Development Level

Tbio 287 | 11,651
Tchem 58 | 1,388
Tdark 17 | 6,593
Tclin 16 | 612

IMPC Phenotype

preweaning lethality, complete... 53 | 979
embryonic lethality prior to t... 17 | 278
abnormal behavior 12 | 298
embryonic lethality prior to o... 12 | 239
preweaning lethality, incomple... 12 | 499
abnormal embryo size 10 | 220
decreased bone mineral density 9 | 126
decreased lean body mass 9 | 135
decreased total body fat amoun... 9 | 207
male infertility 8 | 123
enlarged heart 7 | 210
increased total body fat amoun... 7 | 134
abnormal heart morphology 6 | 162
decreased bone mineral content 6 | 151
decreased leukocyte cell numbe... 6 | 73
decreased lymphocyte cell numb... 6 | 83
increased circulating alkaline... 6 | 122
prenatal lethality prior to he... 6 | 87
decreased body weight 5 | 161
decreased circulating choleste... 5 | 93
embryonic growth retardation 5 | 106
hyperactivity 5 | 148
increased bone mineral content 5 | 108
increased bone mineral density 5 | 72
increased startle reflex 5 | 112
abnormal eye morphology 4 | 68
decreased circulating HDL chol... 4 | 68
decreased heart left ventricle... 4 | 28
female infertility 4 | 60
small superior vagus ganglion 4 | 74
abnormal bone mineralization 3 | 38
abnormal bone structure 3 | 187
abnormal coat appearance 3 | 31
abnormal cornea morphology 3 | 31
abnormal craniofacial morpholo... 3 | 33
abnormal gait 3 | 69
abnormal kidney morphology 3 | 65
abnormal neural tube closure 3 | 46
abnormal retina morphology 3 | 71
decreased circulating aspartat... 3 | 34
decreased circulating serum al... 3 | 82
decreased mean platelet volume 3 | 25
decreased neutrophil cell numb... 3 | 42
decreased vertical activity 3 | 208
hydrometra 3 | 53
hypoactivity 3 | 132
increased circulating HDL chol... 3 | 80
increased grip strength 3 | 41
increased mean platelet volume 3 | 45
increased monocyte cell number 3 | 63
long tibia 3 | 25
shortened RR interval 3 | 17
small spleen 3 | 19
thin ventricular wall 3 | 24
abnormal coat-hair pigmentatio... 2 | 64
abnormal epididymis morphology 2 | 42
abnormal lens morphology 2 | 81
abnormal seminal vesicle morph... 2 | 114
abnormal spleen morphology 2 | 55
abnormal tail morphology 2 | 25
absent vibrissae 2 | 12
cataract 2 | 92
corneal opacity 2 | 32
decreased CD4-positive, alpha ... 2 | 7
decreased CD8-positive, alpha-... 2 | 8
decreased T cell number 2 | 15
decreased body length 2 | 101
decreased caudal vertebrae num... 2 | 53
decreased circulating bilirubi... 2 | 19
decreased circulating calcium ... 2 | 36
decreased circulating fructosa... 2 | 30
decreased circulating glucose ... 2 | 126
decreased circulating insulin ... 2 | 76
decreased circulating sodium l... 2 | 22
decreased eosinophil cell numb... 2 | 24
decreased fasted circulating g... 2 | 65
decreased grip strength 2 | 116
decreased large unstained cell... 2 | 11
decreased lumbar vertebrae num... 2 | 2
decreased mean corpuscular hem... 2 | 50
decreased prepulse inhibition 2 | 82
decreased red blood cell distr... 2 | 41
decreased threshold for audito... 2 | 26
edema 2 | 59
enlarged lymph nodes 2 | 37
hemorrhage 2 | 23
improved glucose tolerance 2 | 79
increased body length 2 | 32
increased circulating aspartat... 2 | 15
increased circulating creatini... 2 | 38
increased circulating triglyce... 2 | 42
increased heart weight 2 | 62
increased lean body mass 2 | 172
increased or absent threshold ... 2 | 101
small testis 2 | 58
thrombocytopenia 2 | 56
tremors 2 | 39
vertebral transformation 2 | 12
decreased circulating amylase ... 1 | 28
decreased circulating triglyce... 1 | 79

