Development Level

Tchem 29 | 1,598
Tbio 24 | 11,445
Tclin 5 | 613

IMPC Phenotype

preweaning lethality, complete... 7 | 979
abnormal embryo size 5 | 220
embryonic growth retardation 4 | 106
embryonic lethality prior to t... 4 | 278
abnormal limb bud morphology 2 | 17
abnormal limb morphology 2 | 13
abnormal tail morphology 2 | 25
decreased vertical activity 2 | 208
hemorrhage 2 | 23
increased mean corpuscular vol... 2 | 92
pale yolk sac 2 | 25
pallor 2 | 34
abnormal behavior 1 | 298
abnormal body wall morphology 1 | 9
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal eye morphology 1 | 68
abnormal facial morphology 1 | 17
abnormal liver size 1 | 5
abnormal neural tube closure 1 | 46
abnormal placenta size 1 | 20
abnormal seminal vesicle morph... 1 | 114
abnormal vibrissa morphology 1 | 25
brachydactyly 1 | 19
cleft palate 1 | 8
cyanosis 1 | 7
decreased B cell number 1 | 5
decreased basophil cell number 1 | 16
decreased blood urea nitrogen ... 1 | 51
decreased body weight 1 | 161
decreased circulating HDL chol... 1 | 68
decreased circulating aspartat... 1 | 34
decreased circulating choleste... 1 | 93
decreased granulocyte number 1 | 6
decreased lean body mass 1 | 135
decreased prepulse inhibition 1 | 82
edema 1 | 59
increased T cell number 1 | 6
increased circulating alanine ... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating serum al... 1 | 22
increased startle reflex 1 | 112
pale liver 1 | 6
prenatal lethality prior to he... 1 | 87
preweaning lethality, incomple... 1 | 499
prolonged ST segment 1 | 36
respiratory system phenotype 1 | 2
short tibia 1 | 97
thrombocytopenia 1 | 56
unresponsive to tactile stimul... 1 | 8

Disease

Carcinoma 41 | 11,493
ovarian cancer 27 | 8,520
osteosarcoma 26 | 7,950
psoriasis 24 | 6,694
Cancer 19 | 2,499
lung cancer 18 | 4,740
malignant mesothelioma 18 | 3,232
atypical teratoid / rhabdoid tumor 17 | 5,112
glioblastoma 17 | 5,792
invasive ductal carcinoma 16 | 2,951
medulloblastoma, large-cell 16 | 6,241
ependymoma 15 | 4,679
non-small cell lung cancer 14 | 2,890
Alzheimer's disease 13 | 658
Breast cancer 13 | 3,578
cystic fibrosis 13 | 1,696
lung adenocarcinoma 12 | 2,716
Hypertension 11 | 396
diabetes mellitus 11 | 1,728
ductal carcinoma in situ 11 | 1,745
ulcerative colitis 11 | 1,819
Kidney cancer 10 | 2,613
intraductal papillary-mucinous neoplasm (IPMN) 10 | 3,291
tuberculosis 10 | 2,010
Atherosclerosis 9 | 291
Atopic dermatitis 9 | 952
Kidney disease 9 | 430
Prostatic Neoplasms 9 | 495
breast carcinoma 9 | 1,638
interstitial cystitis 9 | 2,312
pancreatic cancer 9 | 2,398
Astrocytoma, Pilocytic 8 | 3,081
Hypertensive disease 8 | 292
Liver Cirrhosis, Experimental 8 | 769
Neurodegenerative disease 8 | 414
adult high grade glioma 8 | 3,801
lung carcinoma 8 | 2,843
Arthritis 7 | 290
Cerebrovascular disease 7 | 238
Schizophrenia 7 | 1,160
cutaneous lupus erythematosus 7 | 1,057
esophageal adenocarcinoma 7 | 737
group 3 medulloblastoma 7 | 4,104
oligodendroglioma 7 | 2,850
periodontitis 7 | 293
primitive neuroectodermal tumor 7 | 3,035
Autosomal recessive predisposition 6 | 1,442
Bipolar Disorder 6 | 666
Coronary artery disease 6 | 268
Heart disease 6 | 306
Multiple myeloma 6 | 1,332
astrocytoma 6 | 1,146
colon cancer 6 | 1,478
medulloblastoma 6 | 720
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,962
subependymal giant cell astrocytoma 6 | 2,287
Alzheimer Disease 5 | 83
Aortic aneurysm 5 | 38
Breast Neoplasms 5 | 445
Hypersensitivity reaction type II disease 5 | 253
Inflammatory bowel disease 5 | 151
Lung disease 5 | 142
Mammary Neoplasms 5 | 425
Obesity 5 | 678
active ulcerative colitis 5 | 764
adrenocortical carcinoma 5 | 1,428
astrocytic glioma 5 | 2,597
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,989
pediatric high grade glioma 5 | 1,064
Amyloidosis 4 | 67
Anemia 4 | 365
Asthma 4 | 385
Congestive heart failure 4 | 113
Dementia 4 | 175
Endometriosis 4 | 540
Liver disease 4 | 237
Multiple Sclerosis 4 | 540
Periodontal disease 4 | 40
active Crohn's disease 4 | 922
acute quadriplegic myopathy 4 | 1,158
dermatomyositis 4 | 966
juvenile dermatomyositis 4 | 1,187
mucosa-associated lymphoid tissue lymphoma 4 | 484
nasopharyngeal carcinoma 4 | 1,058
nephrosclerosis 4 | 333
non primary Sjogren syndrome sicca 4 | 891
pituitary cancer 4 | 1,972
posterior fossa group B ependymoma 4 | 416
primary pancreatic ductal adenocarcinoma 4 | 1,109
Dermatitis 3 | 157
Down syndrome 3 | 499
Epilepsy 3 | 792
Pick disease 3 | 1,894
Seizures 3 | 596
Vascular disease 3 | 319
acute myeloid leukemia 3 | 783
fibroadenoma 3 | 559
progressive supranuclear palsy 3 | 676
spina bifida 3 | 1,074

Tissue

Digestive Tract 57 | 17,369
Endocrine System 57 | 18,159
Female tissues 57 | 17,400
Male tissues 57 | 17,142
Skin and soft tissues 57 | 17,230
Urinary Tract 57 | 16,678
Blood and immune system 56 | 16,909
Liver and Pancreas 56 | 16,750
Respiratory system 56 | 16,393
Nervous System 53 | 16,725
Cardiovascular System 50 | 15,192

Target Family

Enzyme 48 | 4,145
Non-IDG 10 | 12,091

GO Function

endopeptidase activity 58 | 58
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Endothelin-converting enzyme 1 ECE1 Tchem Enzyme -2.56360 355.0 278
Suppressor of tumorigenicity 14 protein ST14 Tchem Non-IDG -2.50215 338.3 309
Copine-1 CPNE1 Tbio Non-IDG -1.04880 11.6 151
Metalloprotease TIKI1 TRABD2A Tbio Enzyme -0.46489 2.81 55
Prolyl endopeptidase FAP FAP Tchem Enzyme -2.37686 226.2 406
Endoplasmic reticulum aminopeptidase 2 ERAP2 Tchem Enzyme -1.73764 53.1 76
A disintegrin and metalloproteinase with thrombospondin motifs 3 ADAMTS3 Tbio Enzyme -0.75603 4.50 45
Angiotensin-converting enzyme 2 ACE2 Tchem Enzyme -3.00188 1129.3 720
Calpain-7 CAPN7 Tbio Non-IDG -1.51078 32.0 65
Membrane cofactor protein CD46 Tbio Non-IDG -2.94025 875.6 770