Development Level

Tbio 17 | 11,651
Tdark 9 | 6,593
Tchem 1 | 1,388

IMPC Phenotype

preweaning lethality, incomple... 3 | 499
male infertility 2 | 123
preweaning lethality, complete... 2 | 979
abnormal coat appearance 1 | 31
decreased body length 1 | 101
decreased circulating alanine ... 1 | 47
decreased circulating alkaline... 1 | 46
decreased fasted circulating g... 1 | 65
decreased grip strength 1 | 116
decreased startle reflex 1 | 75
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
increased circulating magnesiu... 1 | 10
increased fasted circulating g... 1 | 76
increased heart weight 1 | 62
increased lean body mass 1 | 172
long tibia 1 | 25
short tibia 1 | 97

Disease

Carcinoma 22 | 11,493
Liver cancer 15 | 604
Breast cancer 13 | 3,578
Kidney cancer 13 | 2,613
osteosarcoma 13 | 7,950
ependymoma 12 | 4,679
ovarian cancer 12 | 8,520
Endometrial cancer 10 | 311
Primary ciliary dyskinesia 9 | 76
Melanoma 8 | 711
chronic rhinosinusitis 8 | 512
medulloblastoma, large-cell 8 | 6,241
nasopharyngeal carcinoma 8 | 1,058
psoriasis 8 | 6,694
atypical teratoid / rhabdoid tumor 7 | 5,112
pancreatic cancer 7 | 2,398
Situs Inversus 6 | 65
Skin cancer 6 | 469
glioblastoma 6 | 5,792
lung adenocarcinoma 6 | 2,716
DOID:2627 5 | 94
Male infertility 5 | 206
group 3 medulloblastoma 5 | 4,104
lung cancer 5 | 4,740
lung carcinoma 5 | 2,843
malignant mesothelioma 5 | 3,232
Alzheimer's disease 4 | 658
Autosomal recessive predisposition 4 | 1,442
Large intestine cancer 4 | 126
Multiple myeloma 4 | 1,332
Pick disease 4 | 1,894
pediatric high grade glioma 4 | 1,064
tuberculosis 4 | 2,010
Ciliary Dyskinesia, Primary, 1 3 | 27
Ciliary Motility Disorders 3 | 38
Epilepsy 3 | 792
Immune system cancer 3 | 140
Intellectual disability 3 | 1,016
Kartagener Syndrome 3 | 38
Recurrent respiratory infections 3 | 141
Right atrial isomerism 3 | 29
Seizures 3 | 596
cystic fibrosis and chronic rhinosinusitis 3 | 214
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,291
invasive ductal carcinoma 3 | 2,951
non-small cell lung cancer 3 | 2,890
primitive neuroectodermal tumor 3 | 3,035
Acquired metabolic disease 2 | 336
Asphyxiating thoracic dystrophy 2 | 44
Bipolar Disorder 2 | 666
Bronchiectasis 2 | 64
Cardiovascular system disease 2 | 246
Cerebral atrophy 2 | 178
Ciliopathy 2 | 71
Craniopharyngioma 2 | 16
Downward slant of palpebral fissure 2 | 158
Dull intelligence 2 | 645
Electroencephalogram abnormal 2 | 101
Endometriosis 2 | 540
Low intelligence 2 | 645
Mental Retardation 2 | 645
Mental deficiency 2 | 645
Microcephaly 2 | 166
Muscle hypotonia 2 | 571
Neurodegenerative disease 2 | 414
Nonepidermolytic palmoplantar keratoderma 2 | 12
Pachygyria 2 | 41
Polydactyly 2 | 107
Poor school performance 2 | 645
Short Rib-Polydactyly Syndrome 2 | 13
Short-rib thoracic dysplasia 3 with or without polydactyly 2 | 9
Sinusitis 2 | 65
Situs ambiguus 2 | 25
adrenocortical carcinoma 2 | 1,428
adult high grade glioma 2 | 3,801
astrocytoma 2 | 1,146
cystic fibrosis 2 | 1,696
ductal carcinoma in situ 2 | 1,745
facioscapulohumeral dystrophy 2 | 288
fibroadenoma 2 | 559
group 4 medulloblastoma 2 | 1,855
hepatocellular carcinoma 2 | 547
juvenile dermatomyositis 2 | 1,187
oligodendroglioma 2 | 2,850
subependymal giant cell astrocytoma 2 | 2,287
tuberculosis and treatment for 6 months 2 | 409
Abnormal ciliary motility 1 | 2
Absent outer dynein arms 1 | 1
Bronchitis, Chronic 1 | 12
CILIARY DYSKINESIA, PRIMARY, 18 1 | 1
Generalized anxiety disorder 1 | 29
Nasal inflammation 1 | 7
Panic disorder 1 | 61
Periventricular nodular heterotopia 1 | 30
Recurrent otitis media 1 | 42
Recurrent sinusitis 1 | 22
Respiratory insufficiency due to defective ciliary clearance 1 | 6
Rhinitis 1 | 55

Tissue

Endocrine System 27 | 18,159
Respiratory system 27 | 16,393
Skin and soft tissues 27 | 17,230
Digestive Tract 26 | 17,369
Female tissues 26 | 17,400
Male tissues 26 | 17,142
Blood and immune system 24 | 16,909
Nervous System 24 | 16,725
Urinary Tract 24 | 16,678
Liver and Pancreas 23 | 16,750
Cardiovascular System 20 | 15,192

Target Family

Non-IDG 25 | 12,091
Enzyme 2 | 4,145

GO Function

dynein intermediate chain bind... 27 | 27
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dynein heavy chain 6, axonemal DNAH6 Tbio Non-IDG -0.53057 4.17 18
Spectrin beta chain, non-erythrocytic 5 SPTBN5 Tbio Non-IDG -0.41365 2.99 32
Tctex1 domain-containing protein 2 TCTEX1D2 Tbio Non-IDG -0.72065 5.33 41
Dynein light chain 1, cytoplasmic DYNLL1 Tbio Non-IDG -2.77874 581.3 185
Dynein heavy chain 14, axonemal DNAH14 Tdark Non-IDG -0.25794 1.89 55
Huntingtin HTT Tchem Non-IDG -3.36282 2294.8 599
Dynein light chain 4, axonemal DNAL4 Tdark Non-IDG -0.54818 3.32 171
E3 ubiquitin-protein ligase TRIM58 TRIM58 Tbio Enzyme -1.22144 16.5 88
Dynein heavy chain 11, axonemal DNAH11 Tbio Non-IDG -1.26479 16.9 50
Dynein assembly factor 5, axonemal DNAAF5 Tbio Non-IDG -0.07918 1.36 54