Development Level

Tbio 61 | 11,445
Tchem 8 | 1,598
Tdark 6 | 6,588
Tclin 4 | 613

IMPC Phenotype

preweaning lethality, complete... 8 | 979
embryonic lethality prior to t... 3 | 278
abnormal gait 2 | 69
embryonic lethality prior to o... 2 | 239
increased lymphocyte cell numb... 2 | 32
preweaning lethality, incomple... 2 | 499
vertebral transformation 2 | 12
abnormal bone structure 1 | 187
abnormal coat- hair morphology 1 | 19
abnormal embryo size 1 | 220
abnormal embryo turning 1 | 31
abnormal hair growth 1 | 10
abnormal incisor morphology 1 | 4
abnormal lens morphology 1 | 81
abnormal pharyngeal arch morph... 1 | 8
abnormal vertebrae morphology 1 | 18
abnormal vertebral arch morpho... 1 | 9
abnormal vitreous body morphol... 1 | 10
absent pinna reflex 1 | 23
absent startle reflex 1 | 24
cataract 1 | 92
decreased basophil cell number 1 | 16
decreased blood urea nitrogen ... 1 | 51
decreased body length 1 | 101
decreased body weight 1 | 161
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
decreased circulating fructosa... 1 | 30
decreased circulating glycerol... 1 | 16
decreased circulating iron lev... 1 | 32
decreased circulating serum al... 1 | 82
decreased circulating triglyce... 1 | 79
decreased grip strength 1 | 116
decreased lean body mass 1 | 135
decreased leukocyte cell numbe... 1 | 73
decreased mean corpuscular vol... 1 | 79
decreased mean platelet volume 1 | 25
decreased neutrophil cell numb... 1 | 42
decreased threshold for audito... 1 | 26
decreased total body fat amoun... 1 | 207
embryonic growth retardation 1 | 106
enlarged heart 1 | 210
enlarged lymph nodes 1 | 37
fusion of vertebral arches 1 | 7
hyperactivity 1 | 148
impaired righting response 1 | 26
increased body length 1 | 32
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating choleste... 1 | 66
increased circulating iron lev... 1 | 30
increased circulating triglyce... 1 | 42
increased fasted circulating g... 1 | 76
increased mean corpuscular hem... 1 | 96
increased mean platelet volume 1 | 45
increased neutrophil cell numb... 1 | 46
increased or absent threshold ... 1 | 101
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
thrombocytopenia 1 | 56
tremors 1 | 39

