Development Level

Tbio 54 | 10,625
Tclin 15 | 602
Tchem 13 | 1,890
Tdark 5 | 7,003

IMPC Term

preweaning lethality, complete... 7 | 633
abnormal lens morphology 4 | 73
abnormal heart left ventricle ... 2 | 20
abnormal retina morphology 2 | 100
decreased circulating insulin ... 2 | 75
decreased circulating triglyce... 2 | 83
increased bone mineral content 2 | 92
abnormal QRS complex 1 | 25
abnormal behavior 1 | 226
abnormal bone mineralization 1 | 55
abnormal kidney morphology 1 | 30
abnormal response to tactile s... 1 | 16
abnormal retinal blood vessel ... 1 | 18
abnormal retinal vasculature m... 1 | 15
abnormal seminal vesicle morph... 1 | 47
abnormal startle reflex 1 | 14
abnormal tail movements 1 | 12
abnormal vocalization 1 | 21
cataract 1 | 26
decreased CD4-positive, alpha ... 1 | 19
decreased CD8-positive, alpha-... 1 | 26
decreased Ly6C low monocyte nu... 1 | 23
decreased NK cell number 1 | 16
decreased T cell number 1 | 31
decreased blood urea nitrogen ... 1 | 31
decreased bone mineral content 1 | 157
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 77
decreased circulating LDL chol... 1 | 37
decreased circulating alkaline... 1 | 41
decreased circulating amylase ... 1 | 24
decreased circulating choleste... 1 | 85
decreased circulating thyroxin... 1 | 5
decreased circulating total pr... 1 | 41
decreased erythrocyte cell num... 1 | 43
decreased fasted circulating g... 1 | 49
decreased heart weight 1 | 44
decreased lactate dehydrogenas... 1 | 14
decreased spleen weight 1 | 13
decreased total body fat amoun... 1 | 186
embryonic lethality prior to o... 1 | 148
embryonic lethality prior to t... 1 | 187
hypoactivity 1 | 89
impaired righting response 1 | 19
increased circulating potassiu... 1 | 31
increased fasted circulating g... 1 | 68
increased gamma-delta T cell n... 1 | 16
increased heart weight 1 | 37
increased lean body mass 1 | 107
increased mean corpuscular hem... 1 | 93
increased startle reflex 1 | 38
persistence of hyaloid vascula... 1 | 22
stereotypic behavior 1 | 3
trunk curl 1 | 15

