Development Level

Tbio 30 | 11,445
Tchem 10 | 1,598
Tclin 5 | 613
Tdark 1 | 6,588

IMPC Phenotype

preweaning lethality, complete... 8 | 979
abnormal behavior 3 | 298
abnormal bone structure 3 | 187
decreased bone mineral density 3 | 126
decreased total body fat amoun... 3 | 207
increased hemoglobin content 3 | 45
preweaning lethality, incomple... 3 | 499
thin ventricular wall 3 | 24
abnormal eye morphology 2 | 68
abnormal lens morphology 2 | 81
cataract 2 | 92
decreased body length 2 | 101
decreased body weight 2 | 161
decreased erythrocyte cell num... 2 | 62
decreased grip strength 2 | 116
decreased heart left ventricle... 2 | 28
decreased lean body mass 2 | 135
embryonic lethality prior to t... 2 | 278
enlarged heart 2 | 210
increased circulating triglyce... 2 | 42
increased total body fat amoun... 2 | 134
abnormal bone mineralization 1 | 38
abnormal embryo size 1 | 220
abnormal forebrain development 1 | 20
abnormal gait 1 | 69
abnormal head morphology 1 | 10
abnormal heart left ventricle ... 1 | 16
abnormal heart morphology 1 | 162
abnormal hindbrain development 1 | 16
abnormal iris morphology 1 | 13
abnormal locomotor activation 1 | 16
abnormal neural tube closure 1 | 46
abnormal pupil morphology 1 | 2
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal seminal vesicle morph... 1 | 114
abnormal startle reflex 1 | 15
aorta stenosis 1 | 2
cardiovascular system phenotyp... 1 | 36
decreased CD4-positive, alpha ... 1 | 7
decreased CD8-positive, alpha-... 1 | 8
decreased T cell number 1 | 15
decreased bone mineral content 1 | 151
decreased cardiac output 1 | 3
decreased caudal vertebrae num... 1 | 53
decreased circulating LDL chol... 1 | 38
decreased circulating alkaline... 1 | 46
decreased circulating total pr... 1 | 49
decreased circulating triglyce... 1 | 79
decreased heart rate 1 | 18
decreased hemoglobin content 1 | 68
decreased lumbar vertebrae num... 1 | 2
decreased mean platelet volume 1 | 25
decreased neutrophil cell numb... 1 | 42
decreased sacral vertebrae num... 1 | 1
decreased threshold for audito... 1 | 26
decreased vertical activity 1 | 208
impaired glucose tolerance 1 | 75
increased B cell number 1 | 9
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating calcium ... 1 | 34
increased circulating choleste... 1 | 66
increased circulating fructosa... 1 | 13
increased circulating serum al... 1 | 22
increased circulating total pr... 1 | 28
increased lean body mass 1 | 172
increased lumbar vertebrae num... 1 | 1
increased or absent threshold ... 1 | 101
increased sacral vertebrae num... 1 | 1
mammalian phenotype 1 | 17
short tibia 1 | 97
thrombocytopenia 1 | 56