Disease

Carcinoma 55 | 11,493
ovarian cancer 48 | 8,520
osteosarcoma 43 | 7,950
medulloblastoma, large-cell 36 | 6,241
lung cancer 33 | 4,740
psoriasis 33 | 6,694
Breast cancer 32 | 3,578
group 3 medulloblastoma 29 | 4,104
Cancer 27 | 2,499
glioblastoma 27 | 5,792
atypical teratoid / rhabdoid tumor 25 | 5,112
adult high grade glioma 21 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 20 | 3,291
Kidney cancer 17 | 2,613
ependymoma 17 | 4,679
primitive neuroectodermal tumor 17 | 3,035
invasive ductal carcinoma 16 | 2,951
lung adenocarcinoma 16 | 2,716
malignant mesothelioma 16 | 3,232
non-small cell lung cancer 16 | 2,890
Multiple myeloma 15 | 1,332
Waldenstrons macroglobulinemia 14 | 765
dermatomyositis 14 | 966
Intellectual disability 13 | 1,016
intraductal papillary-mucinous carcinoma (IPMC) 13 | 2,989
subependymal giant cell astrocytoma 13 | 2,287
Autosomal recessive predisposition 11 | 1,442
breast carcinoma 11 | 1,638
juvenile dermatomyositis 11 | 1,187
lung carcinoma 11 | 2,843
pancreatic cancer 11 | 2,398
Astrocytoma, Pilocytic 10 | 3,081
Pick disease 10 | 1,894
acute quadriplegic myopathy 10 | 1,158
cystic fibrosis 10 | 1,696
group 4 medulloblastoma 10 | 1,855
interstitial cystitis 10 | 2,312
pancreatic ductal adenocarcinoma liver metastasis 10 | 1,962
Dull intelligence 9 | 645
Low intelligence 9 | 645
Mental Retardation 9 | 645
Mental deficiency 9 | 645
Poor school performance 9 | 645
astrocytoma 9 | 1,146
colon cancer 9 | 1,478
cutaneous lupus erythematosus 9 | 1,057
nasopharyngeal carcinoma 9 | 1,058
primary Sjogren syndrome 9 | 735
progressive supranuclear palsy 9 | 676
tuberculosis 9 | 2,010
Cognitive delay 8 | 608
Global developmental delay 8 | 608
Mental and motor retardation 8 | 608
Short stature 8 | 531
Small head 8 | 374
Systemic lupus erythematosus 8 | 194
adrenocortical carcinoma 8 | 1,428
oligodendroglioma 8 | 2,850
Breast Neoplasms 7 | 445
Fanconi anemia 7 | 56
Mammary Neoplasms 7 | 425
Melanoma 7 | 711
Multiple Sclerosis 7 | 540
astrocytic glioma 7 | 2,597
ductal carcinoma in situ 7 | 1,745
intraductal papillary-mucinous adenoma (IPMA) 7 | 2,955
pituitary cancer 7 | 1,972
ulcerative colitis 7 | 1,819
Adenocarcinoma of lung 6 | 142
Amyotrophic lateral sclerosis 6 | 451
Cockayne syndrome 6 | 60
Werner syndrome 6 | 29
Xeroderma pigmentosum 6 | 43
acute myeloid leukemia 6 | 783
diabetes mellitus 6 | 1,728
esophageal adenocarcinoma 6 | 737
Acquired scoliosis 5 | 281
Atopic dermatitis 5 | 952
Curvature of spine 5 | 282
Endometriosis 5 | 540
Epilepsy 5 | 792
Influenza 5 | 142
Lung disease 5 | 142
Microcephaly 5 | 166
active Crohn's disease 5 | 922
autosomal dominant Emery-Dreifuss muscular dystrophy 5 | 510
hearing impairment 5 | 199
pediatric high grade glioma 5 | 1,064
tuberculosis and treatment for 6 months 5 | 409
Alzheimer's disease 4 | 658
Carcinoma, Hepatocellular 4 | 228
Chronic Lymphocytic Leukemia 4 | 262
Liver carcinoma 4 | 240
Pancreatic Neoplasms 4 | 85
Rheumatoid arthritis 4 | 1,191
Schizophrenia 4 | 1,160
Seizures 4 | 596
mucosa-associated lymphoid tissue lymphoma 4 | 484
pancreatic carcinoma 4 | 562
primary pancreatic ductal adenocarcinoma 4 | 1,109

Tissue

Endocrine System 79 | 18,159
Respiratory system 79 | 16,393
Skin and soft tissues 79 | 17,230
Blood and immune system 78 | 16,909
Digestive Tract 78 | 17,369
Female tissues 78 | 17,400
Liver and Pancreas 78 | 16,750
Male tissues 78 | 17,142
Nervous System 78 | 16,725
Urinary Tract 78 | 16,678
Cardiovascular System 77 | 15,192

Target Family

Non-IDG 40 | 12,091
Enzyme 18 | 4,145
Transcription Factor 15 | 1,400
Epigenetic 2 | 242
Kinase 2 | 634
Nuclear Receptor 2 | 48

GO Function

double-stranded DNA binding 79 | 79
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 638 ZNF638 Tbio Non-IDG -0.68946 6.04 67
SAFB-like transcription modulator SLTM Tdark Non-IDG -0.51977 2.83 111
Endonuclease III-like protein 1 NTHL1 Tbio Enzyme -1.85066 66.8 155
Tyrosyl-DNA phosphodiesterase 1 TDP1 Tchem Enzyme -2.09041 139.4 210
G/T mismatch-specific thymine DNA glycosylase TDG Tbio Enzyme -2.46252 297.6 225
Heterogeneous nuclear ribonucleoprotein U HNRNPU Tbio Non-IDG -2.33813 207.8 169
Y-box-binding protein 3 YBX3 Tbio Transcription Factor -2.13168 143.1 204
AF4/FMR2 family member 3 AFF3 Tbio Transcription Factor -1.37981 25.3 50
Protein LSM14 homolog A LSM14A Tbio Non-IDG -1.13869 16.0 122
DNA repair protein XRCC3 XRCC3 Tbio Non-IDG -2.50791 314.0 414