Disease

Carcinoma 273 | 11,493
osteosarcoma 208 | 7,950
ovarian cancer 204 | 8,520
medulloblastoma, large-cell 176 | 6,241
psoriasis 153 | 6,694
glioblastoma 152 | 5,792
lung cancer 149 | 4,740
group 3 medulloblastoma 141 | 4,104
Cancer 140 | 2,499
atypical teratoid / rhabdoid tumor 139 | 5,112
malignant mesothelioma 118 | 3,232
ependymoma 108 | 4,679
primitive neuroectodermal tumor 106 | 3,035
Breast cancer 103 | 3,578
Kidney cancer 97 | 2,613
adult high grade glioma 79 | 3,801
non-small cell lung cancer 79 | 2,890
oligodendroglioma 78 | 2,850
invasive ductal carcinoma 72 | 2,951
intraductal papillary-mucinous neoplasm (IPMN) 70 | 3,291
intraductal papillary-mucinous carcinoma (IPMC) 68 | 2,989
lung adenocarcinoma 64 | 2,716
Intellectual disability 62 | 1,016
astrocytic glioma 58 | 2,597
intraductal papillary-mucinous adenoma (IPMA) 58 | 2,955
subependymal giant cell astrocytoma 52 | 2,287
Astrocytoma, Pilocytic 51 | 3,081
Rheumatoid arthritis 51 | 1,191
pancreatic cancer 51 | 2,398
ductal carcinoma in situ 49 | 1,745
breast carcinoma 47 | 1,638
pituitary cancer 45 | 1,972
Multiple myeloma 44 | 1,332
adrenocortical carcinoma 44 | 1,428
colon cancer 44 | 1,478
Short stature 43 | 531
Dull intelligence 42 | 645
Low intelligence 42 | 645
Mental Retardation 42 | 645
Mental deficiency 42 | 645
Poor school performance 42 | 645
astrocytoma 41 | 1,146
diabetes mellitus 41 | 1,728
tuberculosis 41 | 2,010
interstitial cystitis 40 | 2,312
pancreatic ductal adenocarcinoma liver metastasis 40 | 1,962
Schizophrenia 39 | 1,160
Waldenstrons macroglobulinemia 39 | 765
group 4 medulloblastoma 39 | 1,855
lung carcinoma 39 | 2,843
Autosomal recessive predisposition 37 | 1,442
Cognitive delay 37 | 608
Cryptorchidism 37 | 296
Global developmental delay 37 | 608
Mental and motor retardation 37 | 608
ulcerative colitis 37 | 1,819
Epilepsy 36 | 792
Muscle hypotonia 36 | 571
pediatric high grade glioma 36 | 1,064
Pick disease 35 | 1,894
Breast Neoplasms 33 | 445
Seizures 33 | 596
Small head 33 | 374
acute quadriplegic myopathy 33 | 1,158
Mammary Neoplasms 30 | 425
juvenile dermatomyositis 30 | 1,187
nasopharyngeal carcinoma 30 | 1,058
Autistic Disorder 29 | 364
Failure to gain weight 29 | 365
Pediatric failure to thrive 29 | 365
dermatomyositis 29 | 966
Craniofacial Abnormalities 28 | 151
Hypoplastic mandible condyle 27 | 275
Mandibular hypoplasia 27 | 275
Micrognathism 27 | 275
acute myeloid leukemia 27 | 783
Strabismus 25 | 270
cystic fibrosis 25 | 1,696
Atopic dermatitis 24 | 952
Prostatic Neoplasms 24 | 495
spina bifida 24 | 1,074
Concave bridge of nose 23 | 195
Depressed nasal bridge 23 | 195
Depressed nasal root/bridge 23 | 195
Fetal Growth Retardation 23 | 189
Infant, Small for Gestational Age 23 | 176
Intrauterine retardation 23 | 176
Obesity 23 | 678
Endometriosis 22 | 540
Orbital separation excessive 22 | 244
primary Sjogren syndrome 22 | 735
Blepharoptosis 21 | 231
medulloblastoma 21 | 720
Acquired scoliosis 20 | 281
Attention deficit hyperactivity disorder 20 | 278
Cleft Palate 20 | 271
Curvature of spine 20 | 282
Penile hypospadias 20 | 106
aldosterone-producing adenoma 20 | 665
primary pancreatic ductal adenocarcinoma 20 | 1,109

Tissue

Endocrine System 369 | 18,159
Female tissues 363 | 17,400
Digestive Tract 362 | 17,369
Male tissues 359 | 17,142
Skin and soft tissues 359 | 17,230
Blood and immune system 355 | 16,909
Liver and Pancreas 355 | 16,750
Urinary Tract 352 | 16,678
Nervous System 351 | 16,725
Respiratory system 342 | 16,393
Cardiovascular System 334 | 15,192

Target Family

Transcription Factor 129 | 1,400
Non-IDG 125 | 12,091
Epigenetic 61 | 242
Enzyme 40 | 4,145
Kinase 8 | 634
TF/Epigenetic 8 | 38
Nuclear Receptor 5 | 48
GPCR 1 | 408
Transporter 1 | 473

GO Function

chromatin binding 378 | 378
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Myeloperoxidase MPO Tchem Enzyme -3.51470 3209.3 1255
Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific NSD1 Tbio Epigenetic -2.16239 142.5 123
E1A-binding protein p400 EP400 Tbio Non-IDG -1.47248 27.6 69
General transcription factor IIH subunit 1 GTF2H1 Tbio Non-IDG -1.65323 46.0 231
Teashirt homolog 2 TSHZ2 Tbio Non-IDG -0.01649 0.78 90
Chromatin assembly factor 1 subunit A CHAF1A Tbio Non-IDG -1.60312 40.7 157
Chromatin assembly factor 1 subunit B CHAF1B Tbio Non-IDG -1.02167 9.99 181
NAD-dependent protein deacetylase sirtuin-7 SIRT7 Tbio Epigenetic -2.22094 153.0 348
WD repeat-containing protein 82 WDR82 Tbio Non-IDG -1.00294 10.5 68
Estrogen receptor ESR1 Tclin Nuclear Receptor -4.00480 8421.6 2610