Development Level

Tchem 29 | 1,388
Tbio 27 | 11,651

IMPC Phenotype

preweaning lethality, complete... 5 | 979
decreased body weight 2 | 161
decreased lean body mass 2 | 135
decreased prepulse inhibition 2 | 82
increased circulating alkaline... 2 | 122
increased circulating glucose ... 2 | 24
increased mean corpuscular hem... 2 | 96
short tibia 2 | 97
abnormal behavior 1 | 298
abnormal iris morphology 1 | 13
abnormal spine curvature 1 | 9
abnormal vibrissa morphology 1 | 25
decreased KLRG1+ CD4 alpha bet... 1 | 5
decreased KLRG1+ CD8 alpha bet... 1 | 2
decreased basophil cell number 1 | 16
decreased blood urea nitrogen ... 1 | 51
decreased bone mineral content 1 | 151
decreased circulating aspartat... 1 | 34
decreased circulating bilirubi... 1 | 19
decreased circulating serum al... 1 | 82
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular vol... 1 | 79
decreased startle reflex 1 | 75
decreased total body fat amoun... 1 | 207
female infertility 1 | 60
hyperactivity 1 | 148
hypoactivity 1 | 132
increased NK cell number 1 | 3
increased anti-nuclear antigen... 1 | 19
increased blood urea nitrogen ... 1 | 48
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating LDL chol... 1 | 13
increased circulating alanine ... 1 | 13
increased circulating bilirubi... 1 | 16
increased circulating choleste... 1 | 66
increased mean corpuscular vol... 1 | 92
increased mean platelet volume 1 | 45
increased neutrophil cell numb... 1 | 46
increased or absent threshold ... 1 | 101
increased total body fat amoun... 1 | 134
long tibia 1 | 25
male infertility 1 | 123
premature death 1 | 5
preweaning lethality, incomple... 1 | 499
small superior vagus ganglion 1 | 74
thrombocytopenia 1 | 56
thrombocytosis 1 | 27

