Development Level

Tchem 8 | 1,598
Tbio 2 | 11,445

IMPC Phenotype

preweaning lethality, complete... 1 | 979

Disease

Cancer 8 | 2,499
Carcinoma 6 | 11,493
lung cancer 6 | 4,740
ovarian cancer 6 | 8,520
glioblastoma 5 | 5,792
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,291
Myocardial Reperfusion Injury 4 | 37
group 3 medulloblastoma 4 | 4,104
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,989
lung carcinoma 4 | 2,843
osteosarcoma 4 | 7,950
psoriasis 4 | 6,694
Alzheimer's disease 3 | 658
Breast cancer 3 | 3,578
Edema 3 | 81
Toxic encephalopathy 3 | 141
adrenocortical carcinoma 3 | 1,428
adult high grade glioma 3 | 3,801
cutaneous lupus erythematosus 3 | 1,057
ulcerative colitis 3 | 1,819
Amyotrophic lateral sclerosis 2 | 451
Astrocytoma, Pilocytic 2 | 3,081
Atopic dermatitis 2 | 952
Autoimmune lymphoproliferative syndrome 2 | 11
Bipolar Disorder 2 | 666
Brain Ischemia 2 | 110
Breast Neoplasms 2 | 445
Carcinoma, Non-Small-Cell Lung 2 | 107
Cerebral Hemorrhage 2 | 42
Diabetes Mellitus, Non-Insulin-Dependent 2 | 145
Diabetes Mellitus, Type 2 2 | 142
Huntington's disease 2 | 76
Hypertrophic cardiomyopathy 1 2 | 2
Mammary Neoplasms 2 | 425
Melanoma 2 | 711
Nervous System Diseases 2 | 53
Parkinson's disease 2 | 392
Reperfusion Injury 2 | 86
Retinal Detachment 2 | 51
Skin Neoplasms 2 | 69
Somatic mutation 2 | 61
Splenomegaly 2 | 190
Status Epilepticus 2 | 98
Stomach Neoplasms 2 | 300
Type 1 diabetes mellitus 17 2 | 2
Vascular disease 2 | 319
atypical teratoid / rhabdoid tumor 2 | 5,112
colon cancer 2 | 1,478
ependymoma 2 | 4,679
interstitial cystitis 2 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,955
invasive ductal carcinoma 2 | 2,951
juvenile dermatomyositis 2 | 1,187
lung adenocarcinoma 2 | 2,716
malignant mesothelioma 2 | 3,232
medulloblastoma, large-cell 2 | 6,241
nervous system disorder 2 | 53
non-small cell lung carcinoma 2 | 317
primitive neuroectodermal tumor 2 | 3,035
subependymal giant cell astrocytoma 2 | 2,287
Adenocarcinoma 1 | 122
Autoimmune thrombocytopenia 1 | 22
Barrett's esophagus 1 | 182
Brain disease 1 | 96
Calcinosis 1 | 70
Carcinoma, Renal Cell 1 | 124
Carcinoma, Squamous Cell 1 | 110
Carcinoma, squamous cell of head and neck 1 | 31
Diabetes Mellitus, Experimental 1 | 108
Eosinophilia 1 | 28
Esophageal Neoplasms 1 | 69
Heart valve disease 1 | 39
Hyperglycemia 1 | 137
Idiopathic thrombocytopenia 1 | 22
Immune thrombocytopenic purpura 1 | 24
Increased IgM levels 1 | 16
Increased hepatocellular carcinoma risk 1 | 27
Increased incidence of hepatocellular carcinoma 1 | 27
Leukemia, Myelocytic, Acute 1 | 120
Leukemia, Myeloid, Acute 1 | 105
Liver disease 1 | 237
Lymphadenopathy 1 | 62
Lymphoma, Extranodal NK-T-Cell 1 | 2
MYELODYSPLASTIC SYNDROME 1 | 53
Micronodular cirrhosis 1 | 12
Myelodysplastic Syndromes 1 | 26
Neoplasm of stomach 1 | 11
Nephritis 1 | 51
Nephrotic Syndrome 1 | 78
Pancreatitis 1 | 123
Peripheral Neuropathy 1 | 134
Renal Cell Carcinoma 1 | 214
Sepsis 1 | 24
Squamous cell carcinoma 1 | 129
Squamous cell carcinoma of the head and neck 1 | 29
Stomach cancer 1 | 30
Subacute progressive viral hepatitis 1 | 9
Subarachnoid Hemorrhage 1 | 7
Vitiligo 1 | 73
esophageal cancer 1 | 22

Tissue

Digestive Tract 10 | 17,369
Endocrine System 10 | 18,159
Female tissues 10 | 17,400
Skin and soft tissues 10 | 17,230
Urinary Tract 10 | 16,678
Blood and immune system 9 | 16,909
Cardiovascular System 9 | 15,192
Liver and Pancreas 9 | 16,750
Male tissues 9 | 17,142
Nervous System 9 | 16,725
Respiratory system 8 | 16,393

Target Family

Enzyme 9 | 4,145
Non-IDG 1 | 12,091

GO Function

cysteine-type endopeptidase ac... 10 | 10
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Caspase-8 CASP8 Tchem Enzyme -3.54224 3121.4 1045
Caspase-9 CASP9 Tchem Enzyme -3.44725 2332.0 1313
Caspase-7 CASP7 Tchem Enzyme -2.69052 418.1 800
Caspase-3 CASP3 Tchem Enzyme -4.32112 18132.3 1689
CASP8 and FADD-like apoptosis regulator CFLAR Tbio Non-IDG -2.89793 871.7 683
Caspase-2 CASP2 Tchem Enzyme -2.62373 431.8 571
Caspase-6 CASP6 Tchem Enzyme -2.49135 293.6 874
Caspase-10 CASP10 Tchem Enzyme -1.97653 89.1 457
Caspase-14 CASP14 Tchem Enzyme -1.81937 73.7 348
Caspase recruitment domain-containing protein 18 CARD18 Tbio Enzyme -0.58418 4.10 46