Disease

ovarian cancer 54 | 8,484
lung cancer 33 | 4,466
osteosarcoma 33 | 7,933
pancreatic ductal adenocarcinoma liver metastasis 32 | 1,795
psoriasis 32 | 6,685
glioblastoma 24 | 5,572
medulloblastoma, large-cell 23 | 6,234
invasive ductal carcinoma 21 | 2,950
Breast cancer 20 | 3,094
pancreatic cancer 19 | 2,300
intraductal papillary-mucinous neoplasm (IPMN) 18 | 3,289
non-small cell lung cancer 18 | 2,798
ulcerative colitis 18 | 2,087
lung carcinoma 17 | 2,844
malignant mesothelioma 17 | 3,162
Cancer 16 | 2,346
atypical teratoid / rhabdoid tumor 16 | 4,369
interstitial cystitis 16 | 2,299
lung adenocarcinoma 16 | 2,713
intraductal papillary-mucinous adenoma (IPMA) 15 | 2,956
pilocytic astrocytoma 15 | 3,086
ductal carcinoma in situ 14 | 1,745
intraductal papillary-mucinous carcinoma (IPMC) 14 | 2,988
adrenocortical carcinoma 13 | 1,427
primitive neuroectodermal tumor 13 | 3,031
Multiple myeloma 12 | 1,327
ependymoma 12 | 2,514
Multiple acyl-CoA dehydrogenase deficiency 10 | 26
Rheumatoid Arthritis 10 | 1,160
astrocytic glioma 10 | 2,241
cystic fibrosis 10 | 1,665
adult high grade glioma 9 | 2,148
breast carcinoma 9 | 1,614
colon cancer 9 | 1,475
diabetes mellitus 9 | 1,663
posterior fossa group A ependymoma 9 | 1,511
primary pancreatic ductal adenocarcinoma 9 | 1,271
Atopic dermatitis 8 | 944
Leigh disease 8 | 81
MITOCHONDRIAL COMPLEX I DEFICIENCY 8 | 37
medulloblastoma 8 | 1,524
subependymal giant cell astrocytoma 8 | 2,287
tuberculosis 8 | 1,557
Diabetes mellitus type 2 7 | 69
Mammary Neoplasms 7 | 410
Treatment Refractory Type 2 Diabetes Mellitus 7 | 53
aldosterone-producing adenoma 7 | 664
esophageal adenocarcinoma 7 | 737
oligodendroglioma 7 | 2,849
pediatric high grade glioma 7 | 2,712
pituitary cancer 7 | 1,972
Isovaleric acidemia 6 | 14
NADH:Q(1) Oxidoreductase deficiency 6 | 20
Obesity 6 | 616
Propionic acidemia 6 | 20
Prostatic Neoplasms 6 | 471
active Crohn's disease 6 | 918
acute quadriplegic myopathy 6 | 1,157
astrocytoma 6 | 1,493
beta-ketothiolase deficiency 6 | 13
cutaneous lupus erythematosus 6 | 1,056
sonic hedgehog group medulloblastoma 6 | 1,482
Chronic granulomatous disease 5 | 13
Diabetes Mellitus, Experimental 5 | 106
Duchenne muscular dystrophy 5 | 602
Endometriosis 5 | 535
IGA Glomerulonephritis 5 | 454
Kidney disease 5 | 396
Maple syrup urine disease 5 | 25
Pick disease 5 | 1,893
Polycystic Ovary Syndrome 5 | 332
Systemic primary carnitine deficiency disease 5 | 16
Vascular disease 5 | 281
fibroadenoma 5 | 557
group 3 medulloblastoma 5 | 2,254
nephrosclerosis 5 | 329
posterior fossa group B ependymoma 5 | 1,530
3-Methylcrotonyl-CoA carboxylase deficiency 4 | 11
3-methylglutaconic aciduria 4 | 29
Amino acid metabolic disorder 4 | 5
Autistic Disorder 4 | 320
Congenital adrenal hyperplasia 4 | 74
Gastrointestinal stromal tumor 4 | 61
Hypertension 4 | 287
Hypoglycemia 4 | 81
Methylmalonic acidemia 4 | 39
Myopathy 4 | 128
Neoplastic Cell Transformation 4 | 81
Parkinson's disease 4 | 364
Reye syndrome 4 | 11
Schistosomiasis 4 | 38
Waldenstrons macroglobulinemia 4 | 765
atypical teratoid/rhabdoid tumor 4 | 1,095
nasopharyngeal carcinoma 4 | 1,056
Contact Dermatitis 3 | 80
Prostate cancer 3 | 172
dermatomyositis 3 | 933
inflammatory breast cancer 3 | 404
pancreatic carcinoma 3 | 567
progressive supranuclear palsy 3 | 674

Tissue

Digestive Tract 87 | 18,473
Endocrine System 87 | 18,512
Female tissues 87 | 18,647
Nervous System 87 | 18,561
Urinary Tract 87 | 18,444
Blood and immune system 86 | 17,995
Cardiovascular System 86 | 17,958
Liver and Pancreas 86 | 18,136
Male tissues 86 | 17,969
Respiratory system 86 | 17,484
Skin and soft tissues 85 | 18,115