Disease

Carcinoma 45 | 11,493
ovarian cancer 43 | 8,520
glioblastoma 29 | 5,792
osteosarcoma 29 | 7,950
Cancer 24 | 2,499
medulloblastoma, large-cell 24 | 6,241
lung cancer 23 | 4,740
psoriasis 21 | 6,694
atypical teratoid / rhabdoid tumor 17 | 5,112
intraductal papillary-mucinous neoplasm (IPMN) 17 | 3,291
lung carcinoma 17 | 2,843
malignant mesothelioma 16 | 3,232
adult high grade glioma 15 | 3,801
Breast cancer 13 | 3,578
diabetes mellitus 13 | 1,728
juvenile dermatomyositis 13 | 1,187
subependymal giant cell astrocytoma 13 | 2,287
ependymoma 12 | 4,679
intraductal papillary-mucinous adenoma (IPMA) 12 | 2,955
group 3 medulloblastoma 11 | 4,104
primitive neuroectodermal tumor 11 | 3,035
ulcerative colitis 11 | 1,819
Astrocytoma, Pilocytic 10 | 3,081
intraductal papillary-mucinous carcinoma (IPMC) 10 | 2,989
invasive ductal carcinoma 10 | 2,951
Atopic dermatitis 9 | 952
cutaneous lupus erythematosus 9 | 1,057
cystic fibrosis 9 | 1,696
non-small cell lung cancer 9 | 2,890
Alzheimer's disease 8 | 658
Multiple myeloma 8 | 1,332
colon cancer 8 | 1,478
tuberculosis 8 | 2,010
Autosomal recessive predisposition 7 | 1,442
Kidney cancer 7 | 2,613
Parkinson's disease 7 | 392
acute quadriplegic myopathy 7 | 1,158
adrenocortical carcinoma 7 | 1,428
dermatomyositis 7 | 966
lung adenocarcinoma 7 | 2,716
Liver Cirrhosis, Experimental 6 | 769
Vascular disease 6 | 319
active Crohn's disease 6 | 922
astrocytic glioma 6 | 2,597
breast carcinoma 6 | 1,638
esophageal adenocarcinoma 6 | 737
gastric carcinoma 6 | 807
pancreatic cancer 6 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,962
primary Sjogren syndrome 6 | 735
Arthritis 5 | 290
Carcinoma, Hepatocellular 5 | 228
Chronic hepatitis C 5 | 12
Duchenne muscular dystrophy 5 | 601
Liver carcinoma 5 | 240
Myocardial Reperfusion Injury 5 | 37
Neurodegenerative disease 5 | 414
Pick disease 5 | 1,894
group 4 medulloblastoma 5 | 1,855
interstitial cystitis 5 | 2,312
oligodendroglioma 5 | 2,850
Amyotrophic lateral sclerosis 4 | 451
Bipolar Disorder 4 | 666
Fascioliasis 4 | 17
Kidney disease 4 | 430
Obesity 4 | 678
Prostatic Neoplasms 4 | 495
Status Epilepticus 4 | 98
Stomach Neoplasms 4 | 300
Waldenstrons macroglobulinemia 4 | 765
aldosterone-producing adenoma 4 | 665
mucosa-associated lymphoid tissue lymphoma 4 | 484
pediatric high grade glioma 4 | 1,064
Atrophy of cerebellum 3 | 103
Breast Neoplasms 3 | 445
Cerebellar degeneration 3 | 103
Constipation 3 | 181
Dementia 3 | 175
Infratentorial atrophy 3 | 103
Kidney Diseases 3 | 114
Mammary Neoplasms 3 | 425
Melanoma 3 | 711
Multiple Sclerosis 3 | 540
Neoplasm Invasiveness 3 | 161
Osteoporosis 3 | 363
Rheumatoid arthritis 3 | 1,191
Schizophrenia 3 | 1,160
Short stature 3 | 531
Toxic encephalopathy 3 | 141
active ulcerative colitis 3 | 764
acute myeloid leukemia 3 | 783
hepatocellular carcinoma 3 | 547
hereditary spastic paraplegia 3 | 318
medulloblastoma 3 | 720
nephrosclerosis 3 | 333
pancreatic carcinoma 3 | 562
pituitary cancer 3 | 1,972
posterior fossa group A ependymoma 3 | 468
primary pancreatic ductal adenocarcinoma 3 | 1,109
tuberculosis and treatment for 6 months 3 | 409

Tissue

Digestive Tract 56 | 17,369
Endocrine System 56 | 18,159
Skin and soft tissues 56 | 17,230
Urinary Tract 56 | 16,678
Blood and immune system 55 | 16,909
Female tissues 55 | 17,400
Liver and Pancreas 55 | 16,750
Male tissues 55 | 17,142
Nervous System 55 | 16,725
Respiratory system 54 | 16,393
Cardiovascular System 52 | 15,192

Target Family

Enzyme 53 | 4,145
Non-IDG 3 | 12,091

GO Function

cysteine-type endopeptidase ac... 56 | 56
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ubiquitin carboxyl-terminal hydrolase 16 USP16 Tbio Enzyme -0.67094 5.97 248
Ubiquitin carboxyl-terminal hydrolase 1 USP1 Tchem Enzyme -1.88853 73.3 271
Tubulointerstitial nephritis antigen TINAG Tbio Non-IDG -1.39157 27.8 58
Ubiquitin carboxyl-terminal hydrolase 14 USP14 Tbio Enzyme -1.85726 75.4 223
Bleomycin hydrolase BLMH Tbio Enzyme -1.95282 85.4 176
Ubiquitin carboxyl-terminal hydrolase 7 USP7 Tchem Enzyme -2.26799 196.6 427
Probable ubiquitin carboxyl-terminal hydrolase FAF-X USP9X Tbio Enzyme -1.93398 83.3 216
Caspase-5 CASP5 Tchem Enzyme -2.01445 96.1 427
Ubiquitin carboxyl-terminal hydrolase 20 USP20 Tbio Enzyme -1.05149 12.7 257
Caspase-3 CASP3 Tchem Enzyme -4.32112 18132.3 1689