Development Level

Tbio 15 | 11,445
Tchem 10 | 1,598
Tclin 6 | 613

IMPC Phenotype

preweaning lethality, complete... 2 | 979
abnormal behavior 1 | 298
abnormal bone mineralization 1 | 38
abnormal coat-hair pigmentatio... 1 | 64
abnormal head morphology 1 | 10
abnormal lens morphology 1 | 81
abnormal snout morphology 1 | 23
abnormal startle reflex 1 | 15
abnormal tooth morphology 1 | 24
absent pinna reflex 1 | 23
cataract 1 | 92
decreased circulating creatine... 1 | 4
hyperactivity 1 | 148
impaired glucose tolerance 1 | 75
increased bone mineral density 1 | 72
increased circulating creatine... 1 | 5
increased circulating free fat... 1 | 20
increased grip strength 1 | 41
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
male infertility 1 | 123
mammalian phenotype 1 | 17
persistence of hyaloid vascula... 1 | 33
preweaning lethality, incomple... 1 | 499

Disease

ovarian cancer 25 | 8,520
Carcinoma 23 | 11,493
osteosarcoma 20 | 7,950
Cancer 19 | 2,499
lung cancer 19 | 4,740
medulloblastoma, large-cell 19 | 6,241
psoriasis 18 | 6,694
Breast cancer 17 | 3,578
glioblastoma 17 | 5,792
atypical teratoid / rhabdoid tumor 16 | 5,112
oligodendroglioma 15 | 2,850
pancreatic cancer 15 | 2,398
primitive neuroectodermal tumor 15 | 3,035
ependymoma 14 | 4,679
group 3 medulloblastoma 13 | 4,104
diabetes mellitus 12 | 1,728
astrocytic glioma 11 | 2,597
malignant mesothelioma 11 | 3,232
Kidney cancer 10 | 2,613
adult high grade glioma 10 | 3,801
invasive ductal carcinoma 10 | 2,951
Astrocytoma, Pilocytic 9 | 3,081
Breast Neoplasms 9 | 445
Mammary Neoplasms 9 | 425
Schizophrenia 9 | 1,160
subependymal giant cell astrocytoma 9 | 2,287
Hypertension 8 | 396
Prostatic Neoplasms 8 | 495
acute quadriplegic myopathy 8 | 1,158
lung adenocarcinoma 8 | 2,716
pituitary cancer 8 | 1,972
Epilepsy 7 | 792
Waldenstrons macroglobulinemia 7 | 765
interstitial cystitis 7 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 7 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 7 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 7 | 3,291
juvenile dermatomyositis 7 | 1,187
non-small cell lung cancer 7 | 2,890
pancreatic carcinoma 7 | 562
ulcerative colitis 7 | 1,819
Carcinoma, Non-Small-Cell Lung 6 | 107
Heart disease 6 | 306
Liver cancer 6 | 604
Multiple myeloma 6 | 1,332
Rheumatoid arthritis 6 | 1,191
Vascular disease 6 | 319
breast carcinoma 6 | 1,638
ductal carcinoma in situ 6 | 1,745
gastric cancer 6 | 459
hepatocellular carcinoma 6 | 547
non-small cell lung carcinoma 6 | 317
tuberculosis 6 | 2,010
Alzheimer's disease 5 | 658
Amyotrophic lateral sclerosis 5 | 451
Carcinoma, Hepatocellular 5 | 228
Dull intelligence 5 | 645
Intellectual disability 5 | 1,016
Kidney disease 5 | 430
Liver Cirrhosis, Experimental 5 | 769
Liver carcinoma 5 | 240
Low intelligence 5 | 645
Lung Neoplasms 5 | 232
Mental Retardation 5 | 645
Mental deficiency 5 | 645
Neoplasm Metastasis 5 | 168
Osteoarthritis 5 | 184
Pancreatic Neoplasm 5 | 85
Poor school performance 5 | 645
Toxic encephalopathy 5 | 141
adrenocortical carcinoma 5 | 1,428
astrocytoma 5 | 1,146
nasopharyngeal carcinoma 5 | 1,058
Adenocarcinoma 4 | 122
Adenoma 4 | 167
Cerebrovascular disease 4 | 238
Colonic Neoplasms 4 | 142
Down syndrome 4 | 499
Hypertensive disease 4 | 292
Lymphoma 4 | 81
Major Depressive Disorder 4 | 301
Melanoma 4 | 711
Mesothelioma, Malignant 4 | 105
Neurodegenerative disease 4 | 414
Pancreatic Neoplasms 4 | 85
Pick disease 4 | 1,894
Polycystic ovary syndrome 4 | 360
Renal Cell Carcinoma 4 | 214
Small head 4 | 374
Somatic mutation 4 | 61
Squamous cell carcinoma 4 | 129
Stomach Neoplasms 4 | 300
Unipolar Depression 4 | 250
colon cancer 4 | 1,478
dermatomyositis 4 | 966
gastric carcinoma 4 | 807
interstitial lung disease 4 | 298
lung carcinoma 4 | 2,843
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
primary pancreatic ductal adenocarcinoma 4 | 1,109

Tissue

Digestive Tract 30 | 17,369
Endocrine System 30 | 18,159
Female tissues 30 | 17,400
Liver and Pancreas 30 | 16,750
Nervous System 30 | 16,725
Skin and soft tissues 30 | 17,230
Urinary Tract 30 | 16,678
Blood and immune system 29 | 16,909
Male tissues 29 | 17,142
Respiratory system 29 | 16,393
Cardiovascular System 28 | 15,192

Target Family

Non-IDG 21 | 12,091
Enzyme 4 | 4,145
Transcription Factor 3 | 1,400
Epigenetic 1 | 242
Ion Channel 1 | 344
Kinase 1 | 634

GO Function

disordered domain specific bin... 31 | 31
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Cellular tumor antigen p53 TP53 Tchem Transcription Factor -4.74112 54026.3 6298
Catenin beta-1 CTNNB1 Tchem Non-IDG -3.99948 9786.0 3058
Retinoblastoma-associated protein RB1 Tchem Non-IDG -3.07052 1137.4 2150
Glyceraldehyde-3-phosphate dehydrogenase GAPDH Tchem Enzyme -3.68189 4548.4 1886
Fibronectin FN1 Tchem Non-IDG -3.09873 1208.8 1583
Mothers against decapentaplegic homolog 2 SMAD2 Tbio Transcription Factor -3.26675 1515.7 1396
E3 ubiquitin-protein ligase Mdm2 MDM2 Tchem Enzyme -3.41690 2313.9 1252
Heat shock 70 kDa protein 1A HSPA1B Tchem Non-IDG -3.10995 0.00000 1174
Ezrin EZR Tbio Non-IDG -2.99865 981.3 1088
Tumor suppressor ARF CDKN2A Tbio Non-IDG -3.72848 9058.6 1063