Development Level

Tchem 20 | 1,598
Tbio 7 | 11,445
Tclin 2 | 613
Tdark 1 | 6,588

Collection

Kinase: IDG Consortium (Target... 8 | 125
RFA-RM-18-021 8 | 328
Kinase: IDG Consortium (Comple... 5 | 37

IMPC Phenotype

preweaning lethality, complete... 4 | 979
abnormal heart morphology 3 | 162
preweaning lethality, incomple... 3 | 499
abnormal embryo size 2 | 220
abnormal epididymis morphology 2 | 42
abnormal spleen morphology 2 | 55
embryonic lethality prior to o... 2 | 239
embryonic lethality prior to t... 2 | 278
enlarged epididymis 2 | 31
enlarged heart 2 | 210
abnormal embryo turning 1 | 31
abnormal eye morphology 1 | 68
abnormal lung morphology 1 | 26
abnormal neural tube closure 1 | 46
abnormal seminal vesicle morph... 1 | 114
abnormal skin morphology 1 | 50
abnormal testis morphology 1 | 43
decreased circulating insulin ... 1 | 76
decreased circulating magnesiu... 1 | 13
decreased vertical activity 1 | 208
edema 1 | 59
enlarged heart atrium 1 | 4
enlarged spleen 1 | 41
female infertility 1 | 60
hyperactivity 1 | 148
increased heart rate 1 | 23
increased startle reflex 1 | 112
male infertility 1 | 123
microphthalmia 1 | 26
shortened RR interval 1 | 17
small seminal vesicle 1 | 10
small superior vagus ganglion 1 | 74
small testis 1 | 58
urinary bladder obstruction 1 | 4

Disease

ovarian cancer 19 | 8,520
Carcinoma 18 | 11,493
medulloblastoma, large-cell 17 | 6,241
psoriasis 16 | 6,694
Cancer 14 | 2,499
osteosarcoma 14 | 7,950
glioblastoma 13 | 5,792
lung cancer 13 | 4,740
atypical teratoid / rhabdoid tumor 11 | 5,112
group 3 medulloblastoma 11 | 4,104
malignant mesothelioma 11 | 3,232
adult high grade glioma 10 | 3,801
primitive neuroectodermal tumor 10 | 3,035
ependymoma 9 | 4,679
Breast cancer 7 | 3,578
colon cancer 7 | 1,478
oligodendroglioma 7 | 2,850
Astrocytoma, Pilocytic 6 | 3,081
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 6 | 2,989
lung adenocarcinoma 6 | 2,716
nasopharyngeal carcinoma 6 | 1,058
pancreatic cancer 6 | 2,398
tuberculosis 6 | 2,010
adrenocortical carcinoma 5 | 1,428
cystic fibrosis 5 | 1,696
ductal carcinoma in situ 5 | 1,745
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,291
invasive ductal carcinoma 5 | 2,951
non-small cell lung cancer 5 | 2,890
subependymal giant cell astrocytoma 5 | 2,287
Carcinoma, Hepatocellular 4 | 228
Kidney cancer 4 | 2,613
Liver carcinoma 4 | 240
Mammary Neoplasms, Experimental 4 | 154
Pick disease 4 | 1,894
Stomach Neoplasms 4 | 300
astrocytic glioma 4 | 2,597
astrocytoma 4 | 1,146
pituitary cancer 4 | 1,972
primary pancreatic ductal adenocarcinoma 4 | 1,109
Adenoma 3 | 167
Atopic dermatitis 3 | 952
Endometriosis 3 | 540
Hormone receptor positive malignant neoplasm of breast 3 | 10
Human epidermal growth factor 2 negative carcinoma of breast 3 | 3
Hyperparathyroidism 3 | 48
Liver Cirrhosis, Experimental 3 | 769
Lung Neoplasms 3 | 232
Meckel syndrome 3 | 46
Melanoma 3 | 711
Parathyroid Adenoma 3 | 19
Prostatic Neoplasms 3 | 495
Rheumatoid arthritis 3 | 1,191
breast carcinoma 3 | 1,638
interstitial cystitis 3 | 2,312
lung carcinoma 3 | 2,843
medulloblastoma 3 | 720
ulcerative colitis 3 | 1,819
Abdominal pain, episodic 2 | 9
Acromegaly 2 | 51
Adrenal cortical adenoma 2 | 19
Anemia 2 | 365
Animal Mammary Neoplasms 2 | 136
Brain Neoplasms 2 | 33
Breast Neoplasms 2 | 445
Carcinoma, Transitional Cell 2 | 32
Cell Transformation, Neoplastic 2 | 97
Chloracne 2 | 32
Colonic Neoplasms 2 | 142
Congenital hereditary endothelial dystrophy of cornea 2 | 8
Diarrhea 2 | 253
Esophageal Squamous Cell Carcinoma 2 | 77
Esophagitis 2 | 35
Hypercalcemia 2 | 59
Hyperinsulinaemic hypoglycaemia 2 | 16
Increased serum parathyroid hormone 2 | 14
Insulinoma 2 | 24
Intestinal Neoplasms 2 | 12
Kidney Diseases 2 | 114
Kidney Neoplasm 2 | 29
Kidney Neoplasms 2 | 37
Liver neoplasms 2 | 130
Lymphoid leukemia 2 | 160
Mammary Neoplasms 2 | 425
Mammary Neoplasms, Animal 2 | 136
Mesothelioma, Malignant 2 | 105
Neoplasms, Experimental 2 | 40
Neoplastic Cell Transformation 2 | 89
Papilloma 2 | 44
Philadelphia chromosome-positive acute lymphoblastic leukemia 2 | 47
Prolactinoma 2 | 11
Schizophrenia 2 | 1,160
Squamous cell carcinoma of esophagus 2 | 77
Stomach cancer 2 | 30
Waldenstrons macroglobulinemia 2 | 765
acute myeloid leukemia 2 | 783
intermittent abdominal pain 2 | 9
juvenile dermatomyositis 2 | 1,187
primary Sjogren syndrome 2 | 735

