Development Level

Tchem 32 | 1,890
Tbio 24 | 10,625
Tdark 2 | 7,003

IMPC Term

preweaning lethality, complete... 4 | 633
decreased total body fat amoun... 3 | 186
decreased body length 2 | 108
decreased body weight 2 | 174
decreased gamma-delta T cell n... 2 | 18
increased CD4-positive, alpha ... 2 | 15
increased NK cell number 2 | 19
increased alpha-beta T cell nu... 2 | 9
increased circulating alkaline... 2 | 119
increased mean corpuscular hem... 2 | 93
short tibia 2 | 82
abnormal behavior 1 | 226
abnormal bone mineralization 1 | 55
abnormal iris morphology 1 | 12
abnormal retinal pigmentation 1 | 61
abnormal spine curvature 1 | 7
abnormal vibrissa morphology 1 | 17
decreased B cell number 1 | 30
decreased CD4-positive, CD25-p... 1 | 24
decreased Ly6C high monocyte n... 1 | 18
decreased Ly6C low monocyte nu... 1 | 23
decreased bone mineral density 1 | 126
decreased circulating aspartat... 1 | 27
decreased circulating bilirubi... 1 | 14
decreased effector memory CD4-... 1 | 6
decreased lean body mass 1 | 195
decreased leukocyte cell numbe... 1 | 54
decreased mature B cell number 1 | 25
decreased mean corpuscular vol... 1 | 50
decreased monocyte cell number 1 | 28
decreased neutrophil cell numb... 1 | 37
decreased prepulse inhibition 1 | 52
decreased startle reflex 1 | 48
hyperactivity 1 | 108
increased CD8-positive, alpha-... 1 | 11
increased T cell number 1 | 15
increased bone mineral content 1 | 92
increased bone mineral density 1 | 52
increased circulating LDL chol... 1 | 15
increased circulating bilirubi... 1 | 16
increased circulating choleste... 1 | 53
increased circulating glucose ... 1 | 16
increased grip strength 1 | 83
increased monocyte cell number 1 | 27
increased or absent threshold ... 1 | 128
premature death 1 | 5
preweaning lethality, incomple... 1 | 260
straub tail 1 | 26
thrombocytosis 1 | 23

