Development Level

Tbio 31 | 11,445
Tchem 9 | 1,598
Tdark 7 | 6,588
Tclin 1 | 613

IMPC Phenotype

preweaning lethality, complete... 6 | 979
abnormal behavior 2 | 298
abnormal embryo size 2 | 220
abnormal eye morphology 2 | 68
anophthalmia 2 | 33
embryonic lethality prior to o... 2 | 239
hyperactivity 2 | 148
abnormal cornea morphology 1 | 31
abnormal cranium morphology 1 | 36
abnormal embryo turning 1 | 31
abnormal esophagus morphology 1 | 5
abnormal eye size 1 | 7
abnormal heart morphology 1 | 162
abnormal motor learning 1 | 3
abnormal pancreas morphology 1 | 13
abnormal pharyngeal arch morph... 1 | 8
abnormal placement of pupils 1 | 6
abnormal seminal vesicle morph... 1 | 114
abnormal skin coloration 1 | 25
abnormal thyroid gland morphol... 1 | 3
abnormal trachea morphology 1 | 3
absent lymph nodes 1 | 3
athymia 1 | 2
corneal opacity 1 | 32
decreased circulating chloride... 1 | 30
decreased circulating phosphat... 1 | 27
decreased circulating triglyce... 1 | 79
decreased coping response 1 | 8
decreased grip strength 1 | 116
decreased heart rate 1 | 18
decreased total body fat amoun... 1 | 207
embryonic growth retardation 1 | 106
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
enlarged spleen 1 | 41
hydrometra 1 | 53
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating choleste... 1 | 66
increased circulating sodium l... 1 | 71
increased mean corpuscular hem... 1 | 96
increased startle reflex 1 | 112
preweaning lethality, incomple... 1 | 499
prolonged PR interval 1 | 15
prolonged RR interval 1 | 8
small superior vagus ganglion 1 | 74

