Development Level

Tbio 43 | 11,445
Tchem 12 | 1,598
Tclin 4 | 613
Tdark 1 | 6,588

IMPC Phenotype

preweaning lethality, incomple... 5 | 499
preweaning lethality, complete... 4 | 979
abnormal behavior 3 | 298
hyperactivity 3 | 148
abnormal bone structure 2 | 187
abnormal embryo size 2 | 220
abnormal retina morphology 2 | 71
abnormal sleep behavior 2 | 70
decreased bone mineral density 2 | 126
decreased circulating glucose ... 2 | 126
decreased circulating triglyce... 2 | 79
decreased startle reflex 2 | 75
decreased total body fat amoun... 2 | 207
enlarged heart 2 | 210
increased circulating triglyce... 2 | 42
increased mean corpuscular hem... 2 | 96
increased mean corpuscular vol... 2 | 92
abnormal behavioral response t... 1 | 66
abnormal bone mineralization 1 | 38
abnormal coat appearance 1 | 31
abnormal coat-hair pigmentatio... 1 | 64
abnormal eye morphology 1 | 68
abnormal forebrain development 1 | 20
abnormal heart morphology 1 | 162
abnormal locomotor activation 1 | 16
abnormal neural tube closure 1 | 46
abnormal optic disc morphology 1 | 10
abnormal placenta size 1 | 20
abnormal tooth morphology 1 | 24
abnormal vertebrae morphology 1 | 18
absent pinna reflex 1 | 23
corneal opacity 1 | 32
decreased IgE level 1 | 6
decreased IgG1 level 1 | 8
decreased T cell number 1 | 15
decreased blood urea nitrogen ... 1 | 51
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased circulating alkaline... 1 | 46
decreased circulating amylase ... 1 | 28
decreased circulating chloride... 1 | 30
decreased circulating choleste... 1 | 93
decreased circulating fructosa... 1 | 30
decreased circulating serum al... 1 | 82
decreased erythrocyte cell num... 1 | 62
decreased hemoglobin content 1 | 68
decreased lean body mass 1 | 135
decreased mean corpuscular hem... 1 | 50
decreased prepulse inhibition 1 | 82
decreased red blood cell distr... 1 | 41
decreased respiratory quotient 1 | 16
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged uterus 1 | 11
female infertility 1 | 60
hydrometra 1 | 53
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
improved glucose tolerance 1 | 79
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating alkaline... 1 | 122
increased circulating calcium ... 1 | 34
increased circulating glucose ... 1 | 24
increased grip strength 1 | 41
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased monocyte cell number 1 | 63
increased or absent threshold ... 1 | 101
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
irregularly shaped pupil 1 | 7
male infertility 1 | 123
mammalian phenotype 1 | 17
mydriasis 1 | 6
pale yolk sac 1 | 25
pallor 1 | 34
prenatal lethality 1 | 28
short tibia 1 | 97
small superior vagus ganglion 1 | 74
small testis 1 | 58
thrombocytopenia 1 | 56
tremors 1 | 39
vertebral fusion 1 | 23
vertebral transformation 1 | 12

