Development Level

Tbio 17 | 11,445
Tdark 4 | 6,588
Tchem 1 | 1,598
Tclin 1 | 613

IMPC Phenotype

preweaning lethality, complete... 4 | 979
abnormal coat-hair pigmentatio... 1 | 64
abnormal lens morphology 1 | 81
abnormal retina morphology 1 | 71
cataract 1 | 92
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased caudal vertebrae num... 1 | 53
decreased circulating alanine ... 1 | 47
decreased grip strength 1 | 116
decreased lean body mass 1 | 135
decreased mean corpuscular hem... 1 | 50
decreased startle reflex 1 | 75
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
increased circulating creatini... 1 | 38
increased mean platelet volume 1 | 45
prenatal lethality 1 | 28
prenatal lethality prior to he... 1 | 87
preweaning lethality, incomple... 1 | 499
vertebral fusion 1 | 23

Disease

Carcinoma 16 | 11,493
ovarian cancer 15 | 8,520
medulloblastoma, large-cell 13 | 6,241
glioblastoma 12 | 5,792
osteosarcoma 12 | 7,950
atypical teratoid / rhabdoid tumor 11 | 5,112
ependymoma 11 | 4,679
group 3 medulloblastoma 11 | 4,104
lung cancer 11 | 4,740
psoriasis 11 | 6,694
adult high grade glioma 10 | 3,801
oligodendroglioma 9 | 2,850
Breast cancer 8 | 3,578
primitive neuroectodermal tumor 8 | 3,035
Cancer 7 | 2,499
Pick disease 7 | 1,894
astrocytic glioma 7 | 2,597
malignant mesothelioma 7 | 3,232
pancreatic cancer 7 | 2,398
Astrocytoma, Pilocytic 6 | 3,081
Neurodegenerative disease 6 | 414
Depressive disorder 5 | 409
Intellectual disability 5 | 1,016
Kidney cancer 5 | 2,613
colon cancer 5 | 1,478
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,989
non-small cell lung cancer 5 | 2,890
tuberculosis 5 | 2,010
Alzheimer's disease 4 | 658
Amyotrophic lateral sclerosis 4 | 451
Anxiety 4 | 136
Anxiety disease 4 | 113
Cognitive delay 4 | 608
Global developmental delay 4 | 608
Mental and motor retardation 4 | 608
adrenocortical carcinoma 4 | 1,428
astrocytoma 4 | 1,146
gastric cancer 4 | 459
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,291
lung adenocarcinoma 4 | 2,716
pancreatic carcinoma 4 | 562
pediatric high grade glioma 4 | 1,064
pituitary cancer 4 | 1,972
spina bifida 4 | 1,074
Atopic dermatitis 3 | 952
Autistic Disorder 3 | 364
Autosomal recessive predisposition 3 | 1,442
Bradykinesia 3 | 34
Cerebellar Hypoplasia 3 | 61
Dilated ventricles (finding) 3 | 121
Down syndrome 3 | 499
Dysarthria 3 | 192
Fetal Growth Retardation 3 | 189
Frontal bossing 3 | 157
Gaucher disease type 1 3 | 180
Highly variable severity 3 | 157
Hydrocephalus 3 | 152
Hypoplastic feet 3 | 66
Infant, Small for Gestational Age 3 | 176
Intrauterine retardation 3 | 176
Liver cancer 3 | 604
Low set ears 3 | 181
Multiple myeloma 3 | 1,332
Muscle Rigidity 3 | 49
Nerve Degeneration 3 | 121
Neurodegenerative Disorders 3 | 79
Parkinson's disease 3 | 392
Parkinsonian Disorders 3 | 56
Schizophrenia 3 | 1,160
Short nose 3 | 132
Short stature 3 | 531
Sleep disturbances 3 | 37
Small head 3 | 374
Small nose 3 | 132
Variable expressivity 3 | 157
dermatomyositis 3 | 966
group 4 medulloblastoma 3 | 1,855
invasive ductal carcinoma 3 | 2,951
juvenile dermatomyositis 3 | 1,187
lung carcinoma 3 | 2,843
nasopharyngeal carcinoma 3 | 1,058
non primary Sjogren syndrome sicca 3 | 891
subependymal giant cell astrocytoma 3 | 2,287
Anteverted nostril 2 | 191
Delayed bone age 2 | 136
Dementia 2 | 175
Epilepsy 2 | 792
Failure to gain weight 2 | 365
Lissencephaly 2 | 69
Melanoma 2 | 711
Mood Disorders 2 | 184
Multiple Sclerosis 2 | 540
Muscle Spasticity 2 | 195
Pediatric failure to thrive 2 | 365
Seizures 2 | 596
Skin cancer 2 | 469
Thin lips 2 | 49
Toxic encephalopathy 2 | 141
medulloblastoma 2 | 720

Tissue

Endocrine System 23 | 18,159
Female tissues 23 | 17,400
Nervous System 23 | 16,725
Respiratory system 23 | 16,393
Skin and soft tissues 23 | 17,230
Urinary Tract 23 | 16,678
Blood and immune system 22 | 16,909
Liver and Pancreas 22 | 16,750
Male tissues 22 | 17,142
Digestive Tract 21 | 17,369
Cardiovascular System 19 | 15,192

Target Family

Non-IDG 18 | 12,091
Enzyme 3 | 4,145
Epigenetic 2 | 242

GO Function

dynein complex binding 23 | 23
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Nuclear mitotic apparatus protein 1 NUMA1 Tbio Non-IDG -2.76544 575.8 235
Cilia- and flagella-associated protein 100 CFAP100 Tdark Non-IDG -0.65665 4.18 113
Cilia- and flagella-associated protein 73 CFAP73 Tdark Non-IDG 0.00000 21
Nucleoprotein TPR TPR Tbio Non-IDG -2.11491 135.6 161
Centromere protein F CENPF Tbio Non-IDG -2.02939 109.1 186
Structural maintenance of chromosomes protein 3 SMC3 Tbio Non-IDG -2.10209 115.2 244
Protein phosphatase 1 regulatory subunit 42 PPP1R42 Tdark Enzyme -0.42597 2.49 79
Dynein assembly factor 1, axonemal DNAAF1 Tbio Non-IDG -1.03493 11.7 85
G-protein-signaling modulator 2 GPSM2 Tbio Non-IDG -2.92381 834.6 138
Protein bicaudal D homolog 1 BICD1 Tbio Non-IDG -1.55047 35.1 49