Development Level

Tbio 20 | 11,445
Tchem 2 | 1,598
Tdark 1 | 6,588

IMPC Phenotype

preweaning lethality, complete... 3 | 979
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal embryo size 1 | 220
abnormal epididymis morphology 1 | 42
abnormal heart morphology 1 | 162
abnormal kidney morphology 1 | 65
abnormal ovary morphology 1 | 7
abnormal seminal vesicle morph... 1 | 114
absent epididymis 1 | 3
decreased IgG1 level 1 | 8
decreased T cell number 1 | 15
decreased circulating amylase ... 1 | 28
decreased circulating aspartat... 1 | 34
decreased circulating bilirubi... 1 | 19
decreased circulating calcium ... 1 | 36
decreased circulating choleste... 1 | 93
decreased circulating glucose ... 1 | 126
decreased circulating triglyce... 1 | 79
decreased red blood cell distr... 1 | 41
decreased vertical activity 1 | 208
embryonic growth retardation 1 | 106
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
hemorrhage 1 | 23
increased circulating aspartat... 1 | 15
increased circulating triglyce... 1 | 42
increased grip strength 1 | 41
increased lean body mass 1 | 172
increased mean corpuscular vol... 1 | 92
increased or absent threshold ... 1 | 101
preweaning lethality, incomple... 1 | 499
vertebral fusion 1 | 23

Disease

Carcinoma 14 | 11,493
osteosarcoma 14 | 7,950
psoriasis 14 | 6,694
medulloblastoma, large-cell 12 | 6,241
Cancer 11 | 2,499
ovarian cancer 11 | 8,520
Breast cancer 10 | 3,578
glioblastoma 10 | 5,792
atypical teratoid / rhabdoid tumor 9 | 5,112
lung cancer 9 | 4,740
malignant mesothelioma 8 | 3,232
pancreatic cancer 8 | 2,398
adult high grade glioma 7 | 3,801
group 3 medulloblastoma 6 | 4,104
interstitial cystitis 6 | 2,312
intraductal papillary-mucinous carcinoma (IPMC) 6 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,291
primitive neuroectodermal tumor 6 | 3,035
Pick disease 5 | 1,894
Short stature 5 | 531
ductal carcinoma in situ 5 | 1,745
ependymoma 5 | 4,679
invasive ductal carcinoma 5 | 2,951
pituitary cancer 5 | 1,972
Congenital heart disease 4 | 93
Low set ears 4 | 181
cystic fibrosis 4 | 1,696
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
lung adenocarcinoma 4 | 2,716
oligodendroglioma 4 | 2,850
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
Acquired scoliosis 3 | 281
Alcoholic Intoxication, Chronic 3 | 289
Alzheimer's disease 3 | 658
Anemia 3 | 365
Bilateral fifth finger clinodactyly 3 | 110
Bipolar Disorder 3 | 666
Concave bridge of nose 3 | 195
Congenital hypoplasia of penis 3 | 176
Craniofacial Abnormalities 3 | 151
Cryptorchidism 3 | 296
Curvature of little finger 3 | 110
Curvature of spine 3 | 282
Delayed Puberty 3 | 97
Depressed nasal bridge 3 | 195
Depressed nasal ridge 3 | 51
Depressed nasal root/bridge 3 | 195
Fetal Growth Retardation 3 | 189
Infant, Small for Gestational Age 3 | 176
Intellectual disability 3 | 1,016
Intrauterine retardation 3 | 176
Multiple myeloma 3 | 1,332
Muscle hypotonia 3 | 571
Obesity 3 | 678
Penile hypospadias 3 | 106
Polycystic ovary syndrome 3 | 360
Short middle phalanx of the 5th finger 3 | 13
Tetralogy of Fallot 3 | 63
Ventricular Septal Defects 3 | 119
adrenocortical carcinoma 3 | 1,428
astrocytic glioma 3 | 2,597
breast carcinoma 3 | 1,638
cutaneous lupus erythematosus 3 | 1,057
dermatomyositis 3 | 966
diabetes mellitus 3 | 1,728
fibroadenoma 3 | 559
group 4 medulloblastoma 3 | 1,855
non-small cell lung cancer 3 | 2,890
primary pancreatic ductal adenocarcinoma 3 | 1,109
Acquired metabolic disease 2 | 336
Amyotrophic lateral sclerosis 2 | 451
Broad forehead 2 | 59
Congenital deafness 2 | 185
Deafness 2 | 198
Disease Progression 2 | 136
Exophthalmos 2 | 112
Flat face 2 | 52
Hearing Loss, Partial 2 | 185
High forehead 2 | 102
Hydronephrosis 2 | 89
Increased fracture rate 2 | 53
Isolated cases 2 | 72
Joint hyperflexibility 2 | 78
Osteoporosis 2 | 363
Polyhydramnios 2 | 108
Prominent eyes 2 | 96
Prominent globes 2 | 96
Protruding eyes 2 | 96
RENAL ADYSPLASIA 2 | 25
Renal dysplasia 2 | 28
Sensorineural Hearing Loss (disorder) 2 | 284
Short palpebral fissure 2 | 38
Short philtrum 2 | 53
Tall forehead 2 | 102
Underdeveloped brows 2 | 38
Underdeveloped supraorbital ridges 2 | 38
Varying degree of multiple fractures 2 | 53
X-linked cerebral adrenoleukodystrophy 2 | 116
hearing impairment 2 | 199
posterior fossa group A ependymoma 2 | 468

Tissue

Endocrine System 23 | 18,159
Female tissues 23 | 17,400
Digestive Tract 22 | 17,369
Skin and soft tissues 22 | 17,230
Blood and immune system 21 | 16,909
Male tissues 21 | 17,142
Respiratory system 21 | 16,393
Urinary Tract 21 | 16,678
Nervous System 20 | 16,725
Cardiovascular System 19 | 15,192
Liver and Pancreas 19 | 16,750

Target Family

Transcription Factor 17 | 1,400
Non-IDG 4 | 12,091
Nuclear Receptor 1 | 48
Transporter 1 | 473

GO Function

enhancer sequence-specific DNA... 23 | 23
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
X-box-binding protein 1 XBP1 Tchem Transcription Factor -2.90444 780.2 514
Steroid hormone receptor ERR2 ESRRB Tchem Nuclear Receptor -1.95523 86.9 173
LIM domain-binding protein 1 LDB1 Tbio Non-IDG -2.22623 164.4 206
Transcription factor GATA-5 GATA5 Tbio Transcription Factor -1.95925 86.1 183
Insulin gene enhancer protein ISL-1 ISL1 Tbio Transcription Factor -2.63352 410.3 382
High mobility group protein B2 HMGB2 Tbio Transcription Factor -1.52510 34.5 267
LIM domain transcription factor LMO4 LMO4 Tbio Non-IDG -1.08353 14.5 216
Transcription factor SOX-9 SOX9 Tbio Transcription Factor -3.14522 1332.4 657
Homeobox protein Hox-D13 HOXD13 Tbio Transcription Factor -2.30244 199.6 197
Transcription factor SOX-11 SOX11 Tbio Transcription Factor -2.01545 106.1 219