Disease

ovarian cancer 43 | 8,484
osteosarcoma 29 | 7,933
glioblastoma 27 | 5,572
medulloblastoma, large-cell 24 | 6,234
Cancer 23 | 2,346
lung cancer 23 | 4,466
psoriasis 21 | 6,685
intraductal papillary-mucinous neoplasm (IPMN) 17 | 3,289
lung carcinoma 17 | 2,844
malignant mesothelioma 16 | 3,162
atypical teratoid / rhabdoid tumor 15 | 4,369
diabetes mellitus 13 | 1,663
juvenile dermatomyositis 13 | 1,189
subependymal giant cell astrocytoma 13 | 2,287
ulcerative colitis 13 | 2,087
intraductal papillary-mucinous adenoma (IPMA) 12 | 2,956
adult high grade glioma 11 | 2,148
primitive neuroectodermal tumor 11 | 3,031
Breast cancer 10 | 3,094
intraductal papillary-mucinous carcinoma (IPMC) 10 | 2,988
invasive ductal carcinoma 10 | 2,950
pilocytic astrocytoma 10 | 3,086
Alzheimer's disease 9 | 644
cutaneous lupus erythematosus 9 | 1,056
cystic fibrosis 9 | 1,665
non-small cell lung cancer 9 | 2,798
Atopic dermatitis 8 | 944
Multiple myeloma 8 | 1,327
colon cancer 8 | 1,475
lung adenocarcinoma 8 | 2,713
pediatric high grade glioma 8 | 2,712
Carcinoma 7 | 2,147
Parkinson's disease 7 | 364
Vascular disease 7 | 281
acute quadriplegic myopathy 7 | 1,157
adrenocortical carcinoma 7 | 1,427
dermatomyositis 7 | 933
medulloblastoma 7 | 1,524
tuberculosis 7 | 1,557
Myocardial Reperfusion Injury 6 | 34
active Crohn's disease 6 | 918
breast carcinoma 6 | 1,614
ependymoma 6 | 2,514
esophageal adenocarcinoma 6 | 737
gastric carcinoma 6 | 832
group 3 medulloblastoma 6 | 2,254
pancreatic cancer 6 | 2,300
posterior fossa group A ependymoma 6 | 1,511
primary Sjogren syndrome 6 | 789
Arthritis 5 | 248
Chronic hepatitis C 5 | 12
Duchenne muscular dystrophy 5 | 602
Liver carcinoma 5 | 217
Neurodegenerative disease 5 | 383
Pick disease 5 | 1,893
astrocytic glioma 5 | 2,241
inflammatory breast cancer 5 | 404
interstitial cystitis 5 | 2,299
oligodendroglioma 5 | 2,849
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,795
Amyotrophic Lateral Sclerosis 4 | 431
Fascioliasis 4 | 18
Kidney disease 4 | 396
Prostatic Neoplasms 4 | 471
Stomach Neoplasms 4 | 282
Toxic encephalopathy 4 | 131
Waldenstrons macroglobulinemia 4 | 765
aldosterone-producing adenoma 4 | 664
atypical teratoid/rhabdoid tumor 4 | 1,095
primary pancreatic ductal adenocarcinoma 4 | 1,271
sonic hedgehog group medulloblastoma 4 | 1,482
Edema 3 | 38
Heart disease 3 | 279
Kidney Diseases 3 | 86
Leukemia, Myelocytic, Acute 3 | 113
Mammary Neoplasms 3 | 410
Neoplasm Invasiveness 3 | 127
Renal Cell Carcinoma 3 | 199
Rheumatoid Arthritis 3 | 1,160
Status Epilepticus 3 | 85
acute myeloid leukemia 3 | 780
astrocytoma 3 | 1,493
group 4 medulloblastoma 3 | 1,875
mucosa-associated lymphoid tissue lymphoma 3 | 480
nephrosclerosis 3 | 329
non-small cell lung carcinoma 3 | 413
pancreatic carcinoma 3 | 567
pituitary cancer 3 | 1,972
posterior fossa group B ependymoma 3 | 1,530
tuberculosis and treatment for 6 months 3 | 686
Brain Ischemia 2 | 87
Contact Dermatitis 2 | 80
Diabetes Mellitus, Non-Insulin-Dependent 2 | 157
Down syndrome 2 | 548
Endometriosis 2 | 535
Hypersensitivity reaction type II disease 2 | 235
Multiple Sclerosis 2 | 498
hepatocellular carcinoma 2 | 532
progressive supranuclear palsy 2 | 674
spina bifida 2 | 1,064

Tissue

Cardiovascular System 57 | 17,958
Digestive Tract 57 | 18,473
Endocrine System 57 | 18,512
Female tissues 57 | 18,647
Liver and Pancreas 57 | 18,136
Nervous System 57 | 18,561
Skin and soft tissues 57 | 18,115
Urinary Tract 57 | 18,444
Blood and immune system 56 | 17,995
Male tissues 56 | 17,969
Respiratory system 56 | 17,484

