Development Level

Tclin 18 | 612
Tbio 2 | 11,651

Collection

Ion Channel: IDG Consortium (T... 6 | 99
RFA-RM-18-021 6 | 328

IMPC Phenotype

abnormal behavior 3 | 298
hyperactivity 2 | 148
increased mean corpuscular vol... 2 | 92
abnormal behavioral response t... 1 | 66
abnormal brain morphology 1 | 13
abnormal gait 1 | 69
abnormal locomotor behavior 1 | 24
decreased cardiac stroke volum... 1 | 6
decreased circulating iron lev... 1 | 32
decreased erythrocyte cell num... 1 | 62
decreased vertical activity 1 | 208
hydroencephaly 1 | 14
increased bone mineral content 1 | 108
increased circulating magnesiu... 1 | 10
increased heart rate 1 | 23
shortened PQ interval 1 | 7
shortened PR interval 1 | 6
shortened QT interval 1 | 4
shortened ST segment 1 | 10

Disease

Eaton-Lambert syndrome 18 | 40
Multiple Sclerosis 18 | 540
Carcinoma 16 | 11,493
ependymoma 10 | 4,679
group 3 medulloblastoma 9 | 4,104
medulloblastoma, large-cell 9 | 6,241
glioblastoma 8 | 5,792
Astrocytoma, Pilocytic 7 | 3,081
Kidney cancer 7 | 2,613
adult high grade glioma 7 | 3,801
atypical teratoid / rhabdoid tumor 7 | 5,112
osteosarcoma 7 | 7,950
primitive neuroectodermal tumor 7 | 3,035
Epilepsy 6 | 792
Long QT syndrome 6 | 39
astrocytic glioma 6 | 2,597
ovarian cancer 6 | 8,520
Atrial Fibrillation 5 | 124
lung cancer 5 | 4,740
psoriasis 5 | 6,694
ATRIAL FIBRILLATION, FAMILIAL, 1 (disorder) 4 | 21
Atrioventricular block 4 | 35
Brugada syndrome 4 | 29
Cardiac arrest 4 | 36
Cardiomyopathy 4 | 116
Catecholaminergic polymorphic ventricular tachycardia 4 | 12
Familial atrial fibrillation 4 | 23
Prolonged QT interval 4 | 15
Romano-Ward Syndrome 4 | 12
Short QT syndrome 4 | 12
Sudden Cardiac Death 4 | 29
Syncope 4 | 22
Timothy syndrome 4 | 11
Torsades de Pointes 4 | 8
Ventricular Fibrillation 4 | 17
lung carcinoma 4 | 2,843
malignant mesothelioma 4 | 3,232
oligodendroglioma 4 | 2,850
Autosomal recessive predisposition 3 | 1,442
Cardiac Arrhythmia 3 | 103
Episodic ataxia 3 | 22
Heart conduction disease 3 | 83
Infantile onset 3 | 238
Intellectual disability 3 | 1,016
Long QT syndrome 1 3 | 20
Schizophrenia 3 | 1,160
Seizures 3 | 596
Tremor 3 | 113
adrenocortical carcinoma 3 | 1,428
pituitary cancer 3 | 1,972
subependymal giant cell astrocytoma 3 | 2,287
Acquired metabolic disease 2 | 336
Amyotrophic lateral sclerosis 2 | 451
Atrial Fibrillation, Familial, 3 2 | 2
Bipolar Disorder 2 | 666
Cardiomyopathies 2 | 110
Cerebellar Ataxia 2 | 304
Coarse facial features 2 | 108
Cognitive delay 2 | 608
Congenital myasthenic syndrome 5 2 | 11
Diaphragmatic Hernia 2 | 40
Epileptic encephalopathy 2 | 26
Global developmental delay 2 | 608
Hearing Loss, Noise-Induced 2 | 5
Heart disease 2 | 306
Hepatomegaly 2 | 285
Hernia, Diaphragmatic 2 | 40
Hypokalemia 2 | 52
Jervell-Lange Nielsen syndrome 2 | 4
Mental and motor retardation 2 | 608
Muscle hypotonia 2 | 571
Myoclonus 2 | 74
Noise-induced hearing loss 2 | 5
Palpitations 2 | 18
Sensorineural hearing loss 2 | 106
Short QT Syndrome 1 2 | 4
Shortened QT interval 2 | 5
Spinocerebellar ataxia type 13 2 | 5
Sudden infant death syndrome 2 | 32
Thickened facial skin with coarse facial features 2 | 108
Type 2 diabetes mellitus 2 | 272
active Crohn's disease 2 | 922
colon cancer 2 | 1,478
cystic fibrosis 2 | 1,696
gastric carcinoma 2 | 807
invasive ductal carcinoma 2 | 2,951
progressive supranuclear palsy 2 | 676
ulcerative colitis 2 | 1,819
Atrial Fibrillation, Familial, 4 1 | 1
Congenital sensorineural hearing loss 1 | 12
Dilated cardiomyopathy 1D 1 | 3
Gestational diabetes 1 | 26
Intestinal Neoplasms 1 | 12
Intestinal volvulus 1 | 8
LONG QT SYNDROME 5 1 | 2
Language Development Disorders 1 | 11
Long Qt Syndrome 6 1 | 1
Meniere's disease 1 | 24
Nonorganic psychosis 1 | 84
Progressive mental retardation 1 | 37

Tissue

Digestive Tract 19 | 17,369
Endocrine System 19 | 18,159
Female tissues 19 | 17,400
Nervous System 18 | 16,725
Liver and Pancreas 17 | 16,750
Male tissues 17 | 17,142
Urinary Tract 17 | 16,678
Skin and soft tissues 16 | 17,230
Blood and immune system 14 | 16,909
Respiratory system 14 | 16,393
Cardiovascular System 10 | 15,192

Target Family

Ion Channel 20 | 344

GO Function

delayed rectifier potassium ch... 20 | 20
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Potassium voltage-gated channel subfamily E member 2 KCNE2 Tbio Ion Channel -2.00780 91.4 120
Potassium voltage-gated channel subfamily E member 1 KCNE1 Tbio Ion Channel -2.67495 441.7 193
Potassium voltage-gated channel subfamily A member 5 KCNA5 Tclin Ion Channel -2.61528 428.3 209
Potassium voltage-gated channel subfamily C member 1 KCNC1 Tclin Ion Channel -2.46163 275.7 308
Potassium voltage-gated channel subfamily A member 3 KCNA3 Tclin Ion Channel -2.69107 522.2 286
Potassium voltage-gated channel subfamily B member 2 KCNB2 Tclin Ion Channel -1.30979 20.1 110
Potassium voltage-gated channel subfamily B member 1 KCNB1 Tclin Ion Channel -2.57484 386.0 303
Potassium voltage-gated channel subfamily G member 1 KCNG1 Tclin Ion Channel -1.83662 59.3 87
Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 Tclin Ion Channel -2.90675 800.2 365
Potassium voltage-gated channel subfamily A member 1 KCNA1 Tclin Ion Channel -2.59564 379.1 313