Development Level

Tbio 1 | 11,651
Tchem 1 | 1,388

IMPC Phenotype

decreased fasted circulating g... 1 | 65
persistence of hyaloid vascula... 1 | 33

Disease

pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962
Alcoholic Intoxication, Chronic 1 | 289
Alkaline phosphatase serum increased 1 | 29
Amyotrophic lateral sclerosis 1 | 451
Ankylosing spondylitis 1 | 140
Atopic dermatitis 1 | 952
Atrophic vaginitis 1 | 14
BILIARY TRACT ABNORMALITY 1 | 16
Bile acid synthesis defect, congenital, 2 1 | 1
Biliary Tract Diseases 1 | 16
Bipolar Disorder 1 | 666
Bleeding tendency 1 | 37
Blood Coagulation Disorders 1 | 42
Bursitis 1 | 10
Bursitis of shoulder 1 | 4
Cancer 1 | 2,499
Carotid stenosis 1 | 5
Cell Transformation, Neoplastic 1 | 97
Cholestasis 1 | 155
Chronic Liver Failure 1 | 2
Common variable immunodeficiency 1 | 101
Congenital bile acid synthesis defect 1 | 15
Contraception 1 | 15
Diarrhea 1 | 253
Disorders of Sex Development 1 | 5
Dysfunctional uterine bleeding 1 | 9
Dysmenorrhea 1 | 21
Elevated hepatic transaminases 1 | 81
Endometrial Hyperplasia Prevention 1 | 9
Endometrial Neoplasms 1 | 55
Endometrial carcinoma 1 | 15
Endometriosis 1 | 540
Failure to gain weight 1 | 365
Fever 1 | 138
Gout 1 | 104
Headache disorder 1 | 19
Hemochromatosis 1 | 54
Hepatic enzyme increased 1 | 81
Hepatomegaly 1 | 285
Icterus 1 | 82
Increased bilirubin level (finding) 1 | 18
Intrahepatic cholestasis 1 | 20
Joint pain 1 | 8
Juvenile rheumatoid arthritis 1 | 111
Liver Cirrhosis 1 | 181
Liver Cirrhosis, Experimental 1 | 769
Liver Dysfunction 1 | 99
Liver Failure 1 | 73
Liver enzymes abnormal 1 | 81
Liver function test increased 1 | 81
Liver function tests abnormal finding 1 | 81
Malabsorption 1 | 82
Manic 1 | 14
Manic mood 1 | 6
Menopausal flushing 1 | 17
Menorrhagia 1 | 25
Muscle pain 1 | 3
Nasal discharge 1 | 25
Neonatal cholestatic liver disease 1 | 2
Neonatal onset 1 | 21
Neoplasms, Hormone-Dependent 1 | 3
Neoplastic Cell Transformation 1 | 89
Osteoarthritis 1 | 184
Pain 1 | 103
Pediatric failure to thrive 1 | 365
Polycystic ovary syndrome 1 | 360
Postmenopausal osteoporosis 1 | 19
Prostatic Neoplasms, Castration-Resistant 1 | 3
Secondary malignant neoplasm of kidney 1 | 9
Secondary physiologic amenorrhea 1 | 32
Shoulder Tendonitis 1 | 4
Sinus headache 1 | 16
Steatorrhea 1 | 34
Stomach Neoplasms 1 | 300
Subclinical abnormal liver function tests 1 | 81
Synovitis 1 | 78
Tendinitis 1 | 14
Tenosynovitis 1 | 14
Toothache 1 | 6
Transaminases increased 1 | 81
acute quadriplegic myopathy 1 | 1,158
aldosterone-producing adenoma 1 | 665
alpha-methylacyl-CoA racemase deficiency 1 | 9
astrocytoma 1 | 1,146
autosomal dominant Emery-Dreifuss muscular dystrophy 1 | 510
breast carcinoma 1 | 1,638
colon cancer 1 | 1,478
cystic fibrosis 1 | 1,696
dermatomyositis 1 | 966
fascioscapulohumeral muscular dystrophy 1 | 100
fibroadenoma 1 | 559
head and neck cancer 1 | 271
head and neck cancer and chronic obstructive pulmonary disease 1 | 239
medulloblastoma 1 | 720
nasopharyngeal carcinoma 1 | 1,058
nephrosclerosis 1 | 333
pituitary cancer 1 | 1,972
posterior fossa group B ependymoma 1 | 416
pterygium 1 | 76
subependymal giant cell astrocytoma 1 | 2,287

Tissue

Blood and immune system 2 | 16,909
Digestive Tract 2 | 17,369
Endocrine System 2 | 18,159
Female tissues 2 | 17,400
Liver and Pancreas 2 | 16,750
Male tissues 2 | 17,142
Skin and soft tissues 2 | 17,230
Urinary Tract 2 | 16,678
Cardiovascular System 1 | 15,192
Nervous System 1 | 16,725
Respiratory system 1 | 16,393

Target Family

Enzyme 2 | 4,145

GO Function

delta4-3-oxosteroid 5beta-redu... 2 | 2
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 Tbio Enzyme -1.87479 75.7 171
Aldo-keto reductase family 1 member C3 AKR1C3 Tchem Enzyme -2.59131 388.1 301