Target Family

Enzyme 55 | 4,146
Non-IDG 3 | 11,971

GO Function

cysteine-type endopeptidase ac... 58 | 58
metal ion binding 1,917 | 1,917
ATP binding 1,467 | 1,467
DNA binding 1,432 | 1,432
zinc ion binding 1,155 | 1,155
poly(A) RNA binding 1,107 | 1,107
transcription factor activity,... 853 | 853
calcium ion binding 695 | 695
G-protein coupled receptor act... 661 | 661
protein homodimerization activ... 569 | 569
RNA binding 445 | 445
olfactory receptor activity 424 | 424
sequence-specific DNA binding 398 | 398
GTP binding 374 | 374
chromatin binding 372 | 372
protein serine/threonine kinas... 336 | 336
RNA polymerase II core promote... 332 | 332
identical protein binding 311 | 311
nucleotide binding 311 | 311
receptor binding 303 | 303
protein kinase binding 289 | 289
enzyme binding 286 | 286
cadherin binding involved in c... 277 | 277
GTPase activator activity 273 | 273
ubiquitin protein ligase bindi... 258 | 258
ubiquitin-protein transferase ... 253 | 253
serine-type endopeptidase acti... 246 | 246
transcription coactivator acti... 241 | 241
transcription factor binding 240 | 240
structural molecule activity 232 | 232
GTPase activity 231 | 231
transcriptional activator acti... 230 | 230
ligase activity 227 | 227
protein heterodimerization act... 227 | 227
structural constituent of ribo... 212 | 212
transcription regulatory regio... 202 | 202
transmembrane signaling recept... 201 | 201
RNA polymerase II regulatory r... 200 | 200
receptor activity 200 | 200
transcription corepressor acti... 198 | 198
magnesium ion binding 197 | 197
signal transducer activity 196 | 196
nucleic acid binding 184 | 184
protein kinase activity 183 | 183
carbohydrate binding 180 | 180
ubiquitin protein ligase activ... 173 | 173
RNA polymerase II transcriptio... 162 | 162
heparin binding 160 | 160
iron ion binding 141 | 141
lipid binding 136 | 136
transporter activity 136 | 136
actin binding 133 | 133
ATPase activity 132 | 132
protein C-terminus binding 129 | 129
heme binding 127 | 127
microtubule binding 123 | 123
protein tyrosine kinase activi... 119 | 119
cytokine activity 118 | 118
Ras guanyl-nucleotide exchange... 113 | 113
mRNA binding 112 | 112
metalloendopeptidase activity 112 | 112
transcriptional repressor acti... 110 | 110
structural constituent of cyto... 108 | 108
Rab GTPase binding 105 | 105
antigen binding 104 | 104
protein domain specific bindin... 102 | 102
peptide antigen binding 101 | 101
guanyl-nucleotide exchange fac... 98 | 98
protein complex binding 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 92 | 92
oxidoreductase activity 91 | 91
transcriptional activator acti... 91 | 91
actin filament binding 89 | 89
hydrolase activity 89 | 89
ion channel binding 89 | 89
protein tyrosine phosphatase a... 88 | 88
electron carrier activity 87 | 87
protease binding 87 | 87
histone binding 86 | 86
integrin binding 83 | 83
growth factor activity 82 | 82
phospholipid binding 82 | 82
single-stranded DNA binding 81 | 81
unfolded protein binding 77 | 77
kinase activity 75 | 75
thiol-dependent ubiquitin-spec... 75 | 75
phosphatidylinositol binding 74 | 74
calmodulin binding 73 | 73
histone deacetylase binding 73 | 73
Rho guanyl-nucleotide exchange... 72 | 72
drug binding 71 | 71
double-stranded DNA binding 70 | 70
peptidase activity 70 | 70
protein N-terminus binding 70 | 70
virus receptor activity 68 | 68
beta-catenin binding 67 | 67
microtubule motor activity 67 | 67
protein transporter activity 67 | 67
calcium channel activity 66 | 66
ubiquitin binding 66 | 66

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Cysteine protease ATG4A ATG4A Tbio Enzyme -0.98696 7.89 199
Ubiquitin carboxyl-terminal hydrolase 11 USP11 Tbio Enzyme -1.06624 14.9 210
Probable ubiquitin carboxyl-terminal hydrolase FAF-X USP9X Tbio Enzyme -1.79254 69.5 187
Ubiquitin carboxyl-terminal hydrolase 7 USP7 Tchem Enzyme -2.17350 165.7 375
Caspase-4 CASP4 Tchem Enzyme -2.14048 137.5 459
Caspase-5 CASP5 Tchem Enzyme -1.99198 92.6 359
Bleomycin hydrolase BLMH Tbio Enzyme -1.93422 85.3 168
Ubiquitin carboxyl-terminal hydrolase 8 USP8 Tchem Enzyme -1.64199 52.9 189
Dipeptidyl peptidase 1 CTSC Tchem Enzyme -3.22597 1740.5 143
Cysteine protease ATG4B ATG4B Tchem Enzyme -1.63370 46.4 338