Development Level

Tbio 278 | 10,625
Tchem 63 | 1,890
Tclin 16 | 602
Tdark 15 | 7,003

IMPC Phenotype

preweaning lethality, complete... 26 | 633
embryonic lethality prior to t... 11 | 187
preweaning lethality, incomple... 11 | 260
abnormal behavior 7 | 226
decreased lean body mass 7 | 195
increased or absent threshold ... 7 | 128
decreased body length 6 | 108
decreased body weight 6 | 174
decreased total body fat amoun... 6 | 186
embryonic lethality prior to o... 6 | 148
increased circulating alkaline... 6 | 119
abnormal embryo size 5 | 112
decreased circulating choleste... 5 | 85
increased grip strength 5 | 83
prenatal lethality prior to he... 5 | 64
decreased circulating HDL chol... 4 | 77
decreased circulating serum al... 4 | 79
male infertility 4 | 62
abnormal bone structure 3 | 131
abnormal coat-hair pigmentatio... 3 | 54
abnormal cornea morphology 3 | 24
decreased CD8-positive, alpha-... 3 | 26
decreased bone mineral density 3 | 126
decreased caudal vertebrae num... 3 | 49
decreased leukocyte cell numbe... 3 | 54
decreased lumbar vertebrae num... 3 | 62
decreased mean corpuscular hem... 3 | 34
enlarged heart 3 | 111
hyperactivity 3 | 108
increased effector memory CD4-... 3 | 15
increased mean corpuscular hem... 3 | 93
increased sacral vertebrae num... 3 | 62
increased total body fat amoun... 3 | 57
oligodactyly 3 | 14
abnormal bone mineralization 2 | 55
abnormal epididymis morphology 2 | 31
abnormal eye morphology 2 | 38
abnormal gait 2 | 51
abnormal heart morphology 2 | 51
abnormal kidney morphology 2 | 30
abnormal retina morphology 2 | 100
abnormal spleen morphology 2 | 36
abnormal tail morphology 2 | 17
absent vibrissae 2 | 14
corneal opacity 2 | 25
decreased KLRG1-positive NK ce... 2 | 9
decreased Ly6C low monocyte nu... 2 | 23
decreased T cell number 2 | 31
decreased bone mineral content 2 | 157
decreased circulating aspartat... 2 | 27
decreased circulating fructosa... 2 | 31
decreased circulating glucose ... 2 | 121
decreased circulating sodium l... 2 | 18
decreased circulating total pr... 2 | 41
decreased circulating triglyce... 2 | 83
decreased effector memory CD8-... 2 | 24
decreased erythrocyte cell num... 2 | 43
decreased fasted circulating g... 2 | 49
decreased grip strength 2 | 123
decreased mature B cell number 2 | 25
decreased rib number 2 | 59
embryonic growth retardation 2 | 28
increased B cell number 2 | 23
increased bone mineral content 2 | 92
increased bone mineral density 2 | 52
increased circulating choleste... 2 | 53
increased circulating creatini... 2 | 29
increased circulating triglyce... 2 | 24
small spleen 2 | 11
small testis 2 | 37
tremors 2 | 34
abnormal embryo turning 1 | 15
abnormal motor capabilities-co... 1 | 4
abnormal neural tube closure 1 | 37
abnormal neural tube morpholog... 1 | 8
abnormal retinal pigmentation 1 | 61
abnormal rib morphology 1 | 28
abnormal skin appearance 1 | 8
abnormal skin morphology 1 | 23
abnormal testis morphology 1 | 30
abnormal thoracic vertebrae mo... 1 | 16
abnormal vocalization 1 | 21
decreased CD4-positive, alpha ... 1 | 19
decreased blood urea nitrogen ... 1 | 31
decreased circulating chloride... 1 | 32
decreased circulating magnesiu... 1 | 11
decreased hematocrit 1 | 25
enlarged lymph nodes 1 | 27
female infertility 1 | 34
increased body length 1 | 20
increased circulating HDL chol... 1 | 63
increased lactate dehydrogenas... 1 | 3
increased mean corpuscular hem... 1 | 25
increased mean platelet volume 1 | 19
increased startle reflex 1 | 38
long tibia 1 | 13
persistence of hyaloid vascula... 1 | 22
small kidney 1 | 10
thrombocytopenia 1 | 46
trunk curl 1 | 15

