Development Level

Tchem 24 | 1,890
Tbio 19 | 10,625
Tclin 4 | 602
Tdark 2 | 7,003

IMPC Term

preweaning lethality, complete... 4 | 633
increased or absent threshold ... 2 | 128
abnormal behavior 1 | 226
abnormal bone mineralization 1 | 55
abnormal bone structure 1 | 131
abnormal limb bud morphology 1 | 15
abnormal limb morphology 1 | 7
abnormal tail morphology 1 | 17
abnormal vibrissa morphology 1 | 17
brachydactyly 1 | 2
cyanosis 1 | 6
decreased B cell number 1 | 30
decreased CD11b-low dendritic ... 1 | 3
decreased basophil cell number 1 | 11
decreased body weight 1 | 174
decreased granulocyte number 1 | 8
decreased heart weight 1 | 44
decreased lean body mass 1 | 195
edema 1 | 11
embryonic lethality prior to t... 1 | 187
hemorrhage 1 | 12
hydrops fetalis 1 | 22
increased CD11b-high dendritic... 1 | 5
increased T cell number 1 | 15
increased circulating serum al... 1 | 25
increased mean corpuscular vol... 1 | 91
respiratory system phenotype 1 | 2
short tibia 1 | 82

Disease

ovarian cancer 26 | 8,484
osteosarcoma 22 | 7,933
psoriasis 20 | 6,685
glioblastoma 16 | 5,572
malignant mesothelioma 15 | 3,162
medulloblastoma, large-cell 15 | 6,234
atypical teratoid / rhabdoid tumor 14 | 4,369
lung cancer 14 | 4,466
Alzheimer's disease 13 | 644
Cancer 12 | 2,346
non-small cell lung cancer 12 | 2,798
ulcerative colitis 12 | 2,087
cystic fibrosis 11 | 1,665
invasive ductal carcinoma 11 | 2,950
Breast cancer 10 | 3,094
pediatric high grade glioma 10 | 2,712
lung adenocarcinoma 9 | 2,713
tuberculosis 9 | 1,557
Atherosclerosis 8 | 275
ductal carcinoma in situ 8 | 1,745
ependymoma 8 | 2,514
pilocytic astrocytoma 8 | 3,086
Hypertension 7 | 287
IGA Glomerulonephritis 7 | 454
Kidney disease 7 | 396
Neurodegenerative disease 7 | 383
cutaneous lupus erythematosus 7 | 1,056
diabetes mellitus 7 | 1,663
intraductal papillary-mucinous neoplasm (IPMN) 7 | 3,289
lung carcinoma 7 | 2,844
pancreatic cancer 7 | 2,300
primitive neuroectodermal tumor 7 | 3,031
Carcinoma 6 | 2,147
astrocytoma 6 | 1,493
breast carcinoma 6 | 1,614
esophageal adenocarcinoma 6 | 737
subependymal giant cell astrocytoma 6 | 2,287
Arthritis 5 | 248
Coronary artery disease 5 | 240
Heart disease 5 | 279
Hypertensive disease 5 | 193
Lung disease 5 | 132
Mammary Neoplasms 5 | 410
Multiple myeloma 5 | 1,327
Prostatic Neoplasms 5 | 471
adrenocortical carcinoma 5 | 1,427
colon cancer 5 | 1,475
interstitial cystitis 5 | 2,299
oligodendroglioma 5 | 2,849
periodontitis 5 | 269
posterior fossa group A ependymoma 5 | 1,511
sonic hedgehog group medulloblastoma 5 | 1,482
Amyloidosis 4 | 68
Aortic aneurysm 4 | 34
Asthma 4 | 349
Atopic dermatitis 4 | 944
Cerebrovascular disease 4 | 231
Hypersensitivity reaction type II disease 4 | 235
Inflammatory bowel disease 4 | 142
Liver Cirrhosis, Experimental 4 | 108
Obesity 4 | 616
active Crohn's disease 4 | 918
group 3 medulloblastoma 4 | 2,254
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,956
juvenile dermatomyositis 4 | 1,189
medulloblastoma 4 | 1,524
mucosa-associated lymphoid tissue lymphoma 4 | 480
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,795
posterior fossa group B ependymoma 4 | 1,530
Ankylosing spondylitis 3 | 138
Dementia 3 | 129
Diarrhea 3 | 155
Down syndrome 3 | 548
Endometriosis 3 | 535
Liver disease 3 | 219
Neoplasm Invasiveness 3 | 127
Neoplasm Metastasis 3 | 138
Neutropenia 3 | 78
Periodontal disease 3 | 37
Skin disease 3 | 65
Vascular disease 3 | 281
active ulcerative colitis 3 | 477
acute myeloid leukemia 3 | 780
acute quadriplegic myopathy 3 | 1,157
adult high grade glioma 3 | 2,148
atypical teratoid/rhabdoid tumor 3 | 1,095
facioscapulohumeral dystrophy 3 | 286
fibroadenoma 3 | 557
head and neck cancer and chronic obstructive pulmonary disease 3 | 237
inflammatory breast cancer 3 | 404
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,988
nasopharyngeal carcinoma 3 | 1,056
nephrosclerosis 3 | 329
non primary Sjogren syndrome sicca 3 | 840
non-small cell lung carcinoma 3 | 413
primary Sjogren syndrome 3 | 789
primary pancreatic ductal adenocarcinoma 3 | 1,271
progressive supranuclear palsy 3 | 674
sarcoidosis 3 | 358
tuberculosis and treatment for 6 months 3 | 686

