Development Level

Tbio 53 | 11,445
Tchem 10 | 1,598
Tclin 6 | 613
Tdark 1 | 6,588

IMPC Phenotype

preweaning lethality, complete... 8 | 979
decreased body weight 4 | 161
abnormal bone mineralization 3 | 38
abnormal retina morphology 3 | 71
decreased T cell number 3 | 15
decreased bone mineral density 3 | 126
increased circulating triglyce... 3 | 42
abnormal behavior 2 | 298
abnormal bone structure 2 | 187
abnormal embryo size 2 | 220
cataract 2 | 92
decreased CD4-positive, alpha ... 2 | 7
decreased IgG1 level 2 | 8
decreased caudal vertebrae num... 2 | 53
decreased circulating LDL chol... 2 | 38
decreased circulating choleste... 2 | 93
decreased circulating glucose ... 2 | 126
decreased circulating serum al... 2 | 82
decreased circulating triglyce... 2 | 79
decreased erythrocyte cell num... 2 | 62
decreased lean body mass 2 | 135
decreased total body fat amoun... 2 | 207
embryonic growth retardation 2 | 106
embryonic lethality prior to o... 2 | 239
embryonic lethality prior to t... 2 | 278
hypoactivity 2 | 132
increased B cell number 2 | 9
increased circulating alkaline... 2 | 122
increased grip strength 2 | 41
increased mean corpuscular hem... 2 | 96
increased mean corpuscular vol... 2 | 92
thrombocytopenia 2 | 56
abnormal coat appearance 1 | 31
abnormal cornea morphology 1 | 31
abnormal craniofacial morpholo... 1 | 33
abnormal eye morphology 1 | 68
abnormal forebrain development 1 | 20
abnormal forebrain morphology 1 | 10
abnormal forelimb morphology 1 | 2
abnormal gait 1 | 69
abnormal heart morphology 1 | 162
abnormal lens morphology 1 | 81
abnormal neural tube closure 1 | 46
abnormal placenta size 1 | 20
abnormal response to tactile s... 1 | 17
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal sleep behavior 1 | 70
abnormal vertebrae morphology 1 | 18
anophthalmia 1 | 33
aorta stenosis 1 | 2
cardiovascular system phenotyp... 1 | 36
corneal opacity 1 | 32
decreased CD8-positive, alpha-... 1 | 8
decreased circulating HDL chol... 1 | 68
decreased circulating amylase ... 1 | 28
decreased circulating aspartat... 1 | 34
decreased circulating chloride... 1 | 30
decreased circulating fructosa... 1 | 30
decreased circulating glycerol... 1 | 16
decreased circulating sodium l... 1 | 22
decreased heart left ventricle... 1 | 28
decreased heart rate 1 | 18
decreased hematocrit 1 | 46
decreased mature B cell number 1 | 7
decreased mean platelet volume 1 | 25
decreased prepulse inhibition 1 | 82
decreased red blood cell distr... 1 | 41
decreased startle reflex 1 | 75
decreased threshold for audito... 1 | 26
enlarged heart 1 | 210
enlarged lymph nodes 1 | 37
enlarged uterus 1 | 11
hemorrhage 1 | 23
hydrometra 1 | 53
hyperactivity 1 | 148
impaired righting response 1 | 26
increased T cell number 1 | 6
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating calcium ... 1 | 34
increased circulating choleste... 1 | 66
increased heart weight 1 | 62
increased hemoglobin content 1 | 45
increased lactate dehydrogenas... 1 | 3
increased lean body mass 1 | 172
increased lymphocyte cell numb... 1 | 32
increased monocyte cell number 1 | 63
increased or absent threshold ... 1 | 101
increased total body fat amoun... 1 | 134
microphthalmia 1 | 26
pale yolk sac 1 | 25
pallor 1 | 34
prenatal lethality prior to he... 1 | 87
preweaning lethality, incomple... 1 | 499
short tibia 1 | 97
small superior vagus ganglion 1 | 74
syndactyly 1 | 23
thin ventricular wall 1 | 24
vertebral fusion 1 | 23

