Development Level

Tbio 5 | 11,445
Tchem 2 | 1,598
Tclin 2 | 613
Tdark 1 | 6,588

Disease

ovarian cancer 8 | 8,520
osteosarcoma 7 | 7,950
Carcinoma 6 | 11,493
Autosomal recessive predisposition 5 | 1,442
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,955
psoriasis 5 | 6,694
Seizures 4 | 596
ductal carcinoma in situ 4 | 1,745
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,989
lung adenocarcinoma 4 | 2,716
medulloblastoma, large-cell 4 | 6,241
pancreatic cancer 4 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
Cancer 3 | 2,499
Cognitive delay 3 | 608
Dull intelligence 3 | 645
Epilepsy 3 | 792
Global developmental delay 3 | 608
Highly variable severity 3 | 157
Hyperreflexia 3 | 209
Intellectual disability 3 | 1,016
Low intelligence 3 | 645
Mental Retardation 3 | 645
Mental and motor retardation 3 | 608
Mental deficiency 3 | 645
Poor school performance 3 | 645
Schizophrenia 3 | 1,160
Variable expressivity 3 | 157
atypical teratoid / rhabdoid tumor 3 | 5,112
breast carcinoma 3 | 1,638
glioblastoma 3 | 5,792
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,291
invasive ductal carcinoma 3 | 2,951
lung cancer 3 | 4,740
lung carcinoma 3 | 2,843
tuberculosis 3 | 2,010
urothelial carcinoma 3 | 318
Anemia 2 | 365
Cardiovascular system disease 2 | 246
Childhood onset 2 | 38
Dysarthria 2 | 192
Dystonia 2 | 164
Dystonic disease 2 | 106
Gait Ataxia 2 | 51
Hemoglobin low 2 | 124
Highly variable clinical phenotype 2 | 150
Highly variable phenotype and severity 2 | 150
Highly variable phenotype, even within families 2 | 150
Hypertension 2 | 396
Hypertensive disease 2 | 292
Hypokinesia 2 | 19
Infantile onset 2 | 238
Kidney Failure, Chronic 2 | 46
Liver Cirrhosis, Experimental 2 | 769
Muscle Rigidity 2 | 49
Muscle Spasticity 2 | 195
Myocardial Ischemia 2 | 169
Myopathy 2 | 185
Obesity 2 | 678
Phenotypic variability 2 | 150
active ulcerative colitis 2 | 764
adult high grade glioma 2 | 3,801
chronic rhinosinusitis 2 | 512
dermatomyositis 2 | 966
diabetes mellitus 2 | 1,728
ependymoma 2 | 4,679
gastric carcinoma 2 | 807
group 3 medulloblastoma 2 | 4,104
group 4 medulloblastoma 2 | 1,855
malignant mesothelioma 2 | 3,232
non-small cell lung carcinoma 2 | 317
primitive neuroectodermal tumor 2 | 3,035
Abnormal respiratory patterns 1 | 20
Ambiguous Genitalia 1 | 24
Anemia, Hemolytic 1 | 55
Ataxia, Appendicular 1 | 25
Congenital hemolytic anemia 1 | 32
Coughing 1 | 25
Esophagitis 1 | 35
Gynecomastia 1 | 64
Hepatocellular necrosis 1 | 14
Hypertrichosis 1 | 46
Irritation - emotion 1 | 68
Leigh syndrome 1 | 28
Liver Neoplasms, Experimental 1 | 59
Microcytic hypochromic anemia (disorder) 1 | 10
Musculoskeletal Pain 1 | 3
Nystagmus, End-Position 1 | 12
Organic writer's cramp 1 | 10
Pain 1 | 103
Phenylketonuria 1 | 20
Progressive microcephaly 1 | 32
Q fever 1 | 15
Sparse axillary hair 1 | 28
Sparse pubic hair 1 | 31
Staphyloenterotoxemia 1 | 18
Static Tremor 1 | 21
Urologic Neoplasms 1 | 8
Wilson disease 1 | 16
X-linked sideroblastic anemia 1 | 4

Tissue

Blood and immune system 9 | 16,909
Digestive Tract 9 | 17,369
Endocrine System 9 | 18,159
Female tissues 9 | 17,400
Liver and Pancreas 9 | 16,750
Male tissues 9 | 17,142
Respiratory system 9 | 16,393
Skin and soft tissues 9 | 17,230
Urinary Tract 9 | 16,678
Cardiovascular System 8 | 15,192
Nervous System 8 | 16,725

Target Family

Enzyme 9 | 4,145
Epigenetic 1 | 242

GO Function

coenzyme binding 10 | 10
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTP cyclohydrolase 1 GCH1 Tbio Enzyme -2.80099 639.3 247
Inactive L-threonine 3-dehydrogenase, mitochondrial TDH Tdark Enzyme 0.00000 0
5-aminolevulinate synthase, erythroid-specific, mitochondrial ALAS2 Tbio Enzyme -2.18341 149.7 219
WW domain-containing oxidoreductase WWOX Tbio Enzyme -3.61683 3311.4 251
GDP-L-fucose synthase TSTA3 Tbio Enzyme -1.16563 14.3 231
Glutamate--cysteine ligase catalytic subunit GCLC Tchem Enzyme -2.48963 294.6 293
3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR Tclin Enzyme -3.21450 1428.4 229
Acetyl-CoA acetyltransferase, mitochondrial ACAT1 Tchem Enzyme -1.85518 70.4 397
Alpha-tubulin N-acetyltransferase 1 ATAT1 Tbio Epigenetic -2.04403 72.3 80
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial NDUFA9 Tclin Enzyme -1.81339 55.9 170