Tissue

Digestive Tract 49 | 18,473
Female tissues 49 | 18,647
Liver and Pancreas 49 | 18,136
Blood and immune system 48 | 17,995
Cardiovascular System 48 | 17,958
Endocrine System 48 | 18,512
Male tissues 48 | 17,969
Nervous System 48 | 18,561
Respiratory system 48 | 17,484
Skin and soft tissues 48 | 18,115
Urinary Tract 48 | 18,444

Target Family

Enzyme 41 | 4,146
Non-IDG 8 | 11,971

GO Function

endopeptidase activity 49 | 49
metal ion binding 1,917 | 1,917
ATP binding 1,467 | 1,467
DNA binding 1,432 | 1,432
zinc ion binding 1,155 | 1,155
poly(A) RNA binding 1,107 | 1,107
transcription factor activity,... 853 | 853
calcium ion binding 695 | 695
G-protein coupled receptor act... 661 | 661
protein homodimerization activ... 569 | 569
RNA binding 445 | 445
olfactory receptor activity 424 | 424
sequence-specific DNA binding 398 | 398
GTP binding 374 | 374
chromatin binding 372 | 372
protein serine/threonine kinas... 336 | 336
RNA polymerase II core promote... 332 | 332
identical protein binding 311 | 311
nucleotide binding 311 | 311
receptor binding 303 | 303
protein kinase binding 289 | 289
enzyme binding 286 | 286
cadherin binding involved in c... 277 | 277
GTPase activator activity 273 | 273
ubiquitin protein ligase bindi... 258 | 258
ubiquitin-protein transferase ... 253 | 253
serine-type endopeptidase acti... 246 | 246
transcription coactivator acti... 241 | 241
transcription factor binding 240 | 240
structural molecule activity 232 | 232
GTPase activity 231 | 231
transcriptional activator acti... 230 | 230
ligase activity 227 | 227
protein heterodimerization act... 227 | 227
structural constituent of ribo... 212 | 212
transcription regulatory regio... 202 | 202
transmembrane signaling recept... 201 | 201
RNA polymerase II regulatory r... 200 | 200
receptor activity 200 | 200
transcription corepressor acti... 198 | 198
magnesium ion binding 197 | 197
signal transducer activity 196 | 196
nucleic acid binding 184 | 184
protein kinase activity 183 | 183
carbohydrate binding 180 | 180
ubiquitin protein ligase activ... 173 | 173
RNA polymerase II transcriptio... 162 | 162
heparin binding 160 | 160
iron ion binding 141 | 141
lipid binding 136 | 136
transporter activity 136 | 136
actin binding 133 | 133
ATPase activity 132 | 132
protein C-terminus binding 129 | 129
heme binding 127 | 127
microtubule binding 123 | 123
protein tyrosine kinase activi... 119 | 119
cytokine activity 118 | 118
Ras guanyl-nucleotide exchange... 113 | 113
mRNA binding 112 | 112
metalloendopeptidase activity 112 | 112
transcriptional repressor acti... 110 | 110
structural constituent of cyto... 108 | 108
Rab GTPase binding 105 | 105
antigen binding 104 | 104
protein domain specific bindin... 102 | 102
peptide antigen binding 101 | 101
guanyl-nucleotide exchange fac... 98 | 98
protein complex binding 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 92 | 92
oxidoreductase activity 91 | 91
transcriptional activator acti... 91 | 91
actin filament binding 89 | 89
hydrolase activity 89 | 89
ion channel binding 89 | 89
protein tyrosine phosphatase a... 88 | 88
electron carrier activity 87 | 87
protease binding 87 | 87
histone binding 86 | 86
integrin binding 83 | 83
growth factor activity 82 | 82
phospholipid binding 82 | 82
single-stranded DNA binding 81 | 81
unfolded protein binding 77 | 77
kinase activity 75 | 75
thiol-dependent ubiquitin-spec... 75 | 75
phosphatidylinositol binding 74 | 74
calmodulin binding 73 | 73
histone deacetylase binding 73 | 73
Rho guanyl-nucleotide exchange... 72 | 72
drug binding 71 | 71
double-stranded DNA binding 70 | 70
peptidase activity 70 | 70
protein N-terminus binding 70 | 70
virus receptor activity 68 | 68
beta-catenin binding 67 | 67
microtubule motor activity 67 | 67
protein transporter activity 67 | 67
calcium channel activity 66 | 66
ubiquitin binding 66 | 66

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Interstitial collagenase MMP1 Tchem Enzyme -3.40801 2529.5 682
Macrophage metalloelastase MMP12 Tchem Enzyme 0.00000 382
Matrix metalloproteinase-9 MMP9 Tchem Enzyme -3.90528 8199.7 1129
Endoplasmic reticulum aminopeptidase 1 ERAP1 Tchem Enzyme -2.22270 198.7 195
A disintegrin and metalloproteinase with thrombospondin motifs 3 ADAMTS3 Tbio Enzyme -0.45918 3.20 40
Presenilin-2 PSEN2 Tchem Enzyme -2.77295 585.2 282
Calpain-7 CAPN7 Tbio Non-IDG -1.48466 29.4 47
Trafficking protein particle complex subunit 12 TRAPPC12 Tbio Non-IDG -0.22185 1.52 54
Cysteine protease ATG4B ATG4B Tchem Enzyme -1.63370 46.4 338
Endoplasmic reticulum aminopeptidase 2 ERAP2 Tchem Enzyme -1.63940 46.0 70