Disease

Carcinoma 25 | 11,493
ovarian cancer 25 | 8,520
osteosarcoma 24 | 7,950
glioblastoma 17 | 5,792
medulloblastoma, large-cell 16 | 6,241
psoriasis 15 | 6,694
lung cancer 14 | 4,740
intraductal papillary-mucinous neoplasm (IPMN) 11 | 3,291
Cancer 10 | 2,499
atypical teratoid / rhabdoid tumor 10 | 5,112
group 3 medulloblastoma 10 | 4,104
adult high grade glioma 9 | 3,801
intraductal papillary-mucinous carcinoma (IPMC) 9 | 2,989
invasive ductal carcinoma 8 | 2,951
lung carcinoma 8 | 2,843
malignant mesothelioma 8 | 3,232
Astrocytoma, Pilocytic 7 | 3,081
Autosomal recessive predisposition 7 | 1,442
ependymoma 7 | 4,679
lung adenocarcinoma 7 | 2,716
oligodendroglioma 7 | 2,850
adrenocortical carcinoma 6 | 1,428
astrocytoma 6 | 1,146
non-small cell lung cancer 6 | 2,890
subependymal giant cell astrocytoma 6 | 2,287
tuberculosis 6 | 2,010
Breast cancer 5 | 3,578
Kidney cancer 5 | 2,613
Liver Cirrhosis, Experimental 5 | 769
Pick disease 5 | 1,894
active Crohn's disease 5 | 922
acute myeloid leukemia 5 | 783
acute quadriplegic myopathy 5 | 1,158
astrocytic glioma 5 | 2,597
cutaneous lupus erythematosus 5 | 1,057
interstitial cystitis 5 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,955
pancreatic cancer 5 | 2,398
primary pancreatic ductal adenocarcinoma 5 | 1,109
primitive neuroectodermal tumor 5 | 3,035
Asthma 4 | 385
Bipolar Disorder 4 | 666
Multiple Sclerosis 4 | 540
Multiple myeloma 4 | 1,332
Vascular disease 4 | 319
breast carcinoma 4 | 1,638
colon cancer 4 | 1,478
diabetes mellitus 4 | 1,728
group 4 medulloblastoma 4 | 1,855
inflammatory breast cancer 4 | 286
medulloblastoma 4 | 720
non primary Sjogren syndrome sicca 4 | 891
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
primary Sjogren syndrome 4 | 735
ulcerative colitis 4 | 1,819
Asymptomatic dengue 3 | 5
Atherosclerosis 3 | 291
Atopic dermatitis 3 | 952
Cognitive delay 3 | 608
Global developmental delay 3 | 608
Infantile onset 3 | 238
Intellectual disability 3 | 1,016
Mental and motor retardation 3 | 608
Muscle hypotonia 3 | 571
Peripheral Neuropathy 3 | 134
Pneumonia 3 | 174
Rheumatoid arthritis 3 | 1,191
Schizophrenia 3 | 1,160
Seizures 3 | 596
active ulcerative colitis 3 | 764
juvenile dermatomyositis 3 | 1,187
progressive supranuclear palsy 3 | 676
Alcoholic Intoxication, Chronic 2 | 289
Amyotrophic lateral sclerosis 2 | 451
Anemia 2 | 365
Brachycephaly 2 | 88
Broad cranium shape 2 | 88
Chronic obstructive pulmonary disease 2 | 184
Coronary artery disease 2 | 268
Down syndrome 2 | 499
Dysarthria 2 | 192
Dystonia 2 | 164
Epilepsy 2 | 792
Hepatomegaly 2 | 285
Hyperreflexia 2 | 209
Hypoplasia of corpus callosum 2 | 90
Lung disease 2 | 142
Parkinson's disease 2 | 392
Waldenstrons macroglobulinemia 2 | 765
aldosterone-producing adenoma 2 | 665
atypical teratoid/rhabdoid tumor 2 | 357
cystic fibrosis 2 | 1,696
dermatomyositis 2 | 966
ductal carcinoma in situ 2 | 1,745
esophageal adenocarcinoma 2 | 737
gastric carcinoma 2 | 807
hepatocellular carcinoma 2 | 547
nasopharyngeal carcinoma 2 | 1,058
pediatric high grade glioma 2 | 1,064
pituitary cancer 2 | 1,972

Tissue

Digestive Tract 46 | 17,369
Endocrine System 45 | 18,159
Female tissues 45 | 17,400
Nervous System 45 | 16,725
Liver and Pancreas 44 | 16,750
Skin and soft tissues 44 | 17,230
Blood and immune system 43 | 16,909
Male tissues 43 | 17,142
Respiratory system 42 | 16,393
Urinary Tract 42 | 16,678
Cardiovascular System 39 | 15,192

Target Family

Enzyme 22 | 4,145
Non-IDG 21 | 12,091
Kinase 4 | 634
Epigenetic 1 | 242

GO Function

enzyme activator activity 48 | 48
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Matrix metalloproteinase-24 MMP24 Tbio Enzyme -1.38282 25.8 147
Rapamycin-insensitive companion of mTOR RICTOR Tbio Non-IDG -2.79454 597.0 440
ADP-ribosylation factor-like protein 1 ARL1 Tbio Enzyme -0.41493 3.54 208
Leucine-rich colipase-like protein 1 LRCOL1 Tdark Enzyme 0.00000 0
Matrix metalloproteinase-17 MMP17 Tchem Enzyme -1.40823 27.2 217
Sarcoplasmic/endoplasmic reticulum calcium ATPase regulator DWORF N/A Tdark Non-IDG 0.00000 0
Apolipoprotein A-V APOA5 Tbio Non-IDG -2.58826 425.0 481
Matrix metalloproteinase-15 MMP15 Tchem Enzyme -1.69065 43.4 351
Proactivator polypeptide-like 1 PSAPL1 Tdark Non-IDG 0.00000 75
Replication factor C subunit 1 RFC1 Tbio Non-IDG -1.43459 26.5 198