Disease

Carcinoma 55 | 11,493
ovarian cancer 41 | 8,520
Cancer 39 | 2,499
osteosarcoma 35 | 7,950
lung cancer 34 | 4,740
medulloblastoma, large-cell 30 | 6,241
glioblastoma 29 | 5,792
psoriasis 29 | 6,694
group 3 medulloblastoma 25 | 4,104
atypical teratoid / rhabdoid tumor 24 | 5,112
malignant mesothelioma 22 | 3,232
primitive neuroectodermal tumor 22 | 3,035
Breast cancer 21 | 3,578
adult high grade glioma 21 | 3,801
ependymoma 21 | 4,679
Kidney cancer 19 | 2,613
acute quadriplegic myopathy 18 | 1,158
intraductal papillary-mucinous neoplasm (IPMN) 18 | 3,291
Rheumatoid arthritis 17 | 1,191
Multiple myeloma 15 | 1,332
oligodendroglioma 15 | 2,850
intraductal papillary-mucinous carcinoma (IPMC) 14 | 2,989
non-small cell lung cancer 14 | 2,890
pancreatic cancer 13 | 2,398
Astrocytoma, Pilocytic 12 | 3,081
diabetes mellitus 12 | 1,728
intraductal papillary-mucinous adenoma (IPMA) 12 | 2,955
lung adenocarcinoma 12 | 2,716
subependymal giant cell astrocytoma 12 | 2,287
Schizophrenia 11 | 1,160
astrocytoma 11 | 1,146
juvenile dermatomyositis 11 | 1,187
Mental Depression 10 | 333
astrocytic glioma 10 | 2,597
invasive ductal carcinoma 10 | 2,951
tuberculosis 10 | 2,010
Bipolar Disorder 9 | 666
Depressive disorder 9 | 409
Obesity 9 | 678
Pick disease 9 | 1,894
dermatomyositis 9 | 966
ductal carcinoma in situ 9 | 1,745
lung carcinoma 9 | 2,843
Atopic dermatitis 8 | 952
Endometriosis 8 | 540
Intellectual disability 8 | 1,016
colon cancer 8 | 1,478
group 4 medulloblastoma 8 | 1,855
interstitial cystitis 8 | 2,312
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,962
Short stature 7 | 531
adrenocortical carcinoma 7 | 1,428
nasopharyngeal carcinoma 7 | 1,058
pituitary cancer 7 | 1,972
ulcerative colitis 7 | 1,819
Alcoholic Intoxication, Chronic 6 | 289
Breast Neoplasms 6 | 445
Down syndrome 6 | 499
Epilepsy 6 | 792
Mammary Neoplasms 6 | 425
Mood Disorders 6 | 184
Multiple Sclerosis 6 | 540
Muscle hypotonia 6 | 571
Primary cutaneous T-cell lymphoma 6 | 29
Prostatic Neoplasms 6 | 495
Waldenstrons macroglobulinemia 6 | 765
breast carcinoma 6 | 1,638
cutaneous lupus erythematosus 6 | 1,057
cystic fibrosis 6 | 1,696
gastric carcinoma 6 | 807
primary pancreatic ductal adenocarcinoma 6 | 1,109
Alzheimer's disease 5 | 658
Cognitive delay 5 | 608
Dull intelligence 5 | 645
Global developmental delay 5 | 608
Immune system cancer 5 | 140
Low intelligence 5 | 645
Major Depressive Disorder 5 | 301
Melanoma 5 | 711
Mental Retardation 5 | 645
Mental and motor retardation 5 | 608
Mental deficiency 5 | 645
Peripheral T-cell lymphoma 5 | 25
Poor school performance 5 | 645
Seizures 5 | 596
active Crohn's disease 5 | 922
acute myeloid leukemia 5 | 783
non primary Sjogren syndrome sicca 5 | 891
pediatric high grade glioma 5 | 1,064
progressive supranuclear palsy 5 | 676
spina bifida 5 | 1,074
Arthritis, Rheumatoid 4 | 174
Asthma 4 | 385
Congenital Epicanthus 4 | 177
Failure to gain weight 4 | 365
Hypoplastic mandible condyle 4 | 275
Prostate cancer 4 | 175
autosomal dominant Emery-Dreifuss muscular dystrophy 4 | 510
esophageal adenocarcinoma 4 | 737
primary Sjogren syndrome 4 | 735

Tissue

Digestive Tract 70 | 17,369
Endocrine System 69 | 18,159
Blood and immune system 68 | 16,909
Male tissues 68 | 17,142
Skin and soft tissues 68 | 17,230
Female tissues 67 | 17,400
Respiratory system 67 | 16,393
Nervous System 66 | 16,725
Urinary Tract 66 | 16,678
Liver and Pancreas 65 | 16,750
Cardiovascular System 60 | 15,192

Target Family

Transcription Factor 35 | 1,400
Non-IDG 20 | 12,091
Epigenetic 8 | 242
Enzyme 4 | 4,145
Nuclear Receptor 2 | 48
TF/Epigenetic 1 | 38

GO Function

core promoter binding 70 | 70
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Paraspeckle component 1 PSPC1 Tbio Non-IDG -1.75415 48.3 19
X-box-binding protein 1 XBP1 Tchem Transcription Factor -2.90444 780.2 514
Transcription factor PU.1 SPI1 Tbio Transcription Factor -3.05079 1139.0 397
Lysine-specific demethylase 3A KDM3A Tchem Epigenetic -1.83544 74.7 253
Steroid hormone receptor ERR2 ESRRB Tchem Nuclear Receptor -1.95523 86.9 173
Homeobox protein Nkx-3.1 NKX3-1 Tbio Transcription Factor -2.13442 140.5 524
Zinc finger protein 281 ZNF281 Tbio Transcription Factor -0.58845 5.38 140
Metal regulatory transcription factor 1 MTF1 Tbio Transcription Factor -1.98140 101.0 135
Heterogeneous nuclear ribonucleoprotein U HNRNPU Tbio Non-IDG -2.33813 207.8 169
Krueppel-like factor 4 KLF4 Tbio Transcription Factor -2.89447 774.1 686