Development Level

Tbio 44 | 11,445
Tchem 11 | 1,598
Tclin 1 | 613
Tdark 1 | 6,588

IMPC Phenotype

preweaning lethality, complete... 4 | 979
embryonic lethality prior to o... 3 | 239
embryonic lethality prior to t... 3 | 278
abnormal bone structure 2 | 187
increased mean corpuscular vol... 2 | 92
abnormal coat- hair morphology 1 | 19
abnormal embryo turning 1 | 31
abnormal hair texture 1 | 4
abnormal retina morphology 1 | 71
decreased blood urea nitrogen ... 1 | 51
decreased body weight 1 | 161
decreased bone mineral density 1 | 126
decreased circulating glucose ... 1 | 126
decreased lean body mass 1 | 135
decreased total body fat amoun... 1 | 207
hypoactivity 1 | 132
increased circulating alkaline... 1 | 122
increased circulating potassiu... 1 | 29
increased erythrocyte cell num... 1 | 39
increased heart weight 1 | 62
increased hematocrit 1 | 46
increased mean corpuscular hem... 1 | 36
increased total body fat amoun... 1 | 134

Disease

ovarian cancer 39 | 8,520
Carcinoma 37 | 11,493
osteosarcoma 34 | 7,950
Cancer 30 | 2,499
lung cancer 27 | 4,740
group 3 medulloblastoma 26 | 4,104
medulloblastoma, large-cell 23 | 6,241
psoriasis 23 | 6,694
Breast cancer 22 | 3,578
glioblastoma 20 | 5,792
Xeroderma pigmentosum 19 | 43
atypical teratoid / rhabdoid tumor 19 | 5,112
Autosomal recessive predisposition 16 | 1,442
Cockayne syndrome 15 | 60
primitive neuroectodermal tumor 15 | 3,035
Waldenstrons macroglobulinemia 14 | 765
intraductal papillary-mucinous neoplasm (IPMN) 13 | 3,291
malignant mesothelioma 13 | 3,232
Adenocarcinoma of lung 12 | 142
Melanoma 12 | 711
ependymoma 12 | 4,679
adult high grade glioma 11 | 3,801
lung adenocarcinoma 11 | 2,716
Adenocarcinoma of lung (disorder) 10 | 60
Kidney cancer 10 | 2,613
Short stature 10 | 531
intraductal papillary-mucinous carcinoma (IPMC) 10 | 2,989
invasive ductal carcinoma 10 | 2,951
nasopharyngeal carcinoma 10 | 1,058
non-small cell lung cancer 10 | 2,890
Basal cell carcinoma 9 | 54
Cryptorchidism 9 | 296
Intellectual disability 9 | 1,016
Multiple myeloma 9 | 1,332
Photosensitivity of skin 9 | 51
Small head 9 | 374
Atrophic condition of skin 8 | 25
Cataract 8 | 297
Dull intelligence 8 | 645
Electroencephalogram abnormal 8 | 101
Lens Opacities 8 | 231
Low intelligence 8 | 645
Mental Retardation 8 | 645
Mental deficiency 8 | 645
Poor school performance 8 | 645
Prostatic Neoplasms 8 | 495
Seizures 8 | 596
Stomach Neoplasms 8 | 300
diabetes mellitus 8 | 1,728
oligodendroglioma 8 | 2,850
subependymal giant cell astrocytoma 8 | 2,287
Basal cell nevi 7 | 23
Colorectal Neoplasms 7 | 243
Dry skin 7 | 75
Epilepsy 7 | 792
Failure to gain weight 7 | 365
Fanconi anemia 7 | 56
Fatigue 7 | 182
Hyperpigmented macules 7 | 42
Hypogonadism 7 | 173
Hypoplastic mandible condyle 7 | 275
Impaired cognition 7 | 96
Keratitis 7 | 62
Mandibular hypoplasia 7 | 275
Mental impairment 7 | 95
Micrognathism 7 | 275
Pediatric failure to thrive 7 | 365
Sensorineural Hearing Loss (disorder) 7 | 284
Strabismus 7 | 270
Xerosis 7 | 75
breast carcinoma 7 | 1,638
dermatomyositis 7 | 966
Acquired scoliosis 6 | 281
Cerebellar Ataxia 6 | 304
Conjunctival telangiectasis 6 | 14
Curvature of spine 6 | 282
Deafness 6 | 198
Dental abnormalities 6 | 60
Fever 6 | 138
Freckles 6 | 33
Hyperkeratosis 6 | 50
Lung Neoplasms 6 | 232
Lynch syndrome 6 | 35
Muscle hypotonia 6 | 571
Neurodegenerative disease 6 | 414
Papilloma 6 | 44
Photodysphoria 6 | 121
Photophobia 6 | 121
Pick disease 6 | 1,894
Poikiloderma 6 | 14
Thin skin 6 | 47
Tooth Abnormalities 6 | 69
astrocytoma 6 | 1,146
hypopigmented skin patch 6 | 59
Endometrial cancer 5 | 311
Loss of developmental milestones 5 | 95
hepatocellular carcinoma 5 | 547
juvenile dermatomyositis 5 | 1,187
pancreatic cancer 5 | 2,398
pituitary cancer 5 | 1,972

Tissue

Blood and immune system 56 | 16,909
Digestive Tract 56 | 17,369
Endocrine System 56 | 18,159
Female tissues 56 | 17,400
Liver and Pancreas 56 | 16,750
Male tissues 56 | 17,142
Nervous System 56 | 16,725
Respiratory system 56 | 16,393
Skin and soft tissues 56 | 17,230
Urinary Tract 56 | 16,678
Cardiovascular System 54 | 15,192

Target Family

Non-IDG 27 | 12,091
Enzyme 21 | 4,145
Transcription Factor 5 | 1,400
Epigenetic 4 | 242

GO Function

damaged DNA binding 57 | 57
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA endonuclease RBBP8 RBBP8 Tbio Enzyme -2.17933 148.4 308
G/T mismatch-specific thymine DNA glycosylase TDG Tbio Enzyme -2.46252 297.6 225
TP53-binding protein 1 TP53BP1 Tbio Epigenetic -2.69485 464.8 577
Uracil-DNA glycosylase UNG Tbio Enzyme -2.82957 680.9 352
DNA polymerase iota POLI Tbio Enzyme -3.24008 1701.9 333
N-glycosylase/DNA lyase OGG1 Tbio Enzyme -3.26147 1834.9 293
40S ribosomal protein S3 RPS3 Tbio Non-IDG -2.19489 157.7 218
Replication protein A 14 kDa subunit RPA3 Tbio Non-IDG -1.85941 67.1 171
High mobility group protein B2 HMGB2 Tbio Transcription Factor -1.52510 34.5 267
Putative short transient receptor potential channel 2-like protein N/A Tdark Non-IDG 0.00000 2