Development Level

Tbio 43 | 11,445
Tclin 15 | 613
Tchem 11 | 1,598
Tdark 4 | 6,588

IMPC Phenotype

preweaning lethality, complete... 9 | 979
abnormal lens morphology 3 | 81
cataract 3 | 92
embryonic lethality prior to o... 3 | 239
embryonic lethality prior to t... 3 | 278
abnormal behavior 2 | 298
decreased circulating choleste... 2 | 93
decreased circulating insulin ... 2 | 76
decreased circulating triglyce... 2 | 79
decreased erythrocyte cell num... 2 | 62
increased bone mineral content 2 | 108
increased lean body mass 2 | 172
abnormal bone mineralization 1 | 38
abnormal kidney morphology 1 | 65
abnormal response to tactile s... 1 | 17
abnormal retina morphology 1 | 71
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal seminal vesicle morph... 1 | 114
abnormal startle reflex 1 | 15
abnormal tail movements 1 | 12
abnormal vocalization 1 | 21
decreased CD4-positive, alpha ... 1 | 7
decreased CD8-positive, alpha-... 1 | 8
decreased T cell number 1 | 15
decreased blood urea nitrogen ... 1 | 51
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating alkaline... 1 | 46
decreased circulating amylase ... 1 | 28
decreased circulating total pr... 1 | 49
decreased fasted circulating g... 1 | 65
decreased lactate dehydrogenas... 1 | 16
decreased lean body mass 1 | 135
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
hypoactivity 1 | 132
impaired righting response 1 | 26
increased circulating alkaline... 1 | 122
increased circulating calcium ... 1 | 34
increased circulating phosphat... 1 | 26
increased circulating potassiu... 1 | 29
increased circulating sodium l... 1 | 71
increased heart weight 1 | 62
increased mean corpuscular hem... 1 | 96
male infertility 1 | 123
persistence of hyaloid vascula... 1 | 33
stereotypic behavior 1 | 3
trunk curl 1 | 16

