive neuroectodermal tumor 5 | 2,957
subependymal giant cell astrocytoma 5 | 2,230
Asthma 4 | 370
Astrocytoma, Pilocytic 4 | 3,006
Liver Cirrhosis, Experimental 4 | 733
Multiple myeloma 4 | 1,296
Vascular disease 4 | 294
active Crohn's disease 4 | 882
astrocytic glioma 4 | 2,530
breast carcinoma 4 | 1,589
colon cancer 4 | 1,428
diabetes mellitus 4 | 1,683
medulloblastoma 4 | 702
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,911
primary pancreatic ductal adenocarcinoma 4 | 1,071
ulcerative colitis 4 | 1,765
Atherosclerosis 3 | 276
Atopic dermatitis 3 | 915
Bipolar Disorder 3 | 646
Cognitive delay 3 | 596
Global developmental delay 3 | 596
Infantile onset 3 | 236
Intellectual disability 3 | 998
Mental and motor retardation 3 | 596
Multiple Sclerosis 3 | 527
Muscle hypotonia 3 | 562
Peripheral Neuropathy 3 | 131
Pneumonia 3 | 169
Seizures 3 | 584
active ulcerative colitis 3 | 736
non primary Sjogren syndrome sicca 3 | 861
primary Sjogren syndrome 3 | 710
progressive supranuclear palsy 3 | 656
Alcoholic Intoxication, Chronic 2 | 283
Amyotrophic lateral sclerosis 2 | 437
Anemia 2 | 353
Brachycephaly 2 | 86
Broad cranium shape 2 | 86
Cardiomyopathies 2 | 109
Coronary artery disease 2 | 253
Death in early childhood 2 | 82
Death in infancy 2 | 82
Down syndrome 2 | 480
Dysarthria 2 | 190
Dystonia 2 | 163
Epilepsy 2 | 775
Hepatomegaly 2 | 280
Hyperreflexia 2 | 208
Hypoplasia of corpus callosum 2 | 85
Lung disease 2 | 135
Parkinson's disease 2 | 378
Recurrent respiratory infections 2 | 138
Respiratory Failure 2 | 101
Rheumatoid arthritis 2 | 1,156
Schizophrenia 2 | 1,136
Waldenstrons macroglobulinemia 2 | 742
Wide skull shape 2 | 86
aldosterone-producing adenoma 2 | 646
atypical teratoid/rhabdoid tumor 2 | 349
dermatomyositis 2 | 941
ductal carcinoma in situ 2 | 1,686
esophageal adenocarcinoma 2 | 696
gastric carcinoma 2 | 781
hepatocellular carcinoma 2 | 536
juvenile dermatomyositis 2 | 1,147
nasopharyngeal carcinoma 2 | 1,024
pediatric high grade glioma 2 | 1,035

Tissue

Digestive Tract 46 | 17,369
Endocrine System 45 | 18,159
Female tissues 45 | 17,400
Nervous System 45 | 16,725
Liver and Pancreas 44 | 16,750
Skin and soft tissues 44 | 17,230
Blood and immune system 43 | 16,909
Male tissues 43 | 17,142
Respiratory system 42 | 16,393
Urinary Tract 42 | 16,678
Cardiovascular System 39 | 15,192

Target Family

Enzyme 22 | 4,145
Non-IDG 21 | 12,091
Kinase 4 | 634
Epigenetic 1 | 242

GO Function

enzyme activator activity 48 | 48
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
SUMO-activating enzyme subunit 1 SAE1 Tbio Non-IDG -1.52808 27.9 381
Caspase-9 CASP9 Tchem Enzyme -3.44725 2332.0 1313
Leukotriene C4 synthase LTC4S Tbio Enzyme -1.98032 93.9 89
mRNA-decapping enzyme 1A DCP1A Tbio Non-IDG 0.00000 261
ADP-ribosylation factor-like protein 1 ARL1 Tbio Enzyme -0.41493 3.54 208
Matrix metalloproteinase-24 MMP24 Tbio Enzyme -1.38282 25.8 147
Replication factor C subunit 1 RFC1 Tbio Non-IDG -1.43459 26.5 198
Proactivator polypeptide-like 1 PSAPL1 Tdark Non-IDG 0.00000 75
Sarcoplasmic/endoplasmic reticulum calcium ATPase regulator DWORF N/A Tdark Non-IDG 0.00000 0
Leucine-rich colipase-like protein 1 LRCOL1 Tdark Enzyme 0.00000 0