Target Family

Enzyme 66 | 4,146
Non-IDG 21 | 11,971

GO Function

electron carrier activity 87 | 87
metal ion binding 1,917 | 1,917
ATP binding 1,467 | 1,467
DNA binding 1,432 | 1,432
zinc ion binding 1,155 | 1,155
poly(A) RNA binding 1,107 | 1,107
transcription factor activity,... 853 | 853
calcium ion binding 695 | 695
G-protein coupled receptor act... 661 | 661
protein homodimerization activ... 569 | 569
RNA binding 445 | 445
olfactory receptor activity 424 | 424
sequence-specific DNA binding 398 | 398
GTP binding 374 | 374
chromatin binding 372 | 372
protein serine/threonine kinas... 336 | 336
RNA polymerase II core promote... 332 | 332
identical protein binding 311 | 311
nucleotide binding 311 | 311
receptor binding 303 | 303
protein kinase binding 289 | 289
enzyme binding 286 | 286
cadherin binding involved in c... 277 | 277
GTPase activator activity 273 | 273
ubiquitin protein ligase bindi... 258 | 258
ubiquitin-protein transferase ... 253 | 253
serine-type endopeptidase acti... 246 | 246
transcription coactivator acti... 241 | 241
transcription factor binding 240 | 240
structural molecule activity 232 | 232
GTPase activity 231 | 231
transcriptional activator acti... 230 | 230
ligase activity 227 | 227
protein heterodimerization act... 227 | 227
structural constituent of ribo... 212 | 212
transcription regulatory regio... 202 | 202
transmembrane signaling recept... 201 | 201
RNA polymerase II regulatory r... 200 | 200
receptor activity 200 | 200
transcription corepressor acti... 198 | 198
magnesium ion binding 197 | 197
signal transducer activity 196 | 196
nucleic acid binding 184 | 184
protein kinase activity 183 | 183
carbohydrate binding 180 | 180
ubiquitin protein ligase activ... 173 | 173
RNA polymerase II transcriptio... 162 | 162
heparin binding 160 | 160
iron ion binding 141 | 141
lipid binding 136 | 136
transporter activity 136 | 136
actin binding 133 | 133
ATPase activity 132 | 132
protein C-terminus binding 129 | 129
heme binding 127 | 127
microtubule binding 123 | 123
protein tyrosine kinase activi... 119 | 119
cytokine activity 118 | 118
Ras guanyl-nucleotide exchange... 113 | 113
mRNA binding 112 | 112
metalloendopeptidase activity 112 | 112
transcriptional repressor acti... 110 | 110
structural constituent of cyto... 108 | 108
Rab GTPase binding 105 | 105
antigen binding 104 | 104
protein domain specific bindin... 102 | 102
peptide antigen binding 101 | 101
guanyl-nucleotide exchange fac... 98 | 98
protein complex binding 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 92 | 92
oxidoreductase activity 91 | 91
transcriptional activator acti... 91 | 91
actin filament binding 89 | 89
hydrolase activity 89 | 89
ion channel binding 89 | 89
protein tyrosine phosphatase a... 88 | 88
protease binding 87 | 87
histone binding 86 | 86
integrin binding 83 | 83
growth factor activity 82 | 82
phospholipid binding 82 | 82
single-stranded DNA binding 81 | 81
unfolded protein binding 77 | 77
kinase activity 75 | 75
thiol-dependent ubiquitin-spec... 75 | 75
phosphatidylinositol binding 74 | 74
calmodulin binding 73 | 73
histone deacetylase binding 73 | 73
Rho guanyl-nucleotide exchange... 72 | 72
drug binding 71 | 71
double-stranded DNA binding 70 | 70
peptidase activity 70 | 70
protein N-terminus binding 70 | 70
virus receptor activity 68 | 68
beta-catenin binding 67 | 67
microtubule motor activity 67 | 67
protein transporter activity 67 | 67
calcium channel activity 66 | 66
ubiquitin binding 66 | 66

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial IDH3B Tbio Enzyme -1.13428 13.6 146
Cytochrome b-245 light chain CYBA Tbio Non-IDG -2.56294 358.8 154
Cytochrome b MT-CYB Tbio Non-IDG -3.74473 5676.0 122
NADP-dependent malic enzyme ME1 Tchem Non-IDG -1.96870 90.3 172
Glycine dehydrogenase (decarboxylating), mitochondrial GLDC Tbio Enzyme -1.68278 53.7 117
Medium-chain specific acyl-CoA dehydrogenase, mitochondrial ACADM Tbio Enzyme -2.58670 387.0 269
NAD-dependent malic enzyme, mitochondrial ME2 Tbio Non-IDG -1.91597 82.7 90
Peroxisomal acyl-coenzyme A oxidase 3 ACOX3 Tdark Enzyme -1.21608 14.6 47
Glutathione reductase, mitochondrial GSR Tclin Enzyme -2.97339 830.6 224
Retina-specific copper amine oxidase AOC2 Tchem Enzyme -2.24632 179.3 53