Disease

ovarian cancer 47 | 8,520
Carcinoma 36 | 11,493
lung cancer 28 | 4,740
osteosarcoma 28 | 7,950
pancreatic ductal adenocarcinoma liver metastasis 26 | 1,962
psoriasis 26 | 6,694
glioblastoma 25 | 5,792
Autosomal recessive predisposition 24 | 1,442
medulloblastoma, large-cell 22 | 6,241
Breast cancer 20 | 3,578
Cancer 19 | 2,499
atypical teratoid / rhabdoid tumor 19 | 5,112
invasive ductal carcinoma 19 | 2,951
ependymoma 17 | 4,679
intraductal papillary-mucinous neoplasm (IPMN) 17 | 3,291
pancreatic cancer 17 | 2,398
non-small cell lung cancer 15 | 2,890
Epilepsy 14 | 792
group 3 medulloblastoma 14 | 4,104
lung carcinoma 14 | 2,843
malignant mesothelioma 14 | 3,232
primitive neuroectodermal tumor 14 | 3,035
Astrocytoma, Pilocytic 13 | 3,081
Multiple myeloma 13 | 1,332
adult high grade glioma 13 | 3,801
ductal carcinoma in situ 13 | 1,745
interstitial cystitis 13 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 13 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 13 | 2,989
Muscle hypotonia 12 | 571
Seizures 12 | 596
breast carcinoma 12 | 1,638
lung adenocarcinoma 12 | 2,716
Cognitive delay 11 | 608
Dull intelligence 11 | 645
Global developmental delay 11 | 608
Intellectual disability 11 | 1,016
Liver Cirrhosis, Experimental 11 | 769
Low intelligence 11 | 645
Mental Retardation 11 | 645
Mental and motor retardation 11 | 608
Mental deficiency 11 | 645
Poor school performance 11 | 645
adrenocortical carcinoma 11 | 1,428
astrocytic glioma 11 | 2,597
tuberculosis 11 | 2,010
ulcerative colitis 11 | 1,819
Cerebellar Ataxia 10 | 304
Hypoglycemia 10 | 152
Muscle Weakness 10 | 170
cystic fibrosis 10 | 1,696
Leigh disease 9 | 100
Nystagmus 9 | 317
Rheumatoid arthritis 9 | 1,191
colon cancer 9 | 1,478
Hyperreflexia 8 | 209
Hypertrophic Cardiomyopathy 8 | 117
Mitochondrial complex I deficiency 8 | 46
Prostatic Neoplasms 8 | 495
Schizophrenia 8 | 1,160
Vomiting 8 | 116
diabetes mellitus 8 | 1,728
oligodendroglioma 8 | 2,850
pituitary cancer 8 | 1,972
primary pancreatic ductal adenocarcinoma 8 | 1,109
Abnormal mitochondria in muscle tissue 7 | 20
Acidosis, Lactic 7 | 97
Alcoholic Intoxication, Chronic 7 | 289
Babinski Reflex 7 | 100
Blepharoptosis 7 | 231
Breast Neoplasms 7 | 445
Developmental regression 7 | 95
Diabetes mellitus type 2 7 | 69
Growth delay 7 | 114
Growth failure 7 | 114
Growth retardation 7 | 115
Hepatomegaly 7 | 285
Highly variable clinical phenotype 7 | 150
Highly variable phenotype and severity 7 | 150
Highly variable phenotype, even within families 7 | 150
Impaired exercise tolerance 7 | 42
Lactic acidemia 7 | 95
Lethargy 7 | 77
Loss of developmental milestones 7 | 95
Mammary Neoplasms 7 | 425
Mental deterioration in childhood 7 | 95
Muscle Spasticity 7 | 195
Neurodevelopmental regression 7 | 95
Phenotypic variability 7 | 150
Poor growth 7 | 114
Psychomotor regression 7 | 95
Psychomotor regression beginning in infancy 7 | 95
Psychomotor regression in infants 7 | 95
Psychomotor regression, progressive 7 | 95
Sensorineural Hearing Loss (disorder) 7 | 284
Treatment Refractory Type 2 Diabetes Mellitus 7 | 53
Very poor growth 7 | 114
active ulcerative colitis 7 | 764
esophageal adenocarcinoma 7 | 737
subependymal giant cell astrocytoma 7 | 2,287

Tissue

Endocrine System 73 | 18,159
Male tissues 73 | 17,142
Digestive Tract 72 | 17,369
Female tissues 72 | 17,400
Liver and Pancreas 72 | 16,750
Skin and soft tissues 72 | 17,230
Urinary Tract 72 | 16,678
Blood and immune system 71 | 16,909
Respiratory system 71 | 16,393
Nervous System 69 | 16,725
Cardiovascular System 66 | 15,192

Target Family

Enzyme 54 | 4,145
Non-IDG 19 | 12,091

GO Function

electron transfer activity 73 | 73
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Cytochrome c oxidase assembly protein COX11, mitochondrial COX11 Tbio Enzyme -1.42359 24.4 86
D-3-phosphoglycerate dehydrogenase PHGDH Tbio Enzyme -3.17330 1408.2 293
Thioredoxin reductase 3 TXNRD3 Tdark Enzyme -1.72626 60.0 0
Dimethylglycine dehydrogenase, mitochondrial DMGDH Tbio Enzyme -1.39556 25.3 115
NADPH--cytochrome P450 reductase POR Tbio Enzyme -2.43541 216.2 257
Succinate dehydrogenase cytochrome b560 subunit, mitochondrial SDHC Tbio Enzyme -2.73791 419.9 129
Aflatoxin B1 aldehyde reductase member 2 AKR7A2 Tbio Enzyme -2.57327 369.6 197
Ferredoxin-2, mitochondrial FDX2 Tdark Non-IDG -0.85150 6.83 4
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase DHDH Tbio Enzyme -2.59951 390.9 103
NADP-dependent malic enzyme ME1 Tchem Non-IDG -1.98857 92.8 234