Development Level

Tbio 15 | 11,445
Tchem 2 | 1,598
Tdark 1 | 6,588

Collection

Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 3 | 979
embryonic lethality prior to o... 2 | 239
abnormal kidney morphology 1 | 65
abnormal retina morphology 1 | 71
absent spleen 1 | 3
decreased bone mineral density 1 | 126
decreased fasted circulating g... 1 | 65
decreased neutrophil cell numb... 1 | 42
decreased red blood cell distr... 1 | 41
decreased spleen weight 1 | 10
embryonic lethality prior to t... 1 | 278
increased bone mineral density 1 | 72
increased fasted circulating g... 1 | 76
prenatal lethality prior to he... 1 | 87
preweaning lethality, incomple... 1 | 499

Disease

Carcinoma 13 | 11,493
medulloblastoma, large-cell 7 | 6,241
osteosarcoma 7 | 7,950
psoriasis 6 | 6,694
Cancer 5 | 2,499
atypical teratoid / rhabdoid tumor 5 | 5,112
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,291
ovarian cancer 5 | 8,520
glioblastoma 4 | 5,792
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,989
malignant mesothelioma 4 | 3,232
Kidney cancer 3 | 2,613
adrenocortical carcinoma 3 | 1,428
cystic fibrosis 3 | 1,696
group 3 medulloblastoma 3 | 4,104
hepatocellular carcinoma 3 | 547
lung cancer 3 | 4,740
medulloblastoma 3 | 720
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
primitive neuroectodermal tumor 3 | 3,035
spina bifida 3 | 1,074
Breast cancer 2 | 3,578
Infertility 2 | 188
Male infertility 2 | 206
Pick disease 2 | 1,894
Rheumatoid arthritis 2 | 1,191
acute quadriplegic myopathy 2 | 1,158
astrocytic glioma 2 | 2,597
gastric cancer 2 | 459
group 4 medulloblastoma 2 | 1,855
hereditary spastic paraplegia 2 | 318
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,955
juvenile dermatomyositis 2 | 1,187
pancreatic cancer 2 | 2,398
pituitary cancer 2 | 1,972
posterior fossa group B ependymoma 2 | 416
subependymal giant cell astrocytoma 2 | 2,287
tuberculosis 2 | 2,010
tuberculosis and treatment for 6 months 2 | 409
ulcerative colitis 2 | 1,819
Abnormality of metabolism/homeostasis 1 | 134
Adenocarcinoma of lung 1 | 142
Alcoholic Intoxication, Chronic 1 | 289
Alzheimer's disease 1 | 658
Amyotrophic lateral sclerosis 1 | 451
Atopic dermatitis 1 | 952
Basal cell carcinoma 1 | 54
Basal cell nevi 1 | 23
Cardiovascular system disease 1 | 246
Chromosome 18p deletion syndrome 1 | 5
Cocaine-Related Disorders 1 | 92
Disease Models, Animal 1 | 155
Disseminated intravascular coagulation 1 | 38
Down syndrome 1 | 499
Edwards syndrome 1 | 17
Endometrial cancer 1 | 311
Endometriosis 1 | 540
Epilepsy 1 | 792
Fragile X syndrome 1 | 34
Gaucher disease type 1 1 | 180
Granulosa cell tumor 1 | 6
Hepatitis B 1 | 108
Influenza 1 | 142
Klinefelter's syndrome 1 | 56
Leukemia, Myeloid 1 | 18
Liver Cirrhosis, Experimental 1 | 769
Liver cancer 1 | 604
Malignant neoplasm of prostate 1 | 11
Mesothelioma, Malignant 1 | 105
Microphthalmia with limb anomalies 1 | 40
Mucoepidermoid carcinoma 1 | 26
Multiple Sclerosis 1 | 540
Myeloid Leukemia 1 | 19
Osteoporosis 1 | 363
Pancytopenia 1 | 45
Papillary thyroid carcinoma 1 | 43
Patau syndrome 1 | 14
Peripheral vascular disease 1 | 87
Prostate cancer 1 | 175
Renal Cell Carcinoma 1 | 214
Rhabdomyosarcoma 1 | 39
Seminoma 1 | 15
Shwachman-Diamond syndrome 1 | 17
Substance-Related Disorders 1 | 115
Thrombocytopenia 1 | 197
Turner syndrome 1 | 28
Waldenstrons macroglobulinemia 1 | 765
Wilms Tumor 1 | 28
X-linked cerebral adrenoleukodystrophy 1 | 116
active Crohn's disease 1 | 922
active ulcerative colitis 1 | 764
adrenocortical adenoma 1 | 131
colon cancer 1 | 1,478
inflammatory breast cancer 1 | 286
ovarian neoplasm 1 | 99
pancreatic carcinoma 1 | 562
pediatric high grade glioma 1 | 1,064
permanent atrial fibrillation 1 | 45
progressive supranuclear palsy 1 | 676
sarcoidosis 1 | 370

Tissue

Digestive Tract 18 | 17,369
Endocrine System 18 | 18,159
Female tissues 18 | 17,400
Blood and immune system 17 | 16,909
Respiratory system 17 | 16,393
Cardiovascular System 16 | 15,192
Liver and Pancreas 16 | 16,750
Male tissues 16 | 17,142
Skin and soft tissues 16 | 17,230
Nervous System 15 | 16,725
Urinary Tract 15 | 16,678

Target Family

Non-IDG 9 | 12,091
Enzyme 7 | 4,145
Kinase 2 | 634

GO Function

endoribonuclease activity 18 | 18
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Cleavage and polyadenylation specificity factor subunit 3 CPSF3 Tbio Non-IDG -1.47182 27.3 190
Telomerase-binding protein EST1A SMG6 Tbio Enzyme -1.48788 32.6 37
Ribonuclease kappa RNASEK Tbio Enzyme -0.92082 8.72 51
Endoribonuclease ZC3H12A ZC3H12A Tbio Enzyme -1.81028 77.8 134
Poly(U)-specific endoribonuclease ENDOU Tbio Enzyme -1.53618 34.6 40
Piwi-like protein 2 PIWIL2 Tbio Non-IDG -2.20460 154.8 204
Protein SLFN14 SLFN14 Tbio Non-IDG -0.61542 3.98 53
2-5A-dependent ribonuclease RNASEL Tchem Kinase -2.71673 525.8 127
RNA 3'-terminal phosphate cyclase-like protein RCL1 Tbio Enzyme -1.86512 69.8 113
Protein argonaute-2 AGO2 Tbio Non-IDG -2.97243 867.1 202