Disease

Carcinoma 39 | 11,493
ovarian cancer 29 | 8,520
osteosarcoma 28 | 7,950
psoriasis 27 | 6,694
atypical teratoid / rhabdoid tumor 24 | 5,112
glioblastoma 24 | 5,792
medulloblastoma, large-cell 24 | 6,241
primitive neuroectodermal tumor 24 | 3,035
lung cancer 22 | 4,740
Cancer 21 | 2,499
Breast cancer 17 | 3,578
intraductal papillary-mucinous adenoma (IPMA) 17 | 2,955
adult high grade glioma 16 | 3,801
ependymoma 16 | 4,679
group 3 medulloblastoma 16 | 4,104
intraductal papillary-mucinous neoplasm (IPMN) 16 | 3,291
Schizophrenia 15 | 1,160
intraductal papillary-mucinous carcinoma (IPMC) 15 | 2,989
Pick disease 13 | 1,894
Kidney cancer 12 | 2,613
Obesity 12 | 678
ductal carcinoma in situ 12 | 1,745
oligodendroglioma 12 | 2,850
Rheumatoid arthritis 11 | 1,191
astrocytic glioma 11 | 2,597
invasive ductal carcinoma 11 | 2,951
malignant mesothelioma 11 | 3,232
non-small cell lung cancer 11 | 2,890
subependymal giant cell astrocytoma 11 | 2,287
colon cancer 10 | 1,478
ulcerative colitis 10 | 1,819
Alzheimer's disease 9 | 658
Bipolar Disorder 9 | 666
pancreatic cancer 9 | 2,398
Astrocytoma, Pilocytic 8 | 3,081
Endometriosis 8 | 540
acute quadriplegic myopathy 8 | 1,158
breast carcinoma 8 | 1,638
group 4 medulloblastoma 8 | 1,855
interstitial cystitis 8 | 2,312
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,962
Depressive disorder 7 | 409
adrenocortical carcinoma 7 | 1,428
astrocytoma 7 | 1,146
cystic fibrosis 7 | 1,696
diabetes mellitus 7 | 1,728
lung adenocarcinoma 7 | 2,716
pituitary cancer 7 | 1,972
spina bifida 7 | 1,074
Amyotrophic lateral sclerosis 6 | 451
Breast Neoplasms 6 | 445
Epilepsy 6 | 792
Liver cancer 6 | 604
Mammary Neoplasms 6 | 425
Mental Depression 6 | 333
Mood Disorders 6 | 184
Multiple myeloma 6 | 1,332
Seasonal affective disorder 6 | 28
Vascular disease 6 | 319
esophageal adenocarcinoma 6 | 737
juvenile dermatomyositis 6 | 1,187
Acquired metabolic disease 5 | 336
Adenocarcinoma 5 | 122
Atopic dermatitis 5 | 952
Autosomal recessive predisposition 5 | 1,442
Diabetes Mellitus, Experimental 5 | 108
Diabetes Mellitus, Non-Insulin-Dependent 5 | 145
Diabetes Mellitus, Type 2 5 | 142
Intellectual disability 5 | 1,016
Major Depressive Disorder 5 | 301
Neoplasm Metastasis 5 | 168
Osteoporosis 5 | 363
Prostatic Neoplasms 5 | 495
Waldenstrons macroglobulinemia 5 | 765
aldosterone-producing adenoma 5 | 665
cutaneous lupus erythematosus 5 | 1,057
gastric cancer 5 | 459
lung carcinoma 5 | 2,843
Animal Mammary Neoplasms 4 | 136
Atherosclerosis 4 | 291
Bladder Neoplasm 4 | 112
Carcinoma, Hepatocellular 4 | 228
Female infertility 4 | 30
Heart disease 4 | 306
Infertility 4 | 188
Infertility, Female 4 | 28
Liver Cirrhosis, Experimental 4 | 769
Liver carcinoma 4 | 240
Lung Neoplasms 4 | 232
Male infertility 4 | 206
Mammary Neoplasms, Experimental 4 | 154
Myocardial Infarction 4 | 151
Seizures 4 | 596
Stomach Neoplasms 4 | 300
Urinary Bladder Neoplasms 4 | 114
dermatomyositis 4 | 966
hepatocellular carcinoma 4 | 547
nasopharyngeal carcinoma 4 | 1,058
pediatric high grade glioma 4 | 1,064
tuberculosis 4 | 2,010

Tissue

Endocrine System 46 | 18,159
Skin and soft tissues 45 | 17,230
Digestive Tract 44 | 17,369
Liver and Pancreas 44 | 16,750
Male tissues 44 | 17,142
Blood and immune system 43 | 16,909
Cardiovascular System 43 | 15,192
Female tissues 43 | 17,400
Nervous System 43 | 16,725
Respiratory system 43 | 16,393
Urinary Tract 43 | 16,678

Target Family

Transcription Factor 22 | 1,400
Non-IDG 7 | 12,091
Nuclear Receptor 7 | 48
Epigenetic 5 | 242
Enzyme 3 | 4,145
TF/Epigenetic 2 | 38

GO Function

core promoter sequence-specifi... 46 | 46
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 750 ZNF750 Tbio Non-IDG -1.00843 12.4 86
Thyroid hormone receptor-associated protein 3 THRAP3 Tbio Non-IDG -0.87769 8.81 136
Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2 SOHLH2 Tbio Transcription Factor -1.26578 21.4 126
DNA topoisomerase 1 TOP1 Tclin Enzyme -3.61701 4015.4 248
Myocardin MYOCD Tbio Non-IDG -2.37801 242.7 84
Nuclear receptor-interacting protein 1 NRIP1 Tbio Non-IDG -2.21323 183.8 155
Transcription factor SOX-9 SOX9 Tbio Transcription Factor -3.14522 1332.4 657
Nuclear receptor subfamily 4 group A member 3 NR4A3 Tbio Nuclear Receptor -2.02752 112.7 289
Pancreas/duodenum homeobox protein 1 PDX1 Tbio Transcription Factor -2.36445 252.7 605
Core histone macro-H2A.1 H2AFY Tbio Non-IDG -1.78572 69.6 95