Development Level

Tbio 19 | 11,445
Tdark 10 | 6,588

IMPC Phenotype

preweaning lethality, incomple... 3 | 499
decreased body length 2 | 101
increased or absent threshold ... 2 | 101
short tibia 2 | 97
abnormal behavior 1 | 298
abnormal bone structure 1 | 187
abnormal coat appearance 1 | 31
abnormal lung morphology 1 | 26
abnormal testis morphology 1 | 43
absent startle reflex 1 | 24
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating alkaline... 1 | 46
decreased circulating glucose ... 1 | 126
decreased circulating triglyce... 1 | 79
decreased total body fat amoun... 1 | 207
hyperactivity 1 | 148
increased bone mineral density 1 | 72
increased circulating alkaline... 1 | 122
increased fasted circulating g... 1 | 76
long tibia 1 | 25
preweaning lethality, complete... 1 | 979
small testis 1 | 58

Disease

Carcinoma 23 | 11,493
osteosarcoma 15 | 7,950
Kidney cancer 14 | 2,613
Liver cancer 14 | 604
Breast cancer 12 | 3,578
ovarian cancer 12 | 8,520
ependymoma 11 | 4,679
Endometrial cancer 9 | 311
medulloblastoma, large-cell 9 | 6,241
Primary ciliary dyskinesia 8 | 76
chronic rhinosinusitis 8 | 512
Melanoma 7 | 711
atypical teratoid / rhabdoid tumor 7 | 5,112
lung carcinoma 7 | 2,843
nasopharyngeal carcinoma 7 | 1,058
lung cancer 6 | 4,740
pancreatic cancer 6 | 2,398
DOID:2627 5 | 94
Male infertility 5 | 206
Skin cancer 5 | 469
lung adenocarcinoma 5 | 2,716
psoriasis 5 | 6,694
Autosomal recessive predisposition 4 | 1,442
Large intestine cancer 4 | 126
Neurodegenerative disease 4 | 414
Situs Inversus 4 | 65
glioblastoma 4 | 5,792
group 3 medulloblastoma 4 | 4,104
invasive ductal carcinoma 4 | 2,951
malignant mesothelioma 4 | 3,232
Ciliary Dyskinesia, Primary, 1 3 | 27
Immune system cancer 3 | 140
Multiple myeloma 3 | 1,332
Pick disease 3 | 1,894
Right atrial isomerism 3 | 29
active ulcerative colitis 3 | 764
acute myeloid leukemia 3 | 783
acute quadriplegic myopathy 3 | 1,158
cystic fibrosis and chronic rhinosinusitis 3 | 214
fibroadenoma 3 | 559
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
juvenile dermatomyositis 3 | 1,187
non primary Sjogren syndrome sicca 3 | 891
non-small cell lung cancer 3 | 2,890
oligodendroglioma 3 | 2,850
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
pediatric high grade glioma 3 | 1,064
primitive neuroectodermal tumor 3 | 3,035
spina bifida 3 | 1,074
Amyotrophic lateral sclerosis 2 | 451
Astrocytoma, Pilocytic 2 | 3,081
Bipolar Disorder 2 | 666
Bronchiectasis 2 | 64
Cardiovascular system disease 2 | 246
Ciliary Motility Disorders 2 | 38
Craniopharyngioma 2 | 16
Decreased tendon reflex 2 | 122
Difficulty running 2 | 7
Epilepsy 2 | 792
Intellectual disability 2 | 1,016
Kartagener Syndrome 2 | 38
Motor delay 2 | 147
Muscular atrophy 2 | 71
No development of motor milestones 2 | 147
Nonepidermolytic palmoplantar keratoderma 2 | 12
Paraplegia 2 | 74
Recurrent respiratory infections 2 | 141
Retinitis pigmentosa 11 2 | 59
Seizures 2 | 596
Sinusitis 2 | 65
Spinal muscular atrophy 2 | 34
Waddling gait 2 | 34
astrocytic glioma 2 | 2,597
astrocytoma 2 | 1,146
breast carcinoma 2 | 1,638
ductal carcinoma in situ 2 | 1,745
group 4 medulloblastoma 2 | 1,855
hepatocellular carcinoma 2 | 547
interstitial cystitis 2 | 2,312
intraductal papillary-mucinous neoplasm (IPMN) 2 | 3,291
pituitary cancer 2 | 1,972
subependymal giant cell astrocytoma 2 | 2,287
tuberculosis 2 | 2,010
tuberculosis and treatment for 6 months 2 | 409
Carcinoma, Renal Cell 1 | 124
Charcot-Marie-Tooth disease 1 | 62
Childhood onset 1 | 38
Chromosome 15q24 deletion syndrome 1 | 12
Ciliopathy 1 | 71
Ellis-Van Creveld syndrome 1 | 19
Generalized anxiety disorder 1 | 29
Griscelli syndrome 1 | 24
Manic 1 | 14
Microvillus inclusion disease 1 | 8
Muscle weakness of limb 1 | 21
Non-immune hydrops fetalis 1 | 11
Open mouth 1 | 45
Panic disorder 1 | 61
Progressive microcephaly 1 | 32
Renal Cell Carcinoma 1 | 214

Tissue

Endocrine System 29 | 18,159
Respiratory system 29 | 16,393
Skin and soft tissues 29 | 17,230
Digestive Tract 28 | 17,369
Female tissues 28 | 17,400
Male tissues 28 | 17,142
Blood and immune system 26 | 16,909
Nervous System 26 | 16,725
Urinary Tract 26 | 16,678
Liver and Pancreas 25 | 16,750
Cardiovascular System 22 | 15,192

Target Family

Non-IDG 29 | 12,091

GO Function

dynein light intermediate chai... 29 | 29
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Protein Hook homolog 1 HOOK1 Tbio Non-IDG -1.16190 13.1 187
Dynein heavy chain 10, axonemal DNAH10 Tdark Non-IDG -0.45693 2.56 10
Cytoplasmic dynein 2 heavy chain 1 DYNC2H1 Tbio Non-IDG -1.60757 39.5 23
Coiled-coil domain-containing protein 88B CCDC88B Tdark Non-IDG -0.77694 6.44 39
Dynein heavy chain 9, axonemal DNAH9 Tbio Non-IDG -1.53036 32.0 31
Dynein heavy chain 7, axonemal DNAH7 Tbio Non-IDG -0.46489 2.39 17
Rab11 family-interacting protein 3 RAB11FIP3 Tbio Non-IDG -0.89095 6.62 68
Girdin CCDC88A Tbio Non-IDG -1.86485 83.3 197
RILP-like protein 2 RILPL2 Tbio Non-IDG -0.86274 7.14 95
Cytoplasmic dynein 1 heavy chain 1 DYNC1H1 Tbio Non-IDG -1.80946 62.1 94