Disease

Carcinoma 49 | 11,493
ovarian cancer 35 | 8,520
psoriasis 32 | 6,694
Cancer 30 | 2,499
osteosarcoma 30 | 7,950
lung cancer 25 | 4,740
medulloblastoma, large-cell 25 | 6,241
glioblastoma 24 | 5,792
Breast cancer 20 | 3,578
atypical teratoid / rhabdoid tumor 19 | 5,112
group 3 medulloblastoma 19 | 4,104
ependymoma 16 | 4,679
oligodendroglioma 14 | 2,850
astrocytoma 13 | 1,146
intraductal papillary-mucinous neoplasm (IPMN) 13 | 3,291
lung adenocarcinoma 13 | 2,716
Multiple myeloma 12 | 1,332
diabetes mellitus 12 | 1,728
malignant mesothelioma 12 | 3,232
Kidney cancer 11 | 2,613
Rheumatoid arthritis 11 | 1,191
non-small cell lung cancer 11 | 2,890
primitive neuroectodermal tumor 11 | 3,035
adult high grade glioma 10 | 3,801
breast carcinoma 10 | 1,638
interstitial cystitis 10 | 2,312
pancreatic ductal adenocarcinoma liver metastasis 10 | 1,962
Astrocytoma, Pilocytic 9 | 3,081
Schizophrenia 9 | 1,160
astrocytic glioma 9 | 2,597
intraductal papillary-mucinous adenoma (IPMA) 9 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 9 | 2,989
invasive ductal carcinoma 9 | 2,951
pituitary cancer 9 | 1,972
Cleft Palate 8 | 271
Immune system cancer 8 | 140
Intellectual disability 8 | 1,016
Lymphoid leukemia 8 | 160
dermatomyositis 8 | 966
ulcerative colitis 8 | 1,819
Breast Neoplasms 7 | 445
Mammary Neoplasms 7 | 425
acute quadriplegic myopathy 7 | 1,158
ductal carcinoma in situ 7 | 1,745
spina bifida 7 | 1,074
Acquired scoliosis 6 | 281
Adenoid Cystic Carcinoma 6 | 99
Carcinoma, Adenoid Cystic 6 | 99
Cognitive delay 6 | 608
Craniofacial Abnormalities 6 | 151
Curvature of spine 6 | 282
Global developmental delay 6 | 608
Mental and motor retardation 6 | 608
Muscle hypotonia 6 | 571
Obesity 6 | 678
Orbital separation excessive 6 | 244
Pick disease 6 | 1,894
Waldenstrons macroglobulinemia 6 | 765
adrenocortical carcinoma 6 | 1,428
colon cancer 6 | 1,478
cystic fibrosis 6 | 1,696
gastric cancer 6 | 459
group 4 medulloblastoma 6 | 1,855
subependymal giant cell astrocytoma 6 | 2,287
Bipolar Disorder 5 | 666
Cataract 5 | 297
Dull intelligence 5 | 645
Failure to gain weight 5 | 365
Low intelligence 5 | 645
Mental Retardation 5 | 645
Mental deficiency 5 | 645
Pediatric failure to thrive 5 | 365
Poor school performance 5 | 645
Prostatic Neoplasms 5 | 495
Short stature 5 | 531
Strabismus 5 | 270
Uranostaphyloschisis 5 | 167
Vascular disease 5 | 319
acute myeloid leukemia 5 | 783
hepatocellular carcinoma 5 | 547
lung carcinoma 5 | 2,843
nasopharyngeal carcinoma 5 | 1,058
tuberculosis 5 | 2,010
Arthritis, Juvenile 4 | 126
Autosomal recessive predisposition 4 | 1,442
Broad flat nasal bridge 4 | 236
Byzanthine arch palate 4 | 194
Depressive disorder 4 | 409
Epilepsy 4 | 792
Heart disease 4 | 306
Juvenile arthritis 4 | 126
Language Delay 4 | 112
Multiple Sclerosis 4 | 540
Nasal bridge wide 4 | 236
Prostate cancer 4 | 175
Seizures 4 | 596
Small head 4 | 374
Umbilical hernia 4 | 93
pancreatic cancer 4 | 2,398
pediatric high grade glioma 4 | 1,064

Tissue

Digestive Tract 58 | 17,369
Endocrine System 58 | 18,159
Skin and soft tissues 58 | 17,230
Female tissues 56 | 17,400
Male tissues 56 | 17,142
Nervous System 56 | 16,725
Blood and immune system 54 | 16,909
Liver and Pancreas 54 | 16,750
Urinary Tract 54 | 16,678
Respiratory system 53 | 16,393
Cardiovascular System 49 | 15,192

Target Family

Transcription Factor 22 | 1,400
Non-IDG 21 | 12,091
Epigenetic 6 | 242
Enzyme 4 | 4,145
Nuclear Receptor 4 | 48
TF/Epigenetic 3 | 38

GO Function

chromatin DNA binding 60 | 60
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
X-box-binding protein 1 XBP1 Tchem Transcription Factor -2.90444 780.2 514
Forkhead box protein C2 FOXC2 Tbio Transcription Factor -2.23435 187.0 419
Lysine-specific demethylase 3A KDM3A Tchem Epigenetic -1.83544 74.7 253
Histone H1.2 HIST1H1C Tbio Non-IDG -2.01718 95.3 142
Histone H1.3 HIST1H1D Tbio Non-IDG -1.83212 63.8 66
Histone H1.5 HIST1H1B Tbio Non-IDG -2.13224 134.1 103
Inner nuclear membrane protein Man1 LEMD3 Tbio Non-IDG -2.30311 196.6 73
Heterogeneous nuclear ribonucleoprotein U HNRNPU Tbio Non-IDG -2.33813 207.8 169
Lysine-specific demethylase hairless HR Tbio Enzyme -1.13301 12.4 99
Forkhead box protein O3 FOXO3 Tbio Transcription Factor -2.94477 863.9 864