Development Level

Tbio 7 | 11,651
Tchem 7 | 1,388
Tdark 7 | 6,593
Tclin 1 | 612

IMPC Phenotype

preweaning lethality, complete... 2 | 979
decreased bone mineral density 1 | 126
hyperactivity 1 | 148
mydriasis 1 | 6
preweaning lethality, incomple... 1 | 499
trunk curl 1 | 16
vertebral transformation 1 | 12

Disease

Carcinoma 14 | 11,493
glioblastoma 11 | 5,792
ovarian cancer 11 | 8,520
ependymoma 9 | 4,679
intraductal papillary-mucinous neoplasm (IPMN) 9 | 3,291
osteosarcoma 9 | 7,950
psoriasis 8 | 6,694
subependymal giant cell astrocytoma 8 | 2,287
Kidney cancer 7 | 2,613
atypical teratoid / rhabdoid tumor 7 | 5,112
group 3 medulloblastoma 7 | 4,104
intraductal papillary-mucinous carcinoma (IPMC) 7 | 2,989
malignant mesothelioma 7 | 3,232
Cancer 6 | 2,499
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,955
lung cancer 6 | 4,740
medulloblastoma, large-cell 6 | 6,241
non-small cell lung cancer 6 | 2,890
oligodendroglioma 6 | 2,850
Astrocytoma, Pilocytic 5 | 3,081
adult high grade glioma 5 | 3,801
astrocytoma 5 | 1,146
lung adenocarcinoma 5 | 2,716
pancreatic cancer 5 | 2,398
primitive neuroectodermal tumor 5 | 3,035
tuberculosis 5 | 2,010
Intellectual disability 4 | 1,016
invasive ductal carcinoma 4 | 2,951
lung carcinoma 4 | 2,843
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
Adenoid Cystic Carcinoma 3 | 99
Carcinoma, Adenoid Cystic 3 | 99
Liver cancer 3 | 604
Pick disease 3 | 1,894
Rheumatoid arthritis 3 | 1,191
astrocytic glioma 3 | 2,597
breast carcinoma 3 | 1,638
dermatomyositis 3 | 966
group 4 medulloblastoma 3 | 1,855
interstitial cystitis 3 | 2,312
spina bifida 3 | 1,074
ulcerative colitis 3 | 1,819
Autistic Disorder 2 | 364
Breast cancer 2 | 3,578
Congenital hypoplasia of penis 2 | 176
Cryptorchidism 2 | 296
Epilepsy 2 | 792
Juvenile rheumatoid arthritis 2 | 111
Kabuki syndrome 2 | 27
Large auricle 2 | 87
Large dysplastic ears 2 | 87
Large pinnae 2 | 87
Large prominent ears 2 | 87
Large protruding ears 2 | 87
Large, floppy ears 2 | 87
Macrotia 2 | 87
Male infertility 2 | 206
Multiple myeloma 2 | 1,332
Persistent hyperplastic primary vitreous 2 | 20
Seizures 2 | 596
Short stature 2 | 531
acute myeloid leukemia 2 | 783
adrenocortical carcinoma 2 | 1,428
atypical teratoid/rhabdoid tumor 2 | 357
cystic fibrosis 2 | 1,696
diabetes mellitus 2 | 1,728
ductal carcinoma in situ 2 | 1,745
juvenile dermatomyositis 2 | 1,187
non diabetic and post-ischemic heart failure 2 | 200
pancreatic carcinoma 2 | 562
pediatric high grade glioma 2 | 1,064
pituitary cancer 2 | 1,972
primary pancreatic ductal adenocarcinoma 2 | 1,109
Abnormal dermatoglyphic pattern 1 | 24
Abnormal vertebral bodies 1 | 16
Allergic conjunctivitis 1 | 22
Alopecia areata 1 | 41
Asthma, Occupational 1 | 10
Bowed and upward slanting eyebrows 1 | 41
Bursitis 1 | 10
Congenital anomaly of spine 1 | 16
Congenital hypothyroidism 1 | 26
Diastema of Teeth 1 | 4
Drug Hypersensitivity 1 | 34
Fissured tongue 1 | 25
Generalized joint laxity 1 | 6
Jensen syndrome 1 | 6
Long palpebral fissure 1 | 17
Multiple vertebral anomalies 1 | 16
Neoplasms 1 | 63
Post-Op Ocular Inflammation 1 | 9
Postnatal growth retardation 1 | 57
Restlessness 1 | 14
Short fifth finger 1 | 9
Stricture of anus 1 | 13
Synovitis 1 | 78
Tendinitis 1 | 14
Tenosynovitis 1 | 14
Thick, flared eyebrows 1 | 41
Widely spaced teeth 1 | 31

Tissue

Blood and immune system 22 | 16,909
Digestive Tract 22 | 17,369
Endocrine System 22 | 18,159
Female tissues 22 | 17,400
Skin and soft tissues 22 | 17,230
Liver and Pancreas 21 | 16,750
Male tissues 21 | 17,142
Nervous System 21 | 16,725
Respiratory system 21 | 16,393
Urinary Tract 21 | 16,678
Cardiovascular System 20 | 15,192

Target Family

Enzyme 9 | 4,145
Epigenetic 9 | 242
TF/Epigenetic 4 | 38

GO Function

dioxygenase activity 22 | 22
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Lysine-specific demethylase 4E KDM4E Tchem Epigenetic -0.86891 5.72 23
Lysine-specific demethylase PHF2 PHF2 Tbio Epigenetic -0.69461 5.14 74
Prostaglandin G/H synthase 1 PTGS1 Tclin Enzyme -3.23035 1641.3 479
Lysine-specific demethylase 6A KDM6A Tbio Epigenetic -2.27999 176.8 119
Aspartate beta-hydroxylase domain-containing protein 2 ASPHD2 Tdark Enzyme 0.60 0.17 82
Phytanoyl-CoA dioxygenase domain-containing protein 1 PHYHD1 Tdark Enzyme -0.45738 0.00000 99
Aspartate beta-hydroxylase domain-containing protein 1 ASPHD1 Tdark Enzyme 0.00000 35
Histone demethylase UTY UTY Tbio Epigenetic -1.58873 35.0 110
Lysine-specific demethylase 4D KDM4D Tchem Epigenetic -1.51327 28.3 162
Lysine-specific demethylase 3B KDM3B Tbio Epigenetic -1.04920 11.3 286