Disease

osteosarcoma 202 | 7,933
ovarian cancer 202 | 8,491
medulloblastoma, large-cell 173 | 6,234
psoriasis 149 | 6,685
lung cancer 144 | 4,473
glioblastoma 139 | 5,572
Cancer 126 | 2,346
atypical teratoid / rhabdoid tumor 117 | 4,369
malignant mesothelioma 105 | 3,163
primitive neuroectodermal tumor 104 | 3,031
Breast cancer 87 | 3,098
Carcinoma 80 | 2,147
group 3 medulloblastoma 80 | 2,254
oligodendroglioma 80 | 2,849
pediatric high grade glioma 79 | 2,712
non-small cell lung cancer 73 | 2,798
invasive ductal carcinoma 72 | 2,950
intraductal papillary-mucinous neoplasm (IPMN) 67 | 3,289
ependymoma 64 | 2,514
intraductal papillary-mucinous carcinoma (IPMC) 64 | 2,988
lung adenocarcinoma 60 | 2,714
subependymal giant cell astrocytoma 57 | 2,287
intraductal papillary-mucinous adenoma (IPMA) 55 | 2,956
pilocytic astrocytoma 54 | 3,086
group 4 medulloblastoma 53 | 1,875
astrocytoma 52 | 1,493
Rheumatoid Arthritis 50 | 1,170
ductal carcinoma in situ 49 | 1,745
pancreatic cancer 49 | 2,300
astrocytic glioma 48 | 2,241
breast carcinoma 46 | 1,614
Multiple myeloma 45 | 1,327
pituitary cancer 43 | 1,972
colon cancer 42 | 1,475
posterior fossa group A ependymoma 41 | 1,511
interstitial cystitis 40 | 2,299
diabetes mellitus 39 | 1,663
Waldenstrons macroglobulinemia 38 | 764
adrenocortical carcinoma 38 | 1,427
lung carcinoma 38 | 2,844
pancreatic ductal adenocarcinoma liver metastasis 38 | 1,795
sonic hedgehog group medulloblastoma 38 | 1,482
ulcerative colitis 38 | 2,087
Intellectual disability 37 | 573
Pick disease 37 | 1,893
tuberculosis 35 | 1,563
acute quadriplegic myopathy 34 | 1,157
medulloblastoma 34 | 1,524
adult high grade glioma 33 | 2,148
juvenile dermatomyositis 33 | 1,189
atypical teratoid/rhabdoid tumor 32 | 1,095
dermatomyositis 30 | 966
Mammary Neoplasms 28 | 410
nasopharyngeal carcinoma 28 | 1,056
Craniofacial Abnormalities 26 | 147
acute myeloid leukemia 26 | 785
cystic fibrosis 26 | 1,670
Atopic dermatitis 24 | 944
primary pancreatic ductal adenocarcinoma 24 | 1,271
spina bifida 24 | 1,064
Endometriosis 23 | 535
primary Sjogren syndrome 22 | 788
Autistic Disorder 20 | 320
Prostatic Neoplasms 20 | 471
aldosterone-producing adenoma 20 | 664
Down syndrome 19 | 548
posterior fossa group B ependymoma 18 | 1,530
Alzheimer's disease 17 | 644
Obesity 17 | 616
non primary Sjogren syndrome sicca 17 | 840
progressive supranuclear palsy 17 | 674
tuberculosis and treatment for 6 months 16 | 686
Colorectal Neoplasms 15 | 217
gastric carcinoma 15 | 832
Liver carcinoma 14 | 217
cutaneous lupus erythematosus 14 | 1,056
esophageal adenocarcinoma 14 | 737
Polycystic Ovary Syndrome 13 | 334
pancreatic carcinoma 13 | 567
Bladder Neoplasm 12 | 109
Crohn's disease 12 | 304
IGA Glomerulonephritis 12 | 454
Lung Neoplasms 12 | 171
hepatocellular carcinoma 12 | 550
nephrosclerosis 12 | 329
Adenoid Cystic Carcinoma 11 | 99
Adenoma 11 | 165
Amyotrophic Lateral Sclerosis 11 | 432
Diabetes Mellitus, Non-Insulin-Dependent 11 | 161
Kidney disease 11 | 397
Parkinson's disease 11 | 364
Peripheral Neuropathy 11 | 303
Schizophrenia 11 | 503
Stomach Neoplasms 11 | 282
autosomal dominant Emery-Dreifuss muscular dystrophy 11 | 499
fibroadenoma 11 | 557
gastric cancer 11 | 436
inflammatory breast cancer 11 | 404
Prostate cancer 10 | 172
non-small cell lung carcinoma 10 | 413

Tissue

Nervous System 372 | 18,560
Female tissues 370 | 18,646
Endocrine System 369 | 18,511
Digestive Tract 367 | 18,472
Liver and Pancreas 366 | 18,135
Urinary Tract 366 | 18,443
Blood and immune system 364 | 17,994
Male tissues 364 | 17,968
Skin and soft tissues 363 | 18,114
Cardiovascular System 360 | 17,957
Respiratory system 353 | 17,483

Target Family

Transcription Factor 132 | 1,400
Non-IDG 118 | 11,969
Epigenetic 62 | 242
Enzyme 36 | 4,146
TF/Epigenetic 9 | 38
Kinase 8 | 634
Nuclear Receptor 5 | 48
GPCR 1 | 408
Transporter 1 | 473