Tissue

Blood and immune system 29 | 16,909
Digestive Tract 29 | 17,369
Endocrine System 29 | 18,159
Female tissues 29 | 17,400
Liver and Pancreas 29 | 16,750
Male tissues 29 | 17,142
Nervous System 29 | 16,725
Respiratory system 29 | 16,393
Skin and soft tissues 29 | 17,230
Urinary Tract 29 | 16,678
Cardiovascular System 28 | 15,192

Target Family

Kinase 23 | 634
Non-IDG 5 | 12,091
Enzyme 2 | 4,145

GO Function

cyclin-dependent protein serin... 30 | 30
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Cyclin-dependent kinase 20 CDK20 Tbio Kinase -1.82269 67.7 248
Cyclin-dependent kinase 12 CDK12 Tchem Kinase -1.38476 29.4 157
MAPK/MAK/MRK overlapping kinase MOK Tbio Kinase -1.78079 60.3 312
Cyclin-dependent kinase 19 CDK19 Tchem Kinase -1.35400 18.0 154
Cyclin-dependent-like kinase 5 CDK5 Tchem Kinase -3.06393 1238.4 694
Cyclin-dependent kinase 6 CDK6 Tclin Kinase -2.71197 390.1 730
Cyclin-dependent kinase 3 CDK3 Tchem Kinase -1.44123 25.3 65
G2/mitotic-specific cyclin-B1 CCNB1 Tchem Non-IDG -3.14393 1189.3 1251
Cyclin-dependent kinase inhibitor 1 CDKN1A Tbio Enzyme -3.43737 3042.8 1509
G1/S-specific cyclin-D1 CCND1 Tchem Non-IDG -3.82232 5737.3 1312