Development Level

Tbio 10 | 11,445

IMPC Phenotype

abnormal embryo size 2 | 220
embryonic lethality prior to o... 2 | 239
preweaning lethality, complete... 2 | 979
abnormal craniofacial morpholo... 1 | 33
abnormal epididymis morphology 1 | 42
abnormal eye morphology 1 | 68
abnormal heart morphology 1 | 162
abnormal lung morphology 1 | 26
anophthalmia 1 | 33
decreased circulating alkaline... 1 | 46
decreased fasted circulating g... 1 | 65
edema 1 | 59
embryonic lethality prior to t... 1 | 278
enlarged lymph nodes 1 | 37
hyperactivity 1 | 148
hypoactivity 1 | 132
increased blood urea nitrogen ... 1 | 48
increased bone mineral density 1 | 72
increased fasted circulating g... 1 | 76
increased mean corpuscular hem... 1 | 96
pallor 1 | 34
preweaning lethality, incomple... 1 | 499
small kidney 1 | 16

Disease

Vitamin B12 deficiency 10 | 20
Carcinoma 8 | 11,493
Autosomal recessive predisposition 7 | 1,442
Methylmalonic acidemia 7 | 37
Anemia, Megaloblastic 6 | 16
osteosarcoma 5 | 7,950
ovarian cancer 5 | 8,520
Anemia 4 | 365
Dull intelligence 4 | 645
Failure to gain weight 4 | 365
Homocystinuria 4 | 21
Intellectual disability 4 | 1,016
Low intelligence 4 | 645
Megaloblastic anemia 4 | 18
Mental Retardation 4 | 645
Mental deficiency 4 | 645
Methylmalonic aciduria 4 | 9
Pediatric failure to thrive 4 | 365
Poor school performance 4 | 645
medulloblastoma, large-cell 4 | 6,241
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
Cognitive delay 3 | 608
Decreased platelet count 3 | 111
Disease of metabolism 3 | 18
Global developmental delay 3 | 608
Hyperhomocysteinemia 3 | 37
Kidney cancer 3 | 2,613
Lethargy 3 | 77
Mental and motor retardation 3 | 608
Muscle hypotonia 3 | 571
Pernicious anemia 3 | 9
Thrombocytopenia 3 | 197
psoriasis 3 | 6,694
3-Methylcrotonyl-CoA carboxylase deficiency 2 | 11
3-methylglutaconic aciduria type 1 2 | 7
Adverse reaction to drug 2 | 61
Anorexia 2 | 43
Biotinidase deficiency 2 | 14
Bipolar Disorder 2 | 666
Bone marrow megaloblastic (finding) 2 | 3
Breast cancer 2 | 3,578
Cerebral atrophy 2 | 178
Cleft Lip 2 | 141
Confusion 2 | 21
Decreased methionine synthase activity 2 | 4
Decreased methylcobalamin 2 | 4
Dementia 2 | 175
Depressive disorder 2 | 409
Drug-Related Side Effects and Adverse Reactions 2 | 62
Epilepsy 2 | 792
Feeding difficulties in infancy 2 | 175
Hyperhomocystinemia 2 | 6
Hypesthesia 2 | 7
Hypomethioninemia 2 | 4
Infantile onset 2 | 238
Leukoencephalopathies 2 | 29
Liver cancer 2 | 604
Malabsorption of vitamin B12 (cyanocobalamin) 2 | 2
Metabolic acidosis 2 | 90
Neutrophil count decreased 2 | 47
Paresthesia 2 | 32
Proteinuria 2 | 144
Schizophrenia 2 | 1,160
Seizures 2 | 596
Vitamin B12 deficiency caused by intestinal malabsorption 2 | 2
Vomiting 2 | 116
active Crohn's disease 2 | 922
lung adenocarcinoma 2 | 2,716
lung cancer 2 | 4,740
Absence of intrinsic factor 1 | 1
Blind loop syndrome 1 | 2
Bone marrow biopsy shows megaloblastic erythroid hyperplasia 1 | 1
Childhood onset 1 | 38
Comatose 1 | 56
Congenital deficiency of intrinsic factor 1 | 1
Dehydration 1 | 40
Diphyllobothriasis 1 | 6
Dyskeratosis congenita 1 | 24
Exocrine pancreatic insufficiency 1 | 32
Extrapyramidal Disorders 1 | 29
Extrapyramidal sign 1 | 29
Fatigue 1 | 182
Gastritis 1 | 47
Glossitis 1 | 4
IgG Deficiency 1 | 22
Immunoglobulin A deficiency (disorder) 1 | 19
Immunologic Deficiency Syndromes 1 | 113
Intrinsic Factor Deficiency 1 | 1
Kidney damage 1 | 25
Mean cell volume increased 1 | 5
Megaloblastic Erythroid Hyperplasia 1 | 1
Nausea and vomiting 1 | 97
Nephritis, Tubulointerstitial 1 | 8
Nephroblastoma 1 | 51
Pallor 1 | 40
Pancreatitis 1 | 123
Poor coordination 1 | 11
Tropical sprue 1 | 5
congenital intrinsic factor deficiency 1 | 1
inflammatory breast cancer 1 | 286

Tissue

Blood and immune system 10 | 16,909
Digestive Tract 10 | 17,369
Endocrine System 10 | 18,159
Female tissues 10 | 17,400
Liver and Pancreas 10 | 16,750
Male tissues 10 | 17,142
Nervous System 10 | 16,725
Skin and soft tissues 10 | 17,230
Urinary Tract 10 | 16,678
Respiratory system 9 | 16,393
Cardiovascular System 8 | 15,192

Target Family

Non-IDG 7 | 12,091
Enzyme 3 | 4,145

GO Function

cobalamin binding 10 | 10
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Methionine synthase MTR Tbio Enzyme -2.56900 300.2 87
Methylmalonic aciduria and homocystinuria type C protein MMACHC Tbio Non-IDG -1.83573 76.5 233
Methylmalonyl-CoA mutase, mitochondrial MUT Tbio Enzyme -2.51690 305.3 99
Transcobalamin-1 TCN1 Tbio Non-IDG -2.37334 221.1 146
CD320 antigen CD320 Tbio Non-IDG -1.51819 33.4 107
Cob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrial MMAB Tbio Enzyme -1.79208 63.7 92
Probable lysosomal cobalamin transporter LMBRD1 Tbio Non-IDG -2.10518 126.1 54
Gastric intrinsic factor GIF Tbio Non-IDG -3.20615 1559.4 172
Transcobalamin-2 TCN2 Tbio Non-IDG -2.72285 544.1 150
Cubilin CUBN Tbio Non-IDG -2.18842 161.0 78