GO Function

chromatin binding 372 | 372
metal ion binding 1,917 | 1,917
ATP binding 1,467 | 1,467
DNA binding 1,432 | 1,432
zinc ion binding 1,155 | 1,155
poly(A) RNA binding 1,107 | 1,107
transcription factor activity,... 853 | 853
calcium ion binding 695 | 695
G-protein coupled receptor act... 661 | 661
protein homodimerization activ... 569 | 569
RNA binding 445 | 445
olfactory receptor activity 424 | 424
sequence-specific DNA binding 398 | 398
GTP binding 374 | 374
protein serine-threonine kinas... 336 | 336
RNA polymerase II core promote... 332 | 332
identical protein binding 311 | 311
nucleotide binding 311 | 311
receptor binding 303 | 303
protein kinase binding 289 | 289
enzyme binding 286 | 286
cadherin binding involved in c... 277 | 277
GTPase activator activity 273 | 273
ubiquitin protein ligase bindi... 258 | 258
ubiquitin-protein transferase ... 253 | 253
serine-type endopeptidase acti... 246 | 246
transcription coactivator acti... 241 | 241
transcription factor binding 240 | 240
structural molecule activity 232 | 232
GTPase activity 231 | 231
transcriptional activator acti... 230 | 230
ligase activity 227 | 227
protein heterodimerization act... 227 | 227
structural constituent of ribo... 212 | 212
transcription regulatory regio... 202 | 202
transmembrane signaling recept... 201 | 201
RNA polymerase II regulatory r... 200 | 200
receptor activity 200 | 200
transcription corepressor acti... 198 | 198
magnesium ion binding 197 | 197
signal transducer activity 196 | 196
nucleic acid binding 184 | 184
protein kinase activity 183 | 183
carbohydrate binding 180 | 180
ubiquitin protein ligase activ... 173 | 173
RNA polymerase II transcriptio... 162 | 162
heparin binding 160 | 160
iron ion binding 141 | 141
lipid binding 136 | 136
transporter activity 136 | 136
actin binding 133 | 133
ATPase activity 132 | 132
protein C-terminus binding 129 | 129
heme binding 127 | 127
microtubule binding 123 | 123
protein tyrosine kinase activi... 119 | 119
cytokine activity 118 | 118
Ras guanyl-nucleotide exchange... 113 | 113
mRNA binding 112 | 112
metalloendopeptidase activity 112 | 112
transcriptional repressor acti... 110 | 110
structural constituent of cyto... 108 | 108
Rab GTPase binding 105 | 105
antigen binding 104 | 104
protein domain specific bindin... 102 | 102
peptide antigen binding 101 | 101
guanyl-nucleotide exchange fac... 98 | 98
protein complex binding 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 92 | 92
oxidoreductase activity 91 | 91
transcriptional activator acti... 91 | 91
actin filament binding 89 | 89
hydrolase activity 89 | 89
ion channel binding 89 | 89
protein tyrosine phosphatase a... 88 | 88
electron carrier activity 87 | 87
protease binding 87 | 87
histone binding 86 | 86
integrin binding 83 | 83
growth factor activity 82 | 82
phospholipid binding 82 | 82
single-stranded DNA binding 81 | 81
unfolded protein binding 77 | 77
kinase activity 75 | 75
thiol-dependent ubiquitin-spec... 75 | 75
phosphatidylinositol binding 74 | 74
calmodulin binding 73 | 73
histone deacetylase binding 73 | 73
Rho guanyl-nucleotide exchange... 72 | 72
drug binding 71 | 71
double-stranded DNA binding 70 | 70
peptidase activity 70 | 70
protein N-terminus binding 70 | 70
virus receptor activity 68 | 68
beta-catenin binding 67 | 67
microtubule motor activity 67 | 67
protein transporter activity 67 | 67
calcium channel activity 66 | 66
ubiquitin binding 66 | 66

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA-directed RNA polymerase II subunit RPB2 POLR2B Tbio Enzyme -2.47495 286.5 135
SKI family transcriptional corepressor 2 SKOR2 Tbio Non-IDG -0.51537 4.32 50
AT-rich interactive domain-containing protein 3A ARID3A Tbio Transcription Factor -2.07434 111.0 153
Mothers against decapentaplegic homolog 6 SMAD6 Tbio Transcription Factor -2.04240 90.2 423
Histone lysine demethylase PHF8 PHF8 Tchem Epigenetic -1.45177 33.5 70
Histone-lysine N-methyltransferase SUV39H1 SUV39H1 Tchem Epigenetic -2.21810 149.4 267
Paired amphipathic helix protein Sin3a SIN3A Tbio Non-IDG -1.89468 62.9 159
DNA-binding protein SATB1 SATB1 Tbio Transcription Factor -2.24334 197.9 293
Protein cramped-like CRAMP1 Tdark Non-IDG -0.35218 2.10 19
Geminin coiled-coil domain-containing protein 1 GMNC Tdark Non-IDG -0.91558 8.83 48